Results: Ligand

Ligand ID: 09L

Drugbank ID:
Olaparib
(DB09074)

Indication:
Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy.

LIST OF BINDING INTERFACES for query '09L'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4TKG_A_09LA1202	4tkg	09L	Olaparib (DB09074)	Homo sapiens	TANKYRASE-2	PARP	23	PHE A1030 HIS A1031 GLY A1032 SER A1033 PHE A1035 ALA A1038 ILE A1039 GLY A1043 PHE A1044 ASP A1045 HIS A1048 ALA A1049 TYR A1050 GLY A1058 ILE A1059 TYR A1060 PHE A1061 ALA A1062 LYS A1067 SER A1068 TYR A1071 ILE A1075 GLU A1138	09L A1202
4TVJ_A_09LA601	4tvj	09L	Olaparib (DB09074)	Homo sapiens	POLY [ADP-RIBOSE] POLYMERASE 2	PARP	20	GLU A 335 TRP A 427 HIS A 428 GLY A 429 GLY A 442 LEU A 443 ARG A 444 ILE A 445 ALA A 446 TYR A 455 GLY A 458 GLY A 460 ILE A 461 TYR A 462 PHE A 463 ALA A 464 LYS A 469 SER A 470 TYR A 473 GLU A 558	09L A 601
5DS3_A_09LA1102	5ds3	09L	Olaparib (DB09074)	Homo sapiens	POLY [ADP-RIBOSE] POLYMERASE 1	PARP	19	TRP A 861 HIS A 862 GLY A 863 GLY A 876 LEU A 877 ARG A 878 ILE A 879 ALA A 880 GLY A 888 TYR A 889 GLY A 894 ILE A 895 TYR A 896 PHE A 897 ALA A 898 LYS A 903 SER A 904 TYR A 907 GLU A 988	09L A1102
7KK4_A_09LA9001	7kk4	09L	Olaparib (DB09074)	Homo sapiens	POLY [ADP-RIBOSE] POLYMERASE 1	PARP PARP_reg	22	TYR A 710 ASP A 766 LEU A 769 ASP A 770 TRP A 861 HIS A 862 GLY A 863 ARG A 878 ILE A 879 ALA A 880 PRO A 881 TYR A 889 GLY A 892 GLY A 894 ILE A 895 TYR A 896 PHE A 897 ALA A 898 LYS A 903 SER A 904 TYR A 907 GLU A 988	09L A9001
7KKO_A_09LA1402	7kko	09L	Olaparib (DB09074)	Homo sapiens	POLY [ADP-RIBOSE] POLYMERASE	PARP	23	PHE A1183 HIS A1184 GLY A1185 SER A1186 PHE A1188 ALA A1191 ILE A1192 GLY A1196 PHE A1197 ASP A1198 HIS A1201 ALA A1202 TYR A1203 GLY A1211 ILE A1212 TYR A1213 PHE A1214 ALA A1215 LYS A1220 SER A1221 TYR A1224 ILE A1228 GLU A1291	09L A1402
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4TKG_A_09LA1202","4tkg","09L","Olaparib (DB09074)","Homo sapiens","TANKYRASE-2","PARP",23,"PHE A1030;HIS A1031;GLY A1032;SER A1033;PHE A1035;ALA A1038;ILE A1039;GLY A1043;PHE A1044;ASP A1045;HIS A1048;ALA A1049;TYR A1050;GLY A1058;ILE A1059;TYR A1060;PHE A1061;ALA A1062;LYS A1067;SER A1068;TYR A1071;ILE A1075;GLU A1138","09L A1202\r"],["4TVJ_A_09LA601","4tvj","09L","Olaparib (DB09074)","Homo sapiens","POLY [ADP-RIBOSE] POLYMERASE 2","PARP",20,"GLU A 335;TRP A 427;HIS A 428;GLY A 429;GLY A 442;LEU A 443;ARG A 444;ILE A 445;ALA A 446;TYR A 455;GLY A 458;GLY A 460;ILE A 461;TYR A 462;PHE A 463;ALA A 464;LYS A 469;SER A 470;TYR A 473;GLU A 558","09L A 601\r"],["5DS3_A_09LA1102","5ds3","09L","Olaparib (DB09074)","Homo sapiens","POLY [ADP-RIBOSE] POLYMERASE 1","PARP",19,"TRP A 861;HIS A 862;GLY A 863;GLY A 876;LEU A 877;ARG A 878;ILE A 879;ALA A 880;GLY A 888;TYR A 889;GLY A 894;ILE A 895;TYR A 896;PHE A 897;ALA A 898;LYS A 903;SER A 904;TYR A 907;GLU A 988","09L A1102\r"],["7KK4_A_09LA9001","7kk4","09L","Olaparib (DB09074)","Homo sapiens","POLY [ADP-RIBOSE] POLYMERASE 1","PARP;PARP_reg",22,"TYR A 710;ASP A 766;LEU A 769;ASP A 770;TRP A 861;HIS A 862;GLY A 863;ARG A 878;ILE A 879;ALA A 880;PRO A 881;TYR A 889;GLY A 892;GLY A 894;ILE A 895;TYR A 896;PHE A 897;ALA A 898;LYS A 903;SER A 904;TYR A 907;GLU A 988","09L A9001\r"],["7KKO_A_09LA1402","7kko","09L","Olaparib (DB09074)","Homo sapiens","POLY [ADP-RIBOSE] POLYMERASE","PARP",23,"PHE A1183;HIS A1184;GLY A1185;SER A1186;PHE A1188;ALA A1191;ILE A1192;GLY A1196;PHE A1197;ASP A1198;HIS A1201;ALA A1202;TYR A1203;GLY A1211;ILE A1212;TYR A1213;PHE A1214;ALA A1215;LYS A1220;SER A1221;TYR A1224;ILE A1228;GLU A1291","09L A1402\r"]]