Results: Ligand

Ligand ID: EST

Drugbank ID:
Estradiol
(DB00783)

Indication:
Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.

LIST OF BINDING INTERFACES for query 'EST'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1AQU_A_ESTA304	1aqu	EST	Estradiol (DB00783)	Mus musculus	ESTROGEN SULFOTRANSFERASE	Sulfotransfer_1	17	ASP A 21 ARG A 23 PHE A 24 TYR A 81 CYS A 84 ASN A 86 ILE A 90 LYS A 106 HIS A 108 PHE A 142 ILE A 146 SER A 148 TYR A 149 TYR A 240 GLU B 246 MET A 247 MET A 248	EST A 304
1E6W_C_ESTC302	1e6w	EST	Estradiol (DB00783)	Rattus norvegicus	SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE	adh_short	9	ALA C 95 SER C 155 GLN C 162 GLN C 165 TYR C 168 GLY C 199 LEU C 200 LEU C 205 LEU C 206	EST C 302
1FDS_A_ESTA350	1fds	EST	Estradiol (DB00783)	Homo sapiens	17-BETA-HYDROXYSTEROID-DEHYDROGENASE	adh_short	17	SER A 142 VAL A 143 GLY A 144 MET A 147 LEU A 149 TYR A 155 CYS A 185 GLY A 186 PRO A 187 TYR A 218 HIS A 221 SER A 222 VAL A 225 PHE A 226 PHE A 259 MET A 279 GLU A 282	EST A 350
1JGL_L_ESTL911	1jgl	EST	Estradiol (DB00783)	Mus musculus	IG GAMMA-1-CHAIN; IG KAPPA-CHAIN	C1-set V-set	13	ALA L 34 GLN H 35 TYR L 36 LEU L 46 TYR L 49 HIS L 89 PHE L 91 TRP H 95 GLY H 96 TRP L 96 GLY H 97 SER H 99 ALA H 101	EST L 911
1JNN_H_ESTH350	1jnn	EST	Estradiol (DB00783)	Mus musculus	MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN; MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN	C1-set V-set	12	ALA L 34 PHE H 35 TYR L 36 LEU L 46 TYR L 49 HIS L 89 PHE L 91 TYR L 96 ILE H 98 GLU H 99 LYS H 100 ASP H 101	EST H 350
2D06_A_ESTA304	2d06	EST	Estradiol (DB00783)	Homo sapiens	SULFOTRANSFERASE 1A1	Sulfotransfer_1	17	ILE A 21 PHE A 24 PRO A 47 LYS A 48 THR A 51 PHE A 81 PHE A 84 LYS A 106 HIS A 108 PHE A 142 ALA A 146 VAL A 148 HIS A 149 TYR A 240 PHE A 247 MET A 248 PHE A 255	EST A 304
3OLL_A_ESTA600	3oll	EST	Estradiol (DB00783)	Homo sapiens; synthetic construct	ESTROGEN RECEPTOR BETA	Hormone_recep	17	MET A 295 LEU A 298 LEU A 301 ALA A 302 GLU A 305 MET A 336 LEU A 339 MET A 340 LEU A 343 ARG A 346 PHE A 356 ILE A 373 ILE A 376 LEU A 380 GLY A 472 HIS A 475 LEU A 476	EST A 600
4JVL_A_ESTA702	4jvl	EST	Estradiol (DB00783)	Homo sapiens	ESTROGEN SULFOTRANSFERASE	Sulfotransfer_1	16	TYR A 20 ASP A 22 PHE A 23 PHE A 80 CYS A 83 LYS A 85 LYS A 105 HIS A 107 PHE A 141 VAL A 145 ALA A 146 GLY A 147 HIS A 148 TYR A 239 ILE A 246 MET A 247	EST A 702
5DXE_A_ESTA1000	5dxe	EST	Estradiol (DB00783)	Homo sapiens; synthetic construct	ESTROGEN RECEPTOR	Hormone_recep	18	MET A 343 LEU A 346 THR A 347 LEU A 349 ALA A 350 GLU A 353 LEU A 384 LEU A 387 MET A 388 LEU A 391 ARG A 394 PHE A 404 MET A 421 ILE A 424 LEU A 428 GLY A 521 HIS A 524 LEU A 525	EST A1000
6IWL_A_ESTA302	6iwl	EST	Estradiol (DB00783)	Moraxella catarrhalis (strain bbh18)	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	8	GLY A 97 PHE A 98 ALA A 99 LEU A 104 TYR A 151 TYR A 161 MET A 164 PHE A 208	EST A 302
6OYV_A_ESTA601	6oyv	EST	Estradiol (DB00783)	Synthetic construct	CYTOCHROME P450 1B1	NA	18	VAL A 126 SER A 127 SER A 131 ALA A 133 PHE A 134 PHE A 231 THR A 325 ASP A 326 GLY A 329 ALA A 330 ASP A 333 THR A 334 VAL A 395 VAL A 397 THR A 398 ILE A 399 LEU A 509 THR A 510	EST A 601
6PYF_A_ESTA302	6pyf	EST	Estradiol (DB00783)	Homo sapiens	SEX HORMONE-BINDING GLOBULIN	Laminin_G_1	21	THR A 40 SER A 41 SER A 42 PHE A 56 GLY A 58 ASP A 59 ASP A 65 PHE A 67 LEU A 80 ASN A 82 VAL A 105 LYS A 106 MET A 107 VAL A 112 SER A 128 LEU A 131 LYS A 134 MET A 139 ILE A 141 TRP A 170 LEU A 171	EST A 302
7AXK_A_ESTA501	7axk	EST	Estradiol (DB00783)	Homo sapiens	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2	Hormone_recep	15	ASP A 205 LEU A 206 SER A 208 LEU A 240 MET A 243 SER A 247 PHE A 251 PHE A 281 HIS A 407 ARG A 410 LEU A 411 ILE A 414 PHE A 420 MET A 425 PHE A 429	EST A 501
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1AQU_A_ESTA304","1aqu","EST","Estradiol (DB00783)","Mus musculus","ESTROGEN SULFOTRANSFERASE","Sulfotransfer_1",17,"ASP A  21;ARG A  23;PHE A  24;TYR A  81;CYS A  84;ASN A  86;ILE A  90;LYS A 106;HIS A 108;PHE A 142;ILE A 146;SER A 148;TYR A 149;TYR A 240;GLU B 246;MET A 247;MET A 248","EST A 304\r"],["1E6W_C_ESTC302","1e6w","EST","Estradiol (DB00783)","Rattus norvegicus","SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE","adh_short",9,"ALA C  95;SER C 155;GLN C 162;GLN C 165;TYR C 168;GLY C 199;LEU C 200;LEU C 205;LEU C 206","EST C 302\r"],["1FDS_A_ESTA350","1fds","EST","Estradiol (DB00783)","Homo sapiens","17-BETA-HYDROXYSTEROID-DEHYDROGENASE","adh_short",17,"SER A 142;VAL A 143;GLY A 144;MET A 147;LEU A 149;TYR A 155;CYS A 185;GLY A 186;PRO A 187;TYR A 218;HIS A 221;SER A 222;VAL A 225;PHE A 226;PHE A 259;MET A 279;GLU A 282","EST A 350\r"],["1JGL_L_ESTL911","1jgl","EST","Estradiol (DB00783)","Mus musculus","IG GAMMA-1-CHAIN;IG KAPPA-CHAIN","C1-set;V-set",13,"ALA L  34;GLN H  35;TYR L  36;LEU L  46;TYR L  49;HIS L  89;PHE L  91;TRP H  95;GLY H  96;TRP L  96;GLY H  97;SER H  99;ALA H 101","EST L 911\r"],["1JNN_H_ESTH350","1jnn","EST","Estradiol (DB00783)","Mus musculus","MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN;MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN","C1-set;V-set",12,"ALA L  34;PHE H  35;TYR L  36;LEU L  46;TYR L  49;HIS L  89;PHE L  91;TYR L  96;ILE H  98;GLU H  99;LYS H 100;ASP H 101","EST H 350\r"],["2D06_A_ESTA304","2d06","EST","Estradiol (DB00783)","Homo sapiens","SULFOTRANSFERASE 1A1","Sulfotransfer_1",17,"ILE A  21;PHE A  24;PRO A  47;LYS A  48;THR A  51;PHE A  81;PHE A  84;LYS A 106;HIS A 108;PHE A 142;ALA A 146;VAL A 148;HIS A 149;TYR A 240;PHE A 247;MET A 248;PHE A 255","EST A 304\r"],["3OLL_A_ESTA600","3oll","EST","Estradiol (DB00783)","Homo sapiens;synthetic construct","ESTROGEN RECEPTOR BETA","Hormone_recep",17,"MET A 295;LEU A 298;LEU A 301;ALA A 302;GLU A 305;MET A 336;LEU A 339;MET A 340;LEU A 343;ARG A 346;PHE A 356;ILE A 373;ILE A 376;LEU A 380;GLY A 472;HIS A 475;LEU A 476","EST A 600\r"],["4JVL_A_ESTA702","4jvl","EST","Estradiol (DB00783)","Homo sapiens","ESTROGEN SULFOTRANSFERASE","Sulfotransfer_1",16,"TYR A  20;ASP A  22;PHE A  23;PHE A  80;CYS A  83;LYS A  85;LYS A 105;HIS A 107;PHE A 141;VAL A 145;ALA A 146;GLY A 147;HIS A 148;TYR A 239;ILE A 246;MET A 247","EST A 702\r"],["5DXE_A_ESTA1000","5dxe","EST","Estradiol (DB00783)","Homo sapiens;synthetic construct","ESTROGEN RECEPTOR","Hormone_recep",18,"MET A 343;LEU A 346;THR A 347;LEU A 349;ALA A 350;GLU A 353;LEU A 384;LEU A 387;MET A 388;LEU A 391;ARG A 394;PHE A 404;MET A 421;ILE A 424;LEU A 428;GLY A 521;HIS A 524;LEU A 525","EST A1000\r"],["6IWL_A_ESTA302","6iwl","EST","Estradiol (DB00783)","Moraxella catarrhalis (strain bbh18)","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",8,"GLY A  97;PHE A  98;ALA A  99;LEU A 104;TYR A 151;TYR A 161;MET A 164;PHE A 208","EST A 302\r"],["6OYV_A_ESTA601","6oyv","EST","Estradiol (DB00783)","Synthetic construct","CYTOCHROME P450 1B1","NA",18,"VAL A 126;SER A 127;SER A 131;ALA A 133;PHE A 134;PHE A 231;THR A 325;ASP A 326;GLY A 329;ALA A 330;ASP A 333;THR A 334;VAL A 395;VAL A 397;THR A 398;ILE A 399;LEU A 509;THR A 510","EST A 601\r"],["6PYF_A_ESTA302","6pyf","EST","Estradiol (DB00783)","Homo sapiens","SEX HORMONE-BINDING GLOBULIN","Laminin_G_1",21,"THR A  40;SER A  41;SER A  42;PHE A  56;GLY A  58;ASP A  59;ASP A  65;PHE A  67;LEU A  80;ASN A  82;VAL A 105;LYS A 106;MET A 107;VAL A 112;SER A 128;LEU A 131;LYS A 134;MET A 139;ILE A 141;TRP A 170;LEU A 171","EST A 302\r"],["7AXK_A_ESTA501","7axk","EST","Estradiol (DB00783)","Homo sapiens","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","Hormone_recep",15,"ASP A 205;LEU A 206;SER A 208;LEU A 240;MET A 243;SER A 247;PHE A 251;PHE A 281;HIS A 407;ARG A 410;LEU A 411;ILE A 414;PHE A 420;MET A 425;PHE A 429","EST A 501\r"]]