Results: Ligand

Ligand ID: FFO

Drugbank ID:
Levoleucovorin
(DB11596)

Indication:
Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.

LIST OF BINDING INTERFACES for query 'FFO'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1DFO_A_FFOA1002	1dfo	FFO	Levoleucovorin (DB11596)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFERASE	SHMT	22	GLU B 57 TYR B 64 TYR B 65 LEU A 121 GLY A 124 GLY A 125 HIS A 126 LEU A 127 VAL A 133 SER A 175 ALA A 176 SER D 245 GLU D 246 GLU D 247 PHE B 257 PRO B 258 ASN A 345 ASN A 347 SER A 355 PRO A 356 PHE A 357 ARG A 363	FFO A1002
1JOM_A_FFOA161	1jom	FFO	Levoleucovorin (DB11596)	Escherichia coli	DIHYDROFOLATE REDUCTASE	DHFR_1	20	ILE A 5 ALA A 6 ALA A 7 GLY A 15 MET A 16 GLU A 17 ASP A 27 LEU A 28 TRP A 30 PHE A 31 LYS A 32 THR A 35 THR A 46 ILE A 50 LEU A 54 PRO A 55 ARG A 57 ILE A 94 TYR A 100 THR A 113	FFO A 161
1PJ7_A_FFOA2887	1pj7	FFO	Levoleucovorin (DB11596)	Arthrobacter globiformis	N,N-DIMETHYLGLYCINE OXIDASE	DAO FAO_M GCV_T GCV_T_C	18	MET A 505 LEU A 508 TYR A 539 ASP A 552 ILE A 553 THR A 554 GLY A 566 ALA A 567 ASN A 568 TYR A 631 PHE A 632 LEU A 649 TYR A 651 GLU A 658 TYR A 660 TYR A 699 ARG A 700 PHE A 719	FFO A2887
1WOP_A_FFOA2887	1wop	FFO	Levoleucovorin (DB11596)	Thermotoga maritima	AMINOMETHYLTRANSFERASE	GCV_T GCV_T_C	20	MET A 51 TYR A 83 ASP A 96 LEU A 97 VAL A 98 TYR A 100 VAL A 110 VAL A 111 ASN A 112 TYR A 168 TYR A 169 GLY A 187 TYR A 188 GLU A 195 ARG A 227 TYR A 236 LEU A 237 TRP A 256 ARG A 357 ARG A 362	FFO A2887
1WOP_A_FFOA2888	1wop	FFO	Levoleucovorin (DB11596)	Thermotoga maritima	AMINOMETHYLTRANSFERASE	GCV_T GCV_T_C	14	LEU A 55 GLU A 106 LEU A 108 ILE A 137 THR A 141 GLU A 160 LYS A 173 SER A 174 ILE A 175 GLU A 180 THR A 181 LEU A 182 MET A 197 LEU A 198	FFO A2888
2VMY_A_FFOA505	2vmy	FFO	Levoleucovorin (DB11596)	Bacillus stearothermophilus	SERINE HYDROXYMETHYLTRANSFERASE	SHMT	22	GLU A 53 TYR A 60 TYR A 61 LEU B 117 GLY B 120 GLY B 121 HIS B 122 LEU B 123 SER B 127 VAL B 129 SER B 172 ALA B 173 LYS A 248 PHE A 251 PRO A 252 ASN B 339 ASN B 341 THR B 342 SER B 349 PRO B 350 GLY B 351 ARG B 357	FFO A 505
6QYA_B_FFOB401	6qya	FFO	Levoleucovorin (DB11596)	Enterococcus faecalis	THYMIDYLATE SYNTHASE	Thymidylat_synt	15	PRO B 52 LEU B 55 ILE B 80 TRP B 81 TRP B 84 LEU B 194 HIS B 198 ASP B 220 LEU B 223 GLY B 224 PHE B 227 ASN B 228 TYR B 260 ILE B 313 ALA B 314	FFO B 401
6QYQ_B_FFOB402	6qyq	FFO	Levoleucovorin (DB11596)	Homo sapiens	THYMIDYLATE SYNTHASE	Thymidylat_synt	15	PHE B 80 ILE B 108 TRP B 109 ASN B 112 LEU B 192 HIS B 196 ASP B 218 LEU B 221 GLY B 222 PHE B 225 ASN B 226 TYR B 258 ILE B 307 MET B 311 ALA B 312	FFO B 402
6UXJ_A_FFOA502	6uxj	FFO	Levoleucovorin (DB11596)	Glycine max	SERINE HYDROXYMETHYLTRANSFERASE	SHMT	21	GLU B 61 TYR B 68 TYR B 69 LEU A 129 GLY A 132 GLY A 133 HIS A 134 LEU A 135 TYR A 139 LYS A 145 ILE A 147 SER A 190 ALA A 191 PHE B 281 PHE B 284 PRO B 285 ASN A 372 ASN A 374 ALA A 382 LEU A 383 ARG A 389	FFO A 502
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1DFO_A_FFOA1002","1dfo","FFO","Levoleucovorin (DB11596)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","SHMT",22,"GLU B  57;TYR B  64;TYR B  65;LEU A 121;GLY A 124;GLY A 125;HIS A 126;LEU A 127;VAL A 133;SER A 175;ALA A 176;SER D 245;GLU D 246;GLU D 247;PHE B 257;PRO B 258;ASN A 345;ASN A 347;SER A 355;PRO A 356;PHE A 357;ARG A 363","FFO A1002\r"],["1JOM_A_FFOA161","1jom","FFO","Levoleucovorin (DB11596)","Escherichia coli","DIHYDROFOLATE REDUCTASE","DHFR_1",20,"ILE A   5;ALA A   6;ALA A   7;GLY A  15;MET A  16;GLU A  17;ASP A  27;LEU A  28;TRP A  30;PHE A  31;LYS A  32;THR A  35;THR A  46;ILE A  50;LEU A  54;PRO A  55;ARG A  57;ILE A  94;TYR A 100;THR A 113","FFO A 161\r"],["1PJ7_A_FFOA2887","1pj7","FFO","Levoleucovorin (DB11596)","Arthrobacter globiformis","N,N-DIMETHYLGLYCINE OXIDASE","DAO;FAO_M;GCV_T;GCV_T_C",18,"MET A 505;LEU A 508;TYR A 539;ASP A 552;ILE A 553;THR A 554;GLY A 566;ALA A 567;ASN A 568;TYR A 631;PHE A 632;LEU A 649;TYR A 651;GLU A 658;TYR A 660;TYR A 699;ARG A 700;PHE A 719","FFO A2887\r"],["1WOP_A_FFOA2887","1wop","FFO","Levoleucovorin (DB11596)","Thermotoga maritima","AMINOMETHYLTRANSFERASE","GCV_T;GCV_T_C",20,"MET A  51;TYR A  83;ASP A  96;LEU A  97;VAL A  98;TYR A 100;VAL A 110;VAL A 111;ASN A 112;TYR A 168;TYR A 169;GLY A 187;TYR A 188;GLU A 195;ARG A 227;TYR A 236;LEU A 237;TRP A 256;ARG A 357;ARG A 362","FFO A2887\r"],["1WOP_A_FFOA2888","1wop","FFO","Levoleucovorin (DB11596)","Thermotoga maritima","AMINOMETHYLTRANSFERASE","GCV_T;GCV_T_C",14,"LEU A  55;GLU A 106;LEU A 108;ILE A 137;THR A 141;GLU A 160;LYS A 173;SER A 174;ILE A 175;GLU A 180;THR A 181;LEU A 182;MET A 197;LEU A 198","FFO A2888\r"],["2VMY_A_FFOA505","2vmy","FFO","Levoleucovorin (DB11596)","Bacillus stearothermophilus","SERINE HYDROXYMETHYLTRANSFERASE","SHMT",22,"GLU A  53;TYR A  60;TYR A  61;LEU B 117;GLY B 120;GLY B 121;HIS B 122;LEU B 123;SER B 127;VAL B 129;SER B 172;ALA B 173;LYS A 248;PHE A 251;PRO A 252;ASN B 339;ASN B 341;THR B 342;SER B 349;PRO B 350;GLY B 351;ARG B 357","FFO A 505\r"],["6QYA_B_FFOB401","6qya","FFO","Levoleucovorin (DB11596)","Enterococcus faecalis","THYMIDYLATE SYNTHASE","Thymidylat_synt",15,"PRO B  52;LEU B  55;ILE B  80;TRP B  81;TRP B  84;LEU B 194;HIS B 198;ASP B 220;LEU B 223;GLY B 224;PHE B 227;ASN B 228;TYR B 260;ILE B 313;ALA B 314","FFO B 401\r"],["6QYQ_B_FFOB402","6qyq","FFO","Levoleucovorin (DB11596)","Homo sapiens","THYMIDYLATE SYNTHASE","Thymidylat_synt",15,"PHE B  80;ILE B 108;TRP B 109;ASN B 112;LEU B 192;HIS B 196;ASP B 218;LEU B 221;GLY B 222;PHE B 225;ASN B 226;TYR B 258;ILE B 307;MET B 311;ALA B 312","FFO B 402\r"],["6UXJ_A_FFOA502","6uxj","FFO","Levoleucovorin (DB11596)","Glycine max","SERINE HYDROXYMETHYLTRANSFERASE","SHMT",21,"GLU B  61;TYR B  68;TYR B  69;LEU A 129;GLY A 132;GLY A 133;HIS A 134;LEU A 135;TYR A 139;LYS A 145;ILE A 147;SER A 190;ALA A 191;PHE B 281;PHE B 284;PRO B 285;ASN A 372;ASN A 374;ALA A 382;LEU A 383;ARG A 389","FFO A 502\r"]]