Ligand ID: TMQ

Drugbank ID:
Trimetrexate
(DB01157)

Indication:
Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.

LIST OF BINDING INTERFACES for query 'TMQ'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1BZF_A_TMQA170	1bzf	TMQ	Trimetrexate (DB01157)	Lactobacillus casei	DIHYDROFOLATE REDUCTASE	NA	29	LEU A   4 TRP A   5 ALA A   6 GLY A  17 HIS A  18 LEU A  19 TRP A  21 HIS A  22 ASP A  26 LEU A  27 TYR A  29 PHE A  30 ARG A  31 GLN A  33 THR A  34 VAL A  41 THR A  45 SER A  48 PHE A  49 PRO A  50 LEU A  54 ARG A  57 VAL A  95 ILE A  96 ALA A  97 GLY A  98 PHE A 103 THR A 116 TYR A 155	TMQ A 170		Details
2X9V_A_TMQA1270	2x9v	TMQ	Trimetrexate (DB01157)	Trypanosoma brucei brucei	PTERIDINE REDUCTASE	adh_short_C2	15	ARG A  14 SER A  95 ALA A  96 PHE A  97 ASP A 161 CYS A 168 PHE A 171 TYR A 174 VAL A 206 LEU A 208 LEU A 209 PRO A 210 MET A 213 GLU A 217 TRP A 221	TMQ A1270		Details
3CLB_A_TMQA611	3clb	TMQ	Trimetrexate (DB01157)	Trypanosoma cruzi	DHFR-TS	DHFR_1 Thymidylat_synt	16	VAL A  26 VAL A  27 ALA A  28 ILE A  41 ASP A  48 MET A  49 PHE A  52 THR A  80 SER A  83 ILE A  84 PRO A  85 PHE A  88 LEU A  91 ILE A 154 TYR A 160 THR A 178	TMQ A 611		Details
4M2X_A_TMQA202	4m2x	TMQ	Trimetrexate (DB01157)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	DHFR_1	18	ILE A   5 TRP A   6 ALA A   7 ASP A  19 ILE A  20 ARG A  23 ASP A  27 GLN A  28 PHE A  31 THR A  46 SER A  49 LEU A  50 PRO A  51 VAL A  54 LEU A  57 ILE A  94 TYR A 100 THR A 113	TMQ A 202		Details
4XT8_A_TMQA302	4xt8	TMQ	Trimetrexate (DB01157)	Mycobacterium tuberculosis (strain atcc 25618 / h37rv)	RV2671	RibD_C	17	ASN A  44 PHE A  45 ILE A  46 SER A  59 GLY A  60 ALA A  63 ASP A  67 ARG A  68 PHE A  71 ASN A  72 ARG A  75 GLU A  91 GLY A  92 TYR A  93 SER A  94 GLU A 193 THR A 214	TMQ A 302		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1BZF_A_TMQA170","1bzf","TMQ","Trimetrexate (DB01157)","Lactobacillus casei","DIHYDROFOLATE REDUCTASE","NA",29,"LEU A 4;TRP A 5;ALA A 6;GLY A 17;HIS A 18;LEU A 19;TRP A 21;HIS A 22;ASP A 26;LEU A 27;TYR A 29;PHE A 30;ARG A 31;GLN A 33;THR A 34;VAL A 41;THR A 45;SER A 48;PHE A 49;PRO A 50;LEU A 54;ARG A 57;VAL A 95;ILE A 96;ALA A 97;GLY A 98;PHE A 103;THR A 116;TYR A 155","TMQ A 170\r"],["2X9V_A_TMQA1270","2x9v","TMQ","Trimetrexate (DB01157)","Trypanosoma brucei brucei","PTERIDINE REDUCTASE","adh_short_C2",15,"ARG A 14;SER A 95;ALA A 96;PHE A 97;ASP A 161;CYS A 168;PHE A 171;TYR A 174;VAL A 206;LEU A 208;LEU A 209;PRO A 210;MET A 213;GLU A 217;TRP A 221","TMQ A1270\r"],["3CLB_A_TMQA611","3clb","TMQ","Trimetrexate (DB01157)","Trypanosoma cruzi","DHFR-TS","DHFR_1;Thymidylat_synt",16,"VAL A 26;VAL A 27;ALA A 28;ILE A 41;ASP A 48;MET A 49;PHE A 52;THR A 80;SER A 83;ILE A 84;PRO A 85;PHE A 88;LEU A 91;ILE A 154;TYR A 160;THR A 178","TMQ A 611\r"],["4M2X_A_TMQA202","4m2x","TMQ","Trimetrexate (DB01157)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","DHFR_1",18,"ILE A 5;TRP A 6;ALA A 7;ASP A 19;ILE A 20;ARG A 23;ASP A 27;GLN A 28;PHE A 31;THR A 46;SER A 49;LEU A 50;PRO A 51;VAL A 54;LEU A 57;ILE A 94;TYR A 100;THR A 113","TMQ A 202\r"],["4XT8_A_TMQA302","4xt8","TMQ","Trimetrexate (DB01157)","Mycobacterium tuberculosis (strain atcc 25618 \/ h37rv)","RV2671","RibD_C",17,"ASN A 44;PHE A 45;ILE A 46;SER A 59;GLY A 60;ALA A 63;ASP A 67;ARG A 68;PHE A 71;ASN A 72;ARG A 75;GLU A 91;GLY A 92;TYR A 93;SER A 94;GLU A 193;THR A 214","TMQ A 302\r"]]