Ligand ID: SOR

Drugbank ID:
Sorbitol
(DB01638)

Indication:
Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.

LIST OF BINDING INTERFACES for query 'DB01638'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1D8C_A_SORA4000	1d8c	SOR	Sorbitol (DB01638)	Escherichia coli	MALATE SYNTHASE G	Malate_synthase	8	ASP A  58 GLN A  61 HIS A 462 VAL A 701 LYS A 702 GLN A 703 PRO A 704 ASN A 705	SOR A4000		Details
1XIH_A_SORA389	1xih	SOR	Sorbitol (DB01638)	Streptomyces rubiginosus	D-XYLOSE ISOMERASE	AP_endonuc_2	14	TRP A  16 HIS A  54 MET A  88 THR A  90 PHE A  94 VAL A 135 TRP A 137 GLU A 181 LYS A 183 GLU A 217 HIS A 220 ASP A 245 ASP A 255 ASP A 287	SOR A 389		Details
2DXR_A_SORA1001	2dxr	SOR	Sorbitol (DB01638)	Bos taurus	LACTOTRANSFERRIN	Transferrin	5	GLU A 659 TYR A 660 LEU A 661 GLY A 662 THR A 663	SOR A1001		Details
2DXR_A_SORA1002	2dxr	SOR	Sorbitol (DB01638)	Bos taurus	LACTOTRANSFERRIN	Transferrin	4	THR A 430 PRO A 593 ASN A 594 TYR A 660	SOR A1002		Details
2VFT_A_SORA1419	2vft	SOR	Sorbitol (DB01638)	Streptomyces coelicolor	XYLITOL OXIDASE	ALO FAD_binding_4	15	SER A 106 PHE A 213 HIS A 248 PRO A 249 VAL A 250 HIS A 274 PHE A 275 GLU A 286 GLN A 288 THR A 318 GLU A 320 ARG A 322 HIS A 343 THR A 345 LYS A 375	SOR A1419		Details
2XIN_A_SORA397	2xin	SOR	Sorbitol (DB01638)	Actinoplanes missouriensis	D-XYLOSE ISOMERASE	AP_endonuc_2	14	TRP A  16 PHE B  26 HIS A  54 THR A  90 PHE A  94 VAL A 135 TRP A 137 GLU A 181 LYS A 183 GLU A 217 HIS A 220 ASP A 245 ASP A 255 ASP A 292	SOR A 397		Details
3BRF_A_SORA1	3brf	SOR	Sorbitol (DB01638)	Caenorhabditis elegans; synthetic construct	LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A	NA	4	GLY A 230 SER A 333 ASP A 334 SER A 335	SOR A   1		Details
3BRF_A_SORA2	3brf	SOR	Sorbitol (DB01638)	Caenorhabditis elegans; synthetic construct	LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A	NA	6	LYS A 227 ASP A 336 LYS A 337 ARG A 338 LYS A 339 VAL A 365	SOR A   2		Details
4XIA_A_SORA400	4xia	SOR	Sorbitol (DB01638)	Arthrobacter sp.	D-XYLOSE ISOMERASE	AP_endonuc_2	14	TRP A  15 HIS A  53 MET A  87 THR A  89 PHE A  93 VAL A 134 TRP A 136 GLU A 180 LYS A 182 GLU A 216 HIS A 219 ASP A 244 ASP A 254 ASP A 292	SOR A 400		Details
5A06_A_SORA1341	5a06	SOR	Sorbitol (DB01638)	Caulobacter crescentus cb15	ALDOSE-ALDOSE OXIDOREDUCTASE	GFO_IDH_MocA GFO_IDH_MocA_C	8	LYS A 104 ARG A 132 PHE A 163 ARG A 172 ASP A 185 ILE A 186 TYR A 189 TYR A 267	SOR A1341		Details
5A06_A_SORA1342	5a06	SOR	Sorbitol (DB01638)	Caulobacter crescentus cb15	ALDOSE-ALDOSE OXIDOREDUCTASE	GFO_IDH_MocA GFO_IDH_MocA_C	12	ILE A 117 CYS A 120 LYS A 121 GLY A 124 ARG A 125 LYS A 126 LEU A 127 GLU A 309 PRO A 310 GLY A 313 GLY A 314 ASP A 315	SOR A1342		Details
5A06_A_SORA1343	5a06	SOR	Sorbitol (DB01638)	Caulobacter crescentus cb15	ALDOSE-ALDOSE OXIDOREDUCTASE	GFO_IDH_MocA GFO_IDH_MocA_C	9	ARG A   5 VAL A  74 ASP A  75 GLY A  97 LYS A  98 HIS A  99 ARG A 125 ILE A 304 LEU A 305	SOR A1343		Details
5A06_A_SORA1344	5a06	SOR	Sorbitol (DB01638)	Caulobacter crescentus cb15	ALDOSE-ALDOSE OXIDOREDUCTASE	GFO_IDH_MocA GFO_IDH_MocA_C	7	GLU A  30 PHE A 135 LYS A 290 ALA A 295 ASP A 298 HIS A 299 GLU A 302	SOR A1344		Details
5JO9_A_SORA302	5jo9	SOR	Sorbitol (DB01638)	Bradyrhizobium japonicum	RIBITOL 2-DEHYDROGENASE	adh_short	17	TYR A  92 SER A 140 LEU A 141 ALA A 142 THR A 147 TRP A 149 GLU A 150 TYR A 153 PRO A 183 GLY A 184 PRO A 185 VAL A 186 SER A 188 LEU A 190 TRP A 194 PHE A 240 LEU A 242	SOR A 302		Details
5K4P_A_SORA611	5k4p	SOR	Sorbitol (DB01638)	Escherichia coli bl21(de3)	PROBABLE PHOSPHATIDYLETHANOLAMINE TRANSFERASE MCR-1	Sulfatase	8	GLY A 282 THR A 283 SER A 284 TYR A 287 GLY A 479 MET A 480 PRO A 481 ASN A 482	SOR A 611		Details
5M6G_A_SORA711	5m6g	SOR	Sorbitol (DB01638)	Saccharopolyspora erythraea d	BETA-GLUCOSIDASE	Glyco_hydro_3 Glyco_hydro_3_C	15	LEU A  89 GLY A  91 GLY A  92 ASP A 129 PHE A 178 ARG A 192 LYS A 231 HIS A 232 MET A 275 ASP A 310 TYR A 311 MET A 340 TRP A 448 TRP A 452 GLU A 505	SOR A 711		Details
5NHA_A_SORA503	5nha	SOR	Sorbitol (DB01638)	Piromyces sp. e2	XYLOSE ISOMERASE	AP_endonuc_2	15	TRP A  50 HIS A  51 PHE C  61 HIS A 102 TRP A 140 THR A 142 PHE A 146 VAL A 187 TRP A 189 GLU A 233 ASN A 267 GLU A 269 HIS A 272 ASP A 297 ASP A 340	SOR A 503		Details
6BJD_B_SORB505	6bjd	SOR	Sorbitol (DB01638)	Homo sapiens	CALPAIN-3	Peptidase_C2	3	TYR B 170 GLU B 229 PHE B 238	SOR B 505		Details
6PEJ_A_SORA301	6pej	SOR	Sorbitol (DB01638)	Sinorhizobium meliloti 1021	SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)	adh_short_C2	14	PHE A  91 SER A 140 GLN A 141 ALA A 142 ARG A 145 GLU A 147 VAL A 150 TYR A 153 GLY A 184 VAL A 185 HIS A 190 TRP A 191 PHE A 198 VAL A 213	SOR A 301		Details
6X39_A_SORA901	6x39	SOR	Sorbitol (DB01638)	Mus musculus	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F	fn3	10	ARG A 750 LEU A 751 GLU A 752 ASN A 753 GLY A 754 THR A 779 GLU A 781 THR A 782 THR A 783 THR A 806	SOR A 901		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1D8C_A_SORA4000","1d8c","SOR","Sorbitol (DB01638)","Escherichia coli","MALATE SYNTHASE G","Malate_synthase",8,"ASP A 58;GLN A 61;HIS A 462;VAL A 701;LYS A 702;GLN A 703;PRO A 704;ASN A 705","SOR A4000\r"],["1XIH_A_SORA389","1xih","SOR","Sorbitol (DB01638)","Streptomyces rubiginosus","D-XYLOSE ISOMERASE","AP_endonuc_2",14,"TRP A 16;HIS A 54;MET A 88;THR A 90;PHE A 94;VAL A 135;TRP A 137;GLU A 181;LYS A 183;GLU A 217;HIS A 220;ASP A 245;ASP A 255;ASP A 287","SOR A 389\r"],["2DXR_A_SORA1001","2dxr","SOR","Sorbitol (DB01638)","Bos taurus","LACTOTRANSFERRIN","Transferrin",5,"GLU A 659;TYR A 660;LEU A 661;GLY A 662;THR A 663","SOR A1001\r"],["2DXR_A_SORA1002","2dxr","SOR","Sorbitol (DB01638)","Bos taurus","LACTOTRANSFERRIN","Transferrin",4,"THR A 430;PRO A 593;ASN A 594;TYR A 660","SOR A1002\r"],["2VFT_A_SORA1419","2vft","SOR","Sorbitol (DB01638)","Streptomyces coelicolor","XYLITOL OXIDASE","ALO;FAD_binding_4",15,"SER A 106;PHE A 213;HIS A 248;PRO A 249;VAL A 250;HIS A 274;PHE A 275;GLU A 286;GLN A 288;THR A 318;GLU A 320;ARG A 322;HIS A 343;THR A 345;LYS A 375","SOR A1419\r"],["2XIN_A_SORA397","2xin","SOR","Sorbitol (DB01638)","Actinoplanes missouriensis","D-XYLOSE ISOMERASE","AP_endonuc_2",14,"TRP A 16;PHE B 26;HIS A 54;THR A 90;PHE A 94;VAL A 135;TRP A 137;GLU A 181;LYS A 183;GLU A 217;HIS A 220;ASP A 245;ASP A 255;ASP A 292","SOR A 397\r"],["3BRF_A_SORA1","3brf","SOR","Sorbitol (DB01638)","Caenorhabditis elegans;synthetic construct","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","NA",4,"GLY A 230;SER A 333;ASP A 334;SER A 335","SOR A 1\r"],["3BRF_A_SORA2","3brf","SOR","Sorbitol (DB01638)","Caenorhabditis elegans;synthetic construct","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","NA",6,"LYS A 227;ASP A 336;LYS A 337;ARG A 338;LYS A 339;VAL A 365","SOR A 2\r"],["4XIA_A_SORA400","4xia","SOR","Sorbitol (DB01638)","Arthrobacter sp.","D-XYLOSE ISOMERASE","AP_endonuc_2",14,"TRP A 15;HIS A 53;MET A 87;THR A 89;PHE A 93;VAL A 134;TRP A 136;GLU A 180;LYS A 182;GLU A 216;HIS A 219;ASP A 244;ASP A 254;ASP A 292","SOR A 400\r"],["5A06_A_SORA1341","5a06","SOR","Sorbitol (DB01638)","Caulobacter crescentus cb15","ALDOSE-ALDOSE OXIDOREDUCTASE","GFO_IDH_MocA;GFO_IDH_MocA_C",8,"LYS A 104;ARG A 132;PHE A 163;ARG A 172;ASP A 185;ILE A 186;TYR A 189;TYR A 267","SOR A1341\r"],["5A06_A_SORA1342","5a06","SOR","Sorbitol (DB01638)","Caulobacter crescentus cb15","ALDOSE-ALDOSE OXIDOREDUCTASE","GFO_IDH_MocA;GFO_IDH_MocA_C",12,"ILE A 117;CYS A 120;LYS A 121;GLY A 124;ARG A 125;LYS A 126;LEU A 127;GLU A 309;PRO A 310;GLY A 313;GLY A 314;ASP A 315","SOR A1342\r"],["5A06_A_SORA1343","5a06","SOR","Sorbitol (DB01638)","Caulobacter crescentus cb15","ALDOSE-ALDOSE OXIDOREDUCTASE","GFO_IDH_MocA;GFO_IDH_MocA_C",9,"ARG A 5;VAL A 74;ASP A 75;GLY A 97;LYS A 98;HIS A 99;ARG A 125;ILE A 304;LEU A 305","SOR A1343\r"],["5A06_A_SORA1344","5a06","SOR","Sorbitol (DB01638)","Caulobacter crescentus cb15","ALDOSE-ALDOSE OXIDOREDUCTASE","GFO_IDH_MocA;GFO_IDH_MocA_C",7,"GLU A 30;PHE A 135;LYS A 290;ALA A 295;ASP A 298;HIS A 299;GLU A 302","SOR A1344\r"],["5JO9_A_SORA302","5jo9","SOR","Sorbitol (DB01638)","Bradyrhizobium japonicum","RIBITOL 2-DEHYDROGENASE","adh_short",17,"TYR A 92;SER A 140;LEU A 141;ALA A 142;THR A 147;TRP A 149;GLU A 150;TYR A 153;PRO A 183;GLY A 184;PRO A 185;VAL A 186;SER A 188;LEU A 190;TRP A 194;PHE A 240;LEU A 242","SOR A 302\r"],["5K4P_A_SORA611","5k4p","SOR","Sorbitol (DB01638)","Escherichia coli bl21(de3)","PROBABLE PHOSPHATIDYLETHANOLAMINE TRANSFERASE MCR-1","Sulfatase",8,"GLY A 282;THR A 283;SER A 284;TYR A 287;GLY A 479;MET A 480;PRO A 481;ASN A 482","SOR A 611\r"],["5M6G_A_SORA711","5m6g","SOR","Sorbitol (DB01638)","Saccharopolyspora erythraea d","BETA-GLUCOSIDASE","Glyco_hydro_3;Glyco_hydro_3_C",15,"LEU A 89;GLY A 91;GLY A 92;ASP A 129;PHE A 178;ARG A 192;LYS A 231;HIS A 232;MET A 275;ASP A 310;TYR A 311;MET A 340;TRP A 448;TRP A 452;GLU A 505","SOR A 711\r"],["5NHA_A_SORA503","5nha","SOR","Sorbitol (DB01638)","Piromyces sp. e2","XYLOSE ISOMERASE","AP_endonuc_2",15,"TRP A 50;HIS A 51;PHE C 61;HIS A 102;TRP A 140;THR A 142;PHE A 146;VAL A 187;TRP A 189;GLU A 233;ASN A 267;GLU A 269;HIS A 272;ASP A 297;ASP A 340","SOR A 503\r"],["6BJD_B_SORB505","6bjd","SOR","Sorbitol (DB01638)","Homo sapiens","CALPAIN-3","Peptidase_C2",3,"TYR B 170;GLU B 229;PHE B 238","SOR B 505\r"],["6PEJ_A_SORA301","6pej","SOR","Sorbitol (DB01638)","Sinorhizobium meliloti 1021","SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)","adh_short_C2",14,"PHE A 91;SER A 140;GLN A 141;ALA A 142;ARG A 145;GLU A 147;VAL A 150;TYR A 153;GLY A 184;VAL A 185;HIS A 190;TRP A 191;PHE A 198;VAL A 213","SOR A 301\r"],["6X39_A_SORA901","6x39","SOR","Sorbitol (DB01638)","Mus musculus","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F","fn3",10,"ARG A 750;LEU A 751;GLU A 752;ASN A 753;GLY A 754;THR A 779;GLU A 781;THR A 782;THR A 783;THR A 806","SOR A 901\r"]]