Ligand ID: CP6

Drugbank ID:
Pyrimethamine
(DB00205)

Indication:
Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.

LIST OF BINDING INTERFACES for query 'CP6'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1J3J_A_CP6A609	1j3j	CP6	Pyrimethamine (DB00205)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE	DHFR_1	13	ILE A  14 CYS A  15 ALA A  16 LEU A  46 ASP A  54 MET A  55 PHE A  58 ASN A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609		Details
2BL9_A_CP6A1240	2bl9	CP6	Pyrimethamine (DB00205)	Plasmodium vivax	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE	DHFR_1	13	ILE A  13 CYS A  14 ALA A  15 LEU A  45 ASP A  53 MET A  54 PHE A  57 SER A 117 SER A 120 ILE A 121 ILE A 173 TYR A 179 THR A 194	CP6 A1240		Details
3LMY_A_CP6A562	3lmy	CP6	Pyrimethamine (DB00205)	Homo sapiens	BETA-HEXOSAMINIDASE SUBUNIT BETA	Glyco_hydro_20 Glycohydro_20b2	14	ARG A 211 HIS A 237 ASP A 240 ASP A 290 HIS A 294 ASP A 354 GLU A 355 TRP A 405 TRP A 424 TYR A 450 ASP A 452 LEU A 453 TRP A 489 GLU A 491	CP6 A 562		Details
3QFX_A_CP6A602	3qfx	CP6	Pyrimethamine (DB00205)	Trypanosoma brucei rhodesiense	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE	DHFR_1	13	VAL A  32 VAL A  33 ALA A  34 ILE A  47 ASP A  54 MET A  55 PHE A  58 THR A  86 SER A  89 LEU A  90 ILE A 160 TYR A 166 THR A 184	CP6 A 602		Details
4KM0_A_CP6A201	4km0	CP6	Pyrimethamine (DB00205)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	DHFR_1	12	ILE A   5 TRP A   6 ALA A   7 ASP A  27 GLN A  28 PHE A  31 THR A  46 LEU A  50 LEU A  57 ILE A  94 TYR A 100 THR A 113	CP6 A 201		Details
6AOG_A_CP6A704	6aog	CP6	Pyrimethamine (DB00205)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE	Thymidylat_synt	14	VAL A   8 VAL A   9 ALA A  10 ASP A  31 PHE A  32 HIS A  34 PHE A  35 THR A  83 SER A  86 MET A  87 VAL A 151 TYR A 157 TYR A 170 THR A 172	CP6 A 704		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1J3J_A_CP6A609","1j3j","CP6","Pyrimethamine (DB00205)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1",13,"ILE A 14;CYS A 15;ALA A 16;LEU A 46;ASP A 54;MET A 55;PHE A 58;ASN A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["2BL9_A_CP6A1240","2bl9","CP6","Pyrimethamine (DB00205)","Plasmodium vivax","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1",13,"ILE A 13;CYS A 14;ALA A 15;LEU A 45;ASP A 53;MET A 54;PHE A 57;SER A 117;SER A 120;ILE A 121;ILE A 173;TYR A 179;THR A 194","CP6 A1240\r"],["3LMY_A_CP6A562","3lmy","CP6","Pyrimethamine (DB00205)","Homo sapiens","BETA-HEXOSAMINIDASE SUBUNIT BETA","Glyco_hydro_20;Glycohydro_20b2",14,"ARG A 211;HIS A 237;ASP A 240;ASP A 290;HIS A 294;ASP A 354;GLU A 355;TRP A 405;TRP A 424;TYR A 450;ASP A 452;LEU A 453;TRP A 489;GLU A 491","CP6 A 562\r"],["3QFX_A_CP6A602","3qfx","CP6","Pyrimethamine (DB00205)","Trypanosoma brucei rhodesiense","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1",13,"VAL A 32;VAL A 33;ALA A 34;ILE A 47;ASP A 54;MET A 55;PHE A 58;THR A 86;SER A 89;LEU A 90;ILE A 160;TYR A 166;THR A 184","CP6 A 602\r"],["4KM0_A_CP6A201","4km0","CP6","Pyrimethamine (DB00205)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","DHFR_1",12,"ILE A 5;TRP A 6;ALA A 7;ASP A 27;GLN A 28;PHE A 31;THR A 46;LEU A 50;LEU A 57;ILE A 94;TYR A 100;THR A 113","CP6 A 201\r"],["6AOG_A_CP6A704","6aog","CP6","Pyrimethamine (DB00205)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","Thymidylat_synt",14,"VAL A 8;VAL A 9;ALA A 10;ASP A 31;PHE A 32;HIS A 34;PHE A 35;THR A 83;SER A 86;MET A 87;VAL A 151;TYR A 157;TYR A 170;THR A 172","CP6 A 704\r"]]