Results: Ligand

Ligand ID: DGJ

Drugbank ID:
Migalastat
(DB05018)

Indication:
Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant.

LIST OF BINDING INTERFACES for query 'DGJ'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3S5Y_A_DGJA801	3s5y	DGJ	Migalastat (DB05018)	Homo sapiens	ALPHA-GALACTOSIDASE A	Melibiase_2 Melibiase_2_C	14	TRP A 47 ASP A 92 ASP A 93 TYR A 134 CYS A 142 ALA A 143 LYS A 168 ASP A 170 GLU A 203 LEU A 206 TYR A 207 ARG A 227 ASP A 231 MET A 267	DGJ A 801
3THD_A_DGJA900	3thd	DGJ	Migalastat (DB05018)	Homo sapiens	BETA-GALACTOSIDASE	BetaGal_dom4_5 Glyco_hydro_35	14	TYR A 83 ILE A 126 CYS A 127 ALA A 128 GLU A 129 ASN A 187 GLU A 188 GLU A 268 TYR A 270 TRP A 273 LEU A 274 TYR A 306 TYR A 331 TYR A 333	DGJ A 900
4CU8_A_DGJA1985	4cu8	DGJ	Migalastat (DB05018)	Streptococcus pneumoniae tigr4	GLYCOSIDE HYDROLASE 2	DUF4982 Glyco_hydro2_C5 Glyco_hydro_2 Glyco_hydro_2_C Glyco_hydro_2_N	12	ARG A 288 HIS A 484 ASN A 563 GLU A 564 ASN A 623 TYR A 624 GLU A 645 SER A 648 TRP A 685 TRP A 708 GLU A 716 PHE A 733	DGJ A1985
4D1J_A_DGJA600	4d1j	DGJ	Migalastat (DB05018)	Cellvibrio japonicus	BETA-GALACTOSIDASE, PUTATIVE, BGL35A	DUF5597 Glyco_hydro_42	14	ASN A 67 LYS A 134 ASN A 135 ASN A 204 GLU A 205 ASN A 281 ASP A 322 TYR A 324 GLU A 349 PHE A 374 ASN A 383 LEU A 386 PHE C 479 ASP C 550	DGJ A 600
4DO5_A_DGJA509	4do5	DGJ	Migalastat (DB05018)	Homo sapiens	ALPHA-N-ACETYLGALACTOSAMINIDASE	Melibiase_2 Melibiase_2_C	12	TRP A 33 ASP A 78 ASP A 79 TYR A 119 CYS A 127 MET A 128 LYS A 154 ASP A 156 TYR A 192 ARG A 213 ASP A 217 MET A 253	DGJ A 509
4FNS_A_DGJA801	4fns	DGJ	Migalastat (DB05018)	Geobacillus stearothermophilus	ALPHA-GALACTOSIDASE AGAA	Glyco_hydro_36C Glyco_hydro_36N Melibiase	13	TRP A 336 ASP A 366 ASP A 367 TRP A 411 ARG A 443 LYS A 476 ASP A 478 ASN A 480 CYS A 526 GLY A 528 GLY A 529 TRP A 545 ASP A 548	DGJ A 801
4UFM_A_DGJA1001	4ufm	DGJ	Migalastat (DB05018)	Mus musculus	GALACTOCEREBROSIDASE	Glyco_hydro_59 Glyco_hydro_59M	13	GLY A 48 THR A 92 THR A 93 TRP A 135 ASN A 181 GLU A 182 TYR A 238 GLU A 258 SER A 261 TRP A 291 TYR A 303 ARG A 380 TRP A 524	DGJ A1001
6EUH_A_DGJA401	6euh	DGJ	Migalastat (DB05018)	Bacteroides thetaiotaomicron (strain atcc 29148 / dsm 2079 / nctc 10582 / e50 / vpi-5482)	BETA-GLUCANASE	Glyco_hydro_43	8	GLU A 87 ARG A 88 TYR A 113 ASP A 191 ALA A 241 GLY A 260 TRP A 261 GLN A 297	DGJ A 401
6TSH_A_DGJA3002	6tsh	DGJ	Migalastat (DB05018)	Escherichia coli	BETA-GALACTOSIDASE	Bgal_small_N DUF4981 Glyco_hydro_2 Glyco_hydro_2_C Glyco_hydro_2_N	13	ASN A 102 ASP A 201 HIS A 391 ASN A 460 GLU A 461 MET A 502 TYR A 503 GLU A 537 HIS A 540 TRP A 568 PHE A 601 ASN A 604 TRP A 999	DGJ A3002
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3S5Y_A_DGJA801","3s5y","DGJ","Migalastat (DB05018)","Homo sapiens","ALPHA-GALACTOSIDASE A","Melibiase_2;Melibiase_2_C",14,"TRP A  47;ASP A  92;ASP A  93;TYR A 134;CYS A 142;ALA A 143;LYS A 168;ASP A 170;GLU A 203;LEU A 206;TYR A 207;ARG A 227;ASP A 231;MET A 267","DGJ A 801\r"],["3THD_A_DGJA900","3thd","DGJ","Migalastat (DB05018)","Homo sapiens","BETA-GALACTOSIDASE","BetaGal_dom4_5;Glyco_hydro_35",14,"TYR A  83;ILE A 126;CYS A 127;ALA A 128;GLU A 129;ASN A 187;GLU A 188;GLU A 268;TYR A 270;TRP A 273;LEU A 274;TYR A 306;TYR A 331;TYR A 333","DGJ A 900\r"],["4CU8_A_DGJA1985","4cu8","DGJ","Migalastat (DB05018)","Streptococcus pneumoniae tigr4","GLYCOSIDE HYDROLASE 2","DUF4982;Glyco_hydro2_C5;Glyco_hydro_2;Glyco_hydro_2_C;Glyco_hydro_2_N",12,"ARG A 288;HIS A 484;ASN A 563;GLU A 564;ASN A 623;TYR A 624;GLU A 645;SER A 648;TRP A 685;TRP A 708;GLU A 716;PHE A 733","DGJ A1985\r"],["4D1J_A_DGJA600","4d1j","DGJ","Migalastat (DB05018)","Cellvibrio japonicus","BETA-GALACTOSIDASE, PUTATIVE, BGL35A","DUF5597;Glyco_hydro_42",14,"ASN A  67;LYS A 134;ASN A 135;ASN A 204;GLU A 205;ASN A 281;ASP A 322;TYR A 324;GLU A 349;PHE A 374;ASN A 383;LEU A 386;PHE C 479;ASP C 550","DGJ A 600\r"],["4DO5_A_DGJA509","4do5","DGJ","Migalastat (DB05018)","Homo sapiens","ALPHA-N-ACETYLGALACTOSAMINIDASE","Melibiase_2;Melibiase_2_C",12,"TRP A  33;ASP A  78;ASP A  79;TYR A 119;CYS A 127;MET A 128;LYS A 154;ASP A 156;TYR A 192;ARG A 213;ASP A 217;MET A 253","DGJ A 509\r"],["4FNS_A_DGJA801","4fns","DGJ","Migalastat (DB05018)","Geobacillus stearothermophilus","ALPHA-GALACTOSIDASE AGAA","Glyco_hydro_36C;Glyco_hydro_36N;Melibiase",13,"TRP A 336;ASP A 366;ASP A 367;TRP A 411;ARG A 443;LYS A 476;ASP A 478;ASN A 480;CYS A 526;GLY A 528;GLY A 529;TRP A 545;ASP A 548","DGJ A 801\r"],["4UFM_A_DGJA1001","4ufm","DGJ","Migalastat (DB05018)","Mus musculus","GALACTOCEREBROSIDASE","Glyco_hydro_59;Glyco_hydro_59M",13,"GLY A  48;THR A  92;THR A  93;TRP A 135;ASN A 181;GLU A 182;TYR A 238;GLU A 258;SER A 261;TRP A 291;TYR A 303;ARG A 380;TRP A 524","DGJ A1001\r"],["6EUH_A_DGJA401","6euh","DGJ","Migalastat (DB05018)","Bacteroides thetaiotaomicron (strain atcc 29148 \/ dsm 2079 \/ nctc 10582 \/ e50 \/ vpi-5482)","BETA-GLUCANASE","Glyco_hydro_43",8,"GLU A  87;ARG A  88;TYR A 113;ASP A 191;ALA A 241;GLY A 260;TRP A 261;GLN A 297","DGJ A 401\r"],["6TSH_A_DGJA3002","6tsh","DGJ","Migalastat (DB05018)","Escherichia coli","BETA-GALACTOSIDASE","Bgal_small_N;DUF4981;Glyco_hydro_2;Glyco_hydro_2_C;Glyco_hydro_2_N",13,"ASN A 102;ASP A 201;HIS A 391;ASN A 460;GLU A 461;MET A 502;TYR A 503;GLU A 537;HIS A 540;TRP A 568;PHE A 601;ASN A 604;TRP A 999","DGJ A3002\r"]]