Results: Ligand

Ligand ID: T44

Drugbank ID:
Levothyroxine
(DB00451)

Indication:
Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer.

LIST OF BINDING INTERFACES for query 'DB00451'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1F86_A_T44A428	1f86	T44	Levothyroxine (DB00451)	Homo sapiens	TRANSTHYRETIN THR119MET VARIANT	Transthyretin	8	LYS A 15 LEU A 17 THR A 106 ALA A 108 ALA A 109 LEU A 110 SER A 117 MET A 119	T44 A 428
1HK4_A_T44A1008	1hk4	T44	Levothyroxine (DB00451)	Homo sapiens	SERUM ALBUMIN	Serum_albumin	14	ASP A 187 GLU A 188 LYS A 190 ALA A 191 LYS A 195 GLU A 425 ASN A 429 LYS A 432 VAL A 433 LYS A 436 ASP A 451 TYR A 452 VAL A 455 VAL A 456	T44 A1008
1IE4_A_T44A128	1ie4	T44	Levothyroxine (DB00451)	Rattus norvegicus	TRANSTHYRETIN	Transthyretin	18	MET A 13 LYS C 15 LYS A 15 LEU C 17 LEU A 17 GLU A 54 GLU C 54 THR C 106 THR A 106 ALA A 108 ALA C 108 ALA A 109 ALA C 109 LEU A 110 LEU C 110 SER C 117 THR C 119 VAL A 121	T44 A 128
1SN0_B_T44B602	1sn0	T44	Levothyroxine (DB00451)	Sparus aurata	TRANSTHYRETIN	Transthyretin	14	LYS B 15 LYS D 15 LEU B 17 LEU D 17 GLU B 54 THR D 106 THR B 106 ALA D 108 ALA B 108 LEU D 109 LEU B 109 LEU D 110 LEU B 110 VAL B 121	T44 B 602
1Y0X_X_T44X500	1y0x	T44	Levothyroxine (DB00451)	Homo sapiens	THYROID HORMONE RECEPTOR BETA-1	Hormone_recep	25	PHE X 269 PHE X 272 ILE X 275 ILE X 276 ALA X 279 ARG X 282 MET X 310 MET X 313 SER X 314 ARG X 316 ALA X 317 ARG X 320 THR X 329 LEU X 330 ASN X 331 GLY X 332 LEU X 341 GLY X 344 GLY X 345 LEU X 346 ILE X 353 HIS X 435 MET X 442 PHE X 455 PHE X 459	T44 X 500
2XN6_A_T44A1370	2xn6	T44	Levothyroxine (DB00451)	Homo sapiens	THYROXINE-BINDING GLOBULIN	NA	16	SER A 23 SER A 24 ALA A 27 GLN A 238 LEU A 246 LEU A 248 SER A 266 LEU A 269 LYS A 270 TRP A 272 ASN A 273 LEU A 276 LEU B 376 GLU B 377 ARG B 378 ARG B 381	T44 A1370
3Q1E_C_T44C128	3q1e	T44	Levothyroxine (DB00451)	Danio rerio	5-HYDROXYISOURATE HYDROLASE	Transthyretin	18	HIS C 12 HIS A 12 LEU A 14 LEU C 14 HIS C 103 HIS A 103 PRO C 105 PRO A 105 LEU C 106 LEU A 106 LEU C 107 LEU A 107 SER C 114 SER A 114 THR A 115 THR C 115 THR A 116 THR C 116	T44 C 128
4LNX_A_T44A501	4lnx	T44	Levothyroxine (DB00451)	Homo sapiens	THYROID HORMONE RECEPTOR ALPHA	NA	9	SER A 326 GLU A 339 GLN A 342 LEU A 346 LEU A 368 MET A 369 VAL A 371 THR A 372 ARG A 375	T44 A 501
5MHE_H_T44H301	5mhe	T44	Levothyroxine (DB00451)	Mus musculus	FAB-FRAGMENT	NA	18	TYR H 33 SER H 35 LEU H 47 ALA H 50 ILE H 51 ASN H 52 SER H 57 THR H 58 TYR H 59 TYR L 93 LEU L 95 GLY H 99 ASP H 100 TYR H 107 TYR H 108 TYR H 109 ALA H 110 MET H 111	T44 H 301
7KJJ_A_T44A201	7kjj	T44	Levothyroxine (DB00451)	Unidentified	TTR ANCESTOR	NA	8	LYS A 18 LEU A 20 GLU A 57 THR A 109 ALA A 111 LEU A 112 LEU A 113 VAL A 124	T44 A 201
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1F86_A_T44A428","1f86","T44","Levothyroxine (DB00451)","Homo sapiens","TRANSTHYRETIN THR119MET VARIANT","Transthyretin",8,"LYS A  15;LEU A  17;THR A 106;ALA A 108;ALA A 109;LEU A 110;SER A 117;MET A 119","T44 A 428\r"],["1HK4_A_T44A1008","1hk4","T44","Levothyroxine (DB00451)","Homo sapiens","SERUM ALBUMIN","Serum_albumin",14,"ASP A 187;GLU A 188;LYS A 190;ALA A 191;LYS A 195;GLU A 425;ASN A 429;LYS A 432;VAL A 433;LYS A 436;ASP A 451;TYR A 452;VAL A 455;VAL A 456","T44 A1008\r"],["1IE4_A_T44A128","1ie4","T44","Levothyroxine (DB00451)","Rattus norvegicus","TRANSTHYRETIN","Transthyretin",18,"MET A  13;LYS C  15;LYS A  15;LEU C  17;LEU A  17;GLU A  54;GLU C  54;THR C 106;THR A 106;ALA A 108;ALA C 108;ALA A 109;ALA C 109;LEU A 110;LEU C 110;SER C 117;THR C 119;VAL A 121","T44 A 128\r"],["1SN0_B_T44B602","1sn0","T44","Levothyroxine (DB00451)","Sparus aurata","TRANSTHYRETIN","Transthyretin",14,"LYS B  15;LYS D  15;LEU B  17;LEU D  17;GLU B  54;THR D 106;THR B 106;ALA D 108;ALA B 108;LEU D 109;LEU B 109;LEU D 110;LEU B 110;VAL B 121","T44 B 602\r"],["1Y0X_X_T44X500","1y0x","T44","Levothyroxine (DB00451)","Homo sapiens","THYROID HORMONE RECEPTOR BETA-1","Hormone_recep",25,"PHE X 269;PHE X 272;ILE X 275;ILE X 276;ALA X 279;ARG X 282;MET X 310;MET X 313;SER X 314;ARG X 316;ALA X 317;ARG X 320;THR X 329;LEU X 330;ASN X 331;GLY X 332;LEU X 341;GLY X 344;GLY X 345;LEU X 346;ILE X 353;HIS X 435;MET X 442;PHE X 455;PHE X 459","T44 X 500\r"],["2XN6_A_T44A1370","2xn6","T44","Levothyroxine (DB00451)","Homo sapiens","THYROXINE-BINDING GLOBULIN","NA",16,"SER A  23;SER A  24;ALA A  27;GLN A 238;LEU A 246;LEU A 248;SER A 266;LEU A 269;LYS A 270;TRP A 272;ASN A 273;LEU A 276;LEU B 376;GLU B 377;ARG B 378;ARG B 381","T44 A1370\r"],["3Q1E_C_T44C128","3q1e","T44","Levothyroxine (DB00451)","Danio rerio","5-HYDROXYISOURATE HYDROLASE","Transthyretin",18,"HIS C  12;HIS A  12;LEU A  14;LEU C  14;HIS C 103;HIS A 103;PRO C 105;PRO A 105;LEU C 106;LEU A 106;LEU C 107;LEU A 107;SER C 114;SER A 114;THR A 115;THR C 115;THR A 116;THR C 116","T44 C 128\r"],["4LNX_A_T44A501","4lnx","T44","Levothyroxine (DB00451)","Homo sapiens","THYROID HORMONE RECEPTOR ALPHA","NA",9,"SER A 326;GLU A 339;GLN A 342;LEU A 346;LEU A 368;MET A 369;VAL A 371;THR A 372;ARG A 375","T44 A 501\r"],["5MHE_H_T44H301","5mhe","T44","Levothyroxine (DB00451)","Mus musculus","FAB-FRAGMENT","NA",18,"TYR H  33;SER H  35;LEU H  47;ALA H  50;ILE H  51;ASN H  52;SER H  57;THR H  58;TYR H  59;TYR L  93;LEU L  95;GLY H  99;ASP H 100;TYR H 107;TYR H 108;TYR H 109;ALA H 110;MET H 111","T44 H 301\r"],["7KJJ_A_T44A201","7kjj","T44","Levothyroxine (DB00451)","Unidentified","TTR ANCESTOR","NA",8,"LYS A  18;LEU A  20;GLU A  57;THR A 109;ALA A 111;LEU A 112;LEU A 113;VAL A 124","T44 A 201\r"]]