Ligand ID: LOC

Drugbank ID:
Colchicine
(DB01394)

Indication:
Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF).

LIST OF BINDING INTERFACES for query 'LOC'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
5EYP_B_LOCB502	5eyp	LOC	Colchicine (DB01394)	Synthetic construct; ovis aries	TUBULIN ALPHA CHAIN; TUBULIN BETA CHAIN	Tubulin Tubulin_C	24	ASN A 101 SER A 178 THR A 179 ALA A 180 VAL A 181 VAL B 238 CYS B 241 LEU B 242 LEU B 248 ALA B 250 ASP B 251 LYS B 254 LEU B 255 ASN B 258 MET B 259 THR B 314 VAL B 315 ALA B 316 ILE B 318 ASN B 350 LYS B 352 THR B 353 ALA B 354 ILE B 378	LOC B 502		Details
5NKN_A_LOCA201	5nkn	LOC	Colchicine (DB01394)	Homo sapiens	NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN	Lipocalin	18	GLY A  40 PHE A  41 TYR A  56 VAL A  66 PHE A  68 GLN A  69 LYS A  70 PHE A  71 MET A  73 MET A  79 LEU A  94 TRP A 106 PHE A 123 ARG A 130 ASP A 132 PHE A 134 THR A 136 TYR A 138	LOC A 201		Details
6AJZ_A_LOCA200	6ajz	LOC	Colchicine (DB01394)	Homo sapiens	BROMODOMAIN-CONTAINING PROTEIN 4	Bromodomain	14	TRP A  81 PRO A  82 PHE A  83 VAL A  87 LEU A  92 LEU A  94 TYR A  97 CYS A 136 TYR A 139 ASN A 140 LYS A 141 ASP A 144 ILE A 146 MET A 149	LOC A 200		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["5EYP_B_LOCB502","5eyp","LOC","Colchicine (DB01394)","Synthetic construct;ovis aries","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","Tubulin;Tubulin_C",24,"ASN A 101;SER A 178;THR A 179;ALA A 180;VAL A 181;VAL B 238;CYS B 241;LEU B 242;LEU B 248;ALA B 250;ASP B 251;LYS B 254;LEU B 255;ASN B 258;MET B 259;THR B 314;VAL B 315;ALA B 316;ILE B 318;ASN B 350;LYS B 352;THR B 353;ALA B 354;ILE B 378","LOC B 502\r"],["5NKN_A_LOCA201","5nkn","LOC","Colchicine (DB01394)","Homo sapiens","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Lipocalin",18,"GLY A 40;PHE A 41;TYR A 56;VAL A 66;PHE A 68;GLN A 69;LYS A 70;PHE A 71;MET A 73;MET A 79;LEU A 94;TRP A 106;PHE A 123;ARG A 130;ASP A 132;PHE A 134;THR A 136;TYR A 138","LOC A 201\r"],["6AJZ_A_LOCA200","6ajz","LOC","Colchicine (DB01394)","Homo sapiens","BROMODOMAIN-CONTAINING PROTEIN 4","Bromodomain",14,"TRP A 81;PRO A 82;PHE A 83;VAL A 87;LEU A 92;LEU A 94;TYR A 97;CYS A 136;TYR A 139;ASN A 140;LYS A 141;ASP A 144;ILE A 146;MET A 149","LOC A 200\r"]]