Results: Ligand

Ligand ID: CL6

Drugbank ID:
Clotrimazole
(DB00257)

Indication:
Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.

LIST OF BINDING INTERFACES for query 'DB00257'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2XFH_A_CL6A1413	2xfh	CL6	Clotrimazole (DB00257)	Saccharopolyspora erythraea	ERYTHROMYCIN B/D C-12 HYDROXYLASE	p450	11	MET A 86 HIS A 88 GLN A 173 ALA A 237 LEU A 240 ALA A 241 ILE A 244 THR A 245 PHE A 288 CYS A 353 ILE A 392	CL6 A1413
2XFH_A_CL6A1414	2xfh	CL6	Clotrimazole (DB00257)	Saccharopolyspora erythraea	ERYTHROMYCIN B/D C-12 HYDROXYLASE	p450	9	MET A 86 HIS A 88 LEU A 169 GLN A 173 ILE A 186 LEU A 190 THR A 236 ALA A 237 LEU A 240	CL6 A1414
3MDV_A_CL6A506	3mdv	CL6	Clotrimazole (DB00257)	Homo sapiens	CHOLESTEROL 24-HYDROXYLASE	NA	16	TYR A 109 LEU A 112 PHE A 121 VAL A 126 SER A 127 LEU A 219 ILE A 222 ARG A 226 THR A 298 ILE A 301 ALA A 302 GLU A 305 THR A 306 ALA A 367 ALA A 474 THR A 475	CL6 A 506
4XE3_A_CL6A502	4xe3	CL6	Clotrimazole (DB00257)	Streptomyces antibioticus	CYTOCHROME P-450	p450	9	LEU A 94 ALA A 244 THR A 248 VAL A 291 SER A 295 PHE A 296 CYS A 356 LEU A 396 ILE A 397	CL6 A 502
6H1T_A_CL6A502	6h1t	CL6	Clotrimazole (DB00257)	Bacillus megaterium	BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE	p450	14	LEU A 75 PHE A 82 VAL A 87 THR A 260 ILE A 263 ALA A 264 GLU A 267 THR A 268 THR A 327 ALA A 328 ALA A 330 CYS A 400 LEU A 437 THR A 438	CL6 A 502
6UW2_A_CL6A502	6uw2	CL6	Clotrimazole (DB00257)	Acanthamoeba castellanii str. neff	OBTUSIFOLIOL 14ALPHADEMETHYLASE	p450	15	TYR A 114 PHE A 116 SER A 117 PHE A 121 VAL A 126 TYR A 127 ALA A 290 LEU A 291 PHE A 293 ALA A 294 HIS A 297 THR A 298 LEU A 363 VAL A 366 CYS A 434	CL6 A 502
7AXA_A_CL6A501	7axa	CL6	Clotrimazole (DB00257)	Homo sapiens	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2	Hormone_recep	16	SER A 208 LEU A 209 LYS A 210 VAL A 211 MET A 243 SER A 247 PHE A 281 GLN A 285 PHE A 288 TRP A 299 TYR A 306 LEU A 308 MET A 323 LEU A 324 HIS A 327 HIS A 407	CL6 A 501
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2XFH_A_CL6A1413","2xfh","CL6","Clotrimazole (DB00257)","Saccharopolyspora erythraea","ERYTHROMYCIN B\/D C-12 HYDROXYLASE","p450",11,"MET A  86;HIS A  88;GLN A 173;ALA A 237;LEU A 240;ALA A 241;ILE A 244;THR A 245;PHE A 288;CYS A 353;ILE A 392","CL6 A1413\r"],["2XFH_A_CL6A1414","2xfh","CL6","Clotrimazole (DB00257)","Saccharopolyspora erythraea","ERYTHROMYCIN B\/D C-12 HYDROXYLASE","p450",9,"MET A  86;HIS A  88;LEU A 169;GLN A 173;ILE A 186;LEU A 190;THR A 236;ALA A 237;LEU A 240","CL6 A1414\r"],["3MDV_A_CL6A506","3mdv","CL6","Clotrimazole (DB00257)","Homo sapiens","CHOLESTEROL 24-HYDROXYLASE","NA",16,"TYR A 109;LEU A 112;PHE A 121;VAL A 126;SER A 127;LEU A 219;ILE A 222;ARG A 226;THR A 298;ILE A 301;ALA A 302;GLU A 305;THR A 306;ALA A 367;ALA A 474;THR A 475","CL6 A 506\r"],["4XE3_A_CL6A502","4xe3","CL6","Clotrimazole (DB00257)","Streptomyces antibioticus","CYTOCHROME P-450","p450",9,"LEU A  94;ALA A 244;THR A 248;VAL A 291;SER A 295;PHE A 296;CYS A 356;LEU A 396;ILE A 397","CL6 A 502\r"],["6H1T_A_CL6A502","6h1t","CL6","Clotrimazole (DB00257)","Bacillus megaterium","BIFUNCTIONAL CYTOCHROME P450\/NADPH--P450 REDUCTASE","p450",14,"LEU A  75;PHE A  82;VAL A  87;THR A 260;ILE A 263;ALA A 264;GLU A 267;THR A 268;THR A 327;ALA A 328;ALA A 330;CYS A 400;LEU A 437;THR A 438","CL6 A 502\r"],["6UW2_A_CL6A502","6uw2","CL6","Clotrimazole (DB00257)","Acanthamoeba castellanii str. neff","OBTUSIFOLIOL 14ALPHADEMETHYLASE","p450",15,"TYR A 114;PHE A 116;SER A 117;PHE A 121;VAL A 126;TYR A 127;ALA A 290;LEU A 291;PHE A 293;ALA A 294;HIS A 297;THR A 298;LEU A 363;VAL A 366;CYS A 434","CL6 A 502\r"],["7AXA_A_CL6A501","7axa","CL6","Clotrimazole (DB00257)","Homo sapiens","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","Hormone_recep",16,"SER A 208;LEU A 209;LYS A 210;VAL A 211;MET A 243;SER A 247;PHE A 281;GLN A 285;PHE A 288;TRP A 299;TYR A 306;LEU A 308;MET A 323;LEU A 324;HIS A 327;HIS A 407","CL6 A 501\r"]]