Ligand ID: 478

Drugbank ID:
Amprenavir
(DB00701)

Indication:
Amprenavir is a protease inhibitor used to treat HIV infection.

LIST OF BINDING INTERFACES for query '478'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3EKP_B_478B200	3ekp	478	Amprenavir (DB00701)	Hiv-1 m:b_arv2/sf2	PROTEASE	RVP	26	LEU B  23 LEU A  23 ASP B  25 ASP A  25 GLY A  27 GLY B  27 ALA B  28 ALA A  28 ASP B  29 ASP A  29 ASP B  30 ASP A  30 VAL B  32 VAL A  32 ILE A  47 ILE B  47 VAL B  48 VAL A  48 GLY A  49 GLY B  49 ILE B  50 ILE A  50 PRO B  81 ALA B  82 ILE B  84 ILE A  84	478 B 200		Details
3NU3_B_478B401	3nu3	478	Amprenavir (DB00701)	Human immunodeficiency virus 1	PROTEASE	RVP	31	ARG A   8 LEU A  23 ASP A  25 GLY A  27 ALA A  28 ASP A  29 ASP A  30 VAL A  32 ILE A  47 GLY A  48 GLY A  49 ILE A  50 LEU A  76 PRO A  81 VAL A  82 ILE A  84 ARG B 108 LEU B 123 ASP B 125 GLY B 127 ALA B 128 ASP B 129 ASP B 130 VAL B 132 ILE B 147 GLY B 148 GLY B 149 ILE B 150 PRO B 181 VAL B 182 ILE B 184	478 B 401		Details
3S45_B_478B201	3s45	478	Amprenavir (DB00701)	Human immunodeficiency virus 2	PROTEASE	RVP	27	LEU B  23 LEU A  23 ASP B  25 ASP A  25 GLY A  27 GLY B  27 ALA B  28 ALA A  28 ASP B  29 ASP A  29 ASP B  30 ASP A  30 ILE B  32 ILE A  32 VAL B  47 VAL A  47 GLY A  48 GLY B  48 GLY A  49 GLY B  49 ILE B  50 ILE A  50 PRO A  81 ILE A  82 ILE B  82 ILE B  84 ILE A  84	478 B 201		Details
3SM2_A_478A126	3sm2	478	Amprenavir (DB00701)	Dg-75 murine leukemia virus	GAG-PRO-POL POLYPROTEIN	RVP	31	LEU B  30 LEU A  30 ASP A  32 ASP B  32 GLY B  34 GLY A  34 ALA A  35 ALA B  35 GLN B  36 GLN A  36 HIS B  37 HIS A  37 VAL B  39 VAL A  39 VAL B  54 VAL A  54 GLN B  55 GLN A  55 GLY A  56 GLY B  56 ALA B  57 ALA A  57 LEU B  83 CYS A  88 CYS B  88 PRO A  89 PRO B  89 TYR A  90 TYR B  90 LEU A  92 LEU B  92	478 A 126		Details
4J5J_B_478B401	4j5j	478	Amprenavir (DB00701)	Human immunodeficiency virus 1	PROTEASE	RVP	28	LEU A  23 ASP A  25 GLY A  27 ALA A  28 ASP A  29 ASN A  30 ILE A  32 VAL A  47 GLY A  48 GLY A  49 ILE A  50 VAL A  82 VAL A  84 LEU B 123 ASP B 125 GLY B 127 ALA B 128 ASP B 129 ASN B 130 ILE B 132 VAL B 147 GLY B 148 GLY B 149 ILE B 150 LEU B 176 PRO B 181 VAL B 182 VAL B 184	478 B 401		Details
4J5J_B_478B402	4j5j	478	Amprenavir (DB00701)	Human immunodeficiency virus 1	PROTEASE	RVP	10	TRP B 142 PRO B 144 LYS B 145 MET B 146 LYS B 155 VAL B 156 ARG B 157 VAL B 177 GLY B 178 PRO B 179	478 B 402		Details
4RVJ_B_478B101	4rvj	478	Amprenavir (DB00701)	Human immunodeficiency virus 1	HIV-1 PROTEASE	RVP	29	LEU B  23 LEU A  23 ASP B  25 ASP A  25 GLY A  27 GLY B  27 ALA B  28 ALA A  28 ASP B  29 ASP A  29 ASP B  30 ASP A  30 VAL B  32 VAL A  32 ILE A  47 ILE B  47 GLY A  48 GLY B  48 GLY A  49 GLY B  49 ILE B  50 ILE A  50 LEU A  76 PRO B  81 PRO A  81 THR A  82 THR B  82 ILE B  84 ILE A  84	478 B 101		Details
6P9B_A_478A101	6p9b	478	Amprenavir (DB00701)	Human immunodeficiency virus type 1 group m subtype b (isolate bru/lai)	HIV-1 PROTEASE	RVP	29	LEU B  23 LEU A  23 ASP B  25 ASP A  25 GLY A  27 GLY B  27 ALA B  28 ALA A  28 ASP B  29 ASP A  29 ASP B  30 ASP A  30 VAL B  32 VAL A  32 ILE A  47 ILE B  47 GLY A  48 GLY B  48 GLY A  49 GLY B  49 ILE B  50 ILE A  50 LEU B  76 THR B  80 PRO B  81 VAL B  82 VAL A  82 VAL B  84 VAL A  84	478 A 101		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3EKP_B_478B200","3ekp","478","Amprenavir (DB00701)","Hiv-1 m:b_arv2\/sf2","PROTEASE","RVP",26,"LEU B 23;LEU A 23;ASP B 25;ASP A 25;GLY A 27;GLY B 27;ALA B 28;ALA A 28;ASP B 29;ASP A 29;ASP B 30;ASP A 30;VAL B 32;VAL A 32;ILE A 47;ILE B 47;VAL B 48;VAL A 48;GLY A 49;GLY B 49;ILE B 50;ILE A 50;PRO B 81;ALA B 82;ILE B 84;ILE A 84","478 B 200\r"],["3NU3_B_478B401","3nu3","478","Amprenavir (DB00701)","Human immunodeficiency virus 1","PROTEASE","RVP",31,"ARG A 8;LEU A 23;ASP A 25;GLY A 27;ALA A 28;ASP A 29;ASP A 30;VAL A 32;ILE A 47;GLY A 48;GLY A 49;ILE A 50;LEU A 76;PRO A 81;VAL A 82;ILE A 84;ARG B 108;LEU B 123;ASP B 125;GLY B 127;ALA B 128;ASP B 129;ASP B 130;VAL B 132;ILE B 147;GLY B 148;GLY B 149;ILE B 150;PRO B 181;VAL B 182;ILE B 184","478 B 401\r"],["3S45_B_478B201","3s45","478","Amprenavir (DB00701)","Human immunodeficiency virus 2","PROTEASE","RVP",27,"LEU B 23;LEU A 23;ASP B 25;ASP A 25;GLY A 27;GLY B 27;ALA B 28;ALA A 28;ASP B 29;ASP A 29;ASP B 30;ASP A 30;ILE B 32;ILE A 32;VAL B 47;VAL A 47;GLY A 48;GLY B 48;GLY A 49;GLY B 49;ILE B 50;ILE A 50;PRO A 81;ILE A 82;ILE B 82;ILE B 84;ILE A 84","478 B 201\r"],["3SM2_A_478A126","3sm2","478","Amprenavir (DB00701)","Dg-75 murine leukemia virus","GAG-PRO-POL POLYPROTEIN","RVP",31,"LEU B 30;LEU A 30;ASP A 32;ASP B 32;GLY B 34;GLY A 34;ALA A 35;ALA B 35;GLN B 36;GLN A 36;HIS B 37;HIS A 37;VAL B 39;VAL A 39;VAL B 54;VAL A 54;GLN B 55;GLN A 55;GLY A 56;GLY B 56;ALA B 57;ALA A 57;LEU B 83;CYS A 88;CYS B 88;PRO A 89;PRO B 89;TYR A 90;TYR B 90;LEU A 92;LEU B 92","478 A 126\r"],["4J5J_B_478B401","4j5j","478","Amprenavir (DB00701)","Human immunodeficiency virus 1","PROTEASE","RVP",28,"LEU A 23;ASP A 25;GLY A 27;ALA A 28;ASP A 29;ASN A 30;ILE A 32;VAL A 47;GLY A 48;GLY A 49;ILE A 50;VAL A 82;VAL A 84;LEU B 123;ASP B 125;GLY B 127;ALA B 128;ASP B 129;ASN B 130;ILE B 132;VAL B 147;GLY B 148;GLY B 149;ILE B 150;LEU B 176;PRO B 181;VAL B 182;VAL B 184","478 B 401\r"],["4J5J_B_478B402","4j5j","478","Amprenavir (DB00701)","Human immunodeficiency virus 1","PROTEASE","RVP",10,"TRP B 142;PRO B 144;LYS B 145;MET B 146;LYS B 155;VAL B 156;ARG B 157;VAL B 177;GLY B 178;PRO B 179","478 B 402\r"],["4RVJ_B_478B101","4rvj","478","Amprenavir (DB00701)","Human immunodeficiency virus 1","HIV-1 PROTEASE","RVP",29,"LEU B 23;LEU A 23;ASP B 25;ASP A 25;GLY A 27;GLY B 27;ALA B 28;ALA A 28;ASP B 29;ASP A 29;ASP B 30;ASP A 30;VAL B 32;VAL A 32;ILE A 47;ILE B 47;GLY A 48;GLY B 48;GLY A 49;GLY B 49;ILE B 50;ILE A 50;LEU A 76;PRO B 81;PRO A 81;THR A 82;THR B 82;ILE B 84;ILE A 84","478 B 101\r"],["6P9B_A_478A101","6p9b","478","Amprenavir (DB00701)","Human immunodeficiency virus type 1 group m subtype b (isolate bru\/lai)","HIV-1 PROTEASE","RVP",29,"LEU B 23;LEU A 23;ASP B 25;ASP A 25;GLY A 27;GLY B 27;ALA B 28;ALA A 28;ASP B 29;ASP A 29;ASP B 30;ASP A 30;VAL B 32;VAL A 32;ILE A 47;ILE B 47;GLY A 48;GLY B 48;GLY A 49;GLY B 49;ILE B 50;ILE A 50;LEU B 76;THR B 80;PRO B 81;VAL B 82;VAL A 82;VAL B 84;VAL A 84","478 A 101\r"]]