Ligand ID: IRE

Drugbank ID:
Gefitinib
(DB00317)

Indication:
Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.

LIST OF BINDING INTERFACES for query 'IRE'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4I22_A_IREA9001	4i22	IRE	Gefitinib (DB00317)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PK_Tyr_Ser-Thr	19	LEU A 718 GLY A 719 VAL A 726 ALA A 743 ILE A 744 LYS A 745 LEU A 788 ILE A 789 MET A 790 GLN A 791 LEU A 792 MET A 793 PRO A 794 GLY A 796 CYS A 797 ASP A 800 LEU A 844 THR A 854 ASP A 855	IRE A9001		Details
5Y80_A_IREA401	5y80	IRE	Gefitinib (DB00317)	Homo sapiens; lama glama	CYCLIN-G-ASSOCIATED KINASE	Pkinase	17	LEU A  46 ALA A  47 VAL A  54 ALA A  67 LYS A  69 GLU A  85 LEU A 121 THR A 123 GLU A 124 LEU A 125 CYS A 126 LYS A 127 GLY A 128 GLN A 129 LEU A 180 CYS A 190 ASP A 191	IRE A 401		Details
5Y80_A_IREA402	5y80	IRE	Gefitinib (DB00317)	Homo sapiens; lama glama	CYCLIN-G-ASSOCIATED KINASE	Pkinase	16	GLU A  77 LYS A  78 ALA A  81 ARG A 172 ASP A 173 GLY A 193 SER A 194 HIS A 200 TRP A 206 VAL A 214 ILE A 218 ASN A 221 THR A 222 ILE A 231 ILE A 240 GLN A 244	IRE A 402		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4I22_A_IREA9001","4i22","IRE","Gefitinib (DB00317)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PK_Tyr_Ser-Thr",19,"LEU A 718;GLY A 719;VAL A 726;ALA A 743;ILE A 744;LYS A 745;LEU A 788;ILE A 789;MET A 790;GLN A 791;LEU A 792;MET A 793;PRO A 794;GLY A 796;CYS A 797;ASP A 800;LEU A 844;THR A 854;ASP A 855","IRE A9001\r"],["5Y80_A_IREA401","5y80","IRE","Gefitinib (DB00317)","Homo sapiens;lama glama","CYCLIN-G-ASSOCIATED KINASE","Pkinase",17,"LEU A 46;ALA A 47;VAL A 54;ALA A 67;LYS A 69;GLU A 85;LEU A 121;THR A 123;GLU A 124;LEU A 125;CYS A 126;LYS A 127;GLY A 128;GLN A 129;LEU A 180;CYS A 190;ASP A 191","IRE A 401\r"],["5Y80_A_IREA402","5y80","IRE","Gefitinib (DB00317)","Homo sapiens;lama glama","CYCLIN-G-ASSOCIATED KINASE","Pkinase",16,"GLU A 77;LYS A 78;ALA A 81;ARG A 172;ASP A 173;GLY A 193;SER A 194;HIS A 200;TRP A 206;VAL A 214;ILE A 218;ASN A 221;THR A 222;ILE A 231;ILE A 240;GLN A 244","IRE A 402\r"]]