Results: Ligand

Ligand ID: 8PR

Drugbank ID:
Paroxetine
(DB00715)

Indication:
Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.

LIST OF BINDING INTERFACES for query 'DB00715'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3V5W_A_8PRA701	3v5w	8PR	Paroxetine (DB00715)	Homo sapiens; bos taurus	G-PROTEIN COUPLED RECEPTOR KINASE 2	PH Pkinase RGS	24	ILE A 197 GLY A 198 ARG A 199 GLY A 200 PHE A 202 GLY A 203 GLU A 204 VAL A 205 ALA A 218 LYS A 220 LEU A 222 VAL A 255 LEU A 271 ASP A 272 LEU A 273 MET A 274 ASP A 278 ALA A 321 LEU A 324 SER A 334 ASP A 335 ALA A 480 ASP A 481 ALA A 482	8PR A 701
4JLT_A_8PRA505	4jlt	8PR	Paroxetine (DB00715)	Oryctolagus cuniculus	CYTOCHROME P450 2B4	p450	19	LEU A 51 ARG A 98 ILE A 101 ILE A 114 PHE A 115 PHE A 206 ILE A 209 GLU A 218 PHE A 297 ALA A 298 GLU A 301 THR A 302 ILE A 363 PHE A 365 GLY A 366 VAL A 367 PRO A 368 PHE A 389 VAL A 477	8PR A 505
4L9I_A_8PRA601	4l9i	8PR	Paroxetine (DB00715)	Bos taurus	RHODOPSIN KINASE	Pkinase RGS	19	LEU A 193 GLY A 194 ARG A 195 GLY A 196 PHE A 198 GLY A 199 GLU A 200 VAL A 201 ALA A 214 LYS A 216 LEU A 218 VAL A 248 MET A 264 THR A 265 ILE A 266 MET A 267 ASP A 271 GLU A 318 LEU A 321	8PR A 601
4MM4_A_8PRA603	4mm4	8PR	Paroxetine (DB00715)	Aquifex aeolicus	TRANSPORTER	SNF	19	TYR A 21 ALA A 22 ASP A 24 PRO A 101 VAL A 104 ALA A 105 TYR A 107 TYR A 108 VAL A 109 PHE A 253 SER A 254 GLY A 256 PHE A 259 SER A 355 SER A 356 GLY A 359 MET A 360 ASP A 404 THR A 408	8PR A 603
5I6X_A_8PRA705	5i6x	8PR	Paroxetine (DB00715)	Homo sapiens; mus musculus	SODIUM-DEPENDENT SEROTONIN TRANSPORTER	SNF	17	TYR A 95 ALA A 96 ASP A 98 ALA A 169 ILE A 172 ALA A 173 TYR A 176 PHE A 335 SER A 336 LEU A 337 GLY A 338 PHE A 341 SER A 438 SER A 439 GLY A 442 THR A 497 VAL A 501	8PR A 705
6F6I_A_8PRA509	6f6i	8PR	Paroxetine (DB00715)	Ebola virus	ENVELOPE GLYCOPROTEIN; ENVELOPE GLYCOPROTEIN,GP,GP1	NA	15	ARG A 64 VAL A 66 GLY A 67 LEU A 68 GLU A 100 ALA A 101 GLY A 102 GLU A 103 LEU A 184 LEU A 186 LEU B 515 TYR B 517 THR B 519 MET B 548 LEU B 558	8PR A 509
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3V5W_A_8PRA701","3v5w","8PR","Paroxetine (DB00715)","Homo sapiens;bos taurus","G-PROTEIN COUPLED RECEPTOR KINASE 2","PH;Pkinase;RGS",24,"ILE A 197;GLY A 198;ARG A 199;GLY A 200;PHE A 202;GLY A 203;GLU A 204;VAL A 205;ALA A 218;LYS A 220;LEU A 222;VAL A 255;LEU A 271;ASP A 272;LEU A 273;MET A 274;ASP A 278;ALA A 321;LEU A 324;SER A 334;ASP A 335;ALA A 480;ASP A 481;ALA A 482","8PR A 701\r"],["4JLT_A_8PRA505","4jlt","8PR","Paroxetine (DB00715)","Oryctolagus cuniculus","CYTOCHROME P450 2B4","p450",19,"LEU A  51;ARG A  98;ILE A 101;ILE A 114;PHE A 115;PHE A 206;ILE A 209;GLU A 218;PHE A 297;ALA A 298;GLU A 301;THR A 302;ILE A 363;PHE A 365;GLY A 366;VAL A 367;PRO A 368;PHE A 389;VAL A 477","8PR A 505\r"],["4L9I_A_8PRA601","4l9i","8PR","Paroxetine (DB00715)","Bos taurus","RHODOPSIN KINASE","Pkinase;RGS",19,"LEU A 193;GLY A 194;ARG A 195;GLY A 196;PHE A 198;GLY A 199;GLU A 200;VAL A 201;ALA A 214;LYS A 216;LEU A 218;VAL A 248;MET A 264;THR A 265;ILE A 266;MET A 267;ASP A 271;GLU A 318;LEU A 321","8PR A 601\r"],["4MM4_A_8PRA603","4mm4","8PR","Paroxetine (DB00715)","Aquifex aeolicus","TRANSPORTER","SNF",19,"TYR A  21;ALA A  22;ASP A  24;PRO A 101;VAL A 104;ALA A 105;TYR A 107;TYR A 108;VAL A 109;PHE A 253;SER A 254;GLY A 256;PHE A 259;SER A 355;SER A 356;GLY A 359;MET A 360;ASP A 404;THR A 408","8PR A 603\r"],["5I6X_A_8PRA705","5i6x","8PR","Paroxetine (DB00715)","Homo sapiens;mus musculus","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","SNF",17,"TYR A  95;ALA A  96;ASP A  98;ALA A 169;ILE A 172;ALA A 173;TYR A 176;PHE A 335;SER A 336;LEU A 337;GLY A 338;PHE A 341;SER A 438;SER A 439;GLY A 442;THR A 497;VAL A 501","8PR A 705\r"],["6F6I_A_8PRA509","6f6i","8PR","Paroxetine (DB00715)","Ebola virus","ENVELOPE GLYCOPROTEIN;ENVELOPE GLYCOPROTEIN,GP,GP1","NA",15,"ARG A  64;VAL A  66;GLY A  67;LEU A  68;GLU A 100;ALA A 101;GLY A 102;GLU A 103;LEU A 184;LEU A 186;LEU B 515;TYR B 517;THR B 519;MET B 548;LEU B 558","8PR A 509\r"]]