Results: Ligand

Ligand ID: NOV

Drugbank ID:
Novobiocin
(DB01051)

Indication:
Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,...

LIST OF BINDING INTERFACES for query 'NOV'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1AJ6_A_NOVA1	1aj6	NOV	Novobiocin (DB01051)	Escherichia coli	GYRASE	HATPase_c	13	ASN A 46 ALA A 47 ASP A 49 GLU A 50 ASP A 73 ARG A 76 GLY A 77 ILE A 78 PRO A 79 ALA A 90 ILE A 94 VAL A 120 THR A 165	NOV A 1
1KIJ_A_NOVA400	1kij	NOV	Novobiocin (DB01051)	Thermus thermophilus	DNA GYRASE SUBUNIT B	DNA_gyraseB HATPase_c	22	ALA B 9 ILE B 10 ASN A 45 ALA A 46 ASP A 48 GLU A 49 ASP A 72 ARG A 75 GLY A 76 ILE A 77 PRO A 78 ASP A 80 ALA A 89 ILE A 93 TYR A 94 LYS A 102 PHE A 103 LYS A 109 VAL A 117 ALA A 119 ARG A 135 THR A 166	NOV A 400
1S14_A_NOVA1300	1s14	NOV	Novobiocin (DB01051)	Escherichia coli	TOPOISOMERASE IV SUBUNIT B	HATPase_c	14	ASN A1042 SER A1043 ASP A1045 GLU A1046 ASP A1069 ARG A1072 GLY A1073 MET A1074 PRO A1075 ASP A1077 ALA A1086 ILE A1090 ARG A1132 THR A1163	NOV A1300
3LPS_A_NOVA901	3lps	NOV	Novobiocin (DB01051)	Xanthomonas oryzae pv. oryzae	TOPOISOMERASE IV SUBUNIT B	DNA_gyraseB HATPase_c	14	ASN A 86 SER A 87 ASP A 89 GLU A 90 ASP A 113 ARG A 116 GLY A 117 MET A 118 PRO A 119 ASP A 121 ILE A 134 VAL A 160 ARG A 176 THR A 207	NOV A 901
4URN_A_NOVA2000	4urn	NOV	Novobiocin (DB01051)	Staphylococcus aureus	DNA TOPOISOMERASE IV, B SUBUNIT	NA	20	THR B 34 ASP B 35 LYS B 36 ARG B 37 ASN A 49 SER A 50 ASP A 52 GLU A 53 ASN A 56 ASP A 76 ARG A 79 GLY A 80 MET A 81 PRO A 82 ILE A 96 ARG A 138 THR A 168 LYS B 180 ALA B 181 ASN B 186	NOV A2000
4URO_A_NOVA2000	4uro	NOV	Novobiocin (DB01051)	Staphylococcus aureus	DNA GYRASE SUBUNIT B	HATPase_c	18	ASN A 54 SER A 55 ASP A 57 GLU A 58 ASP A 81 ARG A 84 GLY A 85 ILE A 86 PRO A 87 ASP A 89 GLN A 91 ALA A 98 ILE A 102 GLY A 125 SER A 128 ARG A 144 THR A 173 ARG D 200	NOV A2000
6B89_A_NOVA403	6b89	NOV	Novobiocin (DB01051)	Escherichia coli (strain k12)	LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB	ABC_tran BCA_ABC_TP_C	21	ILE A 52 LEU A 72 HIS A 73 ALA A 76 ILE A 80 TYR A 82 PRO A 84 GLU A 86 ALA A 87 SER A 88 PHE A 90 PHE B 90 ARG B 91 ARG B 92 LEU B 93 ALA B 101 VAL A 102 GLN B 104 GLN B 136 ARG A 150 ALA A 151	NOV A 403
6TBE_A_NOVA201	6tbe	NOV	Novobiocin (DB01051)	Homo sapiens	MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A	NA	18	GLU A 23 GLN A 26 ILE A 27 GLN A 30 HIS A 31 LYS A 34 ILE A 39 LYS A 53 LYS A 55 PHE A 56 LEU A 57 VAL A 58 PRO A 59 VAL A 62 LEU A 67 ILE A 70 ILE A 71 ARG A 74	NOV A 201
6Y8L_A_NOVA501	6y8l	NOV	Novobiocin (DB01051)	Mycolicibacterium thermoresistibile	DNA GYRASE SUBUNIT B	HATPase_c	21	ARG B 29 GLY B 31 MET B 32 GLY B 35 ASN A 52 ALA A 53 ASP A 55 GLU A 56 ASP A 79 ARG A 82 GLY A 83 ILE A 84 PRO A 85 GLU A 87 THR A 95 VAL A 99 MET A 100 VAL A 123 VAL A 125 ARG A 141 THR A 169	NOV A 501
6Y8O_A_NOVA301	6y8o	NOV	Novobiocin (DB01051)	Mycolicibacterium smegmatis	DNA GYRASE SUBUNIT B	HATPase_c	17	ASN A 52 ALA A 53 GLU A 56 ASP A 79 ARG A 82 GLY A 83 ILE A 84 PRO A 85 GLU A 87 THR A 95 VAL A 99 MET A 100 VAL A 123 VAL A 125 ARG A 141 THR A 169 ILE A 171	NOV A 301
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1AJ6_A_NOVA1","1aj6","NOV","Novobiocin (DB01051)","Escherichia coli","GYRASE","HATPase_c",13,"ASN A  46;ALA A  47;ASP A  49;GLU A  50;ASP A  73;ARG A  76;GLY A  77;ILE A  78;PRO A  79;ALA A  90;ILE A  94;VAL A 120;THR A 165","NOV A   1\r"],["1KIJ_A_NOVA400","1kij","NOV","Novobiocin (DB01051)","Thermus thermophilus","DNA GYRASE SUBUNIT B","DNA_gyraseB;HATPase_c",22,"ALA B   9;ILE B  10;ASN A  45;ALA A  46;ASP A  48;GLU A  49;ASP A  72;ARG A  75;GLY A  76;ILE A  77;PRO A  78;ASP A  80;ALA A  89;ILE A  93;TYR A  94;LYS A 102;PHE A 103;LYS A 109;VAL A 117;ALA A 119;ARG A 135;THR A 166","NOV A 400\r"],["1S14_A_NOVA1300","1s14","NOV","Novobiocin (DB01051)","Escherichia coli","TOPOISOMERASE IV SUBUNIT B","HATPase_c",14,"ASN A1042;SER A1043;ASP A1045;GLU A1046;ASP A1069;ARG A1072;GLY A1073;MET A1074;PRO A1075;ASP A1077;ALA A1086;ILE A1090;ARG A1132;THR A1163","NOV A1300\r"],["3LPS_A_NOVA901","3lps","NOV","Novobiocin (DB01051)","Xanthomonas oryzae pv. oryzae","TOPOISOMERASE IV SUBUNIT B","DNA_gyraseB;HATPase_c",14,"ASN A  86;SER A  87;ASP A  89;GLU A  90;ASP A 113;ARG A 116;GLY A 117;MET A 118;PRO A 119;ASP A 121;ILE A 134;VAL A 160;ARG A 176;THR A 207","NOV A 901\r"],["4URN_A_NOVA2000","4urn","NOV","Novobiocin (DB01051)","Staphylococcus aureus","DNA TOPOISOMERASE IV, B SUBUNIT","NA",20,"THR B  34;ASP B  35;LYS B  36;ARG B  37;ASN A  49;SER A  50;ASP A  52;GLU A  53;ASN A  56;ASP A  76;ARG A  79;GLY A  80;MET A  81;PRO A  82;ILE A  96;ARG A 138;THR A 168;LYS B 180;ALA B 181;ASN B 186","NOV A2000\r"],["4URO_A_NOVA2000","4uro","NOV","Novobiocin (DB01051)","Staphylococcus aureus","DNA GYRASE SUBUNIT B","HATPase_c",18,"ASN A  54;SER A  55;ASP A  57;GLU A  58;ASP A  81;ARG A  84;GLY A  85;ILE A  86;PRO A  87;ASP A  89;GLN A  91;ALA A  98;ILE A 102;GLY A 125;SER A 128;ARG A 144;THR A 173;ARG D 200","NOV A2000\r"],["6B89_A_NOVA403","6b89","NOV","Novobiocin (DB01051)","Escherichia coli (strain k12)","LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB","ABC_tran;BCA_ABC_TP_C",21,"ILE A  52;LEU A  72;HIS A  73;ALA A  76;ILE A  80;TYR A  82;PRO A  84;GLU A  86;ALA A  87;SER A  88;PHE A  90;PHE B  90;ARG B  91;ARG B  92;LEU B  93;ALA B 101;VAL A 102;GLN B 104;GLN B 136;ARG A 150;ALA A 151","NOV A 403\r"],["6TBE_A_NOVA201","6tbe","NOV","Novobiocin (DB01051)","Homo sapiens","MICROTUBULE-ASSOCIATED PROTEINS 1A\/1B LIGHT CHAIN 3A","NA",18,"GLU A  23;GLN A  26;ILE A  27;GLN A  30;HIS A  31;LYS A  34;ILE A  39;LYS A  53;LYS A  55;PHE A  56;LEU A  57;VAL A  58;PRO A  59;VAL A  62;LEU A  67;ILE A  70;ILE A  71;ARG A  74","NOV A 201\r"],["6Y8L_A_NOVA501","6y8l","NOV","Novobiocin (DB01051)","Mycolicibacterium thermoresistibile","DNA GYRASE SUBUNIT B","HATPase_c",21,"ARG B  29;GLY B  31;MET B  32;GLY B  35;ASN A  52;ALA A  53;ASP A  55;GLU A  56;ASP A  79;ARG A  82;GLY A  83;ILE A  84;PRO A  85;GLU A  87;THR A  95;VAL A  99;MET A 100;VAL A 123;VAL A 125;ARG A 141;THR A 169","NOV A 501\r"],["6Y8O_A_NOVA301","6y8o","NOV","Novobiocin (DB01051)","Mycolicibacterium smegmatis","DNA GYRASE SUBUNIT B","HATPase_c",17,"ASN A  52;ALA A  53;GLU A  56;ASP A  79;ARG A  82;GLY A  83;ILE A  84;PRO A  85;GLU A  87;THR A  95;VAL A  99;MET A 100;VAL A 123;VAL A 125;ARG A 141;THR A 169;ILE A 171","NOV A 301\r"]]