Results: Ligand

Ligand ID: IMN

Drugbank ID:
Indomethacin
(DB00328)

Indication:
Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants.

LIST OF BINDING INTERFACES for query 'DB00328'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1Z9H_A_IMNA379	1z9h	IMN	Indomethacin (DB00328)	Macaca fascicularis	MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2	GST_N_3	16	TYR A 107 THR A 109 CYS A 110 PRO A 111 PHE A 112 PRO A 134 VAL A 148 ILE A 246 SER A 247 VAL A 250 TYR A 251 SER A 260 TYR A 263 ILE A 264 VAL A 343 LEU A 347	IMN A 379
2BXK_A_IMNA2001	2bxk	IMN	Indomethacin (DB00328)	Homo sapiens	SERUM ALBUMIN	Serum_albumin	15	LEU A 198 LYS A 199 SER A 202 LEU A 203 PHE A 206 GLY A 207 ALA A 210 PHE A 211 TRP A 214 ALA A 215 ARG A 218 LEU A 219 LEU A 238 VAL A 343 ASP A 451	IMN A2001
2DM6_A_IMNA1401	2dm6	IMN	Indomethacin (DB00328)	Cavia porcellus	NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE	ADH_N_2 ADH_zinc_N	12	TYR A 49 ILE A 52 ALA A 53 ARG A 56 CYS A 239 TYR A 245 PRO B 257 GLU B 258 ILE B 261 TYR B 262 ILE A 271 TYR A 273	IMN A1401
2ZB8_A_IMNA800	2zb8	IMN	Indomethacin (DB00328)	Homo sapiens	PROSTAGLANDIN REDUCTASE 2	ADH_N_2 ADH_zinc_N	12	TYR A 51 CYS A 54 THR A 60 ILE A 65 PHE A 99 TYR A 100 MET A 135 CYS A 253 TYR A 259 LEU A 288 VAL A 289 LEU A 290	IMN A 800
3ADX_A_IMNA2	3adx	IMN	Indomethacin (DB00328)	Homo sapiens	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA	Hormone_recep	19	ILE A 281 PHE A 282 CYS A 285 GLN A 286 SER A 289 HIS A 323 ILE A 326 TYR A 327 LEU A 330 LEU A 353 LEU A 356 PHE A 360 PHE A 363 MET A 364 LYS A 367 HIS A 449 LEU A 453 LEU A 469 TYR A 473	IMN A 2
3FO7_A_IMNA301	3fo7	IMN	Indomethacin (DB00328)	Daboia russelli pulchella	PHOSPHOLIPASE A2 VRV-PL-VIIIA	Phospholip_A2_1	11	HIS A 48 ASP A 49 CYS A 50 TYR A 52 GLY A 53 PRO A 56 CYS A 61 ASN A 67 PRO A 68 LYS A 69 CYS A 133	IMN A 301
3IB1_A_IMNA701	3ib1	IMN	Indomethacin (DB00328)	Bos taurus	LACTOTRANSFERRIN	Transferrin	6	PRO A 429 THR A 430 GLU A 431 GLY A 662 THR A 663 GLU A 664	IMN A 701
3OGW_A_IMNA597	3ogw	IMN	Indomethacin (DB00328)	Bos taurus	LACTOPEROXIDASE	An_peroxidase	13	GLN A 105 ASP A 108 HIS A 109 PHE A 113 ALA A 114 PRO A 115 GLU A 116 PHE A 254 ARG A 255 GLU A 258 PHE A 381 GLN A 423 PRO A 424	IMN A 597
3UGR_A_IMNA2001	3ugr	IMN	Indomethacin (DB00328)	Homo sapiens	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3	Aldo_ket_red	22	TYR A 24 LEU A 54 TYR A 55 TRP A 86 HIS A 117 SER A 118 MET A 120 ASN A 167 GLU A 192 TYR A 216 SER A 217 SER A 221 GLN A 222 ARG A 223 TRP A 227 VAL A 228 TYR A 305 PHE A 306 PHE A 311 TYR A 317 PRO A 318 TYR A 319	IMN A2001
4COX_A_IMNA701	4cox	IMN	Indomethacin (DB00328)	Mus musculus	CYCLOOXYGENASE-2	An_peroxidase EGF	17	HIS A 90 ARG A 120 VAL A 349 LEU A 352 SER A 353 TYR A 355 PHE A 381 LEU A 384 TYR A 385 TRP A 387 PHE A 518 MET A 522 VAL A 523 GLY A 526 ALA A 527 SER A 530 LEU A 531	IMN A 701
4IKI_A_IMNA201	4iki	IMN	Indomethacin (DB00328)	Homo sapiens	TRANSTHYRETIN	Transthyretin	5	LYS A 15 LEU A 17 ALA A 108 LEU A 110 THR A 119	IMN A 201
4JQ4_A_IMNA401	4jq4	IMN	Indomethacin (DB00328)	Homo sapiens	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2	Aldo_ket_red	15	TYR A 24 VAL A 54 TYR A 55 HIS A 117 PHE A 118 VAL A 128 ILE A 129 ASN A 167 TYR A 216 GLU A 224 TRP A 227 LEU A 306 THR A 307 LEU A 308 PHE A 319	IMN A 401
4KYK_B_IMNB300	4kyk	IMN	Indomethacin (DB00328)	Mus musculus	LACTOYLGLUTATHIONE LYASE	Glyoxalase	16	LEU A 61 PHE A 63 ALA A 65 MET A 66 PHE A 68 LEU A 70 PHE A 93 LYS B 151 ASP B 155 GLY B 156 LYS B 157 MET B 158 LEU B 161 PHE B 163 GLU B 173 ILE B 180	IMN B 300
4YIA_B_IMNB401	4yia	IMN	Indomethacin (DB00328)	Homo sapiens	THYROXINE-BINDING GLOBULIN	NA	17	SER A 23 SER A 24 ALA A 27 GLN A 238 LEU A 246 LEU A 248 SER A 266 LEU A 269 LYS A 270 TRP A 272 ASN A 273 LEU A 276 LEU B 376 GLU B 377 ARG B 378 ARG B 381 SER B 382	IMN B 401
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1Z9H_A_IMNA379","1z9h","IMN","Indomethacin (DB00328)","Macaca fascicularis","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","GST_N_3",16,"TYR A 107;THR A 109;CYS A 110;PRO A 111;PHE A 112;PRO A 134;VAL A 148;ILE A 246;SER A 247;VAL A 250;TYR A 251;SER A 260;TYR A 263;ILE A 264;VAL A 343;LEU A 347","IMN A 379\r"],["2BXK_A_IMNA2001","2bxk","IMN","Indomethacin (DB00328)","Homo sapiens","SERUM ALBUMIN","Serum_albumin",15,"LEU A 198;LYS A 199;SER A 202;LEU A 203;PHE A 206;GLY A 207;ALA A 210;PHE A 211;TRP A 214;ALA A 215;ARG A 218;LEU A 219;LEU A 238;VAL A 343;ASP A 451","IMN A2001\r"],["2DM6_A_IMNA1401","2dm6","IMN","Indomethacin (DB00328)","Cavia porcellus","NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE","ADH_N_2;ADH_zinc_N",12,"TYR A  49;ILE A  52;ALA A  53;ARG A  56;CYS A 239;TYR A 245;PRO B 257;GLU B 258;ILE B 261;TYR B 262;ILE A 271;TYR A 273","IMN A1401\r"],["2ZB8_A_IMNA800","2zb8","IMN","Indomethacin (DB00328)","Homo sapiens","PROSTAGLANDIN REDUCTASE 2","ADH_N_2;ADH_zinc_N",12,"TYR A  51;CYS A  54;THR A  60;ILE A  65;PHE A  99;TYR A 100;MET A 135;CYS A 253;TYR A 259;LEU A 288;VAL A 289;LEU A 290","IMN A 800\r"],["3ADX_A_IMNA2","3adx","IMN","Indomethacin (DB00328)","Homo sapiens","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","Hormone_recep",19,"ILE A 281;PHE A 282;CYS A 285;GLN A 286;SER A 289;HIS A 323;ILE A 326;TYR A 327;LEU A 330;LEU A 353;LEU A 356;PHE A 360;PHE A 363;MET A 364;LYS A 367;HIS A 449;LEU A 453;LEU A 469;TYR A 473","IMN A   2\r"],["3FO7_A_IMNA301","3fo7","IMN","Indomethacin (DB00328)","Daboia russelli pulchella","PHOSPHOLIPASE A2 VRV-PL-VIIIA","Phospholip_A2_1",11,"HIS A  48;ASP A  49;CYS A  50;TYR A  52;GLY A  53;PRO A  56;CYS A  61;ASN A  67;PRO A  68;LYS A  69;CYS A 133","IMN A 301\r"],["3IB1_A_IMNA701","3ib1","IMN","Indomethacin (DB00328)","Bos taurus","LACTOTRANSFERRIN","Transferrin",6,"PRO A 429;THR A 430;GLU A 431;GLY A 662;THR A 663;GLU A 664","IMN A 701\r"],["3OGW_A_IMNA597","3ogw","IMN","Indomethacin (DB00328)","Bos taurus","LACTOPEROXIDASE","An_peroxidase",13,"GLN A 105;ASP A 108;HIS A 109;PHE A 113;ALA A 114;PRO A 115;GLU A 116;PHE A 254;ARG A 255;GLU A 258;PHE A 381;GLN A 423;PRO A 424","IMN A 597\r"],["3UGR_A_IMNA2001","3ugr","IMN","Indomethacin (DB00328)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","Aldo_ket_red",22,"TYR A  24;LEU A  54;TYR A  55;TRP A  86;HIS A 117;SER A 118;MET A 120;ASN A 167;GLU A 192;TYR A 216;SER A 217;SER A 221;GLN A 222;ARG A 223;TRP A 227;VAL A 228;TYR A 305;PHE A 306;PHE A 311;TYR A 317;PRO A 318;TYR A 319","IMN A2001\r"],["4COX_A_IMNA701","4cox","IMN","Indomethacin (DB00328)","Mus musculus","CYCLOOXYGENASE-2","An_peroxidase;EGF",17,"HIS A  90;ARG A 120;VAL A 349;LEU A 352;SER A 353;TYR A 355;PHE A 381;LEU A 384;TYR A 385;TRP A 387;PHE A 518;MET A 522;VAL A 523;GLY A 526;ALA A 527;SER A 530;LEU A 531","IMN A 701\r"],["4IKI_A_IMNA201","4iki","IMN","Indomethacin (DB00328)","Homo sapiens","TRANSTHYRETIN","Transthyretin",5,"LYS A  15;LEU A  17;ALA A 108;LEU A 110;THR A 119","IMN A 201\r"],["4JQ4_A_IMNA401","4jq4","IMN","Indomethacin (DB00328)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","Aldo_ket_red",15,"TYR A  24;VAL A  54;TYR A  55;HIS A 117;PHE A 118;VAL A 128;ILE A 129;ASN A 167;TYR A 216;GLU A 224;TRP A 227;LEU A 306;THR A 307;LEU A 308;PHE A 319","IMN A 401\r"],["4KYK_B_IMNB300","4kyk","IMN","Indomethacin (DB00328)","Mus musculus","LACTOYLGLUTATHIONE LYASE","Glyoxalase",16,"LEU A  61;PHE A  63;ALA A  65;MET A  66;PHE A  68;LEU A  70;PHE A  93;LYS B 151;ASP B 155;GLY B 156;LYS B 157;MET B 158;LEU B 161;PHE B 163;GLU B 173;ILE B 180","IMN B 300\r"],["4YIA_B_IMNB401","4yia","IMN","Indomethacin (DB00328)","Homo sapiens","THYROXINE-BINDING GLOBULIN","NA",17,"SER A  23;SER A  24;ALA A  27;GLN A 238;LEU A 246;LEU A 248;SER A 266;LEU A 269;LYS A 270;TRP A 272;ASN A 273;LEU A 276;LEU B 376;GLU B 377;ARG B 378;ARG B 381;SER B 382","IMN B 401\r"]]