Results: Ligand

Ligand ID: TOP

Drugbank ID:
Trimethoprim
(DB00440)

Indication:
Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.

LIST OF BINDING INTERFACES for query 'DB00440'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2BFM_A_TOPA1290	2bfm	TOP	Trimethoprim (DB00440)	Leishmania major	PTERIDINE REDUCTASE 1	adh_short_C2	11	PHE A 113 ASP A 181 LEU A 188 TYR A 191 TYR A 194 GLY A 225 LEU A 226 LEU A 229 HIS A 241 TYR A 283 ARG D 287	TOP A1290
2W3A_A_TOPA1190	2w3a	TOP	Trimethoprim (DB00440)	Homo sapiens	DIHYDROFOLATE REDUCTASE	DHFR_1	14	ILE A 7 VAL A 8 ALA A 9 LEU A 22 GLU A 30 PHE A 31 PHE A 34 THR A 56 ILE A 60 PRO A 61 LEU A 67 VAL A 115 TYR A 121 THR A 136	TOP A1190
2W3V_A_TOPA1169	2w3v	TOP	Trimethoprim (DB00440)	Mycobacterium avium	DIHYDROFOLATE REDUCTASE	DHFR_1	14	VAL A 9 TRP A 10 ALA A 11 ILE A 24 ASP A 31 LEU A 32 PHE A 35 SER A 53 LEU A 54 PRO A 55 LEU A 61 ILE A 102 TYR A 108 THR A 121	TOP A1169
2W9H_A_TOPA1160	2w9h	TOP	Trimethoprim (DB00440)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE	DHFR_1	14	LEU A 5 VAL A 6 ALA A 7 ASN A 18 GLN A 19 LEU A 20 ASP A 27 LEU A 28 VAL A 31 SER A 49 ILE A 50 PHE A 92 PHE A 98 THR A 111	TOP A1160
2W9S_A_TOPA1160	2w9s	TOP	Trimethoprim (DB00440)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	DHFR_1	13	ILE A 5 VAL A 6 ALA A 7 LEU A 20 ASP A 27 LEU A 28 ILE A 31 SER A 49 ILE A 50 LEU A 54 PHE A 92 TYR A 98 THR A 111	TOP A1160
3FL9_A_TOPA200	3fl9	TOP	Trimethoprim (DB00440)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	DHFR_1	14	MET A 6 VAL A 7 ALA A 8 LEU A 21 GLU A 28 LEU A 29 VAL A 32 ASN A 47 ALA A 50 ILE A 51 LEU A 55 PHE A 96 TYR A 102 THR A 115	TOP A 200
3TQ8_A_TOPA2001	3tq8	TOP	Trimethoprim (DB00440)	Coxiella burnetii	DIHYDROFOLATE REDUCTASE	DHFR_1	14	ILE A 6 ALA A 7 ALA A 8 LEU A 21 ASP A 28 LEU A 29 HIS A 31 PHE A 32 SER A 50 ILE A 51 LEU A 55 ILE A 96 PHE A 102 THR A 115	TOP A2001
4G8Z_X_TOPX301	4g8z	TOP	Trimethoprim (DB00440)	Pneumocystis jirovecii	DIHYDROFOLATE REDUCTASE	DHFR_1	16	ILE X 10 VAL X 11 ALA X 12 SER X 24 LEU X 25 GLU X 32 ILE X 33 PHE X 36 SER X 64 ILE X 65 PRO X 66 LEU X 72 ILE X 123 GLY X 124 TYR X 129 THR X 144	TOP X 301
4KM2_A_TOPA202	4km2	TOP	Trimethoprim (DB00440)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	DHFR_1	15	ILE A 5 TRP A 6 ALA A 7 ILE A 20 ASP A 27 GLN A 28 PHE A 31 MET A 42 THR A 46 LEU A 50 VAL A 54 LEU A 57 ILE A 94 TYR A 100 THR A 113	TOP A 202
4XT7_A_TOPA302	4xt7	TOP	Trimethoprim (DB00440)	Mycobacterium tuberculosis (strain atcc 25618 / h37rv)	RV2671	RibD_C	13	ASN A 44 PHE A 45 ILE A 46 THR A 58 SER A 59 GLY A 60 ALA A 63 ASP A 67 ARG A 68 PHE A 71 GLU A 91 GLU A 193 THR A 214	TOP A 302
6RUM_A_TOPA301	6rum	TOP	Trimethoprim (DB00440)	Lama glama; escherichia coli (strain k12)	GFP-LAMA-G97 A GFP ENHANCER NANOBODY WITH CPDHFR INSERTION	NA	17	ASN A 95 ASP A 101 LEU A 102 TRP A 104 PHE A 105 SER A 123 ILE A 124 ARG A 126 LEU A 128 ILE A 168 TYR A 174 THR A 187 ILE A 243 ALA A 244 ALA A 245 MET A 258 ASN A 261	TOP A 301
6XG5_A_TOPA303	6xg5	TOP	Trimethoprim (DB00440)	Escherichia coli (strain k12)	DIHYDROFOLATE REDUCTASE	DHFR_1	14	ILE A 5 ALA A 6 ALA A 7 MET A 20 ASP A 27 LEU A 28 TRP A 30 PHE A 31 SER A 49 ILE A 50 LEU A 54 ILE A 94 TYR A 100 THR A 113	TOP A 303
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2BFM_A_TOPA1290","2bfm","TOP","Trimethoprim (DB00440)","Leishmania major","PTERIDINE REDUCTASE 1","adh_short_C2",11,"PHE A 113;ASP A 181;LEU A 188;TYR A 191;TYR A 194;GLY A 225;LEU A 226;LEU A 229;HIS A 241;TYR A 283;ARG D 287","TOP A1290\r"],["2W3A_A_TOPA1190","2w3a","TOP","Trimethoprim (DB00440)","Homo sapiens","DIHYDROFOLATE REDUCTASE","DHFR_1",14,"ILE A   7;VAL A   8;ALA A   9;LEU A  22;GLU A  30;PHE A  31;PHE A  34;THR A  56;ILE A  60;PRO A  61;LEU A  67;VAL A 115;TYR A 121;THR A 136","TOP A1190\r"],["2W3V_A_TOPA1169","2w3v","TOP","Trimethoprim (DB00440)","Mycobacterium avium","DIHYDROFOLATE REDUCTASE","DHFR_1",14,"VAL A   9;TRP A  10;ALA A  11;ILE A  24;ASP A  31;LEU A  32;PHE A  35;SER A  53;LEU A  54;PRO A  55;LEU A  61;ILE A 102;TYR A 108;THR A 121","TOP A1169\r"],["2W9H_A_TOPA1160","2w9h","TOP","Trimethoprim (DB00440)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE","DHFR_1",14,"LEU A   5;VAL A   6;ALA A   7;ASN A  18;GLN A  19;LEU A  20;ASP A  27;LEU A  28;VAL A  31;SER A  49;ILE A  50;PHE A  92;PHE A  98;THR A 111","TOP A1160\r"],["2W9S_A_TOPA1160","2w9s","TOP","Trimethoprim (DB00440)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","DHFR_1",13,"ILE A   5;VAL A   6;ALA A   7;LEU A  20;ASP A  27;LEU A  28;ILE A  31;SER A  49;ILE A  50;LEU A  54;PHE A  92;TYR A  98;THR A 111","TOP A1160\r"],["3FL9_A_TOPA200","3fl9","TOP","Trimethoprim (DB00440)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","DHFR_1",14,"MET A   6;VAL A   7;ALA A   8;LEU A  21;GLU A  28;LEU A  29;VAL A  32;ASN A  47;ALA A  50;ILE A  51;LEU A  55;PHE A  96;TYR A 102;THR A 115","TOP A 200\r"],["3TQ8_A_TOPA2001","3tq8","TOP","Trimethoprim (DB00440)","Coxiella burnetii","DIHYDROFOLATE REDUCTASE","DHFR_1",14,"ILE A   6;ALA A   7;ALA A   8;LEU A  21;ASP A  28;LEU A  29;HIS A  31;PHE A  32;SER A  50;ILE A  51;LEU A  55;ILE A  96;PHE A 102;THR A 115","TOP A2001\r"],["4G8Z_X_TOPX301","4g8z","TOP","Trimethoprim (DB00440)","Pneumocystis jirovecii","DIHYDROFOLATE REDUCTASE","DHFR_1",16,"ILE X  10;VAL X  11;ALA X  12;SER X  24;LEU X  25;GLU X  32;ILE X  33;PHE X  36;SER X  64;ILE X  65;PRO X  66;LEU X  72;ILE X 123;GLY X 124;TYR X 129;THR X 144","TOP X 301\r"],["4KM2_A_TOPA202","4km2","TOP","Trimethoprim (DB00440)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","DHFR_1",15,"ILE A   5;TRP A   6;ALA A   7;ILE A  20;ASP A  27;GLN A  28;PHE A  31;MET A  42;THR A  46;LEU A  50;VAL A  54;LEU A  57;ILE A  94;TYR A 100;THR A 113","TOP A 202\r"],["4XT7_A_TOPA302","4xt7","TOP","Trimethoprim (DB00440)","Mycobacterium tuberculosis (strain atcc 25618 \/ h37rv)","RV2671","RibD_C",13,"ASN A  44;PHE A  45;ILE A  46;THR A  58;SER A  59;GLY A  60;ALA A  63;ASP A  67;ARG A  68;PHE A  71;GLU A  91;GLU A 193;THR A 214","TOP A 302\r"],["6RUM_A_TOPA301","6rum","TOP","Trimethoprim (DB00440)","Lama glama;escherichia coli (strain k12)","GFP-LAMA-G97 A GFP ENHANCER NANOBODY WITH CPDHFR INSERTION","NA",17,"ASN A  95;ASP A 101;LEU A 102;TRP A 104;PHE A 105;SER A 123;ILE A 124;ARG A 126;LEU A 128;ILE A 168;TYR A 174;THR A 187;ILE A 243;ALA A 244;ALA A 245;MET A 258;ASN A 261","TOP A 301\r"],["6XG5_A_TOPA303","6xg5","TOP","Trimethoprim (DB00440)","Escherichia coli (strain k12)","DIHYDROFOLATE REDUCTASE","DHFR_1",14,"ILE A   5;ALA A   6;ALA A   7;MET A  20;ASP A  27;LEU A  28;TRP A  30;PHE A  31;SER A  49;ILE A  50;LEU A  54;ILE A  94;TYR A 100;THR A 113","TOP A 303\r"]]