Results: Ligand

Ligand ID: HFG

Drugbank ID:
Halofuginone
(DB04866)

Indication:
Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis...

LIST OF BINDING INTERFACES for query 'HFG'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4HVC_A_HFGA1602	4hvc	HFG	Halofuginone (DB04866)	Homo sapiens	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	18	LEU A1087 HIS A1093 PHE A1097 GLU A1100 VAL A1101 PRO A1120 THR A1121 GLU A1123 ARG A1152 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 HIS A1242 SER A1272 TRP A1273 GLY A1274	HFG A1602
4YDQ_A_HFGA802	4ydq	HFG	Halofuginone (DB04866)	Plasmodium falciparum	PROLINE--TRNA LIGASE	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	17	LEU A 325 PHE A 335 GLU A 338 VAL A 339 PRO A 358 THR A 359 GLU A 361 ARG A 390 TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 HIS A 480 SER A 508 TRP A 509 GLY A 510	HFG A 802
5F9Z_A_HFGA702	5f9z	HFG	Halofuginone (DB04866)	Cryptosporidium parvum	AMINOACYL-TRNA SYNTHETASE	NA	19	LEU A 266 GLU A 274 GLY A 275 PHE A 276 GLU A 279 VAL A 280 PRO A 299 THR A 300 GLU A 302 ARG A 331 TRP A 348 GLU A 350 HIS A 352 PHE A 395 THR A 419 HIS A 421 SER A 449 TRP A 450 GLY A 451	HFG A 702
5XIP_A_HFGA1003	5xip	HFG	Halofuginone (DB04866)	Eimeria tenella	PROLYL-TRNA SYNTHETASE, PUTATIVE	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	17	LEU A 325 PHE A 335 GLU A 338 VAL A 339 PRO A 358 THR A 359 GLU A 361 ARG A 390 TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 HIS A 480 SER A 508 TRP A 509 GLY A 510	HFG A1003
5XIQ_A_HFGA1002	5xiq	HFG	Halofuginone (DB04866)	Toxoplasma gondii (strain atcc 50611 / me49)	PROLYL-TRNA SYNTHETASE (PRORS)	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	17	LEU A 405 PHE A 415 GLU A 418 VAL A 419 PRO A 438 THR A 439 GLU A 441 ARG A 470 TRP A 487 GLU A 489 HIS A 491 PHE A 534 THR A 558 HIS A 560 SER A 588 TRP A 589 GLY A 590	HFG A1002
5ZNJ_A_HFGA602	5znj	HFG	Halofuginone (DB04866)	Staphylococcus aureus	PROLINE--TRNA LIGASE	NA	16	TRP A 80 ARG A 85 TYR A 89 GLU A 92 LEU A 93 PRO A 108 THR A 109 GLU A 111 ARG A 140 MET A 157 ASP A 159 TYR A 161 GLN A 409 CYS A 439 TYR A 440 GLY A 441	HFG A 602
6MN8_A_HFGA603	6mn8	HFG	Halofuginone (DB04866)	Onchocerca volvulus	UNCHARACTERIZED PROTEIN	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	16	LEU A 125 PHE A 135 GLU A 138 VAL A 139 PRO A 158 THR A 159 GLU A 161 ARG A 190 TRP A 207 GLU A 209 HIS A 211 THR A 278 HIS A 280 SER A 309 TRP A 310 GLY A 311	HFG A 603
6UYH_A_HFGA602	6uyh	HFG	Halofuginone (DB04866)	Naegleria fowleri	PROLYL-TRNA SYNTHETASE	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	17	LEU A 77 PHE A 87 GLU A 90 VAL A 91 PRO A 110 THR A 111 GLU A 113 ARG A 142 TRP A 159 GLU A 161 HIS A 163 PHE A 206 THR A 230 HIS A 232 SER A 260 TRP A 261 GLY A 262	HFG A 602
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4HVC_A_HFGA1602","4hvc","HFG","Halofuginone (DB04866)","Homo sapiens","BIFUNCTIONAL GLUTAMATE\/PROLINE--TRNA LIGASE","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b",18,"LEU A1087;HIS A1093;PHE A1097;GLU A1100;VAL A1101;PRO A1120;THR A1121;GLU A1123;ARG A1152;TRP A1169;GLU A1171;HIS A1173;PHE A1216;THR A1240;HIS A1242;SER A1272;TRP A1273;GLY A1274","HFG A1602\r"],["4YDQ_A_HFGA802","4ydq","HFG","Halofuginone (DB04866)","Plasmodium falciparum","PROLINE--TRNA LIGASE","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b",17,"LEU A 325;PHE A 335;GLU A 338;VAL A 339;PRO A 358;THR A 359;GLU A 361;ARG A 390;TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;HIS A 480;SER A 508;TRP A 509;GLY A 510","HFG A 802\r"],["5F9Z_A_HFGA702","5f9z","HFG","Halofuginone (DB04866)","Cryptosporidium parvum","AMINOACYL-TRNA SYNTHETASE","NA",19,"LEU A 266;GLU A 274;GLY A 275;PHE A 276;GLU A 279;VAL A 280;PRO A 299;THR A 300;GLU A 302;ARG A 331;TRP A 348;GLU A 350;HIS A 352;PHE A 395;THR A 419;HIS A 421;SER A 449;TRP A 450;GLY A 451","HFG A 702\r"],["5XIP_A_HFGA1003","5xip","HFG","Halofuginone (DB04866)","Eimeria tenella","PROLYL-TRNA SYNTHETASE, PUTATIVE","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b",17,"LEU A 325;PHE A 335;GLU A 338;VAL A 339;PRO A 358;THR A 359;GLU A 361;ARG A 390;TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;HIS A 480;SER A 508;TRP A 509;GLY A 510","HFG A1003\r"],["5XIQ_A_HFGA1002","5xiq","HFG","Halofuginone (DB04866)","Toxoplasma gondii (strain atcc 50611 \/ me49)","PROLYL-TRNA SYNTHETASE (PRORS)","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b",17,"LEU A 405;PHE A 415;GLU A 418;VAL A 419;PRO A 438;THR A 439;GLU A 441;ARG A 470;TRP A 487;GLU A 489;HIS A 491;PHE A 534;THR A 558;HIS A 560;SER A 588;TRP A 589;GLY A 590","HFG A1002\r"],["5ZNJ_A_HFGA602","5znj","HFG","Halofuginone (DB04866)","Staphylococcus aureus","PROLINE--TRNA LIGASE","NA",16,"TRP A  80;ARG A  85;TYR A  89;GLU A  92;LEU A  93;PRO A 108;THR A 109;GLU A 111;ARG A 140;MET A 157;ASP A 159;TYR A 161;GLN A 409;CYS A 439;TYR A 440;GLY A 441","HFG A 602\r"],["6MN8_A_HFGA603","6mn8","HFG","Halofuginone (DB04866)","Onchocerca volvulus","UNCHARACTERIZED PROTEIN","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b",16,"LEU A 125;PHE A 135;GLU A 138;VAL A 139;PRO A 158;THR A 159;GLU A 161;ARG A 190;TRP A 207;GLU A 209;HIS A 211;THR A 278;HIS A 280;SER A 309;TRP A 310;GLY A 311","HFG A 603\r"],["6UYH_A_HFGA602","6uyh","HFG","Halofuginone (DB04866)","Naegleria fowleri","PROLYL-TRNA SYNTHETASE","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b",17,"LEU A  77;PHE A  87;GLU A  90;VAL A  91;PRO A 110;THR A 111;GLU A 113;ARG A 142;TRP A 159;GLU A 161;HIS A 163;PHE A 206;THR A 230;HIS A 232;SER A 260;TRP A 261;GLY A 262","HFG A 602\r"]]