Results: Ligand

Ligand ID: STR

Drugbank ID:
Progesterone
(DB00396)

Indication:
Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia.

LIST OF BINDING INTERFACES for query 'DB00396'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1A28_A_STRA1	1a28	STR	Progesterone (DB00396)	Homo sapiens	PROGESTERONE RECEPTOR	Hormone_recep	20	LEU A 715 LEU A 718 ASN A 719 LEU A 721 GLY A 722 GLN A 725 TRP A 755 MET A 756 MET A 759 VAL A 760 LEU A 763 ARG A 766 PHE A 778 LEU A 797 MET A 801 TYR A 890 CYS A 891 THR A 894 PHE A 905 MET A 909	STR A 1
1DBB_H_STRH229	1dbb	STR	Progesterone (DB00396)	Mus musculus	IGG1-KAPPA DB3 FAB (HEAVY CHAIN); IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	C1-set	15	HIS L 27 GLY H 33 ASN H 35 TRP H 50 SER L 91 SER L 92 HIS L 93 VAL L 94 GLY H 95 ASP H 96 PRO L 96 TYR H 97 TRP H 100 TYR H 100 PHE H 100	STR H 229
1MRQ_A_STRA501	1mrq	STR	Progesterone (DB00396)	Homo sapiens	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1	Aldo_ket_red	12	TYR A 24 LEU A 54 TYR A 55 GLU A 127 VAL A 128 ILE A 129 HIS A 222 GLU A 224 TRP A 227 LEU A 306 LEU A 308 ILE A 310	STR A 501
2AA6_A_STRA401	2aa6	STR	Progesterone (DB00396)	Homo sapiens	MINERALOCORTICOID RECEPTOR	Hormone_recep	21	LEU A 766 LEU A 769 ASN A 770 LEU A 772 ALA A 773 GLN A 776 TRP A 806 MET A 807 LEU A 810 SER A 811 LEU A 814 ARG A 817 PHE A 829 MET A 845 MET A 852 LEU A 938 PHE A 941 CYS A 942 THR A 945 VAL A 954 PHE A 956	STR A 401
2ABA_A_STRA1500	2aba	STR	Progesterone (DB00396)	Enterobacter cloacae	PENTAERYTHRITOL TETRANITRATE REDUCTASE	Oxidored_FMN	13	THR A 26 TYR A 68 TRP A 102 ARG A 130 THR A 131 SER A 132 ARG A 142 HIS A 181 HIS A 184 TYR A 186 GLN A 241 LEU A 275 TYR A 351	STR A1500
2HZQ_A_STRA300	2hzq	STR	Progesterone (DB00396)	Homo sapiens	APOLIPOPROTEIN D	Lipocalin	13	GLU A 28 THR A 34 ILE A 42 ALA A 44 TYR A 46 VAL A 56 ASN A 58 ILE A 70 VAL A 87 PHE A 89 TYR A 98 TRP A 127 LEU A 129	STR A 300
2O5Y_H_STRH249	2o5y	STR	Progesterone (DB00396)	Mus musculus; homo sapiens	CHIMERIC ANTIBODY FAB 1E9-DB3	NA	11	ASN H 35 TRP H 47 TRP H 50 PHE L 89 SER L 91 GLY H 95 PRO L 96 THR H 97 TRP H 100 ALA H 100 MET H 100	STR H 249
3COT_A_STRA1501	3cot	STR	Progesterone (DB00396)	Homo sapiens	3-OXO-5-BETA-STEROID 4-DEHYDROGENASE	Aldo_ket_red	13	TYR A 26 TYR A 58 LYS A 87 TRP A 89 GLU A 120 TYR A 132 TRP A 140 ILE A 229 TRP A 230 VAL A 309 LEU A 311 MET A 313 TRP A 314	STR A1501
4BB2_B_STRB1384	4bb2	STR	Progesterone (DB00396)	Homo sapiens	CORTICOSTEROID-BINDING GLOBULIN	NA	13	ALA A 18 SER A 19 VAL A 22 GLN A 232 THR A 240 PHE A 242 ARG A 260 ILE A 263 ASN A 264 SER A 267 PHE B 366 HIS B 368 TRP B 371	STR B1384
4J6C_A_STRA501	4j6c	STR	Progesterone (DB00396)	Nocardia farcinica	CYTOCHROME P450 MONOOXYGENASE	p450	14	GLY A 83 MET A 84 VAL A 87 PHE A 92 PHE A 179 PHE A 180 GLN A 239 ALA A 240 ALA A 243 ALA A 244 THR A 248 VAL A 291 LEU A 294 GLN A 398	STR A 501
4LTW_A_STRA301	4ltw	STR	Progesterone (DB00396)	Ancestral gene	ANCESTRAL STEROID RECEPTOR 2	NA	23	LEU A 31 LEU A 34 ASN A 35 LEU A 37 ALA A 38 GLN A 41 TRP A 71 MET A 72 MET A 75 ALA A 76 MET A 79 ARG A 82 PHE A 94 MET A 110 LEU A 113 MET A 117 LEU A 203 PHE A 206 CYS A 207 THR A 210 VAL A 219 PHE A 221 LEU A 225	STR A 301
4NKX_A_STRA601	4nkx	STR	Progesterone (DB00396)	Homo sapiens	STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE	p450	20	LEU A 105 ALA A 113 PHE A 114 TYR A 201 ASN A 202 ILE A 205 ILE A 206 LEU A 209 ARG A 239 GLY A 297 ASP A 298 GLY A 301 ALA A 302 GLU A 305 THR A 306 VAL A 366 ALA A 367 ILE A 371 VAL A 482 VAL A 483	STR A 601
4R21_A_STRA601	4r21	STR	Progesterone (DB00396)	Danio rerio	CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2	p450	12	ALA A 120 PHE A 121 ILE A 212 VAL A 213 ILE A 216 GLY A 301 ALA A 302 THR A 306 SER A 367 LEU A 370 ILE A 371 VAL A 480	STR A 601
4Y8W_A_STRA604	4y8w	STR	Progesterone (DB00396)	Homo sapiens	CYTOCHROME P450 21-HYDROXYLASE	NA	18	VAL A 101 ASP A 107 SER A 109 LEU A 110 VAL A 198 LEU A 199 TRP A 202 ILE A 231 ARG A 234 VAL A 287 ASP A 288 ILE A 291 GLY A 292 THR A 296 VAL A 360 LEU A 364 VAL A 470 ILE A 471	STR A 604
5A1R_A_STRA600	5a1r	STR	Progesterone (DB00396)	Homo sapiens	CYTOCHROME P450 3A4	p450	9	ARG A 212 PHE A 213 ASP A 214 ASP A 217 PHE A 219 PHE A 220 ILE A 238 CYS A 239 VAL A 240	STR A 600
5LUR_A_STRA201	5lur	STR	Progesterone (DB00396)	Gallus gallus	AVIDIN	Avidin	13	MET A 14 HIS A 16 TYR A 33 ALA A 35 THR A 36 VAL A 37 TRP A 70 PHE A 72 THR A 77 PHE A 79 TRP A 97 LEU A 99 ASN A 118	STR A 201
5MLM_A_STRA401	5mlm	STR	Progesterone (DB00396)	Plantago major	PROGESTERONE 5-BETA-REDUCTASE	NA	17	ARG A 146 LYS A 147 MET A 150 PHE A 153 ILE A 156 ASN A 205 MET A 215 ALA A 243 SER A 248 TRP A 284 PHE A 343 ALA A 346 VAL A 347 ILE A 350 PRO A 351 CYS A 352 PRO A 353	STR A 401
6F88_A_STRA502	6f88	STR	Progesterone (DB00396)	Sorangium cellulosum (strain so ce56)	CYTOCHROME P450 CYP260A1	p450	16	PHE A 64 LEU A 69 ALA A 74 LEU A 159 LEU A 162 VAL A 163 SER A 225 LEU A 228 GLY A 229 THR A 233 ASN A 276 PHE A 277 GLY A 278 LEU A 280 TYR A 376 VAL A 382	STR A 502
6HGK_A_STRA401	6hgk	STR	Progesterone (DB00396)	Homo sapiens	ALPHA-1-ANTICHYMOTRYPSIN	NA	13	ARG A 24 ALA A 27 SER A 28 VAL A 31 GLN A 242 PHE A 252 ARG A 270 LEU A 273 ALA A 274 GLY A 277 VAL B 381 HIS B 383 TRP B 386	STR A 401
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1A28_A_STRA1","1a28","STR","Progesterone (DB00396)","Homo sapiens","PROGESTERONE RECEPTOR","Hormone_recep",20,"LEU A 715;LEU A 718;ASN A 719;LEU A 721;GLY A 722;GLN A 725;TRP A 755;MET A 756;MET A 759;VAL A 760;LEU A 763;ARG A 766;PHE A 778;LEU A 797;MET A 801;TYR A 890;CYS A 891;THR A 894;PHE A 905;MET A 909","STR A   1\r"],["1DBB_H_STRH229","1dbb","STR","Progesterone (DB00396)","Mus musculus","IGG1-KAPPA DB3 FAB (HEAVY CHAIN);IGG1-KAPPA DB3 FAB (LIGHT CHAIN)","C1-set",15,"HIS L  27;GLY H  33;ASN H  35;TRP H  50;SER L  91;SER L  92;HIS L  93;VAL L  94;GLY H  95;ASP H  96;PRO L  96;TYR H  97;TRP H 100;TYR H 100;PHE H 100","STR H 229\r"],["1MRQ_A_STRA501","1mrq","STR","Progesterone (DB00396)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","Aldo_ket_red",12,"TYR A  24;LEU A  54;TYR A  55;GLU A 127;VAL A 128;ILE A 129;HIS A 222;GLU A 224;TRP A 227;LEU A 306;LEU A 308;ILE A 310","STR A 501\r"],["2AA6_A_STRA401","2aa6","STR","Progesterone (DB00396)","Homo sapiens","MINERALOCORTICOID RECEPTOR","Hormone_recep",21,"LEU A 766;LEU A 769;ASN A 770;LEU A 772;ALA A 773;GLN A 776;TRP A 806;MET A 807;LEU A 810;SER A 811;LEU A 814;ARG A 817;PHE A 829;MET A 845;MET A 852;LEU A 938;PHE A 941;CYS A 942;THR A 945;VAL A 954;PHE A 956","STR A 401\r"],["2ABA_A_STRA1500","2aba","STR","Progesterone (DB00396)","Enterobacter cloacae","PENTAERYTHRITOL TETRANITRATE REDUCTASE","Oxidored_FMN",13,"THR A  26;TYR A  68;TRP A 102;ARG A 130;THR A 131;SER A 132;ARG A 142;HIS A 181;HIS A 184;TYR A 186;GLN A 241;LEU A 275;TYR A 351","STR A1500\r"],["2HZQ_A_STRA300","2hzq","STR","Progesterone (DB00396)","Homo sapiens","APOLIPOPROTEIN D","Lipocalin",13,"GLU A  28;THR A  34;ILE A  42;ALA A  44;TYR A  46;VAL A  56;ASN A  58;ILE A  70;VAL A  87;PHE A  89;TYR A  98;TRP A 127;LEU A 129","STR A 300\r"],["2O5Y_H_STRH249","2o5y","STR","Progesterone (DB00396)","Mus musculus;homo sapiens","CHIMERIC ANTIBODY FAB 1E9-DB3","NA",11,"ASN H  35;TRP H  47;TRP H  50;PHE L  89;SER L  91;GLY H  95;PRO L  96;THR H  97;TRP H 100;ALA H 100;MET H 100","STR H 249\r"],["3COT_A_STRA1501","3cot","STR","Progesterone (DB00396)","Homo sapiens","3-OXO-5-BETA-STEROID 4-DEHYDROGENASE","Aldo_ket_red",13,"TYR A  26;TYR A  58;LYS A  87;TRP A  89;GLU A 120;TYR A 132;TRP A 140;ILE A 229;TRP A 230;VAL A 309;LEU A 311;MET A 313;TRP A 314","STR A1501\r"],["4BB2_B_STRB1384","4bb2","STR","Progesterone (DB00396)","Homo sapiens","CORTICOSTEROID-BINDING GLOBULIN","NA",13,"ALA A  18;SER A  19;VAL A  22;GLN A 232;THR A 240;PHE A 242;ARG A 260;ILE A 263;ASN A 264;SER A 267;PHE B 366;HIS B 368;TRP B 371","STR B1384\r"],["4J6C_A_STRA501","4j6c","STR","Progesterone (DB00396)","Nocardia farcinica","CYTOCHROME P450 MONOOXYGENASE","p450",14,"GLY A  83;MET A  84;VAL A  87;PHE A  92;PHE A 179;PHE A 180;GLN A 239;ALA A 240;ALA A 243;ALA A 244;THR A 248;VAL A 291;LEU A 294;GLN A 398","STR A 501\r"],["4LTW_A_STRA301","4ltw","STR","Progesterone (DB00396)","Ancestral gene","ANCESTRAL STEROID RECEPTOR 2","NA",23,"LEU A  31;LEU A  34;ASN A  35;LEU A  37;ALA A  38;GLN A  41;TRP A  71;MET A  72;MET A  75;ALA A  76;MET A  79;ARG A  82;PHE A  94;MET A 110;LEU A 113;MET A 117;LEU A 203;PHE A 206;CYS A 207;THR A 210;VAL A 219;PHE A 221;LEU A 225","STR A 301\r"],["4NKX_A_STRA601","4nkx","STR","Progesterone (DB00396)","Homo sapiens","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","p450",20,"LEU A 105;ALA A 113;PHE A 114;TYR A 201;ASN A 202;ILE A 205;ILE A 206;LEU A 209;ARG A 239;GLY A 297;ASP A 298;GLY A 301;ALA A 302;GLU A 305;THR A 306;VAL A 366;ALA A 367;ILE A 371;VAL A 482;VAL A 483","STR A 601\r"],["4R21_A_STRA601","4r21","STR","Progesterone (DB00396)","Danio rerio","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","p450",12,"ALA A 120;PHE A 121;ILE A 212;VAL A 213;ILE A 216;GLY A 301;ALA A 302;THR A 306;SER A 367;LEU A 370;ILE A 371;VAL A 480","STR A 601\r"],["4Y8W_A_STRA604","4y8w","STR","Progesterone (DB00396)","Homo sapiens","CYTOCHROME P450 21-HYDROXYLASE","NA",18,"VAL A 101;ASP A 107;SER A 109;LEU A 110;VAL A 198;LEU A 199;TRP A 202;ILE A 231;ARG A 234;VAL A 287;ASP A 288;ILE A 291;GLY A 292;THR A 296;VAL A 360;LEU A 364;VAL A 470;ILE A 471","STR A 604\r"],["5A1R_A_STRA600","5a1r","STR","Progesterone (DB00396)","Homo sapiens","CYTOCHROME P450 3A4","p450",9,"ARG A 212;PHE A 213;ASP A 214;ASP A 217;PHE A 219;PHE A 220;ILE A 238;CYS A 239;VAL A 240","STR A 600\r"],["5LUR_A_STRA201","5lur","STR","Progesterone (DB00396)","Gallus gallus","AVIDIN","Avidin",13,"MET A  14;HIS A  16;TYR A  33;ALA A  35;THR A  36;VAL A  37;TRP A  70;PHE A  72;THR A  77;PHE A  79;TRP A  97;LEU A  99;ASN A 118","STR A 201\r"],["5MLM_A_STRA401","5mlm","STR","Progesterone (DB00396)","Plantago major","PROGESTERONE 5-BETA-REDUCTASE","NA",17,"ARG A 146;LYS A 147;MET A 150;PHE A 153;ILE A 156;ASN A 205;MET A 215;ALA A 243;SER A 248;TRP A 284;PHE A 343;ALA A 346;VAL A 347;ILE A 350;PRO A 351;CYS A 352;PRO A 353","STR A 401\r"],["6F88_A_STRA502","6f88","STR","Progesterone (DB00396)","Sorangium cellulosum (strain so ce56)","CYTOCHROME P450 CYP260A1","p450",16,"PHE A  64;LEU A  69;ALA A  74;LEU A 159;LEU A 162;VAL A 163;SER A 225;LEU A 228;GLY A 229;THR A 233;ASN A 276;PHE A 277;GLY A 278;LEU A 280;TYR A 376;VAL A 382","STR A 502\r"],["6HGK_A_STRA401","6hgk","STR","Progesterone (DB00396)","Homo sapiens","ALPHA-1-ANTICHYMOTRYPSIN","NA",13,"ARG A  24;ALA A  27;SER A  28;VAL A  31;GLN A 242;PHE A 252;ARG A 270;LEU A 273;ALA A 274;GLY A 277;VAL B 381;HIS B 383;TRP B 386","STR A 401\r"]]