Ligand ID: 3JW

Drugbank ID:
Baricitinib
(DB11817)

Indication:
Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.

LIST OF BINDING INTERFACES for query 'DB11817'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4W9X_A_3JWA403	4w9x	3JW	Baricitinib (DB11817)	Homo sapiens	BMP-2-INDUCIBLE PROTEIN KINASE	Pkinase	21	LEU A  57 ALA A  58 GLU A  59 GLY A  60 SER A  63 THR A  64 VAL A  65 ALA A  77 LYS A  79 VAL A 109 MET A 130 GLU A 131 TYR A 132 CYS A 133 GLN A 137 LYS A 182 GLU A 184 ASN A 185 LEU A 187 CYS A 197 ASP A 198	3JW A 403		Details
6WTO_A_3JWA1203	6wto	3JW	Baricitinib (DB11817)	Homo sapiens	TYROSINE-PROTEIN KINASE JAK2	PK_Tyr_Ser-Thr	19	LEU A 855 GLY A 856 LYS A 857 GLY A 858 GLY A 861 SER A 862 VAL A 863 ALA A 880 LYS A 882 VAL A 911 MET A 929 GLU A 930 TYR A 931 LEU A 932 ARG A 980 ASN A 981 LEU A 983 GLY A 993 ASP A 994	3JW A1203		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4W9X_A_3JWA403","4w9x","3JW","Baricitinib (DB11817)","Homo sapiens","BMP-2-INDUCIBLE PROTEIN KINASE","Pkinase",21,"LEU A 57;ALA A 58;GLU A 59;GLY A 60;SER A 63;THR A 64;VAL A 65;ALA A 77;LYS A 79;VAL A 109;MET A 130;GLU A 131;TYR A 132;CYS A 133;GLN A 137;LYS A 182;GLU A 184;ASN A 185;LEU A 187;CYS A 197;ASP A 198","3JW A 403\r"],["6WTO_A_3JWA1203","6wto","3JW","Baricitinib (DB11817)","Homo sapiens","TYROSINE-PROTEIN KINASE JAK2","PK_Tyr_Ser-Thr",19,"LEU A 855;GLY A 856;LYS A 857;GLY A 858;GLY A 861;SER A 862;VAL A 863;ALA A 880;LYS A 882;VAL A 911;MET A 929;GLU A 930;TYR A 931;LEU A 932;ARG A 980;ASN A 981;LEU A 983;GLY A 993;ASP A 994","3JW A1203\r"]]