(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 13gs | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | GLUTATHIONE S-TRANSFERASE (Homo sapiens) | GST_C_3GST_N | ||
| 1a28 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | PROGESTERONE RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 1am6 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | CARBONIC ANHYDRASE (Homo sapiens) | Carb_anhydrase | ||
| 1avn | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | CARBONIC ANHYDRASE II (Homo sapiens) | Carb_anhydrase | ||
| 1azm | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE I (Homo sapiens) | Carb_anhydrase | ||
| 1b2i | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | PROTEIN (PLASMINOGEN) (Homo sapiens) | Kringle | ||
| 1bcu | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | ALPHA-THROMBIN (Hirudo medicinalis;homo sapiens) | Trypsin | ||
| 1bkf | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | FK506 BINDING PROTEIN (Homo sapiens) | FKBP_C | ||
| 1bzm | MZM | Methazolamide (DB00703) | Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. | CARBONIC ANHYDRASE I (Homo sapiens) | Carb_anhydrase | ||
| 1cea | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PLASMINOGEN (Homo sapiens) | Kringle | ||
| 1ceb | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | PLASMINOGEN (Homo sapiens) | Kringle | ||
| 1cil | ETS | Dorzolamide (DB00869) | Dorzolamide is a carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma. | CARBONIC ANHYDRASE II (Homo sapiens) | Carb_anhydrase | ||
| 1cqp | 803 | Lovastatin (DB00227) | Lovastatin is an HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. | ANTIGEN CD11A (P180) (Homo sapiens) | VWA | ||
| 1d3h | A26 | Teriflunomide (DB08880) | Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. | DIHYDROOROTATE DEHYDROGENASE (Homo sapiens) | DHO_dh | ||
| 1dit | 2PP | Valproic acid (DB00313) | Valproic acid is an anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. | ALPHA-THROMBIN;PEPTIDE INHIBITOR CVS995 (Homo sapiens) | Trypsin | ||
| 1dvt | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1dvx | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1e7b | HLT | Halothane (DB01159) | Halothane is a general inhalation anesthetic used for the induction and maintenance of general anesthesia. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 1f5l | AMR | Amiloride (DB00594) | Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. | UROKINASE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Trypsin | ||
| 1f86 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | TRANSTHYRETIN THR119MET VARIANT (Homo sapiens) | Transthyretin | ||
| 1fdq | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | FATTY ACID-BINDING PROTEIN, BRAIN (Homo sapiens) | Lipocalin | ||
| 1fds | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE (Homo sapiens) | adh_short | ||
| 1fkb | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | FK506 BINDING PROTEIN (Homo sapiens) | FKBP_C | ||
| 1gs4 | ZK5 | Fludrocortisone (DB00687) | Fludrocortisone is a mineralocorticoid used to treat adrenocortical insufficiency and salt-losing adrenogenital syndrome. | ANDROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 1gse | EAA | Etacrynic acid (DB00903) | Etacrynic acid is a diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. | GLUTATHIONE TRANSFERASE (Homo sapiens) | GST_CGST_N | ||
| 1hk4 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 1hvy | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Homo sapiens) | Thymidylat_synt | ||
| 1hwi | 115 | Fluvastatin (DB01095) | Fluvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | HMG-COA REDUCTASE (Homo sapiens) | HMG-CoA_red | ||
| 1hwj | 116 | Cerivastatin (DB00439) | Cerivastatin is a statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. | HMG-COA REDUCTASE (Homo sapiens) | HMG-CoA_red | ||
| 1hwk | 117 | Atorvastatin (DB01076) | Atorvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | HMG-COA REDUCTASE (Homo sapiens) | HMG-CoA_red | ||
| 1hwl | FBI | Rosuvastatin (DB01098) | Rosuvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | HMG-COA REDUCTASE (Homo sapiens) | HMG-CoA_red | ||
| 1ihi | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 1ilp | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | C-X-C CHEMOKINE RECEPTOR TYPE 1;INTERLEUKIN-8 (PRECURSOR) (Homo sapiens;synthetic construct) | IL8 | ||
| 1itu | CIL | Cilastatin (DB01597) | Cilastatin is a renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections. | RENAL DIPEPTIDASE (Homo sapiens) | Peptidase_M19 | ||
| 1j96 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (Homo sapiens) | Aldo_ket_red | ||
| 1jd0 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE XII (Homo sapiens) | Carb_anhydrase | ||
| 1jqd | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 1jtv | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (Homo sapiens) | adh_short | ||
| 1l2i | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 1lhv | NOG | Levonorgestrel (DB00367) | Levonorgestrel is a progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives. | SEX HORMONE-BINDING GLOBULIN (Homo sapiens) | Laminin_G_1 | ||
| 1m17 | AQ4 | Erlotinib (DB00530) | Erlotinib is an EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1m9j | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens) | NO_synthase | ||
| 1mrq | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens) | Aldo_ket_red | ||
| 1mv9 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | RXR RETINOID X RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 1mx1 | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | LIVER CARBOXYLESTERASE I (Homo sapiens) | COesterase | ||
| 1o86 | LPR | Lisinopril (DB00722) | Lisinopril is an ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction. | ANGIOTENSIN CONVERTING ENZYME (Homo sapiens) | Peptidase_M2 | ||
| 1oq5 | CEL | Celecoxib (DB00482) | Celecoxib is an NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. | CARBONIC ANHYDRASE II (Homo sapiens) | Carb_anhydrase | ||
| 1p5z | AR3 | Cytarabine (DB00987) | Cytarabine is a pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 1pk2 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Kringle | ||
| 1pwy | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | PURINE NUCLEOSIDE PHOSPHORYLASE (Homo sapiens) | PNP_UDP_1 | ||
| 1q20 | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2B, MEMBER 1 ISOFORM B (Homo sapiens) | Sulfotransfer_1 | ||
| 1qur | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | BIVALENT INHIBITOR (BZA-2 HIRULOG);HUMAN THROMBIN (BETA CHAIN) (Homo sapiens;synthetic construct) | Trypsin | ||
| 1r9o | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYTOCHROME P450 2C9 (Homo sapiens) | p450 | ||
| 1s19 | MC9 | Calcipotriol (DB02300) | Calcipotriol is a topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis. | VITAMIN D3 RECEPTOR (Homo sapiens) | NA | ||
| 1s2c | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 1sqn | NDR | Norethisterone (DB00717) | Norethisterone is a synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis. | PROGESTERONE RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 1sr7 | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | PROGESTERONE RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 1stf | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PAPAIN;STEFIN B (CYSTATIN B) (Carica papaya;homo sapiens) | CystatinPeptidase_C1 | ||
| 1t46 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1tbf | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1tlm | MIL | Milrinone (DB00235) | Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1tt6 | DES | Diethylstilbestrol (DB00255) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report... | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1tyl | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | INSULIN (Homo sapiens) | NA | ||
| 1tyr | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1uou | CMU | Tipiracil (DB09343) | Tipiracil is a thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies. | THYMIDINE PHOSPHORYLASE (Homo sapiens) | Glycos_trans_3NGlycos_transf_3PYNP_C | ||
| 1uze | EAL | Enalaprilat (DB09477) | Enalaprilat is an antihypertensive agent used for the management of hypertension when oral therapy is not practical. | ANGIOTENSIN CONVERTING ENZYME (Homo sapiens) | Peptidase_M2 | ||
| 1v3q | 2DI | Didanosine (DB00900) | Didanosine is a reverse transcriptase inhibitor used to treat HIV. | PURINE NUCLEOSIDE PHOSPHORYLASE (Homo sapiens) | PNP_UDP_1 | ||
| 1wrk | TFP | Trifluoperazine (DB00831) | Trifluoperazine is a phenothiazine used to treat depression, anxiety, and agitation. | TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES (Homo sapiens) | EF-hand_8 | ||
| 1wsv | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | AMINOMETHYLTRANSFERASE (Homo sapiens) | GCV_TGCV_T_C | ||
| 1x70 | 715 | Sitagliptin (DB01261) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE IV (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 1x9q | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | 4M5.3 ANTI-FLUORESCEIN SINGLE CHAIN ANTIBODY FRAGMENT (Homo sapiens) | NA | ||
| 1xbb | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE SYK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1xkk | FMM | Lapatinib (DB01259) | Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1xmu | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoq | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 1xos | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xot | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoz | CIA | Tadalafil (DB00820) | Tadalafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xp0 | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1y0x | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | THYROID HORMONE RECEPTOR BETA-1 (Homo sapiens) | Hormone_recep | ||
| 1y7v | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | GLUCOSYLCERAMIDASE (Homo sapiens) | Glyco_hydro_30Glyco_hydro_30C | ||
| 1y93 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | MACROPHAGE METALLOELASTASE (Homo sapiens) | Peptidase_M10 | ||
| 1ya4 | CTX | Tamoxifen (DB00675) | Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. | CES1 PROTEIN (Homo sapiens) | COesterase | ||
| 1z11 | 8MO | Methoxsalen (DB00553) | Methoxsalen is a furocoumarin used to treat psoriasis and vitiligo. | CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6 (Homo sapiens) | p450 | ||
| 207l | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | LYSOZYME (Homo sapiens) | Lys | ||
| 2a1h | GBN | Gabapentin (DB00996) | Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. | BRANCHED CHAIN AMINOTRANSFERASE (Homo sapiens) | Aminotran_4 | ||
| 2a3r | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | MONOAMINE-SULFATING PHENOL SULFOTRANSFERASE (Homo sapiens) | Sulfotransfer_1 | ||
| 2a7q | CFB | Clofarabine (DB00631) | Clofarabine is a purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2aa6 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2aax | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2ab2 | SNL | Spironolactone (DB00421) | Spironolactone is an aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2am9 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | ANDROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2aot | 2PM | Diphenhydramine (DB01075) | Diphenhydramine is a H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 2aou | CQA | Amodiaquine (DB00613) | Amodiaquine is an antimalarial drug. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 2aow | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 2aw1 | COX | Valdecoxib (DB00580) | Valdecoxib is a COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. | CARBONIC ANHYDRASE II (Homo sapiens) | Carb_anhydrase | ||
| 2bk4 | RAS | Rasagiline (DB01367) | Rasagiline is an irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. | AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens) | Amino_oxidase | ||
| 2bxe | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxf | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxg | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxk | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxn | IDB | Iodipamide (DB04711) | Iodipamide is a contrast agent used in cholangiography and cholecystography. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxo | OPB | Oxyphenbutazone (DB03585) | Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxp | P1Z | Phenylbutazone (DB00812) | Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2c6n | LPR | Lisinopril (DB00722) | Lisinopril is an ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction. | ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM (Homo sapiens) | Peptidase_M2 | ||
| 2coi | GBN | Gabapentin (DB00996) | Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. | BRANCHED CHAIN AMINOTRANSFERASE 1, CYTOSOLIC (Homo sapiens) | Aminotran_4 | ||
| 2d06 | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SULFOTRANSFERASE 1A1 (Homo sapiens) | Sulfotransfer_1 | ||
| 2dqy | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | LIVER CARBOXYLESTERASE 1 (Homo sapiens) | COesterase | ||
| 2f0z | ZMR | Zanamivir (DB00558) | Zanamivir is a neuraminidase inhibitor used to treat influenza A and B. | SIALIDASE 2 (Homo sapiens) | BNR_2 | ||
| 2f10 | BCZ | Peramivir (DB06614) | Peramivir is an intravenous antiviral agent used to treat acute uncomplicated influenza in patients aged 2 years and older who are shown to be symptomatic for no more than two days. | SIALIDASE 2 (Homo sapiens) | BNR_2 | ||
| 2f38 | 15M | Bimatoprost (DB00905) | Bimatoprost is a prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 2f94 | BFQ | Ibandronate (DB00710) | Ibandronate is a bisphosphonate used to treat osteoporosis in postmenopausal women. | FARNESYL DIPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 2geh | NHY | Hydroxyurea (DB01005) | Hydroxyurea is an antimetabolite used to treat sickle cell anemia crisis. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 2gqg | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2h79 | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | THRA PROTEIN (Homo sapiens) | NA | ||
| 2hkk | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 2hzq | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | APOLIPOPROTEIN D (Homo sapiens) | Lipocalin | ||
| 2i2z | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2ine | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 2it4 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | CARBONIC ANHYDRASE 1 (Homo sapiens) | Carb_anhydrase | ||
| 2ivu | ZD6 | Vandetanib (DB05294) | Vandetanib is an antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2j0d | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 2j0h | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | FICOLIN-2 (Homo sapiens) | Fibrinogen_C | ||
| 2j1g | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | FICOLIN-2 (Homo sapiens) | Fibrinogen_C | ||
| 2kot | ANW | Amlexanox (DB01025) | Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent... | PROTEIN S100-A13 (Homo sapiens) | S_100 | ||
| 2kug | HLT | Halothane (DB01159) | Halothane is a general inhalation anesthetic used for the induction and maintenance of general anesthesia. | CALMODULIN (Homo sapiens) | EF-hand_7 | ||
| 2mji | KTR | Ketorolac (DB00465) | Ketorolac is an NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. | FATTY ACID-BINDING PROTEIN, INTESTINAL (Homo sapiens) | Lipocalin | ||
| 2n27 | 4DY | Capsaicin (DB06774) | Capsaicin is a topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. | CALMODULIN (Homo sapiens) | EF-hand_7 | ||
| 2nnh | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | CYTOCHROME P450 2C8 (Homo sapiens) | p450 | ||
| 2nni | MTK | Montelukast (DB00471) | Montelukast is a leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. | CYTOCHROME P450 2C8 (Homo sapiens) | p450 | ||
| 2nnj | 225 | Felodipine (DB01023) | Felodipine is a calcium channel blocker used to treat hypertension. | CYTOCHROME P450 2C8 (Homo sapiens) | p450 | ||
| 2no0 | GEO | Gemcitabine (DB00441) | Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2no6 | ETV | Emtricitabine (DB00879) | Emtricitabine is a nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2noa | 3TC | Lamivudine (DB00709) | Lamivudine is a reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2o5y | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CHIMERIC ANTIBODY FAB 1E9-DB3 (Mus musculus;homo sapiens) | NA | ||
| 2okj | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GLUTAMATE DECARBOXYLASE 1 (Homo sapiens) | Pyridoxal_deC | ||
| 2okk | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GLUTAMATE DECARBOXYLASE 2 (Homo sapiens) | Pyridoxal_deC | ||
| 2os9 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PULMONARY SURFACTANT-ASSOCIATED PROTEIN D (Homo sapiens) | Lectin_CSurfac_D-trimer | ||
| 2ow9 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | COLLAGENASE 3 (Homo sapiens) | Peptidase_M10 | ||
| 2oz7 | CA4 | Cyproterone acetate (DB04839) | Cyproterone acetate is a steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer | ANDROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2p16 | GG2 | Apixaban (DB06605) | Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. | COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR) (Homo sapiens) | Trypsin | ||
| 2piv | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | ANDROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2pix | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | ANDROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2pk4 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | HUMAN PLASMINOGEN KRINGLE 4 (Homo sapiens) | Kringle | ||
| 2pl0 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2pou | I7A | Diclofenamide (DB01144) | Diclofenamide is a carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 2qmz | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE (Homo sapiens) | Flavodoxin_2 | ||
| 2qxs | RAL | Raloxifene (DB00481) | Raloxifene is a selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. | ESTROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2rgu | 356 | Linagliptin (DB08882) | Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 2v0z | C41 | Aliskiren (DB09026) | Aliskiren is a direct renin inhibitor used to manage hypertension. | RENIN (Homo sapiens) | Asp | ||
| 2v3d | NBV | Miglustat (DB00419) | Miglustat is a glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement. | GLUCOSYLCERAMIDASE (Homo sapiens) | Glyco_hydro_30Glyco_hydro_30C | ||
| 2vdb | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | SERUM ALBUMIN (Peptostreptococcus magnus;homo sapiens) | Serum_albumin | ||
| 2vdm | AGG | Tirofiban (DB00775) | Tirofiban is a platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. | INTEGRIN ALPHA-IIB;INTEGRIN BETA-3 (Homo sapiens;mus musculus) | FG-GAPIntegrin_betaPSI_integrin | ||
| 2vdy | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) | Serpin | ||
| 2vuf | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2vv0 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 2w26 | RIV | Rivaroxaban (DB06228) | Rivaroxaban is a factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. | ACTIVATED FACTOR XA HEAVY CHAIN (Homo sapiens) | Trypsin | ||
| 2w3a | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Homo sapiens) | DHFR_1 | ||
| 2w8y | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | PROGESTERONE RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2w98 | P1Z | Phenylbutazone (DB00812) | Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis. | PROSTAGLANDIN REDUCTASE 2 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2wd9 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens) | AMP-bindingAMP-binding_C | ||
| 2wek | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2wey | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 2wgj | VGH | Crizotinib (DB08865) | Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | HEPATOCYTE GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2x7h | PFN | Fenoprofen (DB00573) | Fenoprofen is an anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2xn3 | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 2xn5 | FUN | Furosemide (DB00695) | Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 2xn6 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 2y05 | RAL | Raloxifene (DB00481) | Raloxifene is a selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. | PROSTAGLANDIN REDUCTASE 1 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2y7j | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens) | Pkinase | ||
| 2yfx | VGH | Crizotinib (DB08865) | Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | TYROSINE-PROTEIN KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2yk1 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FAB FRAGMENT, HEAVY CHAIN;FAB FRAGMENT, LIGHT CHAIN (Homo sapiens) | NA | ||
| 2zb8 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PROSTAGLANDIN REDUCTASE 2 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2zia | CL9 | Cladribine (DB00242) | Cladribine is a purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 3adx | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 3aox | EMH | Alectinib (DB11363) | Alectinib is a kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3apv | TP0 | Amitriptyline (DB00321) | Amitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3apw | DP0 | Disopyramide (DB00280) | Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3apx | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3b0w | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | NUCLEAR RECEPTOR ROR-GAMMA (Homo sapiens) | Hormone_recep | ||
| 3b6h | MXD | Minoxidil (DB00350) | Minoxidil is an antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. | PROSTACYCLIN SYNTHASE (Homo sapiens) | p450 | ||
| 3b9l | AZZ | Zidovudine (DB00495) | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 3bbt | FMM | Lapatinib (DB01259) | Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3buf | AEG | Hydroxyamphetamine (DB09352) | Hydroxyamphetamine is an indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes. | BETA-SECRETASE 1 (Homo sapiens) | Asp | ||
| 3bur | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3c0z | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 7A (Homo sapiens) | Hist_deacetyl | ||
| 3c7q | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3cld | GW6 | Fluticasone furoate (DB08906) | Fluticasone furoate is an inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3cmf | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3cot | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3csj | CBL | Chlorambucil (DB00291) | Chlorambucil is a chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas. | GLUTATHIONE S-TRANSFERASE P (Homo sapiens) | GST_C_3GST_N | ||
| 3czv | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 13 (Homo sapiens) | Carb_anhydrase | ||
| 3d90 | NOG | Levonorgestrel (DB00367) | Levonorgestrel is a progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives. | PROGESTERONE RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 3dds | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | GLYCOGEN PHOSPHORYLASE, LIVER FORM (Homo sapiens) | Phosphorylase | ||
| 3dgq | EAA | Etacrynic acid (DB00903) | Etacrynic acid is a diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. | GLUTATHIONE S-TRANSFERASE P (Homo sapiens) | GST_C_3GST_N | ||
| 3dl9 | V2H | Doxercalciferol (DB06410) | Doxercalciferol is a synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis. | CYTOCHROME P450 2R1 (Homo sapiens) | p450 | ||
| 3dpf | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | NEUTROPHIL COLLAGENASE (Homo sapiens) | Peptidase_M10 | ||
| 3e4e | 4PZ | Fomepizole (DB01213) | Fomepizole is an inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. | CYTOCHROME P450 2E1 (Homo sapiens) | p450 | ||
| 3eyg | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3f78 | ICF | Isoflurane (DB00753) | Isoflurane is an inhaled general anesthetic used in surgery. | INTEGRIN ALPHA-L (Homo sapiens) | VWA | ||
| 3fup | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3fw1 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 3fw3 | ETS | Dorzolamide (DB00869) | Dorzolamide is a carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma. | CARBONIC ANHYDRASE 4 (Homo sapiens) | NA | ||
| 3g0b | T22 | Alogliptin (DB06203) | Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 3g0e | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | MAST/STEM CELL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3g1r | FIT | Finasteride (DB01216) | Finasteride is an antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3gcs | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Homo sapiens) | Pkinase | ||
| 3gp0 | NIL | Nilotinib (DB04868) | Nilotinib is a kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. | MITOGEN-ACTIVATED PROTEIN KINASE 11 (Homo sapiens) | Pkinase | ||
| 3gvu | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3gws | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | THYROID HORMONE RECEPTOR BETA (Homo sapiens) | Hormone_recep | ||
| 3h0a | 9RA | Bexarotene (DB00307) | Bexarotene is a retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy. | RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3hcn | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | FERROCHELATASE, MITOCHONDRIAL (Homo sapiens) | Ferrochelatase | ||
| 3hec | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Homo sapiens) | Pkinase | ||
| 3hii | PNT | Pentamidine (DB00738) | Pentamidine is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. | AMILORIDE-SENSITIVE AMINE OXIDASE (Homo sapiens) | Cu_amine_oxidCu_amine_oxidN2Cu_amine_oxidN3 | ||
| 3hku | TOR | Topiramate (DB00273) | Topiramate is an anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 3hm1 | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3hs4 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 3iai | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 9 (Homo sapiens) | NA | ||
| 3iak | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 3ieo | AMJ | Lacosamide (DB06218) | Lacosamide is an antiepileptic drug used to treat partial onset seizures in adults. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 3iwx | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | COPPER TRANSPORT PROTEIN ATOX1 (Homo sapiens) | HMA | ||
| 3jqz | LQZ | Lidocaine (DB00281) | Lidocaine is a local anesthetic used in a wide variety of superficial and invasive procedures. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 3jwq | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA (Homo sapiens) | PDEase_I | ||
| 3k54 | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3kb7 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) | Pkinase | ||
| 3kcx | CQL | Clioquinol (DB04815) | Clioquinol is an antifungal cream used to treat a variety of fungal infections. | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens) | Cupin_8 | ||
| 3kdm | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | IMMUNOGLOBULIN HEAVY CHAIN;IMMUNOGLOBULIN LIGHT CHAIN (Homo sapiens) | NA | ||
| 3kiv | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | APOLIPOPROTEIN (Homo sapiens) | Kringle | ||
| 3ko0 | TFP | Trifluoperazine (DB00831) | Trifluoperazine is a phenothiazine used to treat depression, anxiety, and agitation. | PROTEIN S100-A4 (Homo sapiens) | S_100 | ||
| 3l4w | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) | Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 3ld6 | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | LANOSTEROL 14-ALPHA DEMETHYLASE (Homo sapiens) | p450 | ||
| 3lfa | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Homo sapiens) | Pkinase | ||
| 3lmy | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BETA-HEXOSAMINIDASE SUBUNIT BETA (Homo sapiens) | Glyco_hydro_20Glycohydro_20b2 | ||
| 3lxe | TOR | Topiramate (DB00273) | Topiramate is an anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. | CARBONIC ANHYDRASE 1 (Homo sapiens) | Carb_anhydrase | ||
| 3lxk | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3lxn | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3m0w | P77 | Prochlorperazine (DB00433) | Prochlorperazine is a phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. | PROTEIN S100-A4 (Homo sapiens) | S_100 | ||
| 3mdt | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 3mdv | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 3miy | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3mjr | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 3ml5 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 7 (Homo sapiens) | Carb_anhydrase | ||
| 3n45 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 3nbq | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URIDINE PHOSPHORYLASE 1 (Homo sapiens) | PNP_UDP_1 | ||
| 3nsq | CHZ | Dantron (DB04816) | Dantron is a drug used to relieve acute and chronic inflammation of the oral cavity and oropharynx. | RETINOID X RECEPTOR, ALPHA (Homo sapiens) | Hormone_recep | ||
| 3nxu | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 3o5r | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5 (Homo sapiens) | FKBP_C | ||
| 3og7 | 032 | Vemurafenib (DB08881) | Vemurafenib is a kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. | AKAP9-BRAF FUSION PROTEIN (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3oll | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN RECEPTOR BETA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3owx | XRA | Prazosin (DB00457) | Prazosin is an alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 3ozl | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 3p6g | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | FATTY ACID-BINDING PROTEIN, ADIPOCYTE (Homo sapiens) | Lipocalin | ||
| 3p6h | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | FATTY ACID-BINDING PROTEIN, ADIPOCYTE (Homo sapiens) | Lipocalin | ||
| 3po7 | ZON | Zonisamide (DB00909) | Zonisamide is a sulfonamide anticonvulsant used to treat partial seizures. | AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens) | Amino_oxidase | ||
| 3pqz | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | CYCLIC PEPTIDE;GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 (Homo sapiens;synthetic construct) | SH2 | ||
| 3q95 | ESL | Estriol (DB04573) | Estriol is a weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3qeo | LLT | Telbivudine (DB01265) | Telbivudine is a thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 3qt0 | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 3qx3 | EVP | Etoposide (DB00773) | Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 3r43 | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r58 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r6i | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r7m | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r8g | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3rcf | BS4 | Sulfabenzamide (DB09355) | Sulfabenzamide is a sulfonamide antibacterial used as an ingredient in various topical and vaginal preparations to treat certain infections, but has been discontinued by the FDA. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL (Homo sapiens) | Pro_isomerase | ||
| 3re0 | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | SUPEROXIDE DISMUTASE [CU-ZN] (Homo sapiens) | Sod_Cu | ||
| 3rfm | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | ADENOSINE RECEPTOR A2A (Homo sapiens) | 7tm_1 | ||
| 3rgf | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | CYCLIN-DEPENDENT KINASE 8 (Homo sapiens) | Pkinase | ||
| 3rul | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | UBIQUITIN (Homo sapiens;synthetic construct) | ubiquitin | ||
| 3s3g | TLT | Tolmetin (DB00500) | Tolmetin is an NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 3s5y | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | ALPHA-GALACTOSIDASE A (Homo sapiens) | Melibiase_2Melibiase_2_C | ||
| 3s7s | EXM | Exemestane (DB00990) | Exemestane is an aromatase inhibitor used to treat breast cancer in postmenopausal women after treatment with tamoxifen. | CYTOCHROME P450 19A1 (Homo sapiens) | p450 | ||
| 3soa | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER (Homo sapiens) | CaMKII_ADPkinase | ||
| 3som | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN (Homo sapiens) | MMACHC | ||
| 3sp6 | IL2 | Iloprost (DB01088) | Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3sp9 | IL2 | Iloprost (DB01088) | Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) | Hormone_recep | ||
| 3sxr | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3t3q | 9PL | Pilocarpine (DB01085) | Pilocarpine is a muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy. | CYTOCHROME P450 2A6 (Homo sapiens) | p450 | ||
| 3t3z | 9PL | Pilocarpine (DB01085) | Pilocarpine is a muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy. | CYTOCHROME P450 2E1 (Homo sapiens) | p450 | ||
| 3tc5 | 3T5 | Betamethasone phosphate (DB14669) | Betamethasone phosphate is a fast acting ester prodrug of a corticosteroid used to treat inflammatory conditions. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (Homo sapiens) | RotamaseWW | ||
| 3teg | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL (Homo sapiens) | FDX-ACBtRNA-synt_2d | ||
| 3thd | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GALACTOSIDASE (Homo sapiens) | BetaGal_dom4_5Glyco_hydro_35 | ||
| 3ti1 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | CYCLIN-DEPENDENT KINASE 2 (Homo sapiens) | Pkinase | ||
| 3tvx | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (Homo sapiens) | PDEase_I | ||
| 3u2c | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 3u5j | 08H | Alprazolam (DB00404) | Alprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 3u5k | 08J | Midazolam (DB00683) | Midazolam is a short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 3u88 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | MENIN (Homo sapiens) | Menin | ||
| 3ua1 | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 3ua5 | 06X | Amlodipine (DB00381) | Amlodipine is a calcium channel blocker used to treat hypertension and angina. | CYTOCHROME P450 2B6 (Homo sapiens) | p450 | ||
| 3ue4 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3ufn | ROC | Saquinavir (DB01232) | Saquinavir is an HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | HIV-1 PROTEASE (Homo sapiens) | RVP | ||
| 3ugr | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3uiv | 308 | Amantadine (DB00915) | Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 3v35 | NTI | Nitazoxanide (DB00507) | Nitazoxanide is a thiazolide anti-infective used to treat infections by protozoa, helminths, anaerobic bacteria, microaerophilic bacteria, and viruses. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 3v5w | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | G-PROTEIN COUPLED RECEPTOR KINASE 2 (Homo sapiens;bos taurus) | PHPkinaseRGS | ||
| 3vhu | SNL | Spironolactone (DB00421) | Spironolactone is an aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 3vkx | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | PROLIFERATING CELL NUCLEAR ANTIGEN (Homo sapiens) | PCNA_CPCNA_N | ||
| 3vn2 | TLS | Telmisartan (DB00966) | Telmisartan is an ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3vri | 1KX | Abacavir (DB01048) | Abacavir is an antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. | 10-MER PEPTIDE;HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN (Homo sapiens;synthetic construct) | C1-setMHC_I | ||
| 3vw7 | VPX | Vorapaxar (DB09030) | Vorapaxar is a platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). | PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 3w1w | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | FERROCHELATASE, MITOCHONDRIAL (Homo sapiens) | Ferrochelatase | ||
| 3wzd | LEV | Lenvatinib (DB09078) | Lenvatinib is a receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3wze | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3zbf | VGH | Crizotinib (DB08865) | Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3zos | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4a7t | 5FW | Isoprenaline (DB01064) | Isoprenaline is a catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. | SUPEROXIDE DISMUTASE [CU-ZN] (Homo sapiens) | Sod_Cu | ||
| 4a7u | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | SUPEROXIDE DISMUTASE [CU-ZN] (Homo sapiens) | Sod_Cu | ||
| 4a7v | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | SUPEROXIDE DISMUTASE [CU-ZN] (Homo sapiens) | Sod_Cu | ||
| 4a9j | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | BROMODOMAIN CONTAINING 2 (Homo sapiens) | Bromodomain | ||
| 4a9k | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | CREB-BINDING PROTEIN (Homo sapiens) | Bromodomain | ||
| 4ag8 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4agd | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4ajx | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | INSULIN (Homo sapiens) | NA | ||
| 4an2 | EUI | Cobimetinib (DB05239) | Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4aql | TXC | Valaciclovir (DB00577) | Valaciclovir is an guanine nucleoside antiviral used to treat herpes exacerbations. | GUANINE DEAMINASE (Homo sapiens) | Amidohydro_1 | ||
| 4bb2 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 4bds | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4bjc | RPB | Rucaparib (DB12332) | Rucaparib is an anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer. | TANKYRASE-2 (Homo sapiens) | PARP | ||
| 4bkj | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4bvv | CPF | Ciprofloxacin (DB00537) | Ciprofloxacin is a second generation fluoroquinolone used to treat various susceptible bacterial infections. | APOLIPOPROTEIN(A) (Homo sapiens) | Kringle | ||
| 4c2p | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) | Peptidase_M2 | ||
| 4c8b | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4c9w | VGH | Crizotinib (DB08865) | Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE (Homo sapiens) | NUDIX | ||
| 4cg4 | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | PYRIN (Homo sapiens) | PRYSPRY | ||
| 4cp3 | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | B-CELL LYMPHOMA 6 PROTEIN (Homo sapiens) | NA | ||
| 4cut | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B (Homo sapiens) | Bromodomain | ||
| 4d7b | TCW | Tolcapone (DB00323) | Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4dm3 | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | PHENYLETHANOLAMINE N-METHYLTRANSFERASE (Homo sapiens) | NNMT_PNMT_TEMT | ||
| 4do5 | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | ALPHA-N-ACETYLGALACTOSAMINIDASE (Homo sapiens) | Melibiase_2Melibiase_2_C | ||
| 4dpr | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | LEUKOTRIENE A-4 HYDROLASE (Homo sapiens) | Leuk-A4-hydro_CPeptidase_M1Peptidase_M1_N | ||
| 4dri | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 4drj | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 4e3h | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4e49 | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4ejj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | CYTOCHROME P450 2A6 (Homo sapiens) | p450 | ||
| 4enh | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 4eoh | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | PYRIDOXAL KINASE (Homo sapiens) | Phos_pyr_kin | ||
| 4ey5 | HUP | Huperzine a (DB04864) | Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of... | ACETYLCHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4ey6 | GNT | Galantamine (DB00674) | Galantamine is a cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. | ACETYLCHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4f92 | SAN | Sulfanilamide (DB00259) | Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. | U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens) | DEADHelicase_CSec63 | ||
| 4fgj | 1PQ | Primaquine (DB01087) | Primaquine is an antimalarial indicated to prevent relapse of vivax malaria. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4fgl | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4fr8 | TNG | Nitroglycerin (DB00727) | Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively. | ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens) | Aldedh | ||
| 4g0u | ASW | Amsacrine (DB00276) | Amsacrine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g0v | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g5j | 0WM | Afatinib (DB08916) | Afatinib is an antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4hfp | 15U | Argatroban (DB00278) | Argatroban is a synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. | PROTHROMBIN (Homo sapiens) | Trypsin | ||
| 4his | 3MI | Tafamidis (DB11644) | Tafamidis is a medication used to treat transthyretin-mediated amyloidosis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4hvc | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 4hwk | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | SEPIAPTERIN REDUCTASE (Homo sapiens) | adh_short | ||
| 4i1r | LZU | Thioridazine (DB00679) | Thioridazine is a phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. | MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1 (Homo sapiens) | MALT1_IgPeptidase_C14 | ||
| 4i22 | IRE | Gefitinib (DB00317) | Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4i24 | 1C9 | Dacomitinib (DB11963) | Dacomitinib is a medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4i41 | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | SERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) | Pkinase | ||
| 4i5x | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 (Homo sapiens) | Aldo_ket_red | ||
| 4iaq | 2GM | Dihydroergotamine (DB00320) | Dihydroergotamine is an ergot alkaloid used in the acute treatment of migraine headache and cluster headache. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4iar | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4ib4 | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4ik6 | LUR | Lumiracoxib (DB01283) | Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in... | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4iki | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4ikk | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4j03 | FVS | Fulvestrant (DB00947) | Fulvestrant is an estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. | BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens) | Abhydrolase_1Hydrolase | ||
| 4j14 | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 4j7u | YTZ | Sulfathiazole (DB06147) | Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination... | SEPIAPTERIN REDUCTASE (Homo sapiens) | adh_short | ||
| 4j7x | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | SEPIAPTERIN REDUCTASE (Homo sapiens) | adh_short | ||
| 4jps | 1LT | Alpelisib (DB12015) | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid... | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4jq1 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jq2 | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jq4 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jqa | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtq | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtr | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtr | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jvl | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN SULFOTRANSFERASE (Homo sapiens) | Sulfotransfer_1 | ||
| 4k7a | MXD | Minoxidil (DB00350) | Minoxidil is an antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. | ANDROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 4kpj | 210 | Pamidronic acid (DB00282) | Pamidronic acid is a bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions. | FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 4ks8 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | SERINE/THREONINE-PROTEIN KINASE PAK 6 (Homo sapiens) | Pkinase | ||
| 4l9q | 9TP | Teniposide (DB00444) | Teniposide is a cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4lax | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4 (Homo sapiens) | FKBP_C | ||
| 4lb2 | DM5 | Idarubicin (DB01177) | Idarubicin is an anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4lb9 | EVP | Etoposide (DB00773) | Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4ldo | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | LYSOZYME, BETA-2 ADRENERGIC RECEPTOR (Enterobacteria phage t4;homo sapiens;lama glama) | 7tm_1Phage_lysozyme | ||
| 4lmn | EUI | Cobimetinib (DB05239) | Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4lnx | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | THYROID HORMONE RECEPTOR ALPHA (Homo sapiens) | NA | ||
| 4lu3 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 14 (Homo sapiens) | Carb_anhydrase | ||
| 4lv9 | 20J | Diazoxide (DB01119) | Diazoxide is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (Homo sapiens) | NAMPT_NNAPRTase | ||
| 4lxz | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 2 (Homo sapiens) | Hist_deacetyl | ||
| 4lys | 2SJ | Colchiceine (DB15534) | Colchiceine is one of several metabolites of the anti-gout medication colchicine. | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 4m2v | BZ1 | Brinzolamide (DB01194) | Brinzolamide is a carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4mbs | MRV | Maraviroc (DB04835) | Maraviroc is a CCR5 co-receptor antagonist used with other antiretroviral medications to treat CCR5-tropic HIV-1 infection. | CHIMERA PROTEIN OF C-C CHEMOKINE RECEPTOR TYPE 5 AND RUBREDOXIN (Homo sapiens;clostridium pasteurianum) | 7tm_1Rubredoxin | ||
| 4mg8 | 27J | Zeranol (DB11478) | Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4mkc | 4MK | Ceritinib (DB09063) | Ceritinib is an antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4ms3 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1 (Homo sapiens) | ANF_receptor | ||
| 4mxo | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4n16 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4nct | 2K2 | Midostaurin (DB06595) | Midostaurin is an antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A (Homo sapiens) | Pkinase | ||
| 4nkw | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 4nkx | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 4nnr | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2 (Homo sapiens) | FKBP_C | ||
| 4o33 | TZN | Terazosin (DB01162) | Terazosin is an alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. | PHOSPHOGLYCERATE KINASE 1 (Homo sapiens) | PGK | ||
| 4o75 | 2RC | Fostamatinib (DB12010) | Fostamatinib is a spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment. | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 4o8z | BBI | Amiodarone (DB01118) | Amiodarone is a class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (Homo sapiens) | SIR2 | ||
| 4odr | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA (Thermus thermophilus;homo sapiens) | FKBP_C | ||
| 4oha | HFT | Flutamide (DB00499) | Flutamide is an antiandrogen used for locally confined stage B2-C and D-2 metastatic prostate carcinoma. | ANDROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4oj4 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 4okn | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | L-LACTATE DEHYDROGENASE A CHAIN (Homo sapiens) | Ldh_1_CLdh_1_N | ||
| 4oti | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) | PkinasePkinase_C | ||
| 4p6w | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4p6x | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4pjv | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens) | PARP | ||
| 4pom | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | THIOREDOXIN (Homo sapiens) | Thioredoxin | ||
| 4ps5 | 2TA | Fedratinib (DB12500) | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was... | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 4pwj | 30Z | Masoprocol (DB00179) | A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in... | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4qkn | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 4qmn | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qms | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qmz | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4r67 | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | NA | ||
| 4r67 | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Proteasome | ||
| 4r67 | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5 (Homo sapiens) | Proteasome | ||
| 4r7h | P31 | Pexidartinib (DB12978) | Pexidartinib is an antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor. | MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4r7i | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4r7l | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | LEUKOTRIENE A-4 HYDROLASE (Homo sapiens) | Leuk-A4-hydro_CPeptidase_M1Peptidase_M1_N | ||
| 4rqr | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | GLUTAREDOXIN-1 (Homo sapiens) | Glutaredoxin | ||
| 4rqx | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | PEROXIREDOXIN-4 (Homo sapiens) | 1-cysPrx_CAhpC-TSA | ||
| 4s0v | SUV | Suvorexant (DB09034) | Suvorexant is a orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. | HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 4s1y | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4tkg | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | TANKYRASE-2 (Homo sapiens) | PARP | ||
| 4tt7 | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4tv1 | 36M | Propylparaben (DB14177) | Propylparaben is used in allergenic testing. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4tvj | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens) | PARP | ||
| 4u0i | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4u7z | 3EW | Selumetinib (DB11689) | Selumetinib is a MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN). | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4uda | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 4uhx | LZU | Thioridazine (DB00679) | Thioridazine is a phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. | ALDEHYDE OXIDASE (Homo sapiens) | Ald_Xan_dh_CAld_Xan_dh_C2CO_deh_flav_CFAD_binding_5Fer2Fer2_2 | ||
| 4uxl | 5P8 | Lorlatinib (DB12130) | Lorlatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4uxq | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | FIBROBLAST GROWTH FACTOR RECEPTOR 4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4v04 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4v2o | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | SAPOSIN-B (Homo sapiens) | SapB_1SapB_2 | ||
| 4w9n | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (Homo sapiens) | ADH_zinc_N | ||
| 4w9n | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (Homo sapiens) | ADH_zinc_N | ||
| 4w9x | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 4wa9 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | NA | ||
| 4wev | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 (Homo sapiens) | Aldo_ket_red | ||
| 4wnu | QDN | Quinidine (DB00908) | Quinidine is a medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. | CYTOCHROME P450 2D6 (Homo sapiens) | p450 | ||
| 4wnv | QI9 | Quinine (DB00468) | Quinine is an alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | CYTOCHROME P450 2D6 (Homo sapiens) | NA | ||
| 4wvd | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | BILE ACID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 4x1f | 3WF | Ethinylestradiol (DB00977) | Ethinylestradiol is an estradiol used as a contraceptive. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 4xv2 | P06 | Dabrafenib (DB08912) | Dabrafenib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) | NA | ||
| 4y03 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PROTEIN POLYBROMO-1 (Homo sapiens) | Bromodomain | ||
| 4y8w | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 21-HYDROXYLASE (Homo sapiens) | NA | ||
| 4yia | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 4yvp | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens) | Aldo_ket_red | ||
| 4yvv | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4yvx | GMR | Glimepiride (DB00222) | Glimepiride is a sulfonylurea drug used to treat type 2 diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4z69 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4zfc | GCZ | Gliclazide (DB01120) | Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4zj8 | SUV | Suvorexant (DB09034) | Suvorexant is a orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. | HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi (strain ge5 / orsay)) | 7tm_1Glycos_transf_1 | ||
| 4zn7 | DES | Diethylstilbestrol (DB00255) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report... | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4zs2 | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 4zud | OLM | Olmesartan (DB00275) | Olmesartan is an angiotensin receptor blocker (ARB) used in the treatment of hypertension. | CHIMERA PROTEIN OF SOLUBLE CYTOCHROME B562 AND TYPE-1 ANGIOTENSIN II RECEPTOR (Escherichia coli;homo sapiens) | 7tm_1Cytochrom_B562 | ||
| 4zvm | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4zz3 | 4DW | Pemetrexed (DB00642) | Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. | TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 (Homo sapiens) | Formyl_trans_N | ||
| 5a1r | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 5a9u | 5P8 | Lorlatinib (DB12130) | Lorlatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5acl | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | MCG (Homo sapiens) | V-set | ||
| 5ajq | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) | Pkinase | ||
| 5alc | TIQ | Ticagrelor (DB08816) | Ticagrelor is a P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. | ANTI-TICAGRELOR FAB 72, HEAVY CHAIN;ANTI-TICAGRELOR FAB 72, LIGHT CHAIN (Homo sapiens) | NA | ||
| 5ayf | C7H | Cyproheptadine (DB00434) | Cyproheptadine is a combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. | HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 (Homo sapiens) | SET | ||
| 5boj | 4TX | Gemfibrozil (DB01241) | Gemfibrozil is a lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 5bpp | A4Z | Bufexamac (DB13346) | Bufexamac is an NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. | LEUKOTRIENE A-4 HYDROLASE (Homo sapiens) | Leuk-A4-hydro_CPeptidase_M1Peptidase_M1_N | ||
| 5bvw | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5c8i | MZM | Methazolamide (DB00703) | Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 5cg5 | RIS | Risedronic acid (DB00884) | Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease. | FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 5cxv | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M1 (Homo sapiens;enterobacteria phage t4;synthetic construct) | 7tm_1Phage_lysozyme | ||
| 5d0r | B1T | Bithionol (DB04813) | Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... | ADENYLATE CYCLASE TYPE 10 (Homo sapiens) | Guanylate_cyc | ||
| 5d75 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 (Homo sapiens) | FKBP_C | ||
| 5dq8 | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 (Homo sapiens) | YBD | ||
| 5ds3 | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARP | ||
| 5dsg | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4 (Homo sapiens;enterobacteria phage t4) | 7tm_1 | ||
| 5dv4 | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE (Homo sapiens) | Exo_endo_phos | ||
| 5dwq | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE-ARGININE METHYLTRANSFERASE CARM1;METHYLATED H3 PEPTIDE (Homo sapiens;synthetic construct) | PrmA | ||
| 5dxe | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5ew8 | 5SF | Erdafitinib (DB12147) | Erdafitinib is a fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma. | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5f1a | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5flc | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | FKBP;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens;spodoptera frugiperda) | FATFATCFRB_domPI3_PI4_kinase | ||
| 5fpd | PZA | Pyrazinamide (DB00339) | Pyrazinamide is an antituberculosis agent used as a component of tuberculosis (TB) treatment. | HEAT SHOCK-RELATED 70KDA PROTEIN 2 (Homo sapiens) | NA | ||
| 5fto | YMX | Entrectinib (DB11986) | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019... | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5g2n | 6E2 | Copanlisib (DB12483) | Copanlisib is a medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments. | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5g44 | YTZ | Sulfathiazole (DB06147) | Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination... | NUCLEAR RECEPTOR ROR-GAMMA (Homo sapiens) | Hormone_recep | ||
| 5g5j | MF8 | Metformin (DB00331) | Metformin is a biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS). | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 5gpg | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 5h2u | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PROTEIN-TYROSINE KINASE 6 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5ha9 | TP0 | Amitriptyline (DB00321) | Amitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 5hes | 032 | Vemurafenib (DB08881) | Vemurafenib is a kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5hi2 | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5hkg | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B (Homo sapiens) | FKBP_C | ||
| 5hs6 | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) | adh_short_C2 | ||
| 5i6x | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i71 | 68P | Escitalopram (DB01175) | Escitalopram is a selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i73 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i96 | 69Q | Enasidenib (DB13874) | Enasidenib is an isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. | ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL (Homo sapiens) | Iso_dh | ||
| 5i9x | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5i9y | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5icx | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | CETUXIMAB FAB LIGHT CHAIN;MEDITOPE (Mus musculus;homo sapiens;synthetic construct) | NA | ||
| 5ikq | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikr | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikt | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikv | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ji0 | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5jkw | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | AROMATASE (Homo sapiens) | p450 | ||
| 5jn8 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 4 (Homo sapiens) | NA | ||
| 5jna | TOR | Topiramate (DB00273) | Topiramate is an anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. | CARBONIC ANHYDRASE 4 (Homo sapiens) | NA | ||
| 5jnc | 6LH | Mafenide (DB06795) | Mafenide is an antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds. | CARBONIC ANHYDRASE 4 (Homo sapiens) | NA | ||
| 5k9d | CE9 | Polidocanol (DB06811) | Polidocanol is a sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity. | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL (Homo sapiens) | DHO_dh | ||
| 5kir | RCX | Rofecoxib (DB00533) | Rofecoxib is a COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5km8 | L8P | Cidofovir (DB00369) | Cidofovir is an antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. | HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL (Homo sapiens) | HIT | ||
| 5ku6 | MZM | Methazolamide (DB00703) | Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. | CARBONIC ANHYDRASE 4 (Homo sapiens) | NA | ||
| 5kvt | YMX | Entrectinib (DB11986) | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019... | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5l2i | LQQ | Palbociclib (DB09073) | Palbociclib is an endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l2s | 6ZV | Abemaciclib (DB12001) | Abemaciclib is a medication used to treat HR+ HER2- advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l2t | 6ZZ | Ribociclib (DB11730) | Ribociclib is a kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l5e | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 (Saccharomyces cerevisiae (strain atcc 204508 / s288c);homo sapiens;saccharomyces cerevisiae) | Proteasome | ||
| 5l5f | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 (Saccharomyces cerevisiae (strain atcc 204508 / s288c);homo sapiens;saccharomyces cerevisiae) | Proteasome | ||
| 5l5y | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6 (Homo sapiens;saccharomyces cerevisiae (strain atcc 204508 / s288c);saccharomyces cerevisiae) | Proteasome | ||
| 5l5z | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6 (Homo sapiens;saccharomyces cerevisiae (strain atcc 204508 / s288c);saccharomyces cerevisiae) | Proteasome | ||
| 5l7i | VIS | Vismodegib (DB08828) | Vismodegib is a hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. | SMOOTHENED HOMOLOG,SOLUBLE CYTOCHROME B562,SMOOTHENED HOMOLOG (Homo sapiens;escherichia coli) | FrizzledFz | ||
| 5l8o | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | GASTROTROPIN (Homo sapiens) | Lipocalin_7 | ||
| 5lbt | 6T0 | Imiquimod (DB00724) | Imiquimod is a toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 5lf3 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Pr_beta_CProteasome | ||
| 5lf3 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5 (Homo sapiens) | Proteasome | ||
| 5lf3 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Pr_beta_C | ||
| 5lf7 | 6V8 | Ixazomib (DB09570) | Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already. | PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Pr_beta_CProteasome | ||
| 5lf7 | 6V8 | Ixazomib (DB09570) | Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5 (Homo sapiens) | Proteasome | ||
| 5lf7 | 6V8 | Ixazomib (DB09570) | Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already. | PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Pr_beta_C | ||
| 5lrv | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | OTU DOMAIN-CONTAINING PROTEIN 7B;POLYUBIQUITIN-B (Homo sapiens;synthetic construct) | OTUubiquitin | ||
| 5lxm | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | AURORA KINASE A;TARGETING PROTEIN FOR XKLP2 (Homo sapiens;synthetic construct) | Pkinase | ||
| 5m24 | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RETINOIC ACID RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 5m78 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 5maf | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens) | Pkinase | ||
| 5mo4 | NIL | Nilotinib (DB04868) | Nilotinib is a kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-ThrSH2SH3_1 | ||
| 5mql | G65 | Masitinib (DB11526) | Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 5mqt | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 5mra | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | SORCIN (Homo sapiens) | EF-hand_6EF-hand_8 | ||
| 5mwy | YNU | Eplerenone (DB00700) | Eplerenone is an aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 5mzj | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 5mzp | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 5n26 | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | FERRITIN HEAVY CHAIN (Homo sapiens) | Ferritin | ||
| 5nfp | 8W5 | Budesonide (DB01222) | Budesonide is a corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5nkn | LOC | Colchicine (DB01394) | Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). | NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (Homo sapiens) | Lipocalin | ||
| 5nn4 | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | LYSOSOMAL ALPHA-GLUCOSIDASE (Homo sapiens) | Gal_mutarotas_2Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 5nn6 | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | LYSOSOMAL ALPHA-GLUCOSIDASE (Homo sapiens) | Gal_mutarotas_2Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 5now | L89 | Amifampridine (DB11640) | Amifampridine is a voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (Homo sapiens) | Pro_isomerase | ||
| 5nr3 | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B (Homo sapiens) | PWWP | ||
| 5nzx | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5nzy | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5o45 | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 5o4y | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2 (Homo sapiens;synthetic construct) | NA | ||
| 5ock | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | CEP1 PEPTIDE (FROM ENOLASE);HUMAN ACPA E4 FAB FRAGMENT - LIGHT CHAIN (Homo sapiens;synthetic construct) | NA | ||
| 5om2 | DXT | Doxycycline (DB00254) | Doxycycline is a tetracycline antibiotic used to treat a wide variety of bacterial infections. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 5om7 | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 5oog | A0B | Phloxine b (DB13911) | Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to... | FLAVIN REDUCTASE (NADPH) (Homo sapiens) | NAD_binding_10 | ||
| 5owr | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) | Pkinase | ||
| 5p9i | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5pah | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | PHENYLALANINE 4-MONOOXYGENASE (Homo sapiens) | NA | ||
| 5phh | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | LYSINE-SPECIFIC DEMETHYLASE 4D (Homo sapiens) | JmjCJmjN | ||
| 5q1s | AWY | Agomelatine (DB06594) | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine... | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5rzb | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | ISOFORM 2 OF BAND 4.1-LIKE PROTEIN 3 (Homo sapiens) | FERM_MFERM_N | ||
| 5s96 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PH-INTERACTING PROTEIN (Homo sapiens) | Bromodomain | ||
| 5swr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA;PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_P85_iSH2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinaseSH2 | ||
| 5sxc | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5te0 | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | AP2-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | ||
| 5te8 | 08J | Midazolam (DB00683) | Midazolam is a short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 5u1r | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | MAIT T-CELL RECEPTOR ALPHA CHAIN;MAIT T-CELL RECEPTOR BETA CHAIN;MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN (Homo sapiens) | C1-setMHC_I | ||
| 5uc3 | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | GLUCOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 5v02 | 657 | Riluzole (DB00740) | Riluzole is a glutamate antagonist used to treat amyotrophic lateral sclerosis. | CALMODULIN-1;SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2 (Homo sapiens) | CaMBDEF-hand_7 | ||
| 5vc3 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | WEE1-LIKE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 5vcv | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | ||
| 5vcy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | ||
| 5vdh | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | GLYCINE RECEPTOR SUBUNIT ALPHA-3 (Homo sapiens) | Neur_chan_LBD | ||
| 5veu | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | CYTOCHROME P450 3A5 (Homo sapiens) | p450 | ||
| 5vnl | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | PROTEIN TRANSPORT PROTEIN SEC24A (Homo sapiens;mus musculus) | GelsolinSec23_BSSec23_helicalSec23_trunkzf-Sec23_Sec24 | ||
| 5w5v | ANW | Amlexanox (DB01025) | Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent... | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) | PkinaseTBK1_CCD1TBK1_ULD | ||
| 5x23 | LSN | Losartan (DB00678) | Losartan is an angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. | CYTOCHROME P450 2C9 (Homo sapiens) | p450 | ||
| 5x2s | PEM | Bezafibrate (DB01393) | Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. | HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA (Homo sapiens) | Globin | ||
| 5xej | 6UV | Methotrexate (DB00563) | Methotrexate is an antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. | MACROPHAGE MIGRATION INHIBITORY FACTOR (Homo sapiens) | MIF | ||
| 5xpr | K86 | Bosentan (DB00559) | Bosentan is a dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. | ENDOTHELIN B RECEPTOR,ENDOLYSIN,ENDOTHELIN B RECEPTOR (Homo sapiens;enterobacteria phage t4) | 7tm_1 | ||
| 5xu8 | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2 (Homo sapiens;bos taurus) | UCH | ||
| 5xv7 | EMH | Alectinib (DB11363) | Alectinib is a kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | SERINE-ARGININE (SR) PROTEIN KINASE 1 (Homo sapiens) | Pkinase | ||
| 5y2o | 8N6 | Pioglitazone (DB01132) | Pioglitazone is a thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 5y80 | IRE | Gefitinib (DB00317) | Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. | CYCLIN-G-ASSOCIATED KINASE (Homo sapiens;lama glama) | Pkinase | ||
| 5yoq | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 5yu9 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5zkc | 3C0 | Methscopolamine (DB11315) | Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... | MUSCARINIC ACETYLCHOLINE RECEPTOR M2,APO-CYTOCHROME B562,MUSCARINIC ACETYLCHOLINE RECEPTOR M2 (Homo sapiens) | 7tm_1 | ||
| 5zv2 | LEV | Lenvatinib (DB09078) | Lenvatinib is a receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6a7p | 9SC | Aripiprazole (DB01238) | Aripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 6a93 | 8NU | Risperidone (DB00734) | Risperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | 5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6a94 | ZOT | Zotepine (DB09225) | Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India... | 5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6a96 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Lama glama;homo sapiens) | Neur_chan_LBDNeur_chan_memb | ||
| 6ajz | LOC | Colchicine (DB01394) | Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 6ak3 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6ak4 | PD9 | Entacapone (DB00494) | Entacapone is a selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 6avs | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | LYSINE-SPECIFIC DEMETHYLASE 8 (Homo sapiens) | Cupin_8 | ||
| 6awo | SRE | Sertraline (DB01104) | Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 6awp | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 6ayl | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | FATTY ACID-BINDING PROTEIN, ADIPOCYTE (Homo sapiens) | Lipocalin | ||
| 6b1e | LF7 | Vildagliptin (DB04876) | Vildagliptin is a once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 6bjd | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | CALPAIN-3 (Homo sapiens) | Peptidase_C2 | ||
| 6bqg | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | 5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6cm4 | 8NU | Risperidone (DB00734) | Risperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | D(2) DOPAMINE RECEPTOR, ENDOLYSIN CHIMERA (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6cnj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6dcm | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PLASMINOGEN (Homo sapiens) | NA | ||
| 6de9 | FUN | Furosemide (DB00695) | Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. | CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens) | zf-CDGSH | ||
| 6dew | 64Z | Geraniol (DB14183) | Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from... | UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL (Homo sapiens) | COQ9 | ||
| 6dgo | GD4 | Troglitazone (DB00197) | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 6djz | GMJ | Haloperidol (DB00502) | Haloperidol is an antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens) | ERG2_Sigma1R | ||
| 6dk1 | GM4 | Pentazocine (DB00652) | Pentazocine is an analgesic used to treat moderate to severe pain. | SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens) | ERG2_Sigma1R | ||
| 6drx | H8G | Lisuride (DB00589) | An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at... | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6dry | H8D | Methylergometrine (DB00353) | Methylergometrine is an ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6drz | H8J | Methysergide (DB00247) | Methysergide is an ergot alkaloid used for the prophylaxis of migraine and cluster headaches. | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6dwn | AQ4 | Erlotinib (DB00530) | Erlotinib is an EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. | CYTOCHROME P450 1A1 (Homo sapiens) | p450 | ||
| 6e5z | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1 (Homo sapiens) | DJ-1_PfpI | ||
| 6e78 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 6eg9 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6emm | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) | adh_short_C2 | ||
| 6ep4 | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 6eqp | BUW | Profenamine (DB00392) | Profenamine is an antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 6esm | PZE | Piperazine (DB00592) | Piperazine is a medication used to treat roundworm and pinworm. | MATRIX METALLOPROTEINASE-9 (Homo sapiens) | Peptidase_M10 | ||
| 6fdy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE ULK3 (Homo sapiens) | Pkinase | ||
| 6fnm | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | EPHRIN TYPE-B RECEPTOR 4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6ftp | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6g0g | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens) | Bromodomain | ||
| 6g31 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | GERANYLGERANYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 6g3q | FO9 | Famotidine (DB00927) | Famotidine is a histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 6g3v | FO9 | Famotidine (DB00927) | Famotidine is a histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. | CARBONIC ANHYDRASE 1 (Homo sapiens) | Carb_anhydrase | ||
| 6gh9 | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens) | UCH | ||
| 6h5w | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) | Peptidase_M2 | ||
| 6hco | FY5 | Estrone sulfate (DB04574) | Estrone sulfate is an estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 6hdr | CC9 | Curcumin (DB11672) | Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial,... | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 (Homo sapiens) | Pkinase | ||
| 6hgf | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hgg | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hgk | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hgl | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hj2 | P06 | Dabrafenib (DB08912) | Dabrafenib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 6hl1 | JN3 | Chenodeoxycholic acid (DB06777) | Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. | BILE ACID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 6hlo | GBQ | Aprepitant (DB00673) | Aprepitant is a substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. | SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6hlp | GAW | Netupitant (DB09048) | Netupitant is an antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy. | SUBSTANCE-P RECEPTOR (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6huj | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6huo | 08H | Alprazolam (DB00404) | Alprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6huo | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6ijx | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens) | Aldo_ket_red | ||
| 6j20 | GBQ | Aprepitant (DB00673) | Aprepitant is a substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. | SUBSTANCE-P RECEPTOR,ENDOLYSIN (Homo sapiens;enterobacteria phage t4) | 7tm_1 | ||
| 6j6m | BA0 | Zanubrutinib (DB15035) | Zanubrutinib is a kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy. | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6jdw | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | PROTEIN (L-ARGININE:GLYCINE AMIDINOTRANSFERASE) (Homo sapiens) | NA | ||
| 6jok | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6jol | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6k41 | CZX | Dexmedetomidine (DB00633) | Dexmedetomidine is an alpha-2 agonist used for sedation during various procedures. | ALPHA-2A ADRENERGIC RECEPTOR,ENDOLYSIN,ALPHA-2B ADRENERGIC RECEPTOR,ALPHA-2B ADRENERGIC RECEPTOR (Homo sapiens;mus musculus;bos taurus;enterobacteria phage rb59) | 7tm_1 | ||
| 6ktn | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 6l6e | E6L | Avanafil (DB06237) | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 6lqa | QDN | Quinidine (DB00908) | Quinidine is a medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. | SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA (Homo sapiens) | Ion_transNa_trans_assocNa_trans_cytopl | ||
| 6lud | YY3 | Osimertinib (DB09330) | Osimertinib is a tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6luq | GMJ | Haloperidol (DB00502) | Haloperidol is an antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | CHIMERA OF D(2) DOPAMINE RECEPTOR AND ENDOLYSIN (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6ma6 | MYT | Metyrapone (DB01011) | Metyrapone is a steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 6ma7 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 6me2 | JEV | Ramelteon (DB00980) | Ramelteon is a melatonin receptor agonist used to treat insomnia. | CHIMERA PROTEIN OF MELATONIN RECEPTOR TYPE 1A AND GLGA GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6me5 | AWY | Agomelatine (DB06594) | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine... | CHIMERA PROTEIN OF MELATONIN RECEPTOR TYPE 1A AND GLGA GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6me9 | JEV | Ramelteon (DB00980) | Ramelteon is a melatonin receptor agonist used to treat insomnia. | SOLUBLE CYTOCHROME B562,MELATONIN RECEPTOR TYPE 1B,RUBREDOXIN (Escherichia coli;homo sapiens;clostridium pasteurianum) | 7tm_1Cytochrom_B562Rubredoxin | ||
| 6mev | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 (Homo sapiens) | JmjC | ||
| 6mne | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | ESTRADIOL 17-BETA-DEHYDROGENASE 1 (Homo sapiens) | adh_short | ||
| 6mp4 | TCI | Dronabinol (DB00470) | Dronabinol is a synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. | FATTY ACID-BINDING PROTEIN, LIVER (Homo sapiens) | Lipocalin_7 | ||
| 6mx8 | 6GY | Brigatinib (DB12267) | Brigatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6mxt | K5Y | Salmeterol (DB00938) | Salmeterol is a long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. | ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;lama glama) | 7tm_1Phage_lysozyme | ||
| 6n2w | 30Z | Masoprocol (DB00179) | A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in... | ARACHIDONATE 5-LIPOXYGENASE (Homo sapiens) | LipoxygenasePLAT | ||
| 6nec | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6ng0 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 6nk0 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens;synthetic construct) | NA | ||
| 6nmb | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | UROKINASE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Trypsin | ||
| 6nwk | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 6nwl | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 6o0k | LBM | Venetoclax (DB11581) | Venetoclax is a BCL-2 inhibitor used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia. | APOPTOSIS REGULATOR BCL-2 (Homo sapiens) | BH4Bcl-2 | ||
| 6o2p | VX7 | Ivacaftor (DB08820) | Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (Homo sapiens) | ABC_membraneABC_tranCFTR_R | ||
| 6och | M4Y | Parthenolide (DB13063) | Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis. | TUBULINYL-TYR CARBOXYPEPTIDASE 1 (Homo sapiens) | NA | ||
| 6ohu | CTX | Tamoxifen (DB00675) | Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. | 3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE (Homo sapiens) | EBP | ||
| 6oi1 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens) | WD40 | ||
| 6oi3 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | MONOMETHYL H3R2 PEPTIDE;WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens;synthetic construct) | WD40 | ||
| 6ol9 | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M5, T4 LYSOZYME FUSION (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6op9 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6p3d | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6pah | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANINE 4-MONOOXYGENASE (Homo sapiens) | NA | ||
| 6ps3 | CVD | Carvedilol (DB01136) | Carvedilol is a non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. | FUSION PROTEIN OF BETA-2 ADRENERGIC RECEPTOR AND T4 LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6ps6 | TIM | Timolol (DB00373) | Timolol is a non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. | FUSION PROTEIN OF BETA-2 ADRENERGIC RECEPTOR AND T4 LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6psj | 29S | Bazedoxifene (DB06401) | Bazedoxifene is a selective estrogen receptor modulator (SERM) used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens. | ESTROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 6pv7 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli o11;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6pyf | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SEX HORMONE-BINDING GLOBULIN (Homo sapiens) | Laminin_G_1 | ||
| 6q6o | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | NUCLEAR RECEPTOR ROR-GAMMA (Homo sapiens) | Hormone_recep | ||
| 6qex | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | MULTIDRUG RESISTANCE PROTEIN 1 (Homo sapiens;mus musculus) | ABC_membraneABC_tran | ||
| 6qvl | 4DW | Pemetrexed (DB00642) | Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. | SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL (Homo sapiens) | SHMT | ||
| 6qyq | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | THYMIDYLATE SYNTHASE (Homo sapiens) | Thymidylat_synt | ||
| 6r4v | BFQ | Ibandronate (DB00710) | Ibandronate is a bisphosphonate used to treat osteoporosis in postmenopausal women. | GERANYLGERANYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 6r7s | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 6rl9 | SAN | Sulfanilamide (DB00259) | Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 6rz5 | ZLK | Zafirlukast (DB00549) | Zafirlukast is a leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. | CYSTEINYL LEUKOTRIENE RECEPTOR 1,SOLUBLE CYTOCHROME B562,CYSTEINYL LEUKOTRIENE RECEPTOR 1 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6sg0 | FUN | Furosemide (DB00695) | Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 6slr | AOQ | Atovaquone (DB01117) | Atovaquone is an antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. | PROSAPOSIN (Homo sapiens) | SapB_1SapB_2 | ||
| 6tbe | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A (Homo sapiens) | NA | ||
| 6tko | H98 | Arformoterol (DB01274) | Arformoterol is a beta-2 adrenergic agonist and bronchodilator used for long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. | BETA-1 ADRENERGIC RECEPTOR (Meleagris gallopavo;homo sapiens;phage display vector ptdisp) | 7tm_1 | ||
| 6to7 | SUV | Suvorexant (DB09034) | Suvorexant is a orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. | OREXIN RECEPTOR TYPE 1 (Homo sapiens) | 7tm_1 | ||
| 6tot | NRK | Lemborexant (DB11951) | Lemborexant is a dual orexin antagonist indicated for the treatment of sleep-onset and/or sleep maintenance insomnia. | OREXIN RECEPTOR TYPE 1 (Homo sapiens) | 7tm_1 | ||
| 6tt3 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) | Peptidase_M2 | ||
| 6tu9 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6tuz | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM (Homo sapiens) | PAE | ||
| 6tv4 | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM (Homo sapiens) | PAE | ||
| 6ulb | QA1 | Danazol (DB01406) | Danazol is a synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. | SEX HORMONE-BINDING GLOBULIN (Homo sapiens) | Laminin_G_1 | ||
| 6umw | CTC | Chlortetracycline (DB09093) | Chlortetracycline is the first tetracycline antibiotic most commonly used for veterinary purposes. | EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6ur8 | QMR | Varenicline (DB01273) | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. | CHIMERA OF SOLUBLE CYTOCHROME B562 (BRIL) AND NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;escherichia coli) | Neur_chan_LBDNeur_chan_memb | ||
| 6v0x | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | BROMODOMAIN-CONTAINING PROTEIN 9 (Homo sapiens) | Bromodomain | ||
| 6vjd | C3D | Lasofoxifene (DB06202) | Lasofoxifene is a non-steroidal 3rd generation selective estrogen receptor modulator (SERM) that selectively binds to both ERα and ERβ with high affinity. It is a naphthalene derivative marketed for prevention... | ESTROGEN RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 6vkk | RPB | Rucaparib (DB12332) | Rucaparib is an anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 6vms | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | ENDOLYSIN,D(2) DOPAMINE RECEPTOR,D(2) DOPAMINE RECEPTOR (Rattus norvegicus;homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6vne | 2TA | Fedratinib (DB12500) | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was... | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6vsn | RG4 | Ruxolitinib (DB08877) | Ruxolitinib is a kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6vxh | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2 (Homo sapiens) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 6wjc | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN FUSION (Homo sapiens;enterobacteria phage t4;dendroaspis angusticeps) | 7tm_1Phage_lysozyme | ||
| 6wr1 | AER | Abiraterone (DB05812) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 6wto | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6wv6 | UAS | Phenindione (DB00498) | An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects.... | VITAMIN K EPOXIDE REDUCTASE, TERMINI RESTRAINED BY GREEN FLUORESCENT PROTEIN (Aequorea victoria;homo sapiens) | GFPVKOR | ||
| 6x27 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE HOMOLOG, MITOCHONDRIAL (Homo sapiens) | NA | ||
| 6x3t | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3u | FYP | Flumazenil (DB01205) | Flumazenil is a benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3v | V8D | Etomidate (DB00292) | Etomidate is a short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6xic | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | PEPTIDE 40;PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (Homo sapiens;synthetic construct) | Peptidase_S8 | ||
| 6xjs | V6A | Selinexor (DB11942) | Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. It is currently approved for the treatment of multiple myeloma, a cancer which forms from antibody-producing plasma cells.[L7117,L7120] This... | EXPORTIN-1 (Homo sapiens;saccharomyces cerevisiae) | CRM1_CCRM1_repeatCRM1_repeat_2CRM1_repeat_3IBN_NXpo1 | ||
| 6y0f | 356 | Linagliptin (DB08882) | Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. | PROLYL ENDOPEPTIDASE FAP (Homo sapiens) | DPPIV_N | ||
| 6ycr | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | FFIVIRDRVFR(CCS)G(NH2);PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 6ymo | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 14-3-3 PROTEIN ZETA/DELTA (Homo sapiens;synthetic construct) | 14-3-3 | ||
| 6ysx | 08D | Sulfamethoxazole (DB01015) | Sulfamethoxazole is an oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. | PROTHROMBIN (Homo sapiens;synthetic construct) | Trypsin | ||
| 6yz4 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 (Homo sapiens) | Pkinase | ||
| 6zu4 | 115 | Fluvastatin (DB01095) | Fluvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6 (Homo sapiens) | SIR2 | ||
| 7a5v | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 7a69 | R1Q | Vincristine (DB00541) | Vincristine is a vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. | MULTIDRUG RESISTANCE PROTEIN 1 (Homo sapiens;mus musculus) | ABC_membraneABC_tran | ||
| 7ab1 | C6F | Gilteritinib (DB12141) | Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. | TYROSINE-PROTEIN KINASE MER (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 7aem | 6GY | Brigatinib (DB12267) | Brigatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 7apv | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | PROTEIN ARTEMIS (Homo sapiens) | DRMBL | ||
| 7awc | BRL | Rosiglitazone (DB00412) | Rosiglitazone is a thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 7axa | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7axh | 27J | Zeranol (DB11478) | Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7axk | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7bi5 | 010 | Benzyl alcohol (DB06770) | Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 7bpz | PEM | Bezafibrate (DB01393) | Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 7bq0 | F5A | Fenofibric acid (DB13873) | Fenofibric acid is a fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 7br3 | F5O | Elagolix (DB11979) | Elagolix is a gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. | GONADOTROPIN-RELEASING HORMONE RECEPTOR,GLGA GLYCOGEN SYNTHASE,GONADOTROPIN-RELEASING HORMONE RECEPTOR (Homo sapiens;pyrococcus abyssi (strain ge5 / orsay)) | 7tm_1Glycos_transf_1 | ||
| 7bts | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | LYSOZYME-BETA-1 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;vicugna pacos) | Phage_lysozyme | ||
| 7bu6 | E5E | Norepinephrine (DB00368) | Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. | ENDOLYSIN,ENDOLYSIN,ENDOLYSIN,BETA-1 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;camelidae mixed library) | Phage_lysozyme | ||
| 7bym | FBX | Ezogabine (DB04953) | Ezogabine is an antiepileptic agent used as an adjuvant treatment of partial-onset seizures. | GREEN FLUORESCENT PROTEIN,POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 (Aequorea victoria;homo sapiens) | GFPIon_transKCNQ_channel | ||
| 7bz2 | H98 | Arformoterol (DB01274) | Arformoterol is a beta-2 adrenergic agonist and bronchodilator used for long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. | BETA2 ADRENERGIC RECEPTOR (Homo sapiens;bos taurus;lama glama) | 7tm_1 | ||
| 7cbq | A9L | Apremilast (DB05676) | Apremilast is a non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 7ckw | G3C | Fenoldopam (DB00800) | Fenoldopam is a dopamine D1 receptor agonist used for the short term management of hypertension. | D(1A) DOPAMINE RECEPTOR (Homo sapiens;lama glama) | 7tm_1 | ||
| 7ckz | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | D(1A) DOPAMINE RECEPTOR (Homo sapiens;lama glama) | 7tm_1 | ||
| 7cmu | G6L | Pramipexole (DB00413) | Pramipexole is a non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). | SOLUBLE CYTOCHROME B562,D(3) DOPAMINE RECEPTOR (Homo sapiens;mus musculus;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7cr2 | FBX | Ezogabine (DB04953) | Ezogabine is an antiepileptic agent used as an adjuvant treatment of partial-onset seizures. | POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2 (Homo sapiens) | Ion_transKCNQ_channel | ||
| 7cx2 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE (Homo sapiens;synthetic construct) | 7tm_1 | ||
| 7d77 | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ADHESION G PROTEIN-COUPLED RECEPTOR G3; GPR97 (Homo sapiens;synthetic construct) | NA | ||
| 7d7m | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE (Homo sapiens;lama glama) | 7tm_1 | ||
| 7dfl | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | HISTAMINE H1 RECEPTOR (Homo sapiens) | 7tm_1 | ||
| 7dhi | 68H | Levosalbutamol (DB13139) | Levosalbutamol is a beta-2 adrenergic receptor agonist used to treat COPD and asthma. | BETA-2 ADRENERGIC RECEPTOR (Homo sapiens;bos taurus;lama glama) | 7tm_1 | ||
| 7dhr | 5FW | Isoprenaline (DB01064) | Isoprenaline is a catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. | BETA-2 ADRENERGIC RECEPTOR (Homo sapiens;bos taurus;lama glama) | 7tm_1 | ||
| 7e2z | 9SC | Aripiprazole (DB01238) | Aripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. | SOLUBLE CYTOCHROME B562,5-HYDROXYTRYPTAMINE RECEPTOR 1A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7jur | QOM | Trametinib (DB08911) | Trametinib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1;KINASE SUPPRESSOR OF RAS 2 (Homo sapiens;oryctolagus cuniculus) | PK_Tyr_Ser-ThrPkinase | ||
| 7jvr | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR (Escherichia coli;homo sapiens;synthetic construct) | 7tm_1 | ||
| 7jvu | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 8 (Homo sapiens) | Hist_deacetyl | ||
| 7jwn | 9KL | Dexketoprofen (DB09214) | Dexketoprofen is an NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. | ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 7kk3 | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 7kk4 | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 7kk5 | 3JD | Niraparib (DB11793) | Niraparib is a poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 7kkn | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE (Homo sapiens) | PARP | ||
| 7kko | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE (Homo sapiens) | PARP | ||
| 7kkp | 3JD | Niraparib (DB11793) | Niraparib is a poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE (Homo sapiens) | PARP | ||
| 7krz | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE HOMOLOG, MITOCHONDRIAL (Homo sapiens;escherichia coli bl21(de3)) | AAA | ||
| 7kxt | XB7 | Astemizole (DB00637) | Astemizole is a second generation antihistamine used to treat allergy symptoms. | POLYCOMB PROTEIN EED (Homo sapiens) | WD40 | ||
| 7m0u | QO7 | Binimetinib (DB11967) | Binimetinib is a medication used to treat metastatic melanoma with specific mutations. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 7nez | TTC | Topotecan (DB01030) | Topotecan is an antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7nfd | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |