Ligand ID: 2TA

Drugbank ID:
Fedratinib
(DB12500)

Indication:
Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was...

LIST OF BINDING INTERFACES for query '2TA'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4PS5_A_2TAA201	4ps5	2TA	Fedratinib (DB12500)	Homo sapiens	BROMODOMAIN-CONTAINING PROTEIN 4	Bromodomain	13	TRP A  81 PRO A  82 PHE A  83 VAL A  87 LEU A  92 LEU A  94 TYR A  97 CYS A 136 TYR A 139 ASN A 140 ASP A 145 ILE A 146 MET A 149	2TA A 201		Details
6VNE_B_2TAB1201	6vne	2TA	Fedratinib (DB12500)	Homo sapiens	TYROSINE-PROTEIN KINASE JAK2	PK_Tyr_Ser-Thr	22	GLN B 853 GLN B 854 LEU B 855 GLY B 856 LYS B 857 GLY B 858 VAL B 863 ALA B 880 LYS B 882 VAL B 911 MET B 929 GLU B 930 TYR B 931 LEU B 932 PRO B 933 GLY B 935 SER B 936 ARG B 980 ASN B 981 LEU B 983 GLY B 993 ASP B 994	2TA B1201		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4PS5_A_2TAA201","4ps5","2TA","Fedratinib (DB12500)","Homo sapiens","BROMODOMAIN-CONTAINING PROTEIN 4","Bromodomain",13,"TRP A 81;PRO A 82;PHE A 83;VAL A 87;LEU A 92;LEU A 94;TYR A 97;CYS A 136;TYR A 139;ASN A 140;ASP A 145;ILE A 146;MET A 149","2TA A 201\r"],["6VNE_B_2TAB1201","6vne","2TA","Fedratinib (DB12500)","Homo sapiens","TYROSINE-PROTEIN KINASE JAK2","PK_Tyr_Ser-Thr",22,"GLN B 853;GLN B 854;LEU B 855;GLY B 856;LYS B 857;GLY B 858;VAL B 863;ALA B 880;LYS B 882;VAL B 911;MET B 929;GLU B 930;TYR B 931;LEU B 932;PRO B 933;GLY B 935;SER B 936;ARG B 980;ASN B 981;LEU B 983;GLY B 993;ASP B 994","2TA B1201\r"]]