Ligand ID: RG4

Drugbank ID:
Ruxolitinib
(DB08877)

Indication:
Ruxolitinib is a kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.

LIST OF BINDING INTERFACES for query 'RG4'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
6VSN_D_RG4D1201	6vsn	RG4	Ruxolitinib (DB08877)	Homo sapiens	TYROSINE-PROTEIN KINASE JAK2	PK_Tyr_Ser-Thr	17	LEU D 855 GLY D 856 LYS D 857 GLY D 858 VAL D 863 ALA D 880 LYS D 882 VAL D 911 MET D 929 GLU D 930 TYR D 931 LEU D 932 ARG D 980 ASN D 981 LEU D 983 GLY D 993 ASP D 994	RG4 D1201		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["6VSN_D_RG4D1201","6vsn","RG4","Ruxolitinib (DB08877)","Homo sapiens","TYROSINE-PROTEIN KINASE JAK2","PK_Tyr_Ser-Thr",17,"LEU D 855;GLY D 856;LYS D 857;GLY D 858;VAL D 863;ALA D 880;LYS D 882;VAL D 911;MET D 929;GLU D 930;TYR D 931;LEU D 932;ARG D 980;ASN D 981;LEU D 983;GLY D 993;ASP D 994","RG4 D1201\r"]]