Ligand ID: 3BV

Drugbank ID:
Carfilzomib
(DB08889)

Indication:
Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.

LIST OF BINDING INTERFACES for query '3BV'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4R67_H_3BVH301	4r67	3BV	Carfilzomib (DB08889)	Homo sapiens	PROTEASOME SUBUNIT BETA TYPE-6; PROTEASOME SUBUNIT BETA TYPE-7	NA	20	THR H   1 ARG H  19 THR H  20 THR H  21 THR H  22 ALA H  27 LYS H  33 ARG H  45 SER H  46 GLY H  47 SER H  48 ALA H  49 THR H  52 MET H  95 TYR I 114 HIS I 116 SER I 118 ASP I 120 SER H 130 SER H 169	3BV H 301		Details
4R67_I_3BVI301	4r67	3BV	Carfilzomib (DB08889)	Homo sapiens	PROTEASOME SUBUNIT BETA TYPE-3; PROTEASOME SUBUNIT BETA TYPE-7	Proteasome	23	THR I   1 MET J   4 ARG I  19 ALA I  20 THR I  21 GLU I  22 ALA I  27 LYS I  33 GLY I  45 ALA I  46 GLY I  47 THR I  48 ALA I  49 THR I  52 ARG J  99 GLU J 106 ASP J 125 LEU J 126 ILE J 127 CYS J 129 SER I 129 MET J 131 GLY I 168	3BV I 301		Details
4R67_L_3BVL301	4r67	3BV	Carfilzomib (DB08889)	Homo sapiens	PROTEASOME SUBUNIT BETA TYPE-1; PROTEASOME SUBUNIT BETA TYPE-5	Proteasome	22	THR L   1 ARG L  19 ALA L  20 THR L  21 ALA L  22 GLY L  23 ALA L  27 LYS L  33 MET L  45 ALA L  46 GLY L  47 GLY L  48 ALA L  49 SER L  96 ARG M 100 PRO M 103 TYR M 107 ASP M 125 PRO M 126 VAL M 127 SER L 130 TYR L 169	3BV L 301		Details
5D0S_H_3BVH301	5d0s	3BV	Carfilzomib (DB08889)	Saccharomyces cerevisiae (strain atcc 204508 / s288c)	PROTEASOME SUBUNIT BETA TYPE-2; PROTEASOME SUBUNIT BETA TYPE-3	Pr_beta_C Proteasome	22	THR H   1 SER I   4 ARG H  19 SER H  20 THR H  21 GLN H  22 ALA H  27 CYS H  31 LYS H  33 GLY H  45 ALA H  46 GLY H  47 THR H  48 ALA H  49 THR H  52 ARG I  98 ASP I 124 LEU I 125 ILE I 126 CYS I 128 SER H 129 GLY H 168	3BV H 301		Details
5D0S_K_3BVK301	5d0s	3BV	Carfilzomib (DB08889)	Saccharomyces cerevisiae (strain atcc 204508 / s288c)	PROTEASOME SUBUNIT BETA TYPE-5; PROTEASOME SUBUNIT BETA TYPE-6	Proteasome	23	THR K   1 ARG K  19 ALA K  20 THR K  21 ALA K  22 ALA K  27 VAL K  31 LYS K  33 MET K  45 ALA K  46 GLY K  47 GLY K  48 ALA K  49 SER K  96 ARG L 101 PRO L 104 HIS L 108 ASP L 126 PRO L 127 VAL L 128 SER L 130 SER K 131 TYR K 170	3BV K 301		Details
5D0S_N_3BVN201	5d0s	3BV	Carfilzomib (DB08889)	Saccharomyces cerevisiae (strain atcc 204508 / s288c)	PROTEASOME SUBUNIT BETA TYPE-1; PROTEASOME SUBUNIT BETA TYPE-2	Pr_beta_C	21	THR N   1 ARG N  19 THR N  20 THR N  21 THR N  22 ALA N  27 LYS N  33 ARG N  45 SER N  46 GLY N  47 SER N  48 ALA N  49 THR N  52 THR N  94 HIS H 114 HIS H 116 SER H 118 ASP H 120 GLY N 128 SER N 129 SER N 168	3BV N 201		Details
5L5E_K_3BVK301	5l5e	3BV	Carfilzomib (DB08889)	Saccharomyces cerevisiae (strain atcc 204508 / s288c); homo sapiens; saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6; PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5	Proteasome	21	THR K   1 ARG K  19 ALA K  20 SER K  21 ALA K  22 SER K  27 VAL K  31 LYS K  33 MET K  45 SER K  46 GLY K  47 CYS K  48 ALA K  49 SER K  96 PRO L 104 TYR L 106 ASP L 126 PRO L 127 VAL L 128 SER K 130 TYR K 169	3BV K 301		Details
5L5Y_K_3BVK301	5l5y	3BV	Carfilzomib (DB08889)	Homo sapiens; saccharomyces cerevisiae (strain atcc 204508 / s288c); saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5; PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6	Proteasome	22	THR K   1 ARG K  19 ALA K  20 THR K  21 ALA K  22 ALA K  27 LYS K  33 MET K  45 ALA K  46 GLY K  47 GLY K  48 ALA K  49 SER K  96 ARG L 101 PRO L 104 ASP L 126 PRO L 127 VAL L 128 SER L 130 SER K 130 GLN L 132 TYR K 169	3BV K 301		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4R67_H_3BVH301","4r67","3BV","Carfilzomib (DB08889)","Homo sapiens","PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-7","NA",20,"THR H 1;ARG H 19;THR H 20;THR H 21;THR H 22;ALA H 27;LYS H 33;ARG H 45;SER H 46;GLY H 47;SER H 48;ALA H 49;THR H 52;MET H 95;TYR I 114;HIS I 116;SER I 118;ASP I 120;SER H 130;SER H 169","3BV H 301\r"],["4R67_I_3BVI301","4r67","3BV","Carfilzomib (DB08889)","Homo sapiens","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","Proteasome",23,"THR I 1;MET J 4;ARG I 19;ALA I 20;THR I 21;GLU I 22;ALA I 27;LYS I 33;GLY I 45;ALA I 46;GLY I 47;THR I 48;ALA I 49;THR I 52;ARG J 99;GLU J 106;ASP J 125;LEU J 126;ILE J 127;CYS J 129;SER I 129;MET J 131;GLY I 168","3BV I 301\r"],["4R67_L_3BVL301","4r67","3BV","Carfilzomib (DB08889)","Homo sapiens","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5","Proteasome",22,"THR L 1;ARG L 19;ALA L 20;THR L 21;ALA L 22;GLY L 23;ALA L 27;LYS L 33;MET L 45;ALA L 46;GLY L 47;GLY L 48;ALA L 49;SER L 96;ARG M 100;PRO M 103;TYR M 107;ASP M 125;PRO M 126;VAL M 127;SER L 130;TYR L 169","3BV L 301\r"],["5D0S_H_3BVH301","5d0s","3BV","Carfilzomib (DB08889)","Saccharomyces cerevisiae (strain atcc 204508 \/ s288c)","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","Pr_beta_C;Proteasome",22,"THR H 1;SER I 4;ARG H 19;SER H 20;THR H 21;GLN H 22;ALA H 27;CYS H 31;LYS H 33;GLY H 45;ALA H 46;GLY H 47;THR H 48;ALA H 49;THR H 52;ARG I 98;ASP I 124;LEU I 125;ILE I 126;CYS I 128;SER H 129;GLY H 168","3BV H 301\r"],["5D0S_K_3BVK301","5d0s","3BV","Carfilzomib (DB08889)","Saccharomyces cerevisiae (strain atcc 204508 \/ s288c)","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","Proteasome",23,"THR K 1;ARG K 19;ALA K 20;THR K 21;ALA K 22;ALA K 27;VAL K 31;LYS K 33;MET K 45;ALA K 46;GLY K 47;GLY K 48;ALA K 49;SER K 96;ARG L 101;PRO L 104;HIS L 108;ASP L 126;PRO L 127;VAL L 128;SER L 130;SER K 131;TYR K 170","3BV K 301\r"],["5D0S_N_3BVN201","5d0s","3BV","Carfilzomib (DB08889)","Saccharomyces cerevisiae (strain atcc 204508 \/ s288c)","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2","Pr_beta_C",21,"THR N 1;ARG N 19;THR N 20;THR N 21;THR N 22;ALA N 27;LYS N 33;ARG N 45;SER N 46;GLY N 47;SER N 48;ALA N 49;THR N 52;THR N 94;HIS H 114;HIS H 116;SER H 118;ASP H 120;GLY N 128;SER N 129;SER N 168","3BV N 201\r"],["5L5E_K_3BVK301","5l5e","3BV","Carfilzomib (DB08889)","Saccharomyces cerevisiae (strain atcc 204508 \/ s288c);homo sapiens;saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5","Proteasome",21,"THR K 1;ARG K 19;ALA K 20;SER K 21;ALA K 22;SER K 27;VAL K 31;LYS K 33;MET K 45;SER K 46;GLY K 47;CYS K 48;ALA K 49;SER K 96;PRO L 104;TYR L 106;ASP L 126;PRO L 127;VAL L 128;SER K 130;TYR K 169","3BV K 301\r"],["5L5Y_K_3BVK301","5l5y","3BV","Carfilzomib (DB08889)","Homo sapiens;saccharomyces cerevisiae (strain atcc 204508 \/ s288c);saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","Proteasome",22,"THR K 1;ARG K 19;ALA K 20;THR K 21;ALA K 22;ALA K 27;LYS K 33;MET K 45;ALA K 46;GLY K 47;GLY K 48;ALA K 49;SER K 96;ARG L 101;PRO L 104;ASP L 126;PRO L 127;VAL L 128;SER L 130;SER K 130;GLN L 132;TYR K 169","3BV K 301\r"]]