Ligand ID: VGH

Drugbank ID:
Crizotinib
(DB08865)

Indication:
Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.

LIST OF BINDING INTERFACES for query 'VGH'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2WGJ_A_VGHA2346	2wgj	VGH	Crizotinib (DB08865)	Homo sapiens	HEPATOCYTE GROWTH FACTOR RECEPTOR	PK_Tyr_Ser-Thr	19	ILE A1084 GLY A1085 VAL A1092 ALA A1108 LEU A1140 LEU A1157 PRO A1158 TYR A1159 MET A1160 LYS A1161 HIS A1162 GLY A1163 ARG A1208 ASN A1209 MET A1211 ALA A1221 ASP A1222 ALA A1226 TYR A1230	VGH A2346		Details
2YFX_A_VGHA9000	2yfx	VGH	Crizotinib (DB08865)	Homo sapiens	TYROSINE-PROTEIN KINASE RECEPTOR	PK_Tyr_Ser-Thr	19	LEU A1122 VAL A1130 ALA A1148 LYS A1150 VAL A1180 MET A1196 GLU A1197 LEU A1198 MET A1199 ALA A1200 GLY A1201 GLY A1202 ASP A1203 ARG A1253 ASN A1254 CYS A1255 LEU A1256 GLY A1269 ASP A1270	VGH A9000		Details
3ZBF_A_VGHA3000	3zbf	VGH	Crizotinib (DB08865)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS	PK_Tyr_Ser-Thr	18	LEU A1951 VAL A1959 ALA A1978 LYS A1980 LEU A2010 LEU A2026 GLU A2027 LEU A2028 MET A2029 GLY A2032 ASP A2033 THR A2036 ARG A2083 ASN A2084 CYS A2085 LEU A2086 GLY A2101 ASP A2102	VGH A3000		Details
4C9W_A_VGHA1158	4c9w	VGH	Crizotinib (DB08865)	Homo sapiens	7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE	NUDIX	13	TYR A   7 LEU A   9 PHE A  27 ASN A  33 PHE A  72 PHE A  74 MET A  81 VAL A  83 TRP A 117 ASP A 119 ASP A 120 PHE A 139 GLN A 142	VGH A1158		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2WGJ_A_VGHA2346","2wgj","VGH","Crizotinib (DB08865)","Homo sapiens","HEPATOCYTE GROWTH FACTOR RECEPTOR","PK_Tyr_Ser-Thr",19,"ILE A1084;GLY A1085;VAL A1092;ALA A1108;LEU A1140;LEU A1157;PRO A1158;TYR A1159;MET A1160;LYS A1161;HIS A1162;GLY A1163;ARG A1208;ASN A1209;MET A1211;ALA A1221;ASP A1222;ALA A1226;TYR A1230","VGH A2346\r"],["2YFX_A_VGHA9000","2yfx","VGH","Crizotinib (DB08865)","Homo sapiens","TYROSINE-PROTEIN KINASE RECEPTOR","PK_Tyr_Ser-Thr",19,"LEU A1122;VAL A1130;ALA A1148;LYS A1150;VAL A1180;MET A1196;GLU A1197;LEU A1198;MET A1199;ALA A1200;GLY A1201;GLY A1202;ASP A1203;ARG A1253;ASN A1254;CYS A1255;LEU A1256;GLY A1269;ASP A1270","VGH A9000\r"],["3ZBF_A_VGHA3000","3zbf","VGH","Crizotinib (DB08865)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS","PK_Tyr_Ser-Thr",18,"LEU A1951;VAL A1959;ALA A1978;LYS A1980;LEU A2010;LEU A2026;GLU A2027;LEU A2028;MET A2029;GLY A2032;ASP A2033;THR A2036;ARG A2083;ASN A2084;CYS A2085;LEU A2086;GLY A2101;ASP A2102","VGH A3000\r"],["4C9W_A_VGHA1158","4c9w","VGH","Crizotinib (DB08865)","Homo sapiens","7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE","NUDIX",13,"TYR A 7;LEU A 9;PHE A 27;ASN A 33;PHE A 72;PHE A 74;MET A 81;VAL A 83;TRP A 117;ASP A 119;ASP A 120;PHE A 139;GLN A 142","VGH A1158\r"]]