Results: Ligand

Ligand ID: MI1

Drugbank ID:
Tofacitinib
(DB08895)

Indication:
Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine.

LIST OF BINDING INTERFACES for query 'DB08895'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3EYG_A_MI1A1	3eyg	MI1	Tofacitinib (DB08895)	Homo sapiens	TYROSINE-PROTEIN KINASE	PK_Tyr_Ser-Thr	21	LEU A 881 GLY A 882 GLU A 883 GLY A 884 GLY A 887 LYS A 888 VAL A 889 ALA A 906 LYS A 908 VAL A 938 MET A 956 GLU A 957 PHE A 958 LEU A 959 GLY A 962 SER A 963 ARG A1007 ASN A1008 LEU A1010 GLY A1020 ASP A1021	MI1 A 1
3FUP_A_MI1A1	3fup	MI1	Tofacitinib (DB08895)	Homo sapiens	TYROSINE-PROTEIN KINASE JAK2	PK_Tyr_Ser-Thr	22	LEU A 855 GLY A 856 LYS A 857 GLY A 858 GLY A 861 SER A 862 VAL A 863 ALA A 880 LYS A 882 VAL A 911 MET A 929 GLU A 930 TYR A 931 LEU A 932 GLY A 935 SER A 936 ARG A 980 ASN A 981 ILE A 982 LEU A 983 GLY A 993 ASP A 994	MI1 A 1
3LXK_A_MI1A1125	3lxk	MI1	Tofacitinib (DB08895)	Homo sapiens	TYROSINE-PROTEIN KINASE JAK3	PK_Tyr_Ser-Thr	22	LEU A 828 GLY A 829 LYS A 830 GLY A 831 GLY A 834 SER A 835 VAL A 836 ALA A 853 LYS A 855 VAL A 884 MET A 902 GLU A 903 TYR A 904 LEU A 905 GLY A 908 CYS A 909 ARG A 953 ASN A 954 ILE A 955 LEU A 956 ALA A 966 ASP A 967	MI1 A1125
3LXN_A_MI1A1	3lxn	MI1	Tofacitinib (DB08895)	Homo sapiens	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2	PK_Tyr_Ser-Thr	22	LEU A 903 GLY A 904 GLU A 905 GLY A 906 HIS A 907 GLY A 909 LYS A 910 VAL A 911 ALA A 928 LYS A 930 ILE A 960 MET A 978 GLU A 979 TYR A 980 VAL A 981 GLY A 984 SER A 985 ARG A1027 ASN A1028 LEU A1030 GLY A1040 ASP A1041	MI1 A 1
4OTI_A_MI1A1001	4oti	MI1	Tofacitinib (DB08895)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE N1	Pkinase Pkinase_C	20	LEU A 627 GLY A 628 ARG A 629 GLY A 630 GLY A 633 LYS A 634 VAL A 635 ALA A 648 LYS A 650 VAL A 685 MET A 701 GLU A 702 TYR A 703 SER A 704 ASP A 750 ASN A 751 LEU A 753 ALA A 763 ASP A 764 PHE A 910	MI1 A1001
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3EYG_A_MI1A1","3eyg","MI1","Tofacitinib (DB08895)","Homo sapiens","TYROSINE-PROTEIN KINASE","PK_Tyr_Ser-Thr",21,"LEU A 881;GLY A 882;GLU A 883;GLY A 884;GLY A 887;LYS A 888;VAL A 889;ALA A 906;LYS A 908;VAL A 938;MET A 956;GLU A 957;PHE A 958;LEU A 959;GLY A 962;SER A 963;ARG A1007;ASN A1008;LEU A1010;GLY A1020;ASP A1021","MI1 A   1\r"],["3FUP_A_MI1A1","3fup","MI1","Tofacitinib (DB08895)","Homo sapiens","TYROSINE-PROTEIN KINASE JAK2","PK_Tyr_Ser-Thr",22,"LEU A 855;GLY A 856;LYS A 857;GLY A 858;GLY A 861;SER A 862;VAL A 863;ALA A 880;LYS A 882;VAL A 911;MET A 929;GLU A 930;TYR A 931;LEU A 932;GLY A 935;SER A 936;ARG A 980;ASN A 981;ILE A 982;LEU A 983;GLY A 993;ASP A 994","MI1 A   1\r"],["3LXK_A_MI1A1125","3lxk","MI1","Tofacitinib (DB08895)","Homo sapiens","TYROSINE-PROTEIN KINASE JAK3","PK_Tyr_Ser-Thr",22,"LEU A 828;GLY A 829;LYS A 830;GLY A 831;GLY A 834;SER A 835;VAL A 836;ALA A 853;LYS A 855;VAL A 884;MET A 902;GLU A 903;TYR A 904;LEU A 905;GLY A 908;CYS A 909;ARG A 953;ASN A 954;ILE A 955;LEU A 956;ALA A 966;ASP A 967","MI1 A1125\r"],["3LXN_A_MI1A1","3lxn","MI1","Tofacitinib (DB08895)","Homo sapiens","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","PK_Tyr_Ser-Thr",22,"LEU A 903;GLY A 904;GLU A 905;GLY A 906;HIS A 907;GLY A 909;LYS A 910;VAL A 911;ALA A 928;LYS A 930;ILE A 960;MET A 978;GLU A 979;TYR A 980;VAL A 981;GLY A 984;SER A 985;ARG A1027;ASN A1028;LEU A1030;GLY A1040;ASP A1041","MI1 A   1\r"],["4OTI_A_MI1A1001","4oti","MI1","Tofacitinib (DB08895)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE N1","Pkinase;Pkinase_C",20,"LEU A 627;GLY A 628;ARG A 629;GLY A 630;GLY A 633;LYS A 634;VAL A 635;ALA A 648;LYS A 650;VAL A 685;MET A 701;GLU A 702;TYR A 703;SER A 704;ASP A 750;ASN A 751;LEU A 753;ALA A 763;ASP A 764;PHE A 910","MI1 A1001\r"]]