Ligand ID: 2TA

Drugbank ID:
Fedratinib
(DB12500)

Indication:
Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was...

LIST OF BINDING INTERFACES for query 'DB12500'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4PS5_A_2TAA201	4ps5	2TA	Fedratinib (DB12500)	Homo sapiens	BROMODOMAIN-CONTAINING PROTEIN 4	Bromodomain	13	TRP A  81 PRO A  82 PHE A  83 VAL A  87 LEU A  92 LEU A  94 TYR A  97 CYS A 136 TYR A 139 ASN A 140 ASP A 145 ILE A 146 MET A 149	2TA A 201		Details
6VNE_B_2TAB1201	6vne	2TA	Fedratinib (DB12500)	Homo sapiens	TYROSINE-PROTEIN KINASE JAK2	PK_Tyr_Ser-Thr	22	GLN B 853 GLN B 854 LEU B 855 GLY B 856 LYS B 857 GLY B 858 VAL B 863 ALA B 880 LYS B 882 VAL B 911 MET B 929 GLU B 930 TYR B 931 LEU B 932 PRO B 933 GLY B 935 SER B 936 ARG B 980 ASN B 981 LEU B 983 GLY B 993 ASP B 994	2TA B1201		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4PS5_A_2TAA201","4ps5","2TA","Fedratinib (DB12500)","Homo sapiens","BROMODOMAIN-CONTAINING PROTEIN 4","Bromodomain",13,"TRP A 81;PRO A 82;PHE A 83;VAL A 87;LEU A 92;LEU A 94;TYR A 97;CYS A 136;TYR A 139;ASN A 140;ASP A 145;ILE A 146;MET A 149","2TA A 201\r"],["6VNE_B_2TAB1201","6vne","2TA","Fedratinib (DB12500)","Homo sapiens","TYROSINE-PROTEIN KINASE JAK2","PK_Tyr_Ser-Thr",22,"GLN B 853;GLN B 854;LEU B 855;GLY B 856;LYS B 857;GLY B 858;VAL B 863;ALA B 880;LYS B 882;VAL B 911;MET B 929;GLU B 930;TYR B 931;LEU B 932;PRO B 933;GLY B 935;SER B 936;ARG B 980;ASN B 981;LEU B 983;GLY B 993;ASP B 994","2TA B1201\r"]]