(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1a4l | DCF | Pentostatin (DB00552) | Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia. | ADENOSINE DEAMINASE (Mus musculus) | A_deaminase | ||
| 1afs | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Rattus norvegicus) | Aldo_ket_red | ||
| 1cet | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | PROTEIN (L-LACTATE DEHYDROGENASE) (Plasmodium falciparum) | Ldh_1_CLdh_1_N | ||
| 1d3h | A26 | Teriflunomide (DB08880) | Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. | DIHYDROOROTATE DEHYDROGENASE (Homo sapiens) | DHO_dh | ||
| 1d7o | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER PROTEIN] REDUCTASE (NADH) PRECURSOR (Brassica napus) | adh_short_C2 | ||
| 1dss | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | D-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE (Palinurus versicolor) | Gp_dh_CGp_dh_N | ||
| 1e3j | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | NADP(H)-DEPENDENT KETOSE REDUCTASE (Bemisia argentifolii) | ADH_NADH_zinc_N | ||
| 1e6w | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (Rattus norvegicus) | adh_short | ||
| 1ee2 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | ALCOHOL DEHYDROGENASE (Equus caballus) | ADH_NADH_zinc_N | ||
| 1ewj | BLM | Bleomycin (DB00290) | Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. | BLEOMYCIN RESISTANCE DETERMINANT (Klebsiella pneumoniae) | NA | ||
| 1f5l | AMR | Amiloride (DB00594) | Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. | UROKINASE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Trypsin | ||
| 1fds | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE (Homo sapiens) | adh_short | ||
| 1ffy | MRC | Mupirocin (DB00410) | Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. | ISOLEUCYL-TRNA SYNTHETASE (Staphylococcus aureus;synthetic construct) | Anticodon_1tRNA-synt_1zf-FPG_IleRS | ||
| 1h7x | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | DIHYDROPYRIMIDINE DEHYDROGENASE (Sus scrofa) | DHO_dhFer4_20Fer4_21Pyr_redox_2 | ||
| 1ihi | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 1itu | CIL | Cilastatin (DB01597) | Cilastatin is a renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections. | RENAL DIPEPTIDASE (Homo sapiens) | Peptidase_M19 | ||
| 1j3j | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium falciparum) | DHFR_1 | ||
| 1j96 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (Homo sapiens) | Aldo_ket_red | ||
| 1jnn | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN;MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN (Mus musculus) | C1-setV-set | ||
| 1jr1 | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulus griseus) | CBSIMPDH | ||
| 1jt6 | DEQ | Dequalinium (DB04209) | Dequalinium is a quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis. | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1jtv | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (Homo sapiens) | adh_short | ||
| 1jtx | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1jzs | MRC | Mupirocin (DB00410) | Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. | ISOLEUCYL-TRNA SYNTHETASE (Thermus thermophilus) | tRNA-synt_1 | ||
| 1kar | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | HISTIDINOL DEHYDROGENASE (Escherichia coli) | Histidinol_dh | ||
| 1ki2 | GA2 | Ganciclovir (DB01004) | Ganciclovir is a DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. | THYMIDINE KINASE (Herpes simplex virus (type 1 / strain 17)) | Herpes_TK | ||
| 1ki3 | PE2 | Penciclovir (DB00299) | Penciclovir is a topical nucleoside polymerase inhibitor used in the treatment of recurrent herpes labialis. | THYMIDINE KINASE (Herpes simplex virus (type 1 / strain 17)) | Herpes_TK | ||
| 1ki7 | ID2 | Idoxuridine (DB00249) | Idoxuridine is a pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. | THYMIDINE KINASE (Herpes simplex virus (type 1 / strain 17)) | Herpes_TK | ||
| 1ki8 | BVD | Brivudine (DB03312) | Brivudine is a drug used to treat herpes zoster. | THYMIDINE KINASE (Herpes simplex virus (type 1 / strain 17)) | Herpes_TK | ||
| 1kij | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA GYRASE SUBUNIT B (Thermus thermophilus) | DNA_gyraseBHATPase_c | ||
| 1kny | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | KANAMYCIN NUCLEOTIDYLTRANSFERASE (Staphylococcus aureus) | KNTase_C | ||
| 1maf | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT) (Paracoccus versutus) | Me-amine-dh_L | ||
| 1meh | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonas foetus) | CBSIMPDH | ||
| 1n5x | TEI | Febuxostat (DB04854) | Febuxostat is a xanthine oxidase inhibitor used for the management of chronic hyperuricemia in adults with gout who have an inadequate response or intolerance to allopurinol. | XANTHINE DEHYDROGENASE (Bos taurus) | Ald_Xan_dh_CAld_Xan_dh_C2CO_deh_flav_CFAD_binding_5Fer2Fer2_2 | ||
| 1p5z | AR3 | Cytarabine (DB00987) | Cytarabine is a pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 1pvs | 7HP | Allopurinol (DB00437) | Allopurinol is a xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. | DNA-3-METHYLADENINE GLYCOSYLASE II (Escherichia coli) | AlkA_NHhH-GPD | ||
| 1qvt | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1qzr | CDX | Dexrazoxane (DB00380) | Dexrazoxane is a cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. | DNA TOPOISOMERASE II (Saccharomyces cerevisiae) | HATPase_c | ||
| 1rkw | PNT | Pentamidine (DB00738) | Pentamidine is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. | TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1tv5 | A26 | Teriflunomide (DB08880) | Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. | DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum) | DHO_dh | ||
| 1wyg | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | XANTHINE DEHYDROGENASE/OXIDASE (Rattus norvegicus) | Ald_Xan_dh_CAld_Xan_dh_C2CO_deh_flav_CFAD_binding_5Fer2Fer2_2 | ||
| 1xbb | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE SYK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1yki | NFZ | Nitrofural (DB00336) | Nitrofural is a topical antibacterial for the prevention and treatment of bacterial infections of the skin. | OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE (Escherichia coli) | Nitroreductase | ||
| 2a3a | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | CHITINASE (Aspergillus fumigatus) | Glyco_hydro_18 | ||
| 2a3b | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | CHITINASE (Aspergillus fumigatus) | Glyco_hydro_18 | ||
| 2a3c | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CHITINASE (Aspergillus fumigatus) | Glyco_hydro_18 | ||
| 2a68 | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD (Thermus thermophilus) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 2a69 | RPT | Rifapentine (DB01201) | Rifapentine is an antibiotic agent used in the treatment of pulmonary tuberculosis. | DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD (Thermus thermophilus) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 2a7q | CFB | Clofarabine (DB00631) | Clofarabine is a purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2aib | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | BETA-ELICITIN CINNAMOMIN (Phytophthora cinnamomi) | Elicitin | ||
| 2b35 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Mycobacterium tuberculosis) | adh_short_C2 | ||
| 2dm6 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE (Cavia porcellus) | ADH_N_2ADH_zinc_N | ||
| 2e6f | OXC | Oteracil (DB03209) | Oteracil is a chemotherapy agent used in combination with tegafur, cisplatin and gimeracil to treat advanced gastric cancer. | DIHYDROOROTATE DEHYDROGENASE (Trypanosoma cruzi) | DHO_dh | ||
| 2fbw | CBE | Carboxin (DB04657) | A systemic agricultural fungicide and seed treatment agent. | SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL (Gallus gallus) | Fer2_3Fer4_17Sdh_cyt | ||
| 2fr6 | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | CYTIDINE DEAMINASE (Mus musculus) | dCMP_cyt_deam_1 | ||
| 2fum | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | PROBABLE SERINE/THREONINE-PROTEIN KINASE PKNB (Mycobacterium tuberculosis h37rv) | Pkinase | ||
| 2gqg | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2gvc | MMZ | Methimazole (DB00763) | Methimazole is a thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. | MONOOXYGENASE (Schizosaccharomyces pombe) | FMO-likeNAD_binding_8 | ||
| 2huo | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL OXYGENASE (Mus musculus) | MIOX | ||
| 2ivu | ZD6 | Vandetanib (DB05294) | Vandetanib is an antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2jap | J01 | Clavulanic acid (DB00766) | Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. | CLAVALDEHYDE DEHYDROGENASE (Streptomyces clavuligerus) | adh_short | ||
| 2jj8 | AZZ | Zidovudine (DB00495) | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. | DEOXYNUCLEOSIDE KINASE (Drosophila melanogaster) | NA | ||
| 2ki5 | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | PROTEIN (THYMIDINE KINASE) (Human herpesvirus 1) | Herpes_TK | ||
| 2mji | KTR | Ketorolac (DB00465) | Ketorolac is an NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. | FATTY ACID-BINDING PROTEIN, INTESTINAL (Homo sapiens) | Lipocalin | ||
| 2no0 | GEO | Gemcitabine (DB00441) | Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2no6 | ETV | Emtricitabine (DB00879) | Emtricitabine is a nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2noa | 3TC | Lamivudine (DB00709) | Lamivudine is a reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2oiq | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Gallus gallus) | PK_Tyr_Ser-Thr | ||
| 2os9 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PULMONARY SURFACTANT-ASSOCIATED PROTEIN D (Homo sapiens) | Lectin_CSurfac_D-trimer | ||
| 2ow9 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | COLLAGENASE 3 (Homo sapiens) | Peptidase_M10 | ||
| 2pd3 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Helicobacter pylori) | adh_short_C2 | ||
| 2pgr | DCF | Pentostatin (DB00552) | Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia. | ADENOSINE DEAMINASE (Plasmodium vivax) | A_deaminase | ||
| 2pl0 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2qmz | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE (Homo sapiens) | Flavodoxin_2 | ||
| 2rk8 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP] (Rattus norvegicus) | PEPCK_GTPPEPCK_N | ||
| 2uxo | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR (Pseudomonas putida) | TetR_C_2TetR_N | ||
| 2uxp | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR (Pseudomonas putida) | TetR_C_2TetR_N | ||
| 2uy4 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | ENDOCHITINASE (Saccharomyces cerevisiae) | NA | ||
| 2v57 | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR (Mycobacterium smegmatis) | TetR_N | ||
| 2v85 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | H3R2ME1K4ME3 PEPTIDE;VDJ RECOMBINATION-ACTIVATING PROTEIN 2 (Mus musculus;synthetic construct) | NA | ||
| 2vh3 | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | RANASMURFIN (Polypedates leucomystax) | NA | ||
| 2vpp | GEO | Gemcitabine (DB00441) | Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. | DEOXYNUCLEOSIDE KINASE (Drosophila melanogaster) | NA | ||
| 2vqs | BVD | Brivudine (DB03312) | Brivudine is a drug used to treat herpes zoster. | DEOXYNUCLEOSIDE KINASE (Drosophila melanogaster) | NA | ||
| 2w4x | STZ | Streptozocin (DB00428) | Streptozocin is a nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. | O-GLCNACASE BT_4395 (Bacteroides thetaiotaomicron) | CBM32Glyco_hydro_20bNAGidase | ||
| 2wdq | CBE | Carboxin (DB04657) | A systemic agricultural fungicide and seed treatment agent. | SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT;SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT;SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT (Escherichia coli) | Fer2_3Fer4_17Sdh_cyt | ||
| 2wek | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2x0y | X0T | Dyphylline (DB00651) | Dyphylline is a theophylline derivative used to treat asthma, bronchospasm, and COPD. | O-GLCNACASE NAGJ (Clostridium perfringens) | Glyco_hydro_20bNAGidase | ||
| 2x7h | PFN | Fenoprofen (DB00573) | Fenoprofen is an anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2xtk | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CLASS III CHITINASE CHIA1 (Aspergillus fumigatus) | Glyco_hydro_18 | ||
| 2y7j | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens) | Pkinase | ||
| 2yfx | VGH | Crizotinib (DB08865) | Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | TYROSINE-PROTEIN KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2zia | CL9 | Cladribine (DB00242) | Cladribine is a purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 2zva | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | TYROSINE-PROTEIN KINASE LYN (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3a3y | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | NA, K-ATPASE ALPHA SUBUNIT (Squalus acanthias) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPase | ||
| 3aox | EMH | Alectinib (DB11363) | Alectinib is a kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3arp | DEQ | Dequalinium (DB04209) | Dequalinium is a quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis. | CHITINASE A (Vibrio harveyi) | Glyco_hydro_18 | ||
| 3arq | DM5 | Idarubicin (DB01177) | Idarubicin is an anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults. | CHITINASE A (Vibrio harveyi) | Glyco_hydro_18 | ||
| 3arr | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CHITINASE A (Vibrio harveyi) | Glyco_hydro_18 | ||
| 3avp | MV2 | Dexpanthenol (DB09357) | Dexpanthenol is an alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN). | PANTOTHENATE KINASE (Mycobacterium tuberculosis) | PRK | ||
| 3b00 | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | LAMINARINASE (Thermotoga maritima) | Glyco_hydro_16 | ||
| 3bbt | FMM | Lapatinib (DB01259) | Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3bpx | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | TRANSCRIPTIONAL REGULATOR (Methanobacterium thermoautotrophicum) | MarR | ||
| 3bti | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | HTH-TYPE TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 3bur | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3cmf | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3cot | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3dcj | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN (Mycobacterium tuberculosis) | Formyl_trans_N | ||
| 3deu | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | TRANSCRIPTIONAL REGULATOR SLYA (Salmonella typhimurium) | MarR | ||
| 3dmt | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL (Trypanosoma cruzi) | Gp_dh_CGp_dh_N | ||
| 3dpf | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | NEUTROPHIL COLLAGENASE (Homo sapiens) | Peptidase_M10 | ||
| 3ete | H3P | Hexachlorophene (DB00756) | Hexachlorophene is a chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser. | GLUTAMATE DEHYDROGENASE (Bos taurus) | ELFV_dehydrogELFV_dehydrog_N | ||
| 3eyg | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3f8f | DM1 | Daunorubicin (DB00694) | Daunorubicin is an anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia. | TRANSCRIPTIONAL REGULATOR, PADR-LIKE FAMILY (Lactococcus lactis subsp. cremoris) | PadR | ||
| 3fup | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3fw1 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 3g1r | FIT | Finasteride (DB01216) | Finasteride is an antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3g5d | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Gallus gallus) | PK_Tyr_Ser-Thr | ||
| 3g6m | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | CHITINASE (Bionectria ochroleuca) | Glyco_hydro_18 | ||
| 3gcs | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Homo sapiens) | Pkinase | ||
| 3gf2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 146AA LONG HYPOTHETICAL TRANSCRIPTIONAL REGULATOR (Sulfolobus tokodaii) | MarR_2 | ||
| 3glq | RAB | Vidarabine (DB00194) | Vidarabine is an antiviral agent used to treat various viral infections. | ADENOSYLHOMOCYSTEINASE (Burkholderia pseudomallei 1710b) | AdoHcyaseAdoHcyase_NAD | ||
| 3gp0 | NIL | Nilotinib (DB04868) | Nilotinib is a kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. | MITOGEN-ACTIVATED PROTEIN KINASE 11 (Homo sapiens) | Pkinase | ||
| 3gvu | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3h7c | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | AGMATINE DEIMINASE (Arabidopsis thaliana) | PAD_porph | ||
| 3hec | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Homo sapiens) | Pkinase | ||
| 3hzs | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | MONOFUNCTIONAL GLYCOSYLTRANSFERASE (Staphylococcus aureus subsp. aureus) | Transgly | ||
| 3ik3 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3ixl | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | ARYLMALONATE DECARBOXYLASE (Bordetella bronchiseptica) | Amdase | ||
| 3k54 | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3k5v | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL1 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3kb7 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) | Pkinase | ||
| 3kd5 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | DNA POLYMERASE (Enterobacteria phage rb69;synthetic construct) | DNA_pol_BDNA_pol_B_exo1 | ||
| 3kp2 | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kp3 | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kp5 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kp6 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3l4w | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) | Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 3lfa | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Homo sapiens) | Pkinase | ||
| 3lt5 | BLQ | Balsalazide (DB01014) | Balsalazide is an aminosalicylate used to treat ulcerative colitis. | FMN-DEPENDENT NADH-AZOREDUCTASE 1 (Pseudomonas aeruginosa) | Flavodoxin_2 | ||
| 3ltw | HLZ | Hydralazine (DB01275) | Hydralazine is an antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . | ARYLAMINE N-ACETYLTRANSFERASE NAT (Mycobacterium marinum) | Acetyltransf_2 | ||
| 3lxk | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3lxn | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3mes | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | CHOLINE KINASE (Cryptosporidium parvum) | Choline_kinase | ||
| 3miy | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3mjr | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 3nai | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | RNA DEPENDENT RNA POLYMERASE (Murine norovirus 1) | RdRP_1 | ||
| 3njz | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | GENTISATE 1,2-DIOXYGENASE (Pseudaminobacter salicylatoxidans) | Cupin_2 | ||
| 3nrc | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (NADH) (Francisella tularensis subsp. tularensis) | adh_short_C2 | ||
| 3ns1 | PM6 | Mercaptopurine (DB01033) | Mercaptopurine is an antineoplastic agent used to treat acute lymphocytic leukemia. | XANTHINE DEHYDROGENASE/OXIDASE (Bos taurus) | Ald_Xan_dh_CAld_Xan_dh_C2 | ||
| 3nt4 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Bacillus subtilis) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 3oid | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] (Bacillus subtilis) | adh_short_C2 | ||
| 3oif | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Bacillus subtilis) | adh_short_C2 | ||
| 3owx | XRA | Prazosin (DB00457) | Prazosin is an alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 3pgh | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 3q1l | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE (Streptococcus pneumoniae) | Semialdhyde_dhSemialdhyde_dhC | ||
| 3q2a | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonas mendocina) | Phenol_Hydrox | ||
| 3q2a | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A;TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN E (Pseudomonas mendocina) | Phenol_Hydrox | ||
| 3qeo | LLT | Telbivudine (DB01265) | Telbivudine is a thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 3qfx | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Trypanosoma brucei rhodesiense) | DHFR_1 | ||
| 3qx3 | EVP | Etoposide (DB00773) | Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 3r2v | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | PB2 C-TERMINAL SUBUNIT (Influenza a virus) | Flu_PB2 | ||
| 3r6w | NFZ | Nitrofural (DB00336) | Nitrofural is a topical antibacterial for the prevention and treatment of bacterial infections of the skin. | FMN-DEPENDENT NADH-AZOREDUCTASE 1 (Pseudomonas aeruginosa) | Flavodoxin_2 | ||
| 3rgf | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | CYCLIN-DEPENDENT KINASE 8 (Homo sapiens) | Pkinase | ||
| 3s42 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | 3-DEHYDROQUINATE DEHYDRATASE (Salmonella enterica subsp. enterica serovar typhimurium) | DHquinase_I | ||
| 3sfe | TMG | Thiabendazole (DB00730) | Thiabendazole is a benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. | SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL (Sus scrofa) | Fer2_3Fer4_17Sdh_cyt | ||
| 3sfu | RBV | Ribavirin (DB00811) | Ribavirin is a guanosine nucleoside used to treat some forms of Hepatitis C. | RNA POLYMERASE (Murine norovirus 1) | RdRP_1 | ||
| 3soa | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER (Homo sapiens) | CaMKII_ADPkinase | ||
| 3sxr | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3teg | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL (Homo sapiens) | FDX-ACBtRNA-synt_2d | ||
| 3teh | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus) | Phe_tRNA-synt_NtRNA-synt_2d | ||
| 3teh | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (Thermus thermophilus) | B3_4B5FDX-ACBtRNA_bindtRNA_synthFbeta | ||
| 3ti1 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | CYCLIN-DEPENDENT KINASE 2 (Homo sapiens) | Pkinase | ||
| 3tz5 | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL (Rattus norvegicus) | BCDHK_Adom3HATPase_c | ||
| 3u6t | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | RIBOSOME INACTIVATING PROTEIN (Momordica balsamina) | RIP | ||
| 3ue4 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3unc | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | XANTHINE DEHYDROGENASE/OXIDASE (Bos taurus) | Ald_Xan_dh_CAld_Xan_dh_C2CO_deh_flav_CFAD_binding_5Fer2Fer2_2 | ||
| 3v5w | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | G-PROTEIN COUPLED RECEPTOR KINASE 2 (Homo sapiens;bos taurus) | PHPkinaseRGS | ||
| 3vw7 | VPX | Vorapaxar (DB09030) | Vorapaxar is a platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). | PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 3w0o | HY0 | Hygromycin b (DB11520) | Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. | HYGROMYCIN-B 4-O-KINASE (Escherichia coli) | APH | ||
| 3zbf | VGH | Crizotinib (DB08865) | Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3zmd | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PUTATIVE TRANSCRIPTIONAL REGULATOR (Streptomyces coelicolor) | MarR_2 | ||
| 4af0 | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Cryptococcus neoformans) | CBSIMPDH | ||
| 4ali | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] (Staphylococcus aureus) | adh_short_C2 | ||
| 4an2 | EUI | Cobimetinib (DB05239) | Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4aql | TXC | Valaciclovir (DB00577) | Valaciclovir is an guanine nucleoside antiviral used to treat herpes exacerbations. | GUANINE DEAMINASE (Homo sapiens) | Amidohydro_1 | ||
| 4atq | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | 4-AMINOBUTYRATE TRANSAMINASE (Arthrobacter aurescens) | Aminotran_3 | ||
| 4bva | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | THIOMORPHOLINE-CARBOXYLATE DEHYDROGENASE (Mus musculus) | OCD_Mu_crystall | ||
| 4c8b | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4coq | SAN | Sulfanilamide (DB00259) | Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. | CARBONATE DEHYDRATASE (Thermovibrio ammonificans) | Carb_anhydrase | ||
| 4cox | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 4csv | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | SRC-ABL TYROSINE KINASE ANCESTOR (Synthetic construct) | NA | ||
| 4df2 | 4CH | Parachlorophenol (DB13154) | Parachlorophenol is an antibacterial agent used to prevent infections in root canals. | NADPH DEHYDROGENASE (Scheffersomyces stipitis cbs 6054) | Oxidored_FMN | ||
| 4dri | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 4drj | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 4eis | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | POLYSACCHARIDE MONOOXYGENASE-3 (Neurospora crassa) | AA9 | ||
| 4ejw | SRY | Streptomycin (DB01082) | Streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 4em0 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4em2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4eoh | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | PYRIDOXAL KINASE (Homo sapiens) | Phos_pyr_kin | ||
| 4fgj | 1PQ | Primaquine (DB01087) | Primaquine is an antimalarial indicated to prevent relapse of vivax malaria. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4fgl | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4fo4 | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae o1 biovar el tor) | IMPDH | ||
| 4fr8 | TNG | Nitroglycerin (DB00727) | Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively. | ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens) | Aldedh | ||
| 4fxs | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae o1 biovar el tor) | CBSIMPDH | ||
| 4g0u | ASW | Amsacrine (DB00276) | Amsacrine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g0v | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g7a | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONATE DEHYDRATASE (Sulfurihydrogenibium sp. yo3aop1) | Carb_anhydrase | ||
| 4hvc | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 4hvr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidus metallidurans) | 3-HAO | ||
| 4i30 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | CONCANAVALIN-A (Canavalia lineata) | Lectin_legB | ||
| 4i41 | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | SERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) | Pkinase | ||
| 4ifg | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | CALMODULIN-DOMAIN PROTEIN KINASE 1 (Toxoplasma gondii) | EF-hand_7Pkinase | ||
| 4j03 | FVS | Fulvestrant (DB00947) | Fulvestrant is an estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. | BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens) | Abhydrolase_1Hydrolase | ||
| 4j6b | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica) | p450 | ||
| 4j6c | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica) | p450 | ||
| 4j6d | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica) | p450 | ||
| 4jps | 1LT | Alpelisib (DB12015) | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid... | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4k90 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | EXTRACELLULAR METALLOPROTEINASE MEP (Aspergillus fumigatus) | FTPPeptidase_M36 | ||
| 4k90 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | EXTRACELLULAR METALLOPROTEINASE MEP (Aspergillus fumigatus) | FTP | ||
| 4ks8 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | SERINE/THREONINE-PROTEIN KINASE PAK 6 (Homo sapiens) | Pkinase | ||
| 4l9i | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | RHODOPSIN KINASE (Bos taurus) | PkinaseRGS | ||
| 4lmn | EUI | Cobimetinib (DB05239) | Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4lv9 | 20J | Diazoxide (DB01119) | Diazoxide is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (Homo sapiens) | NAMPT_NNAPRTase | ||
| 4m5m | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE (Escherichia coli) | HPPK | ||
| 4m89 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Neisseria meningitidis) | adh_short_C2 | ||
| 4miy | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Lactobacillus casei) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 4mjq | 27R | Bromfenac (DB00963) | Bromfenac is an NSAID used to treat postoperative pain and inflammation of the eye. | DNA POLYMERASE III SUBUNIT BETA (Escherichia coli) | DNA_pol3_betaDNA_pol3_beta_2DNA_pol3_beta_3 | ||
| 4mkc | 4MK | Ceritinib (DB09063) | Ceritinib is an antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4mxo | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4nct | 2K2 | Midostaurin (DB06595) | Midostaurin is an antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A (Homo sapiens) | Pkinase | ||
| 4nr0 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI (Pseudomonas aeruginosa) | adh_short_C2 | ||
| 4nsb | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | CHITINASE-3-LIKE PROTEIN 1 (Bubalus bubalis) | Glyco_hydro_18 | ||
| 4o0o | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | RRNA N-GLYCOSIDASE (Momordica balsamina) | RIP | ||
| 4o33 | TZN | Terazosin (DB01162) | Terazosin is an alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. | PHOSPHOGLYCERATE KINASE 1 (Homo sapiens) | PGK | ||
| 4o4p | 1C6 | Omeprazole (DB00338) | Omeprazole is a proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. | BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 4o8z | BBI | Amiodarone (DB01118) | Amiodarone is a class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (Homo sapiens) | SIR2 | ||
| 4oae | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 (Pseudomonas aeruginosa) | Acetyltransf_1 | ||
| 4oir | RFV | Rifamycin (DB11753) | Rifamycin is an antibacterial used to treat traveler's diarrhea. | DNA DIRECTED RNA POLYMERASE SIGMA FACTOR A;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Thermus thermophilus;synthetic construct) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 4okn | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | L-LACTATE DEHYDROGENASE A CHAIN (Homo sapiens) | Ldh_1_CLdh_1_N | ||
| 4oti | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) | PkinasePkinase_C | ||
| 4p6s | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | TYROSINASE (Bacillus megaterium) | Tyrosinase | ||
| 4qc6 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus warneri) | Acetyltransf_8 | ||
| 4qd3 | 5AE | Azacitidine (DB00928) | Azacitidine is a pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. | PEPTIDYL-TRNA HYDROLASE (Pseudomonas aeruginosa) | Pept_tRNA_hydro | ||
| 4qkn | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 4qmn | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qms | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qmz | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4r88 | 1LD | Flucytosine (DB01099) | Flucytosine is an antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus. | CYTOSINE DEAMINASE (Klebsiella pneumoniae) | Amidohydro_3 | ||
| 4rz7 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE (Plasmodium vivax sal-1) | PkinasecNMP_binding | ||
| 4tt7 | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4u7z | 3EW | Selumetinib (DB11689) | Selumetinib is a MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN). | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4uov | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONATE DEHYDRATASE (Thermovibrio ammonificans) | Carb_anhydrase | ||
| 4urn | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA TOPOISOMERASE IV, B SUBUNIT (Staphylococcus aureus) | NA | ||
| 4uro | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA GYRASE SUBUNIT B (Staphylococcus aureus) | HATPase_c | ||
| 4uxl | 5P8 | Lorlatinib (DB12130) | Lorlatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4v04 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4w9x | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 4wa9 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | NA | ||
| 4wbo | ANW | Amlexanox (DB01025) | Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent... | RHODOPSIN KINASE (Bos taurus) | PkinaseRGS | ||
| 4wre | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PULMONARY SURFACTANT-ASSOCIATED PROTEIN A (Rattus norvegicus) | Lectin_C | ||
| 4wrz | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URACIL-DNA GLYCOSYLASE (Mycobacterium tuberculosis) | UDG | ||
| 4x5s | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (Sulfurihydrogenibium azorense) | Carb_anhydrase | ||
| 4xe0 | 40L | Idelalisib (DB09054) | Idelalisib is an antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (Mus musculus) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4xf7 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | CARBOHYDRATE/PYRIMIDINE KINASE, PFKB FAMILY (Thermococcus kodakaraensis kod1) | NA | ||
| 4xp3 | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | MITOGEN-ACTIVATED PROTEIN KINASE 1 (Rattus norvegicus) | Pkinase | ||
| 4xv2 | P06 | Dabrafenib (DB08912) | Dabrafenib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) | NA | ||
| 4ydq | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLINE--TRNA LIGASE (Plasmodium falciparum) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 4zf8 | MYT | Metyrapone (DB01011) | Metyrapone is a steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. | BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 4zs2 | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 4zvm | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4zz3 | 4DW | Pemetrexed (DB00642) | Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. | TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 (Homo sapiens) | Formyl_trans_N | ||
| 5a9u | 5P8 | Lorlatinib (DB12130) | Lorlatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5ajq | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) | Pkinase | ||
| 5axd | RBV | Ribavirin (DB00811) | Ribavirin is a guanosine nucleoside used to treat some forms of Hepatitis C. | ADENOSYLHOMOCYSTEINASE (Mus musculus) | AdoHcyaseAdoHcyase_NAD | ||
| 5cix | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | RIBOSOME INACTIVATING PROTEIN (Momordica balsamina) | RIP | ||
| 5cp3 | YTZ | Sulfathiazole (DB06147) | Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination... | HEAVY CHAIN OF ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY OF 4C7;LIGHT CHAIN OF ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY OF 4C7 (Mus musculus) | NA | ||
| 5dq8 | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 (Homo sapiens) | YBD | ||
| 5f9z | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | AMINOACYL-TRNA SYNTHETASE (Cryptosporidium parvum) | NA | ||
| 5flc | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | FKBP;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens;spodoptera frugiperda) | FATFATCFRB_domPI3_PI4_kinase | ||
| 5fto | YMX | Entrectinib (DB11986) | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019... | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5g2n | 6E2 | Copanlisib (DB12483) | Copanlisib is a medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments. | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5g48 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | DNA POLYMERASE III SUBUNIT BETA (Helicobacter pylori) | DNA_pol3_betaDNA_pol3_beta_2DNA_pol3_beta_3 | ||
| 5gpg | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 5gsn | MMZ | Methimazole (DB00763) | Methimazole is a thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. | FLAVIN-CONTAINING MONOOXYGENASE (Roseovarius nubinhibens (strain atcc baa-591 / dsm 15170 / ism)) | FMO-like | ||
| 5h2u | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PROTEIN-TYROSINE KINASE 6 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5hes | 032 | Vemurafenib (DB08881) | Vemurafenib is a kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5hi2 | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5hs6 | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) | adh_short_C2 | ||
| 5hss | 64Z | Geraniol (DB14183) | Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from... | LINALOOL DEHYDRATASE/ISOMERASE (Castellaniella defragrans) | Ldi | ||
| 5hxw | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | L-AMINO ACID DEAMINASE (Proteus vulgaris) | DAO | ||
| 5i3a | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | TYROSINASE (Bacillus megaterium) | Tyrosinase | ||
| 5i96 | 69Q | Enasidenib (DB13874) | Enasidenib is an isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. | ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL (Homo sapiens) | Iso_dh | ||
| 5iao | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | BIFUNCTIONAL PROTEIN PYRR (Mycobacterium tuberculosis (strain atcc 25177 / h37ra)) | Pribosyltran | ||
| 5ifl | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Burkholderia pseudomallei) | adh_short_C2 | ||
| 5ifu | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | PROLINE--TRNA LIGASE (Plasmodium falciparum (isolate 3d7)) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5iqb | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iqd | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iqe | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5jo9 | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | RIBITOL 2-DEHYDROGENASE (Bradyrhizobium japonicum) | adh_short | ||
| 5k1m | 4KS | Mequinol (DB09516) | Mequinol is a topical agent used in combination with tretinoin to treat solar lentigines. | NAD(P)H:FLAVIN OXIDOREDUCTASE SYE4 (Shewanella oneidensis (strain mr-1)) | Oxidored_FMN | ||
| 5k9d | CE9 | Polidocanol (DB06811) | Polidocanol is a sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity. | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL (Homo sapiens) | DHO_dh | ||
| 5l2i | LQQ | Palbociclib (DB09073) | Palbociclib is an endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l2s | 6ZV | Abemaciclib (DB12001) | Abemaciclib is a medication used to treat HR+ HER2- advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l2t | 6ZZ | Ribociclib (DB11730) | Ribociclib is a kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5lbt | 6T0 | Imiquimod (DB00724) | Imiquimod is a toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 5lxm | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | AURORA KINASE A;TARGETING PROTEIN FOR XKLP2 (Homo sapiens;synthetic construct) | Pkinase | ||
| 5m8w | 4CH | Parachlorophenol (DB13154) | Parachlorophenol is an antibacterial agent used to prevent infections in root canals. | TETRACHLOROETHENE REDUCTIVE DEHALOGENASE CATALYTICALLY ACTIVE SUBUNIT (Sulfurospirillum multivorans) | DehalogenaseFer4_16 | ||
| 5maf | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens) | Pkinase | ||
| 5mo4 | NIL | Nilotinib (DB04868) | Nilotinib is a kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-ThrSH2SH3_1 | ||
| 5mql | G65 | Masitinib (DB11526) | Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 5mqt | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | DEOXYCYTIDINE KINASE (Homo sapiens) | dNK | ||
| 5n3l | E5E | Norepinephrine (DB00368) | Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Cricetulus griseus) | Pkinase | ||
| 5nkn | LOC | Colchicine (DB01394) | Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). | NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (Homo sapiens) | Lipocalin | ||
| 5nr3 | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B (Homo sapiens) | PWWP | ||
| 5nz0 | ZLD | Linezolid (DB00601) | Linezolid is an oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. | HTH-TYPE TRANSCRIPTIONAL REGULATOR ETHR (Mycobacterium tuberculosis) | TetR_N | ||
| 5nzx | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5nzy | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5o1s | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus) | Pkinase | ||
| 5oog | A0B | Phloxine b (DB13911) | Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to... | FLAVIN REDUCTASE (NADPH) (Homo sapiens) | NAD_binding_10 | ||
| 5owr | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) | Pkinase | ||
| 5p9i | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5pah | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | PHENYLALANINE 4-MONOOXYGENASE (Homo sapiens) | NA | ||
| 5q1s | AWY | Agomelatine (DB06594) | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine... | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5r9p | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Mus musculus) | Pkinase | ||
| 5rf8 | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 5row | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | PROTEINASE K (Parengyodontium album) | Peptidase_S8 | ||
| 5rpg | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | PROTEINASE K (Parengyodontium album) | Peptidase_S8 | ||
| 5swr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA;PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_P85_iSH2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinaseSH2 | ||
| 5sxc | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5te0 | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | AP2-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | ||
| 5tzo | 7V7 | Fentanyl (DB00813) | Fentanyl is an opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. | ENDO-1,4-BETA-XYLANASE A (Bacillus subtilis (strain 168)) | NA | ||
| 5v3c | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | QUEUINE TRNA-RIBOSYLTRANSFERASE (Zymomonas mobilis) | TGT | ||
| 5vc3 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | WEE1-LIKE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 5vcv | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | ||
| 5vcy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | ||
| 5vl2 | 9EG | Triclocarban (DB11155) | Triclocarban is an antibacterial agent used in liquid soaps and body washes. | T4 NANOBODY (Lama glama) | NA | ||
| 5vm0 | 9EG | Triclocarban (DB11155) | Triclocarban is an antibacterial agent used in liquid soaps and body washes. | CAMELID NANOBODY VHH T9 (Lama glama) | NA | ||
| 5vm6 | 9EG | Triclocarban (DB11155) | Triclocarban is an antibacterial agent used in liquid soaps and body washes. | SINGLE DOMAIN CAMELID NANOBODY VHH T10 (Lama glama) | NA | ||
| 5w5v | ANW | Amlexanox (DB01025) | Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent... | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) | PkinaseTBK1_CCD1TBK1_ULD | ||
| 5wmk | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE (Arabidopsis thaliana) | Aminotran_1_2 | ||
| 5x03 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR (Bacillus subtilis (strain 168)) | Aminotran_1_2 | ||
| 5x7z | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5x80 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5xip | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE, PUTATIVE (Eimeria tenella) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5xiq | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE (PRORS) (Toxoplasma gondii (strain atcc 50611 / me49)) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5xu8 | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2 (Homo sapiens;bos taurus) | UCH | ||
| 5xv7 | EMH | Alectinib (DB11363) | Alectinib is a kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | SERINE-ARGININE (SR) PROTEIN KINASE 1 (Homo sapiens) | Pkinase | ||
| 5y80 | IRE | Gefitinib (DB00317) | Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. | CYCLIN-G-ASSOCIATED KINASE (Homo sapiens;lama glama) | Pkinase | ||
| 5y9a | AR3 | Cytarabine (DB00987) | Cytarabine is a pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. | PEPTIDYL-TRNA HYDROLASE (Acinetobacter baumannii (strain atcc 19606 / dsm 30007 / cip 70.34 / jcm 6841 / nbrc 109757 / ncimb 12457 / nctc 12156 / 81)) | Pept_tRNA_hydro | ||
| 5ycs | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI (Bacillus cereus (strain atcc 14579 / dsm 31 / jcm 2152 / nbrc 15305 / ncimb 9373 / nrrl b-3711)) | adh_short_C2 | ||
| 5z0f | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | MELC;TYROSINASE (Streptomyces castaneoglobisporus) | MelC1Tyrosinase | ||
| 5z79 | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE-DIHYDROPTEROATE SYNTHASE, PUTATIVE (NA) | HPPKPterin_bind | ||
| 5znj | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLINE--TRNA LIGASE (Staphylococcus aureus) | NA | ||
| 6ah9 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Acinetobacter baumannii atcc 19606 = cip 70.34 = jcm 6841) | adh_short_C2 | ||
| 6ak4 | PD9 | Entacapone (DB00494) | Entacapone is a selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 6aog | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasma gondii) | Thymidylat_synt | ||
| 6bzo | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA;RNA POLYMERASE-BINDING PROTEIN RBPA (Mycobacterium tuberculosis;synthetic construct) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7RbpASigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6cav | 84D | Dibekacin (DB13270) | Dibekacin is an aminoglycoside antibiotic marketed in Japan . | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 6cgd | AKN | Amikacin (DB00479) | Amikacin is an aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 6cnj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6eg9 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6emm | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) | adh_short_C2 | ||
| 6esm | PZE | Piperazine (DB00592) | Piperazine is a medication used to treat roundworm and pinworm. | MATRIX METALLOPROTEINASE-9 (Homo sapiens) | Peptidase_M10 | ||
| 6euh | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GLUCANASE (Bacteroides thetaiotaomicron (strain atcc 29148 / dsm 2079 / nctc 10582 / e50 / vpi-5482)) | Glyco_hydro_43 | ||
| 6fbv | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6fdy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE ULK3 (Homo sapiens) | Pkinase | ||
| 6gh9 | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens) | UCH | ||
| 6h1l | FJQ | Tioconazole (DB01007) | Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1o | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1s | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1t | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6hdr | CC9 | Curcumin (DB11672) | Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial,... | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 (Homo sapiens) | Pkinase | ||
| 6im3 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (Persephonella marina (strain dsm 14350 / ex-h1)) | Carb_anhydrase | ||
| 6iwl | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Moraxella catarrhalis (strain bbh18)) | adh_short_C2 | ||
| 6iy9 | HY0 | Hygromycin b (DB11520) | Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. | HYGROMYCIN-B 7''-O-KINASE (Streptomyces hygroscopicus) | APH | ||
| 6j6m | BA0 | Zanubrutinib (DB15035) | Zanubrutinib is a kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy. | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6jqr | C6F | Gilteritinib (DB12141) | Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. | RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 (NA) | PK_Tyr_Ser-Thr | ||
| 6ju5 | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | TYROSINASE (Aspergillus oryzae) | Tyosinase_CTyrosinase | ||
| 6klk | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | D-HYDANTOINASE/DIHYDROPYRIMIDINASE (Pseudomonas aeruginosa (strain atcc 15692 / dsm 22644 / cip 104116 / jcm 14847 / lmg 12228 / 1c / prs 101 / pao1)) | Amidohydro_1 | ||
| 6ktl | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | SCYLLO-INOSITOL DEHYDROGENASE WITH L-GLUCOSE DEHYDROGENASE ACTIVITY (Paracoccus laeviglucosivorans) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 6l7o | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | NAD(P)H-QUINONE OXIDOREDUCTASE SUBUNIT 2 (Thermosynechococcus elongatus bp-1) | Ndh2_NProton_antipo_M | ||
| 6l8l | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Gallus gallus) | PK_Tyr_Ser-Thr | ||
| 6lgm | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Mus musculus) | Gp_dh_CGp_dh_N | ||
| 6ly4 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium (strain atcc 14581 / dsm 32 / jcm 2506 / nbrc 15308 / ncimb 9376 / nctc 10342 / vkm b-512)) | p450 | ||
| 6mev | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 (Homo sapiens) | JmjC | ||
| 6mne | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | ESTRADIOL 17-BETA-DEHYDROGENASE 1 (Homo sapiens) | adh_short | ||
| 6mx8 | 6GY | Brigatinib (DB12267) | Brigatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6n2w | 30Z | Masoprocol (DB00179) | A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in... | ARACHIDONATE 5-LIPOXYGENASE (Homo sapiens) | LipoxygenasePLAT | ||
| 6n91 | DCF | Pentostatin (DB00552) | Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia. | ADENOSINE DEAMINASE (Vibrio cholerae o1 biovar el tor str. n16961) | A_deaminase | ||
| 6n9m | DCF | Pentostatin (DB00552) | Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia. | ADENOSINE DEAMINASE (Salmonella typhimurium (strain lt2 / sgsc1412 / atcc 700720)) | A_deaminase | ||
| 6nec | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6ng0 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 6nmb | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | UROKINASE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Trypsin | ||
| 6on3 | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | L-DOPA EXTRADIOL DIOXYGENASE (Streptomyces sclerotialus) | Glyoxalase | ||
| 6op9 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6p3d | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6p54 | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | PROBABLE PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PENA (Neisseria gonorrhoeae) | Transpeptidase | ||
| 6pah | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANINE 4-MONOOXYGENASE (Homo sapiens) | NA | ||
| 6pej | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE) (Sinorhizobium meliloti 1021) | adh_short_C2 | ||
| 6pv7 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli o11;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6rum | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | GFP-LAMA-G97 A GFP ENHANCER NANOBODY WITH CPDHFR INSERTION (Lama glama;escherichia coli (strain k12)) | NA | ||
| 6s0s | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | KANAMYCIN B DIOXYGENASE (Streptomyces kanamyceticus) | PhyH | ||
| 6tu9 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6u10 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | PUTATIVE METALLO-BETA-LACTAMASE L1 (BETA-LACTAMASE TYPE II) (EC 3.5.2.6) (PENICILLINASE) (Stenotrophomonas maltophilia (strain k279a)) | Lactamase_B | ||
| 6ug0 | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Azotobacter vinelandii) | Oxidored_nitro | ||
| 6ur8 | QMR | Varenicline (DB01273) | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. | CHIMERA OF SOLUBLE CYTOCHROME B562 (BRIL) AND NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;escherichia coli) | Neur_chan_LBDNeur_chan_memb | ||
| 6uyh | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE (Naegleria fowleri) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 6vne | 2TA | Fedratinib (DB12500) | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was... | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6vsn | RG4 | Ruxolitinib (DB08877) | Ruxolitinib is a kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6wl5 | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | ECMRR TRANSCRIPTIONAL REGULATOR (Escherichia coli) | NA | ||
| 6wto | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6y82 | 308 | Amantadine (DB00915) | Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Mus musculus) | Pkinase | ||
| 6y8l | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA GYRASE SUBUNIT B (Mycolicibacterium thermoresistibile) | HATPase_c | ||
| 6y8o | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA GYRASE SUBUNIT B (Mycolicibacterium smegmatis) | HATPase_c | ||
| 6yk1 | D95 | Artesunate (DB09274) | Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. | PYRIDOXAL KINASE (Mus musculus) | Phos_pyr_kin | ||
| 6yz4 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 (Homo sapiens) | Pkinase | ||
| 6zkm | 970 | Rotenone (DB11457) | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... | MITOCHONDRIAL COMPLEX I, PSST SUBUNIT;NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1 (Ovis aries) | NADHdh | ||
| 6zkm | 970 | Rotenone (DB11457) | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... | NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2;NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 (Ovis aries) | NADH_dehy_S2_COxidored_q5_NProton_antipo_M | ||
| 6zu4 | 115 | Fluvastatin (DB01095) | Fluvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6 (Homo sapiens) | SIR2 | ||
| 7a1u | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7ab1 | C6F | Gilteritinib (DB12141) | Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. | TYROSINE-PROTEIN KINASE MER (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 7aqi | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7awr | S7W | Tegafur (DB09256) | Tegafur is an antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7aww | CLU | Clonidine (DB00575) | Clonidine is an alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7br3 | F5O | Elagolix (DB11979) | Elagolix is a gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. | GONADOTROPIN-RELEASING HORMONE RECEPTOR,GLGA GLYCOGEN SYNTHASE,GONADOTROPIN-RELEASING HORMONE RECEPTOR (Homo sapiens;pyrococcus abyssi (strain ge5 / orsay)) | 7tm_1Glycos_transf_1 | ||
| 7c34 | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | CHITINASE (Serratia marcescens) | Glyco_hydro_18 | ||
| 7d8j | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | SINGLE-STRANDED DNA-BINDING PROTEIN (Staphylococcus aureus (strain ed98)) | SSB | ||
| 7ju7 | G65 | Masitinib (DB11526) | Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7jur | QOM | Trametinib (DB08911) | Trametinib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1;KINASE SUPPRESSOR OF RAS 2 (Homo sapiens;oryctolagus cuniculus) | PK_Tyr_Ser-ThrPkinase | ||
| 7k12 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | 2-AMINO-3-CARBOXYMUCONATE 6-SEMIALDEHYDE DECARBOXYLASE (Pseudomonas fluorescens) | Amidohydro_2 | ||
| 7k6d | SV6 | Telaprevir (DB05521) | Telaprevir is an NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7m0u | QO7 | Binimetinib (DB11967) | Binimetinib is a medication used to treat metastatic melanoma with specific mutations. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 7nay | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | L-LACTATE DEHYDROGENASE (Selenomonas ruminantium) | Ldh_1_CLdh_1_N | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |