(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1eqg | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PROSTAGLANDIN H2 SYNTHASE-1 (Ovis aries) | An_peroxidaseEGF | ||
| 1flr | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | 4-4-20 (IG*G2A=KAPPA=) FAB FRAGMENT (Mus musculus) | C1-set | ||
| 1h8s | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | MUTANT AL2 6E7P9G (Mus musculus) | NA | ||
| 1i8o | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | CYTOCHROME C2 (Rhodopseudomonas palustris) | Cytochrom_C | ||
| 1ibg | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN);IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1igj | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | IGG2A-KAPPA 26-10 FAB (HEAVY CHAIN);IGG2A-KAPPA 26-10 FAB (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1jb0 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Synechococcus elongatus) | PsaA_PsaB | ||
| 1jnn | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN;MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN (Mus musculus) | C1-setV-set | ||
| 1jr1 | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulus griseus) | CBSIMPDH | ||
| 1m4d | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m4g | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m4i | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1nr6 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYTOCHROME P450 2C5 (Oryctolagus cuniculus) | p450 | ||
| 1oxr | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | PHOSPHOLIPASE A2 ISOFORM 3 (Naja sagittifera) | Phospholip_A2_1 | ||
| 1pxx | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 1q13 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | PROSTAGLANDIN-E2 9-REDUCTASE (Oryctolagus cuniculus) | Aldo_ket_red | ||
| 1q20 | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2B, MEMBER 1 ISOFORM B (Homo sapiens) | Sulfotransfer_1 | ||
| 1q7a | OPB | Oxyphenbutazone (DB03585) | Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 1qft | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | PROTEIN (FEMALE-SPECIFIC HISTAMINE BINDING PROTEIN 2) (Rhipicephalus appendiculatus) | His_binding | ||
| 1qur | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | BIVALENT INHIBITOR (BZA-2 HIRULOG);HUMAN THROMBIN (BETA CHAIN) (Homo sapiens;synthetic construct) | Trypsin | ||
| 1r9o | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYTOCHROME P450 2C9 (Homo sapiens) | p450 | ||
| 1sv9 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PHOSPHOLIPASE A2 (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1sxk | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1tgm | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | PHOSPHOLIPASE A2 (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1th6 | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | PHOSPHOLIPASE A2 (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1tpy | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | METHOXY MYCOLIC ACID SYNTHASE 2 (Mycobacterium tuberculosis) | CMAS | ||
| 1y7i | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLIC ACID-BINDING PROTEIN 2 (Nicotiana tabacum) | Abhydrolase_6 | ||
| 1z11 | 8MO | Methoxsalen (DB00553) | Methoxsalen is a furocoumarin used to treat psoriasis and vitiligo. | CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6 (Homo sapiens) | p450 | ||
| 1z9h | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2 (Macaca fascicularis) | GST_N_3 | ||
| 1zr8 | AJM | Ajmaline (DB01426) | Ajmaline is an antiarrhythmic used to manage a variety of forms of tachycardias. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 1zwp | NIM | Nimesulide (DB04743) | Nimesulide is a cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2azy | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | PHOSPHOLIPASE A2, MAJOR ISOENZYME (Sus scrofa) | Phospholip_A2_1 | ||
| 2bdm | TMI | Bifonazole (DB04794) | Bifonazole is an azole antifungal drug used to treat fungal skin infections, such as dermatomycosis. | CYTOCHROME P450 2B4 (Oryctolagus cuniculus) | p450 | ||
| 2dm6 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE (Cavia porcellus) | ADH_N_2ADH_zinc_N | ||
| 2dpz | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2eu7 | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | NITROPHORIN 2 (Rhodnius prolixus) | Nitrophorin | ||
| 2f0z | ZMR | Zanamivir (DB00558) | Zanamivir is a neuraminidase inhibitor used to treat influenza A and B. | SIALIDASE 2 (Homo sapiens) | BNR_2 | ||
| 2f10 | BCZ | Peramivir (DB06614) | Peramivir is an intravenous antiviral agent used to treat acute uncomplicated influenza in patients aged 2 years and older who are shown to be symptomatic for no more than two days. | SIALIDASE 2 (Homo sapiens) | BNR_2 | ||
| 2ft9 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | FATTY ACID-BINDING PROTEIN 2, LIVER (Ambystoma mexicanum) | Lipocalin | ||
| 2geh | NHY | Hydroxyurea (DB01005) | Hydroxyurea is an antimetabolite used to treat sickle cell anemia crisis. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 2hkk | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 2ij7 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYTOCHROME P450 121 (Mycobacterium tuberculosis) | p450 | ||
| 2j0h | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | FICOLIN-2 (Homo sapiens) | Fibrinogen_C | ||
| 2j1g | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | FICOLIN-2 (Homo sapiens) | Fibrinogen_C | ||
| 2jx4 | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | VASOPRESSIN V2 RECEPTOR (NA) | NA | ||
| 2ljc | RIM | Rimantadine (DB00478) | Rimantadine is an RNA synthesis inhibitor used to prevent influenza A infection. | M2 PROTEIN, BM2 PROTEIN CHIMERA (Influenza a virus;influenza b virus) | NA | ||
| 2nnh | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | CYTOCHROME P450 2C8 (Homo sapiens) | p450 | ||
| 2nni | MTK | Montelukast (DB00471) | Montelukast is a leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. | CYTOCHROME P450 2C8 (Homo sapiens) | p450 | ||
| 2nnj | 225 | Felodipine (DB01023) | Felodipine is a calcium channel blocker used to treat hypertension. | CYTOCHROME P450 2C8 (Homo sapiens) | p450 | ||
| 2okk | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GLUTAMATE DECARBOXYLASE 2 (Homo sapiens) | Pyridoxal_deC | ||
| 2olv | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | PENICILLIN-BINDING PROTEIN 2 (Staphylococcus aureus) | TransglyTranspeptidase | ||
| 2p16 | GG2 | Apixaban (DB06605) | Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. | COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR) (Homo sapiens) | Trypsin | ||
| 2pou | I7A | Diclofenamide (DB01144) | Diclofenamide is a carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 2pws | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2qu9 | EUG | Isoeugenol (DB14188) | Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic... | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2qvd | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2v85 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | H3R2ME1K4ME3 PEPTIDE;VDJ RECOMBINATION-ACTIVATING PROTEIN 2 (Mus musculus;synthetic construct) | NA | ||
| 2w98 | P1Z | Phenylbutazone (DB00812) | Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis. | PROSTAGLANDIN REDUCTASE 2 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2wd9 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens) | AMP-bindingAMP-binding_C | ||
| 2wek | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2wq5 | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | PHOSPHOLIPASE A2, ACIDIC (Naja naja) | Phospholip_A2_1 | ||
| 2x7h | PFN | Fenoprofen (DB00573) | Fenoprofen is an anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2xf3 | J01 | Clavulanic acid (DB00766) | Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. | ORF12 (Streptomyces clavuligerus) | Beta-lactamase2ORF_12_N | ||
| 2xfh | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | ERYTHROMYCIN B/D C-12 HYDROXYLASE (Saccharopolyspora erythraea) | p450 | ||
| 2y6r | CTC | Chlortetracycline (DB09093) | Chlortetracycline is the first tetracycline antibiotic most commonly used for veterinary purposes. | TETX2 PROTEIN (Bacteroides thetaiotaomicron) | FAD_binding_3 | ||
| 2zb8 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PROSTAGLANDIN REDUCTASE 2 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 3apv | TP0 | Amitriptyline (DB00321) | Amitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3apw | DP0 | Disopyramide (DB00280) | Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3apx | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3brf | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A (Caenorhabditis elegans;synthetic construct) | NA | ||
| 3c7q | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3dl9 | V2H | Doxercalciferol (DB06410) | Doxercalciferol is a synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis. | CYTOCHROME P450 2R1 (Homo sapiens) | p450 | ||
| 3e4e | 4PZ | Fomepizole (DB01213) | Fomepizole is an inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. | CYTOCHROME P450 2E1 (Homo sapiens) | p450 | ||
| 3eau | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-2 (Rattus norvegicus) | Aldo_ket_red | ||
| 3fo7 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russelli pulchella) | Phospholip_A2_1 | ||
| 3frl | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | LIPL32 (Leptospira interrogans serovar copenhageni) | Lipl32 | ||
| 3fup | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3gvu | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3hku | TOR | Topiramate (DB00273) | Topiramate is an anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 3hs4 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 3hs7 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3ieo | AMJ | Lacosamide (DB06218) | Lacosamide is an antiepileptic drug used to treat partial onset seizures in adults. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 3ik6 | HCZ | Hydrochlorothiazide (DB00999) | Hydrochlorothiazide is a thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3ilu | HFZ | Hydroflumethiazide (DB00774) | Hydroflumethiazide is a thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3kw4 | TIC | Ticlopidine (DB00208) | Ticlopidine is a platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). | CYTOCHROME P450 2B4 (Oryctolagus cuniculus) | p450 | ||
| 3l1m | HQI | Oxyquinoline (DB11145) | Oxyquinoline is a medication used in combination with other medications to restore vaginal pH. | SOLUBLE CYTOCHROME B562 (Escherichia coli) | Cytochrom_B562 | ||
| 3ln1 | CEL | Celecoxib (DB00482) | Celecoxib is an NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3lsf | PZI | Piracetam (DB09210) | Piracetam is a nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3lxn | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3mdt | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 3mdv | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 3nfz | 3NF | N-acetyltyrosine (DB11102) | N-acetyltyrosine is an amino acid used in total parenteral nutrition. | ASPARTOACYLASE-2 (Mus musculus) | AstE_AspA | ||
| 3njz | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | GENTISATE 1,2-DIOXYGENASE (Pseudaminobacter salicylatoxidans) | Cupin_2 | ||
| 3nt1 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3nt4 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Bacillus subtilis) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 3osh | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | PHOSPHOLIPASE A2 ISOFORM 3 (Naja sagittifera) | Phospholip_A2_1 | ||
| 3pgh | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 3q6j | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | 2-OXOPROPYL-COM REDUCTASE, CARBOXYLATING (Xanthobacter autotrophicus) | Pyr_redoxPyr_redox_dim | ||
| 3q70 | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | CANDIDAPEPSIN-2 (Candida albicans) | Asp | ||
| 3qel | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2;NMDA GLUTAMATE RECEPTOR SUBUNIT (Xenopus laevis;rattus norvegicus) | ANF_receptor | ||
| 3qx3 | EVP | Etoposide (DB00773) | Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 3r2v | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | PB2 C-TERMINAL SUBUNIT (Influenza a virus) | Flu_PB2 | ||
| 3rfm | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | ADENOSINE RECEPTOR A2A (Homo sapiens) | 7tm_1 | ||
| 3sg8 | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | APH(2'')-ID (Enterococcus casseliflavus) | APH | ||
| 3t3q | 9PL | Pilocarpine (DB01085) | Pilocarpine is a muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy. | CYTOCHROME P450 2A6 (Homo sapiens) | p450 | ||
| 3t3z | 9PL | Pilocarpine (DB01085) | Pilocarpine is a muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy. | CYTOCHROME P450 2E1 (Homo sapiens) | p450 | ||
| 3ti1 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | CYCLIN-DEPENDENT KINASE 2 (Homo sapiens) | Pkinase | ||
| 3tkd | CYZ | Cyclothiazide (DB00606) | As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides... | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3tmz | 06X | Amlodipine (DB00381) | Amlodipine is a calcium channel blocker used to treat hypertension and angina. | CYTOCHROME P450 2B4 (Oryctolagus cuniculus) | p450 | ||
| 3tz5 | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL (Rattus norvegicus) | BCDHK_Adom3HATPase_c | ||
| 3ua5 | 06X | Amlodipine (DB00381) | Amlodipine is a calcium channel blocker used to treat hypertension and angina. | CYTOCHROME P450 2B6 (Homo sapiens) | p450 | ||
| 3v5w | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | G-PROTEIN COUPLED RECEPTOR KINASE 2 (Homo sapiens;bos taurus) | PHPkinaseRGS | ||
| 3wzd | LEV | Lenvatinib (DB09078) | Lenvatinib is a receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3wze | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3zfz | 1W8 | Ceftaroline fosamil (DB06590) | Ceftaroline fosamil is an antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. | PENICILLIN BINDING PROTEIN 2 PRIME (Staphylococcus aureus subsp. aureus mu50) | PBP_dimerTranspeptidase | ||
| 4a6n | T1C | Tigecycline (DB00560) | Tigecycline is a glycylcycline antibiotic used to treat a number of susceptible bacterial infections. | TETX2 PROTEIN (Bacteroides thetaiotaomicron) | FAD_binding_3 | ||
| 4a99 | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | TETX2 PROTEIN (Bacteroides thetaiotaomicron) | FAD_binding_3 | ||
| 4a9j | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | BROMODOMAIN CONTAINING 2 (Homo sapiens) | Bromodomain | ||
| 4ag8 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4agd | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4bjc | RPB | Rucaparib (DB12332) | Rucaparib is an anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer. | TANKYRASE-2 (Homo sapiens) | PARP | ||
| 4c1d | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE CLASS B VIM-2 (Pseudomonas aeruginosa) | Lactamase_B | ||
| 4c1h | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE 2 (Bacillus cereus) | Lactamase_B | ||
| 4c8b | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4cox | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 4cu8 | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | GLYCOSIDE HYDROLASE 2 (Streptococcus pneumoniae tigr4) | DUF4982Glyco_hydro2_C5Glyco_hydro_2Glyco_hydro_2_CGlyco_hydro_2_N | ||
| 4cut | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B (Homo sapiens) | Bromodomain | ||
| 4dbk | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | PHOSPHOLIPASE A2, MAJOR ISOENZYME (Sus scrofa) | Phospholip_A2_1 | ||
| 4dfb | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | APH(2"")-ID (Enterococcus casseliflavus;streptomyces kanamyceticus) | APH | ||
| 4dki | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | PENICILLIN-BINDING PROTEIN 2' (Staphylococcus aureus) | MecA_NPBP_dimerTranspeptidase | ||
| 4e2j | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | ANCESTRAL GLUCOCORTICOID RECEPTOR 2 (Synthetic construct;synthetic construct) | NA | ||
| 4e3h | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4e49 | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4ejj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | CYTOCHROME P450 2A6 (Homo sapiens) | p450 | ||
| 4em0 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4em2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4enh | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 4eql | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12 (Arabidopsis thaliana) | GH3 | ||
| 4f92 | SAN | Sulfanilamide (DB00259) | Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. | U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens) | DEADHelicase_CSec63 | ||
| 4fab | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN);IGG2A-KAPPA 4-4-20 FAB (LIGHT CHAIN) (Mus musculus) | C1-set | ||
| 4g05 | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | VERSATILE PEROXIDASE VPL2 (Pleurotus eryngii) | peroxidase | ||
| 4g0u | ASW | Amsacrine (DB00276) | Amsacrine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g0v | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g24 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL (Arabidopsis thaliana) | PPR_longPRORP | ||
| 4h1n | CGE | Clopidogrel (DB00758) | Clopidogrel is an antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. | CYTOCHROME P450 2B4 (Oryctolagus cuniculus) | p450 | ||
| 4iaq | 2GM | Dihydroergotamine (DB00320) | Dihydroergotamine is an ergot alkaloid used in the acute treatment of migraine headache and cluster headache. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4iar | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4ib4 | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4ir0 | FCN | Fosfomycin (DB00828) | Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. | METALLOTHIOL TRANSFERASE FOSB 2 (Bacillus anthracis) | Glyoxalase | ||
| 4j03 | FVS | Fulvestrant (DB00947) | Fulvestrant is an estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. | BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens) | Abhydrolase_1Hydrolase | ||
| 4j14 | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 4jlt | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | CYTOCHROME P450 2B4 (Oryctolagus cuniculus) | p450 | ||
| 4jq1 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jq2 | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jq4 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jqa | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtq | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtr | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtr | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4laj | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN (Human immunodeficiency virus 1;lama glama;synthetic construct) | NA | ||
| 4ldo | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | LYSOZYME, BETA-2 ADRENERGIC RECEPTOR (Enterobacteria phage t4;homo sapiens;lama glama) | 7tm_1Phage_lysozyme | ||
| 4ltw | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | ANCESTRAL STEROID RECEPTOR 2 (Ancestral gene) | NA | ||
| 4ltw | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ANCESTRAL STEROID RECEPTOR 2 (Ancestral gene) | NA | ||
| 4lxz | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 2 (Homo sapiens) | Hist_deacetyl | ||
| 4m10 | ICD | Isoxicam (DB08942) | Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4m11 | MXM | Meloxicam (DB00814) | Meloxicam is an NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4m2v | BZ1 | Brinzolamide (DB01194) | Brinzolamide is a carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4m5m | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE (Escherichia coli) | HPPK | ||
| 4miy | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Lactobacillus casei) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 4n16 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 4nkw | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 4nkx | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 4nnr | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2 (Homo sapiens) | FKBP_C | ||
| 4ntx | AMR | Amiloride (DB00594) | Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. | ACID-SENSING ION CHANNEL 1;BASIC PHOSPHOLIPASE A2 HOMOLOG TX-BETA (Gallus gallus;micrurus tener tener) | ASCPhospholip_A2_1 | ||
| 4oty | LUR | Lumiracoxib (DB01283) | Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in... | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4pe5 | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1;GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B (Rattus norvegicus) | ANF_receptorLig_chanLig_chan-Glu_bd | ||
| 4ph9 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4pjv | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens) | PARP | ||
| 4qmn | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qms | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qmz | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) | Pkinase | ||
| 4qu3 | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE GES-2 (Pseudomonas aeruginosa) | Beta-lactamase2 | ||
| 4qvp | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3 (Saccharomyces cerevisiae) | Pr_beta_CProteasome | ||
| 4qvp | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2 (Saccharomyces cerevisiae) | Pr_beta_C | ||
| 4r20 | AER | Abiraterone (DB05812) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2 (Danio rerio) | p450 | ||
| 4r21 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2 (Danio rerio) | p450 | ||
| 4ru1 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | MONOSACCHARIDE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN, CUT2 FAMILY (Acidothermus cellulolyticus) | Peripla_BP_4 | ||
| 4s0v | SUV | Suvorexant (DB09034) | Suvorexant is a orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. | HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 4tkg | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | TANKYRASE-2 (Homo sapiens) | PARP | ||
| 4tvj | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens) | PARP | ||
| 4v04 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4w9x | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 4wg0 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | NUCLEAR RECEPTOR COACTIVATOR 2 (NA) | NA | ||
| 4wnu | QDN | Quinidine (DB00908) | Quinidine is a medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. | CYTOCHROME P450 2D6 (Homo sapiens) | p450 | ||
| 4wnv | QI9 | Quinine (DB00468) | Quinine is an alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | CYTOCHROME P450 2D6 (Homo sapiens) | NA | ||
| 4wql | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | 2''-AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE (Klebsiella pneumoniae) | Aminoglyc_resit | ||
| 4x1f | 3WF | Ethinylestradiol (DB00977) | Ethinylestradiol is an estradiol used as a contraceptive. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 4xt7 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | RV2671 (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RibD_C | ||
| 4xt8 | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | RV2671 (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RibD_C | ||
| 4y8w | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 21-HYDROXYLASE (Homo sapiens) | NA | ||
| 4zud | OLM | Olmesartan (DB00275) | Olmesartan is an angiotensin receptor blocker (ARB) used in the treatment of hypertension. | CHIMERA PROTEIN OF SOLUBLE CYTOCHROME B562 AND TYPE-1 ANGIOTENSIN II RECEPTOR (Escherichia coli;homo sapiens) | 7tm_1Cytochrom_B562 | ||
| 5alc | TIQ | Ticagrelor (DB08816) | Ticagrelor is a P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. | ANTI-TICAGRELOR FAB 72, HEAVY CHAIN;ANTI-TICAGRELOR FAB 72, LIGHT CHAIN (Homo sapiens) | NA | ||
| 5b1a | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2;CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL;CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL (Bos taurus) | COX1COX2COX2_TM | ||
| 5c8i | MZM | Methazolamide (DB00703) | Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 5cfs | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE,GENTAMICIN RESISTANCE PROTEIN (Pseudomonas aeruginosa) | Aminoglyc_resit | ||
| 5d0s | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Pr_beta_CProteasome | ||
| 5d0s | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Pr_beta_C | ||
| 5f1a | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5fpd | PZA | Pyrazinamide (DB00339) | Pyrazinamide is an antituberculosis agent used as a component of tuberculosis (TB) treatment. | HEAT SHOCK-RELATED 70KDA PROTEIN 2 (Homo sapiens) | NA | ||
| 5g08 | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | FREQUENIN 2 (Drosophila melanogaster) | EF-hand_1EF-hand_7 | ||
| 5hko | 62W | Mannitol (DB00742) | Mannitol is a sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis. | ABC TRANSPORTER, CARBOHYDRATE UPTAKE TRANSPORTER-2 (CUT2) FAMILY, PERIPLASMIC SUGAR-BINDING PROTEIN (Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)) | Peripla_BP_4 | ||
| 5i9x | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5i9y | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5igi | ZIT | Azithromycin (DB00207) | Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igj | CTY | Clarithromycin (DB01211) | Clarithromycin is a macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igs | ZIO | Oleandomycin (DB11442) | Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igt | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igv | ZIT | Azithromycin (DB00207) | Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5igw | CTY | Clarithromycin (DB01211) | Clarithromycin is a macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5igz | SPR | Spiramycin (DB06145) | Spiramycin is a macrolide antimicrobial agent used in the treatment of various bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5ikq | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikr | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikt | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikv | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5iwu | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5j2t | VLB | Vinblastine (DB00570) | Vinblastine is a vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
| 5jh7 | 6K9 | Eribulin (DB08871) | Eribulin is a microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
| 5jo9 | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | RIBITOL 2-DEHYDROGENASE (Bradyrhizobium japonicum) | adh_short | ||
| 5jq7 | T0R | Toremifene (DB00539) | Toremifene is a first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers. | ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1;ENVELOPE GLYCOPROTEIN 2 (Ebola virus - mayinga;zaire;1976) | NA | ||
| 5jqb | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1;ENVELOPE GLYCOPROTEIN 2 (Ebola virus - mayinga;zaire;1976) | NA | ||
| 5kir | RCX | Rofecoxib (DB00533) | Rofecoxib is a COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5km8 | L8P | Cidofovir (DB00369) | Cidofovir is an antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. | HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL (Homo sapiens) | HIT | ||
| 5l1f | 6ZP | Perampanel (DB08883) | Perampanel is a non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | ANF_receptorLig_chanLig_chan-Glu_bd | ||
| 5l7i | VIS | Vismodegib (DB08828) | Vismodegib is a hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. | SMOOTHENED HOMOLOG,SOLUBLE CYTOCHROME B562,SMOOTHENED HOMOLOG (Homo sapiens;escherichia coli) | FrizzledFz | ||
| 5li8 | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | PUTATIVE CYTOCHROME P450 126 (Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)) | p450 | ||
| 5lxm | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | AURORA KINASE A;TARGETING PROTEIN FOR XKLP2 (Homo sapiens;synthetic construct) | Pkinase | ||
| 5m78 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 5mzj | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 5mzp | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 5njw | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BLR6230 PROTEIN (Bradyrhizobium diazoefficiens usda 110) | Lactamase_B | ||
| 5no9 | 95Z | Glucosamine (DB01296) | Glucosamine is a common ingredient in nutritional supplements used for the relief of joint pain. | 25 KDA PROTEIN ELICITOR (Pythium aphanidermatum) | NPP1 | ||
| 5o45 | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 5o4y | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2 (Homo sapiens;synthetic construct) | NA | ||
| 5oj0 | 9WT | Cefepime (DB01413) | Cefepime is a fourth-generation cephalosporin antibiotic used in the treatment of various bacterial infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections. | PENICILLIN-BINDING PROTEIN 2X (Streptococcus pneumoniae) | PASTAPBP_dimerTranspeptidase | ||
| 5oy0 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Synechocystis sp. pcc 6803) | PsaA_PsaB | ||
| 5rzb | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | ISOFORM 2 OF BAND 4.1-LIKE PROTEIN 3 (Homo sapiens) | FERM_MFERM_N | ||
| 5te0 | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | AP2-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | ||
| 5u6n | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UDP-GLYCOSYLTRANSFERASE 74F2 (Arabidopsis thaliana) | UDPGT | ||
| 5uxd | ZIT | Azithromycin (DB00207) | Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH (Brachybacterium faecium (strain atcc 43885 / dsm 4810 / ncib 9860)) | APH | ||
| 5v02 | 657 | Riluzole (DB00740) | Riluzole is a glutamate antagonist used to treat amyotrophic lateral sclerosis. | CALMODULIN-1;SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2 (Homo sapiens) | CaMBDEF-hand_7 | ||
| 5vcv | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | ||
| 5vcy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | ||
| 5vnl | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | PROTEIN TRANSPORT PROTEIN SEC24A (Homo sapiens;mus musculus) | GelsolinSec23_BSSec23_helicalSec23_trunkzf-Sec23_Sec24 | ||
| 5x23 | LSN | Losartan (DB00678) | Losartan is an angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. | CYTOCHROME P450 2C9 (Homo sapiens) | p450 | ||
| 5x7z | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5x80 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5xu8 | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2 (Homo sapiens;bos taurus) | UCH | ||
| 5yjs | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | VICILIN-LIKE ANTIMICROBIAL PEPTIDES 2-2 (Capsicum annuum) | Cupin_1 | ||
| 5ys0 | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | MEMBRANE-ANCHORED LIPID-BINDING PROTEIN YSP2 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | VASt | ||
| 5zio | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | METALLO-BETA-LACTAMASE TYPE 2 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5zj8 | 9DC | Dimercaprol (DB06782) | Dimercaprol is a chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium. | METALLO-BETA-LACTAMASE TYPE 2 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5zkc | 3C0 | Methscopolamine (DB11315) | Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... | MUSCARINIC ACETYLCHOLINE RECEPTOR M2,APO-CYTOCHROME B562,MUSCARINIC ACETYLCHOLINE RECEPTOR M2 (Homo sapiens) | 7tm_1 | ||
| 5zwr | 9KL | Dexketoprofen (DB09214) | Dexketoprofen is an NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. | EST-Y29 (Metagenome) | NA | ||
| 6a93 | 8NU | Risperidone (DB00734) | Risperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | 5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6a94 | ZOT | Zotepine (DB09225) | Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India... | 5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6ak3 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6ap6 | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia hybrida) | Abhydrolase_6 | ||
| 6bkk | 308 | Amantadine (DB00915) | Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. | MATRIX PROTEIN 2 (NA) | NA | ||
| 6bkl | RIM | Rimantadine (DB00478) | Rimantadine is an RNA synthesis inhibitor used to prevent influenza A infection. | MATRIX PROTEIN 2 (NA) | NA | ||
| 6bqg | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | 5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6cd7 | EDS | Plazomicin (DB12615) | Plazomicin is an aminoglycoside antibiotic used to treat complicated urinary tract infections. | APH(2'')-ID (Enterococcus casseliflavus) | APH | ||
| 6cm4 | 8NU | Risperidone (DB00734) | Risperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | D(2) DOPAMINE RECEPTOR, ENDOLYSIN CHIMERA (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6cnj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6drx | H8G | Lisuride (DB00589) | An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at... | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6dry | H8D | Methylergometrine (DB00353) | Methylergometrine is an ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6drz | H8J | Methysergide (DB00247) | Methysergide is an ergot alkaloid used for the prophylaxis of migraine and cluster headaches. | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6f88 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 CYP260A1 (Sorangium cellulosum (strain so ce56)) | p450 | ||
| 6g3q | FO9 | Famotidine (DB00927) | Famotidine is a histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 6hco | FY5 | Estrone sulfate (DB04574) | Estrone sulfate is an estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 6hdr | CC9 | Curcumin (DB11672) | Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial,... | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 (Homo sapiens) | Pkinase | ||
| 6hj2 | P06 | Dabrafenib (DB08912) | Dabrafenib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 6huo | 08H | Alprazolam (DB00404) | Alprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6iwg | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BETA-2-MICROGLOBULIN (Macaca mulatta;synthetic construct) | C1-set | ||
| 6jb3 | BJX | Repaglinide (DB00912) | Repaglinide is a antihyperglycemic used to improve glycemic control in diabetes. | ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 ISOFORM X2 (Mesocricetus auratus) | ABC_membraneABC_tran | ||
| 6k41 | CZX | Dexmedetomidine (DB00633) | Dexmedetomidine is an alpha-2 agonist used for sedation during various procedures. | ALPHA-2A ADRENERGIC RECEPTOR,ENDOLYSIN,ALPHA-2B ADRENERGIC RECEPTOR,ALPHA-2B ADRENERGIC RECEPTOR (Homo sapiens;mus musculus;bos taurus;enterobacteria phage rb59) | 7tm_1 | ||
| 6k61 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 1 (Nostoc sp. pcc 7120) | PsaA_PsaB | ||
| 6l35 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Physcomitrium patens) | PsaA_PsaB | ||
| 6l7o | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | NAD(P)H-QUINONE OXIDOREDUCTASE SUBUNIT 2 (Thermosynechococcus elongatus bp-1) | Ndh2_NProton_antipo_M | ||
| 6luq | GMJ | Haloperidol (DB00502) | Haloperidol is an antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | CHIMERA OF D(2) DOPAMINE RECEPTOR AND ENDOLYSIN (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6me9 | JEV | Ramelteon (DB00980) | Ramelteon is a melatonin receptor agonist used to treat insomnia. | SOLUBLE CYTOCHROME B562,MELATONIN RECEPTOR TYPE 1B,RUBREDOXIN (Escherichia coli;homo sapiens;clostridium pasteurianum) | 7tm_1Cytochrom_B562Rubredoxin | ||
| 6mqf | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | BASIC PHOSPHOLIPASE A2 HOMOLOG 2 (Bothrops moojeni) | Phospholip_A2_1 | ||
| 6mwf | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia pseudomallei (strain 1710b)) | YgbB | ||
| 6mwj | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia pseudomallei (strain 1710b)) | YgbB | ||
| 6mxt | K5Y | Salmeterol (DB00938) | Salmeterol is a long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. | ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;lama glama) | 7tm_1Phage_lysozyme | ||
| 6nk0 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens;synthetic construct) | NA | ||
| 6o0k | LBM | Venetoclax (DB11581) | Venetoclax is a BCL-2 inhibitor used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia. | APOPTOSIS REGULATOR BCL-2 (Homo sapiens) | BH4Bcl-2 | ||
| 6oi3 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | MONOMETHYL H3R2 PEPTIDE;WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens;synthetic construct) | WD40 | ||
| 6ot4 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | SOLUBLE CYTOCHROME B562 (Escherichia coli) | Cytochrom_B562 | ||
| 6pej | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE) (Sinorhizobium meliloti 1021) | adh_short_C2 | ||
| 6pnj | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Fischerella thermalis pcc 7521) | PsaA_PsaB | ||
| 6ps3 | CVD | Carvedilol (DB01136) | Carvedilol is a non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. | FUSION PROTEIN OF BETA-2 ADRENERGIC RECEPTOR AND T4 LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6ps6 | TIM | Timolol (DB00373) | Timolol is a non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. | FUSION PROTEIN OF BETA-2 ADRENERGIC RECEPTOR AND T4 LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6pv7 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli o11;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6qwj | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Chroococcidiopsis sp. ts-821) | PsaA_PsaB | ||
| 6rl9 | SAN | Sulfanilamide (DB00259) | Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 6rz5 | ZLK | Zafirlukast (DB00549) | Zafirlukast is a leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. | CYSTEINYL LEUKOTRIENE RECEPTOR 1,SOLUBLE CYTOCHROME B562,CYSTEINYL LEUKOTRIENE RECEPTOR 1 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6sg0 | FUN | Furosemide (DB00695) | Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 6sl5 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Dunaliella salina) | PsaA_PsaB | ||
| 6tz8 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | CALCINEURIN SUBUNIT B;FK506-BINDING PROTEIN 1;SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT A1 (Cryptococcus neoformans var. grubii serotype a (strain h99 / atcc 208821 / cbs 10515 / fgsc 9487)) | EF-hand_7FKBP_CMetallophos | ||
| 6u10 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | PUTATIVE METALLO-BETA-LACTAMASE L1 (BETA-LACTAMASE TYPE II) (EC 3.5.2.6) (PENICILLINASE) (Stenotrophomonas maltophilia (strain k279a)) | Lactamase_B | ||
| 6u88 | P0T | Cannabidiol (DB09061) | Cannabidiol is an active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. | TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2 (Rattus norvegicus) | Ank_2Ion_trans | ||
| 6ur8 | QMR | Varenicline (DB01273) | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. | CHIMERA OF SOLUBLE CYTOCHROME B562 (BRIL) AND NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;escherichia coli) | Neur_chan_LBDNeur_chan_memb | ||
| 6vms | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | ENDOLYSIN,D(2) DOPAMINE RECEPTOR,D(2) DOPAMINE RECEPTOR (Rattus norvegicus;homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6vne | 2TA | Fedratinib (DB12500) | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was... | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6vsn | RG4 | Ruxolitinib (DB08877) | Ruxolitinib is a kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6vta | AKN | Amikacin (DB00479) | Amikacin is an aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (NA) | NA | ||
| 6vxh | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2 (Homo sapiens) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 6wr1 | AER | Abiraterone (DB05812) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 6wto | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6wwr | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | TUBULIN BETA-2B CHAIN (Mus musculus;sus scrofa) | TubulinTubulin_C | ||
| 6x3t | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3u | FYP | Flumazenil (DB01205) | Flumazenil is a benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3v | V8D | Etomidate (DB00292) | Etomidate is a short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6ycr | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | FFIVIRDRVFR(CCS)G(NH2);PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 6zkm | 970 | Rotenone (DB11457) | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... | NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2;NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 (Ovis aries) | NADH_dehy_S2_COxidored_q5_NProton_antipo_M | ||
| 7axa | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7axh | 27J | Zeranol (DB11478) | Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7axk | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7bi5 | 010 | Benzyl alcohol (DB06770) | Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. | CARBONIC ANHYDRASE 2 (Homo sapiens) | Carb_anhydrase | ||
| 7bz2 | H98 | Arformoterol (DB01274) | Arformoterol is a beta-2 adrenergic agonist and bronchodilator used for long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. | BETA2 ADRENERGIC RECEPTOR (Homo sapiens;bos taurus;lama glama) | 7tm_1 | ||
| 7cmu | G6L | Pramipexole (DB00413) | Pramipexole is a non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). | SOLUBLE CYTOCHROME B562,D(3) DOPAMINE RECEPTOR (Homo sapiens;mus musculus;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7coh | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2;CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL (Bos taurus) | COX1COX2COX2_TM | ||
| 7cr2 | FBX | Ezogabine (DB04953) | Ezogabine is an antiepileptic agent used as an adjuvant treatment of partial-onset seizures. | POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2 (Homo sapiens) | Ion_transKCNQ_channel | ||
| 7cx2 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE (Homo sapiens;synthetic construct) | 7tm_1 | ||
| 7d7m | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE (Homo sapiens;lama glama) | 7tm_1 | ||
| 7dhi | 68H | Levosalbutamol (DB13139) | Levosalbutamol is a beta-2 adrenergic receptor agonist used to treat COPD and asthma. | BETA-2 ADRENERGIC RECEPTOR (Homo sapiens;bos taurus;lama glama) | 7tm_1 | ||
| 7dhr | 5FW | Isoprenaline (DB01064) | Isoprenaline is a catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. | BETA-2 ADRENERGIC RECEPTOR (Homo sapiens;bos taurus;lama glama) | 7tm_1 | ||
| 7dkz | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Pisum sativum) | PsaA_PsaB | ||
| 7dwq | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P740 CHLOROPHYLL A APOPROTEIN A2;PHOTOSYSTEM I PROTEIN PSA27 (NA) | NA | ||
| 7e2z | 9SC | Aripiprazole (DB01238) | Aripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. | SOLUBLE CYTOCHROME B562,5-HYDROXYTRYPTAMINE RECEPTOR 1A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7eov | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOSOLIC SULFOTRANSFERASE SULT2A8 (Mus musculus) | Sulfotransfer_1 | ||
| 7jur | QOM | Trametinib (DB08911) | Trametinib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1;KINASE SUPPRESSOR OF RAS 2 (Homo sapiens;oryctolagus cuniculus) | PK_Tyr_Ser-ThrPkinase | ||
| 7jvr | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR (Escherichia coli;homo sapiens;synthetic construct) | 7tm_1 | ||
| 7k12 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | 2-AMINO-3-CARBOXYMUCONATE 6-SEMIALDEHYDE DECARBOXYLASE (Pseudomonas fluorescens) | Amidohydro_2 | ||
| 7nez | TTC | Topotecan (DB01030) | Topotecan is an antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7nfd | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7ocf | CYZ | Cyclothiazide (DB00606) | As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides... | ISOFORM FLIP OF GLUTAMATE RECEPTOR 1;ISOFORM FLIP OF GLUTAMATE RECEPTOR 2 (NA) | NA | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |