(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1afs | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Rattus norvegicus) | Aldo_ket_red | ||
| 1dbb | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | IGG1-KAPPA DB3 FAB (HEAVY CHAIN);IGG1-KAPPA DB3 FAB (LIGHT CHAIN) (Mus musculus) | C1-set | ||
| 1dss | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | D-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE (Palinurus versicolor) | Gp_dh_CGp_dh_N | ||
| 1e6w | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (Rattus norvegicus) | adh_short | ||
| 1ihi | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 1j96 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (Homo sapiens) | Aldo_ket_red | ||
| 1l8t | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE (Enterococcus faecalis) | APH | ||
| 1nd4 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE (Klebsiella pneumoniae) | APH | ||
| 1oxr | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | PHOSPHOLIPASE A2 ISOFORM 3 (Naja sagittifera) | Phospholip_A2_1 | ||
| 1pvs | 7HP | Allopurinol (DB00437) | Allopurinol is a xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. | DNA-3-METHYLADENINE GLYCOSYLASE II (Escherichia coli) | AlkA_NHhH-GPD | ||
| 1s19 | MC9 | Calcipotriol (DB02300) | Calcipotriol is a topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis. | VITAMIN D3 RECEPTOR (Homo sapiens) | NA | ||
| 1s2c | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 1tbf | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1x9q | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | 4M5.3 ANTI-FLUORESCEIN SINGLE CHAIN ANTIBODY FRAGMENT (Homo sapiens) | NA | ||
| 1xmu | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoq | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 1xos | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xot | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoz | CIA | Tadalafil (DB00820) | Tadalafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xp0 | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 2b0q | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE (Enterococcus faecalis) | APH | ||
| 2f38 | 15M | Bimatoprost (DB00905) | Bimatoprost is a prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 2g7z | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | CONSERVED HYPOTHETICAL PROTEIN SPY1493 (Streptococcus pyogenes) | DegV | ||
| 2j0d | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 2kot | ANW | Amlexanox (DB01025) | Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent... | PROTEIN S100-A13 (Homo sapiens) | S_100 | ||
| 2o5y | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CHIMERIC ANTIBODY FAB 1E9-DB3 (Mus musculus;homo sapiens) | NA | ||
| 2ow9 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | COLLAGENASE 3 (Homo sapiens) | Peptidase_M10 | ||
| 2p16 | GG2 | Apixaban (DB06605) | Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. | COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR) (Homo sapiens) | Trypsin | ||
| 2v85 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | H3R2ME1K4ME3 PEPTIDE;VDJ RECOMBINATION-ACTIVATING PROTEIN 2 (Mus musculus;synthetic construct) | NA | ||
| 2vdm | AGG | Tirofiban (DB00775) | Tirofiban is a platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. | INTEGRIN ALPHA-IIB;INTEGRIN BETA-3 (Homo sapiens;mus musculus) | FG-GAPIntegrin_betaPSI_integrin | ||
| 2w4x | STZ | Streptozocin (DB00428) | Streptozocin is a nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. | O-GLCNACASE BT_4395 (Bacteroides thetaiotaomicron) | CBM32Glyco_hydro_20bNAGidase | ||
| 2w9s | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003 (Staphylococcus aureus) | DHFR_1 | ||
| 2wey | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 3bur | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3cmf | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3cot | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3czv | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE 13 (Homo sapiens) | Carb_anhydrase | ||
| 3dmt | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL (Trypanosoma cruzi) | Gp_dh_CGp_dh_N | ||
| 3frl | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | LIPL32 (Leptospira interrogans serovar copenhageni) | Lipl32 | ||
| 3g1r | FIT | Finasteride (DB01216) | Finasteride is an antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. | 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 3iak | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 3jwq | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA (Homo sapiens) | PDEase_I | ||
| 3lxk | MI1 | Tofacitinib (DB08895) | Tofacitinib is a Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. | TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3nt4 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Bacillus subtilis) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 3nxu | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 3oht | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | P38A (Salmo salar) | Pkinase | ||
| 3osh | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | PHOSPHOLIPASE A2 ISOFORM 3 (Naja sagittifera) | Phospholip_A2_1 | ||
| 3pbs | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa) | PBP_dimerTranspeptidase | ||
| 3r43 | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r58 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r6i | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r7m | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r8g | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3s42 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | 3-DEHYDROQUINATE DEHYDRATASE (Salmonella enterica subsp. enterica serovar typhimurium) | DHquinase_I | ||
| 3sug | SUE | Grazoprevir (DB11575) | Grazoprevir is an antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections. | NS3 PROTEASE, NS4A PROTEIN (Hepatitis c virus) | Peptidase_S29 | ||
| 3sv6 | SV6 | Telaprevir (DB05521) | Telaprevir is an NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. | NS3 PROTEASE, NS4A PROTEIN (Hepatitis c virus) | Peptidase_S29 | ||
| 3tvx | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (Homo sapiens) | PDEase_I | ||
| 3tz5 | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL (Rattus norvegicus) | BCDHK_Adom3HATPase_c | ||
| 3ua1 | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 3uf8 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (Saccharomyces cerevisiae;burkholderia pseudomallei) | FKBP_Cubiquitin | ||
| 3ugr | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3zuk | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | ENDOPEPTIDASE, PEPTIDASE FAMILY M13 (Mycobacterium tuberculosis) | Peptidase_M13Peptidase_M13_N | ||
| 4c94 | KXN | Cianidanol (DB14086) | An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. | FRA A 3 ALLERGEN (Fragaria x ananassa) | NA | ||
| 4d1j | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GALACTOSIDASE, PUTATIVE, BGL35A (Cellvibrio japonicus) | DUF5597Glyco_hydro_42 | ||
| 4daj | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME (Rattus norvegicus;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 4dtz | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | CYTOCHROME P450 BM3 VARIANT 8C8 (Bacillus megaterium) | p450 | ||
| 4eis | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | POLYSACCHARIDE MONOOXYGENASE-3 (Neurospora crassa) | AA9 | ||
| 4em0 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4em2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4eql | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12 (Arabidopsis thaliana) | GH3 | ||
| 4g24 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL (Arabidopsis thaliana) | PPR_longPRORP | ||
| 4gkh | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB (Acinetobacter baumannii) | APH | ||
| 4hvr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidus metallidurans) | 3-HAO | ||
| 4jps | 1LT | Alpelisib (DB12015) | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid... | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4miy | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Lactobacillus casei) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 4nsb | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | CHITINASE-3-LIKE PROTEIN 1 (Bubalus bubalis) | Glyco_hydro_18 | ||
| 4o8z | BBI | Amiodarone (DB01118) | Amiodarone is a class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (Homo sapiens) | SIR2 | ||
| 4qvp | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3 (Saccharomyces cerevisiae) | Pr_beta_CProteasome | ||
| 4r67 | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Proteasome | ||
| 4u15 | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3 (Rattus norvegicus;enterobacteria phage t4) | 7tm_1 | ||
| 4u16 | 3C0 | Methscopolamine (DB11315) | Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... | MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3 (Rattus norvegicus;enterobacteria phage t4) | 7tm_1 | ||
| 4uin | QI9 | Quinine (DB00468) | Quinine is an alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | FAB 314.3 (Mus musculus) | NA | ||
| 4wf8 | 2R9 | Asunaprevir (DB11586) | Asunaprevir is an NS3 protease inhibitor used to treat hepatitis C genotype 1b. | NS3 PROTEIN (Hepatitis c virus) | Peptidase_S29 | ||
| 4xe0 | 40L | Idelalisib (DB09054) | Idelalisib is an antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (Mus musculus) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4yvv | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4yvx | GMR | Glimepiride (DB00222) | Glimepiride is a sulfonylurea drug used to treat type 2 diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4zfc | GCZ | Gliclazide (DB01120) | Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4zz3 | 4DW | Pemetrexed (DB00642) | Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. | TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 (Homo sapiens) | Formyl_trans_N | ||
| 5a1r | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 5b1a | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL (Bos taurus) | COX1COX3COX7a | ||
| 5d0s | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Pr_beta_CProteasome | ||
| 5d75 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 (Homo sapiens) | FKBP_C | ||
| 5dwq | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE-ARGININE METHYLTRANSFERASE CARM1;METHYLATED H3 PEPTIDE (Homo sapiens;synthetic construct) | PrmA | ||
| 5dyo | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | FAB 43.1 HEAVY CHAIN;FAB 43.1 LIGHT CHAIN (Mus musculus) | NA | ||
| 5ej0 | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | ENVELOPE PROTEIN H3 (Vaccinia virus (strain western reserve)) | NA | ||
| 5g2n | 6E2 | Copanlisib (DB12483) | Copanlisib is a medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments. | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5g5j | MF8 | Metformin (DB00331) | Metformin is a biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS). | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 5gpg | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 5lf3 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Pr_beta_CProteasome | ||
| 5lf7 | 6V8 | Ixazomib (DB09570) | Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already. | PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7 (Homo sapiens) | Pr_beta_CProteasome | ||
| 5lpa | 71R | Dihydrostreptomycin (DB11512) | Dihydrostreptomycin is an antibiotic. | STREPTOMYCIN 3''-ADENYLYLTRANSFERASE (Salmonella enterica subsp. enterica serovar typhimurium) | DUF4111NTP_transf_2 | ||
| 5luh | SRY | Streptomycin (DB01082) | Streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. | STREPTOMYCIN 3''-ADENYLYLTRANSFERASE (Salmonella enterica subsp. enterica serovar typhimurium) | DUF4111NTP_transf_2 | ||
| 5njw | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BLR6230 PROTEIN (Bradyrhizobium diazoefficiens usda 110) | Lactamase_B | ||
| 5nr3 | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B (Homo sapiens) | PWWP | ||
| 5o1s | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus) | Pkinase | ||
| 5rf8 | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 5rsu | OHB | Salicylamide (DB08797) | Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rtm | PZA | Pyrazinamide (DB00339) | Pyrazinamide is an antituberculosis agent used as a component of tuberculosis (TB) treatment. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rue | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rus | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rvi | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rzb | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | ISOFORM 2 OF BAND 4.1-LIKE PROTEIN 3 (Homo sapiens) | FERM_MFERM_N | ||
| 5s3i | W1P | Edaravone (DB12243) | Edaravone is a free radical scavenger used to delay the progression of ALS. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5s4a | 4AP | Dalfampridine (DB06637) | Dalfampridine is a potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS). | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5swr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA;PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_P85_iSH2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinaseSH2 | ||
| 5sxc | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5te8 | 08J | Midazolam (DB00683) | Midazolam is a short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 5va6 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE H3.1;PROBABLE HISTONE-LYSINE N-METHYLTRANSFERASE ATXR5 (Ricinus communis;synthetic construct) | NA | ||
| 5vdh | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | GLYCINE RECEPTOR SUBUNIT ALPHA-3 (Homo sapiens) | Neur_chan_LBD | ||
| 5veu | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | CYTOCHROME P450 3A5 (Homo sapiens) | p450 | ||
| 6a96 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Lama glama;homo sapiens) | Neur_chan_LBDNeur_chan_memb | ||
| 6ak3 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6beb | RFV | Rifamycin (DB11753) | Rifamycin is an antibacterial used to treat traveler's diarrhea. | SCAFFOLD PROTEIN D13 (Vaccinia virus wr) | Pox_Rif | ||
| 6bec | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | SCAFFOLD PROTEIN D13 (Vaccinia virus wr) | Pox_Rif | ||
| 6bee | RXM | Rifaximin (DB01220) | Rifaximin is a rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults. | SCAFFOLD PROTEIN D13 (Vaccinia virus wr) | Pox_Rif | ||
| 6beh | RPT | Rifapentine (DB01201) | Rifapentine is an antibiotic agent used in the treatment of pulmonary tuberculosis. | SCAFFOLD PROTEIN D13 (Vaccinia virus (strain western reserve)) | Pox_Rif | ||
| 6bjd | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | CALPAIN-3 (Homo sapiens) | Peptidase_C2 | ||
| 6ca3 | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | GLYCOSYL HYDROLASE, FAMILY 31 (Blautia obeum atcc 29174) | Gal_mutarotas_2Glyco_hydro_31 | ||
| 6fdy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE ULK3 (Homo sapiens) | Pkinase | ||
| 6his | TKT | Tropisetron (DB11699) | Tropisetron is a 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6huj | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6huo | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6j2m | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP53 (Arabidopsis thaliana) | FKBP_C | ||
| 6jqr | C6F | Gilteritinib (DB12141) | Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. | RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 (NA) | PK_Tyr_Ser-Thr | ||
| 6l6e | E6L | Avanafil (DB06237) | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 6lgm | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Mus musculus) | Gp_dh_CGp_dh_N | ||
| 6ma6 | MYT | Metyrapone (DB01011) | Metyrapone is a steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 6ma7 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYTOCHROME P450 3A4 (Homo sapiens) | p450 | ||
| 6mb5 | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | AAC(3)-IIIB PROTEIN (Pseudomonas aeruginosa) | Antibiotic_NAT | ||
| 6mb7 | PAR | Paromomycin (DB01421) | Paromomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. | AAC(3)-IIIB PROTEIN (Pseudomonas aeruginosa) | Antibiotic_NAT | ||
| 6mn4 | AM2 | Apramycin (DB04626) | Apramycin is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA (Escherichia coli) | Antibiotic_NAT | ||
| 6np0 | CWB | Granisetron (DB00889) | Granisetron is a 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6np4 | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE (Enterobacter cloacae) | Antibiotic_NAT | ||
| 6nzt | L9P | Voxilaprevir (DB12026) | Voxilaprevir is a nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. | HCV NS3/4A PROTEASE (Hepatitis c virus) | Peptidase_S29 | ||
| 6o5u | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE (Enterobacteriaceae) | Antibiotic_NAT | ||
| 6ohu | CTX | Tamoxifen (DB00675) | Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. | 3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE (Homo sapiens) | EBP | ||
| 6oi3 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | MONOMETHYL H3R2 PEPTIDE;WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens;synthetic construct) | WD40 | ||
| 6op9 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6opv | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE NL4-3 (Human immunodeficiency virus 1) | RVP | ||
| 6p6l | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 1a (isolate 1)) | Peptidase_S29 | ||
| 6p6s | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 3a (isolate nzl1)) | Peptidase_S29 | ||
| 6p6v | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 5a (isolate sa13)) | Peptidase_S29 | ||
| 6p6z | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 4a (isolate ed43)) | Peptidase_S29 | ||
| 6pv7 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli o11;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6sm7 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | 3-SULFOLACTALDEHYDE REDUCTASE (Escherichia coli) | NAD_binding_11NAD_binding_2 | ||
| 6tbe | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A (Homo sapiens) | NA | ||
| 6u10 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | PUTATIVE METALLO-BETA-LACTAMASE L1 (BETA-LACTAMASE TYPE II) (EC 3.5.2.6) (PENICILLINASE) (Stenotrophomonas maltophilia (strain k279a)) | Lactamase_B | ||
| 6w1j | S7Y | Alosetron (DB00969) | Alosetron is a 5-HT3 antagonist used to treat diarrhea-predominant IBS. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6w1m | S87 | Ondansetron (DB00904) | Ondansetron is a serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x7q | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | CHLORAMPHENICOL ACETYLTRANSFERASE 3 (NA) | NA | ||
| 6xz0 | SCM | Spectinomycin (DB00919) | Spectinomycin is an aminocyclitol antibiotic used to treat susceptible strains of Neisseria gonorrhoeae. | STREPTOMYCIN 3''-ADENYLYLTRANSFERASE (Enterococcus faecalis) | DUF4111Polbeta | ||
| 6ymo | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 14-3-3 PROTEIN ZETA/DELTA (Homo sapiens;synthetic construct) | 14-3-3 | ||
| 7a1u | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7a5v | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 7aqi | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7awr | S7W | Tegafur (DB09256) | Tegafur is an antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7aww | CLU | Clonidine (DB00575) | Clonidine is an alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7cbq | A9L | Apremilast (DB05676) | Apremilast is a non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 7cia | MPB | Methylparaben (DB14212) | Methylparaben is used in allergenic testing. | UDP-3-O-ACYL-N-ACETYLGLUCOSAMINE DEACETYLASE (Pseudomonas aeruginosa pao1) | LpxC | ||
| 7cmu | G6L | Pramipexole (DB00413) | Pramipexole is a non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). | SOLUBLE CYTOCHROME B562,D(3) DOPAMINE RECEPTOR (Homo sapiens;mus musculus;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7coh | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3 (Bos taurus) | COX1COX3 | ||
| 7coh | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1 (Bos taurus) | COX3COX7a | ||
| 7d77 | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ADHESION G PROTEIN-COUPLED RECEPTOR G3; GPR97 (Homo sapiens;synthetic construct) | NA | ||
| 7d7k | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA (Bos taurus) | GAFPDEase_I | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA (Bos taurus) | GAFPDEase_I | ||
| 7ju7 | G65 | Masitinib (DB11526) | Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7k12 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | 2-AMINO-3-CARBOXYMUCONATE 6-SEMIALDEHYDE DECARBOXYLASE (Pseudomonas fluorescens) | Amidohydro_2 | ||
| 7k6d | SV6 | Telaprevir (DB05521) | Telaprevir is an NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7kes | AM2 | Apramycin (DB04626) | Apramycin is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE (Uncultured bacterium) | Antibiotic_NAT | ||
| 7llf | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |