(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1a4l | DCF | Pentostatin (DB00552) | Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia. | ADENOSINE DEAMINASE (Mus musculus) | A_deaminase | ||
| 1aqu | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN SULFOTRANSFERASE (Mus musculus) | Sulfotransfer_1 | ||
| 1dbb | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | IGG1-KAPPA DB3 FAB (HEAVY CHAIN);IGG1-KAPPA DB3 FAB (LIGHT CHAIN) (Mus musculus) | C1-set | ||
| 1dmy | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | MURINE CARBONIC ANHYDRASE V (Mus musculus) | NA | ||
| 1flr | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | 4-4-20 (IG*G2A=KAPPA=) FAB FRAGMENT (Mus musculus) | C1-set | ||
| 1gti | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | GLUTATHIONE S-TRANSFERASE (Mus musculus) | GST_C_3GST_N | ||
| 1h8s | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | MUTANT AL2 6E7P9G (Mus musculus) | NA | ||
| 1ibg | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN);IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1igj | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | IGG2A-KAPPA 26-10 FAB (HEAVY CHAIN);IGG2A-KAPPA 26-10 FAB (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1jgl | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | IG GAMMA-1-CHAIN;IG KAPPA-CHAIN (Mus musculus) | C1-setV-set | ||
| 1jnn | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN;MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN (Mus musculus) | C1-setV-set | ||
| 1m8d | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | INDUCIBLE NITRIC OXIDE SYNTHASE (Mus musculus) | NO_synthase | ||
| 1oay | FUR | Furazolidone (DB00614) | Furazolidone is a drug for the treatment of infectious diarrhea. | IMMUNOGLOBULIN E (Mus musculus) | V-set | ||
| 1pxx | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 1q0y | MOI | Morphine (DB00295) | Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. | FAB 9B1, HEAVY CHAIN;FAB 9B1, LIGHT CHAIN (Mus musculus) | V-set | ||
| 1rj6 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE XIV (Mus musculus) | Carb_anhydrase | ||
| 1s9p | DES | Diethylstilbestrol (DB00255) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report... | ESTROGEN-RELATED RECEPTOR GAMMA (Mus musculus) | Hormone_recep | ||
| 1s9q | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | ESTROGEN-RELATED RECEPTOR GAMMA (Mus musculus) | Hormone_recep | ||
| 1vpo | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | ANTI-TESTOSTERONE (HEAVY CHAIN);ANTI-TESTOSTERONE (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1xdk | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RETINOIC ACID RECEPTOR, BETA (Mus musculus;synthetic construct) | Hormone_recep | ||
| 2fr6 | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | CYTIDINE DEAMINASE (Mus musculus) | dCMP_cyt_deam_1 | ||
| 2ha2 | SCK | Succinylcholine (DB00202) | Succinylcholine is a depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2ha4 | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2huo | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL OXYGENASE (Mus musculus) | MIOX | ||
| 2kaw | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1 (Mus musculus) | PDZ | ||
| 2o5y | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CHIMERIC ANTIBODY FAB 1E9-DB3 (Mus musculus;homo sapiens) | NA | ||
| 2v85 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | H3R2ME1K4ME3 PEPTIDE;VDJ RECOMBINATION-ACTIVATING PROTEIN 2 (Mus musculus;synthetic construct) | NA | ||
| 2vdm | AGG | Tirofiban (DB00775) | Tirofiban is a platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. | INTEGRIN ALPHA-IIB;INTEGRIN BETA-3 (Homo sapiens;mus musculus) | FG-GAPIntegrin_betaPSI_integrin | ||
| 2xud | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2y6o | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | EPHRIN TYPE-A RECEPTOR 4 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 2zva | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | TYROSINE-PROTEIN KINASE LYN (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3bgd | PM6 | Mercaptopurine (DB01033) | Mercaptopurine is an antineoplastic agent used to treat acute lymphocytic leukemia. | THIOPURINE S-METHYLTRANSFERASE (Mus musculus) | TPMT | ||
| 3gkz | B40 | Metamfetamine (DB01577) | Metamfetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. | ANTI-METHAMPHETAMINE SINGLE CHAIN FV (Mus musculus) | NA | ||
| 3hs7 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3ik3 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3k5v | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL1 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3ln1 | CEL | Celecoxib (DB00482) | Celecoxib is an NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3ls4 | TCI | Dronabinol (DB00470) | Dronabinol is a synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. | HEAVY CHAIN OF ANTIBODY FAB FRAGMENT;LIGHT CHAIN OF ANTIBODY FAB FRAGMENT (Mus musculus) | NA | ||
| 3mnp | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | GLUCOCORTICOID RECEPTOR (Mus musculus;synthetic construct) | Hormone_recep | ||
| 3nfz | 3NF | N-acetyltyrosine (DB11102) | N-acetyltyrosine is an amino acid used in total parenteral nutrition. | ASPARTOACYLASE-2 (Mus musculus) | AstE_AspA | ||
| 3nt1 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3pgh | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 3rhw | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | AVERMECTIN-SENSITIVE GLUTAMATE-GATED CHLORIDE CHANNEL GLUCL ALPHA (Caenorhabditis elegans;mus musculus) | NA | ||
| 3rox | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | APOLIPOPROTEIN A-I-BINDING PROTEIN (Mus musculus) | YjeF_N | ||
| 3wfh | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | MAB FAB H FRAGMENT;MAB FAB L FRAGMENT (Mus musculus) | NA | ||
| 3whx | XPG | Alprostadil (DB00770) | Alprostadil is a medication used to treat erectile dysfunction. | MAB FAB H FRAGMENT;MAB FAB L FRAGMENT (Mus musculus) | NA | ||
| 3znc | BZ1 | Brinzolamide (DB01194) | Brinzolamide is a carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. | CARBONIC ANHYDRASE IV (Mus musculus) | Carb_anhydrase | ||
| 4bva | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | THIOMORPHOLINE-CARBOXYLATE DEHYDROGENASE (Mus musculus) | OCD_Mu_crystall | ||
| 4cox | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 4eb4 | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Mus musculus) | Thymidylat_synt | ||
| 4fab | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN);IGG2A-KAPPA 4-4-20 FAB (LIGHT CHAIN) (Mus musculus) | C1-set | ||
| 4ffw | 715 | Sitagliptin (DB01261) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Rattus norvegicus;mus musculus) | DPPIV_NPeptidase_S9 | ||
| 4k17 | OHB | Salicylamide (DB08797) | Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... | LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A (Mus musculus) | Carm_PHLRR_6 | ||
| 4k17 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A (Mus musculus) | Carm_PHLRR_6 | ||
| 4kyk | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | LACTOYLGLUTATHIONE LYASE (Mus musculus) | Glyoxalase | ||
| 4lar | 1WE | Dextroamphetamine (DB01576) | Dextroamphetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. | SINGLE CHAIN ANTIBODY FRAGMENT SCFV6H4 (Mus musculus) | NA | ||
| 4m10 | ICD | Isoxicam (DB08942) | Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4m11 | MXM | Meloxicam (DB00814) | Meloxicam is an NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4m48 | 21B | Nortriptyline (DB00540) | Nortriptyline is a tricyclic antidepressant used in the treatment of depression. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4ma7 | P2Z | Promazine (DB00420) | Promazine is a phenothiazine used to manage schizophrenia. | MAJOR PRION PROTEIN (Mus musculus) | NA | ||
| 4ma8 | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | MAJOR PRION PROTEIN (Mus musculus) | NA | ||
| 4oty | LUR | Lumiracoxib (DB01283) | Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in... | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4pd4 | AOQ | Atovaquone (DB01117) | Atovaquone is an antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. | CYTOCHROME B (Mus musculus;saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Cytochrom_B_CCytochrome_B | ||
| 4ph9 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4ufm | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | GALACTOCEREBROSIDASE (Mus musculus) | Glyco_hydro_59Glyco_hydro_59M | ||
| 4uin | QI9 | Quinine (DB00468) | Quinine is an alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | FAB 314.3 (Mus musculus) | NA | ||
| 4xe0 | 40L | Idelalisib (DB09054) | Idelalisib is an antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (Mus musculus) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4xnx | 41X | Reboxetine (DB00234) | Reboxetine is a drug used for the acute treatment of major depression and for maintenance therapy of depression. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4xp1 | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | DOPAMINE TRANSPORTER, ISOFORM B (Drosophila melanogaster;mus musculus) | SNF | ||
| 4xp6 | B40 | Metamfetamine (DB01577) | Metamfetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4xp9 | 1WE | Dextroamphetamine (DB01576) | Dextroamphetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4zph | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR;ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 (Mus musculus) | HLHPASPAS_3 | ||
| 5axd | RBV | Ribavirin (DB00811) | Ribavirin is a guanosine nucleoside used to treat some forms of Hepatitis C. | ADENOSYLHOMOCYSTEINASE (Mus musculus) | AdoHcyaseAdoHcyase_NAD | ||
| 5cp3 | YTZ | Sulfathiazole (DB06147) | Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination... | HEAVY CHAIN OF ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY OF 4C7;LIGHT CHAIN OF ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY OF 4C7 (Mus musculus) | NA | ||
| 5dyo | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | FAB 43.1 HEAVY CHAIN;FAB 43.1 LIGHT CHAIN (Mus musculus) | NA | ||
| 5i6x | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i71 | 68P | Escitalopram (DB01175) | Escitalopram is a selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i73 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5icx | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | CETUXIMAB FAB LIGHT CHAIN;MEDITOPE (Mus musculus;homo sapiens;synthetic construct) | NA | ||
| 5ief | NBV | Miglustat (DB00419) | Miglustat is a glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement. | NEUTRAL ALPHA-GLUCOSIDASE AB (Mus musculus) | Gal_mutarotas_2Glyco_hydro_31 | ||
| 5mhe | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | FAB-FRAGMENT (Mus musculus) | NA | ||
| 5o1s | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus) | Pkinase | ||
| 5ov9 | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 5r9p | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Mus musculus) | Pkinase | ||
| 5vnl | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | PROTEIN TRANSPORT PROTEIN SEC24A (Homo sapiens;mus musculus) | GelsolinSec23_BSSec23_helicalSec23_trunkzf-Sec23_Sec24 | ||
| 5yj1 | 6EL | Thalidomide (DB01041) | Thalidomide is a medication used to treat newly diagnosed multiple myeloma and erythema nodosum leprosum. | PROTEIN CEREBLON (Mus musculus) | NA | ||
| 6awo | SRE | Sertraline (DB01104) | Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 6awp | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 6cnj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6gyj | FGT | Phenolphthalein (DB04824) | Phenolphthalein is a drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures. | THYMIDYLATE SYNTHASE (Mus musculus) | Thymidylat_synt | ||
| 6hco | FY5 | Estrone sulfate (DB04574) | Estrone sulfate is an estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 6his | TKT | Tropisetron (DB11699) | Tropisetron is a 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6k41 | CZX | Dexmedetomidine (DB00633) | Dexmedetomidine is an alpha-2 agonist used for sedation during various procedures. | ALPHA-2A ADRENERGIC RECEPTOR,ENDOLYSIN,ALPHA-2B ADRENERGIC RECEPTOR,ALPHA-2B ADRENERGIC RECEPTOR (Homo sapiens;mus musculus;bos taurus;enterobacteria phage rb59) | 7tm_1 | ||
| 6lgm | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Mus musculus) | Gp_dh_CGp_dh_N | ||
| 6m38 | 29E | Duloxetine (DB00476) | Duloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. | SODIUM-DEPENDENT DOPAMINE TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 6m3z | F0F | Milnacipran (DB04896) | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. | SODIUM-DEPENDENT DOPAMINE TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 6m47 | F1U | Tramadol (DB00193) | Tramadol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. | SODIUM-DEPENDENT DOPAMINE TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 6np0 | CWB | Granisetron (DB00889) | Granisetron is a 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6pv7 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli o11;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6qex | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | MULTIDRUG RESISTANCE PROTEIN 1 (Homo sapiens;mus musculus) | ABC_membraneABC_tran | ||
| 6tfb | N6W | Carbamazepine (DB00564) | Carbamazepine is an anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. | FRIZZLED-8 (Mus musculus) | Fz | ||
| 6w1j | S7Y | Alosetron (DB00969) | Alosetron is a 5-HT3 antagonist used to treat diarrhea-predominant IBS. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6w1m | S87 | Ondansetron (DB00904) | Ondansetron is a serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. | 5-HYDROXYTRYPTAMINE RECEPTOR 3A (Mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6wwr | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | TUBULIN BETA-2B CHAIN (Mus musculus;sus scrofa) | TubulinTubulin_C | ||
| 6x39 | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F (Mus musculus) | fn3 | ||
| 6x3t | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3u | FYP | Flumazenil (DB01205) | Flumazenil is a benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3v | V8D | Etomidate (DB00292) | Etomidate is a short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6y08 | 08D | Sulfamethoxazole (DB01015) | Sulfamethoxazole is an oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. | THYMIDYLATE SYNTHASE (Mus musculus) | Thymidylat_synt | ||
| 6y82 | 308 | Amantadine (DB00915) | Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. | MITOGEN-ACTIVATED PROTEIN KINASE 14 (Mus musculus) | Pkinase | ||
| 6yk1 | D95 | Artesunate (DB09274) | Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. | PYRIDOXAL KINASE (Mus musculus) | Phos_pyr_kin | ||
| 7a69 | R1Q | Vincristine (DB00541) | Vincristine is a vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. | MULTIDRUG RESISTANCE PROTEIN 1 (Homo sapiens;mus musculus) | ABC_membraneABC_tran | ||
| 7cmu | G6L | Pramipexole (DB00413) | Pramipexole is a non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). | SOLUBLE CYTOCHROME B562,D(3) DOPAMINE RECEPTOR (Homo sapiens;mus musculus;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7daf | GZX | Ixabepilone (DB04845) | Ixabepilone is a microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines. | TUBULIN BETA CHAIN (Mus musculus;gallus gallus;sus scrofa) | TubulinTubulin_C | ||
| 7eov | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOSOLIC SULFOTRANSFERASE SULT2A8 (Mus musculus) | Sulfotransfer_1 | ||
| 7nez | TTC | Topotecan (DB01030) | Topotecan is an antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7nfd | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |