(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1ffy | MRC | Mupirocin (DB00410) | Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. | ISOLEUCYL-TRNA SYNTHETASE (Staphylococcus aureus;synthetic construct) | Anticodon_1tRNA-synt_1zf-FPG_IleRS | ||
| 1ilp | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | C-X-C CHEMOKINE RECEPTOR TYPE 1;INTERLEUKIN-8 (PRECURSOR) (Homo sapiens;synthetic construct) | IL8 | ||
| 1l2i | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 1mv9 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | RXR RETINOID X RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 1osv | CHC | Obeticholic acid (DB05990) | Obeticholic acid is a bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA. | BILE ACID RECEPTOR (Rattus norvegicus;synthetic construct) | Hormone_recep | ||
| 1ot7 | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | BILE ACID RECEPTOR (Rattus norvegicus;synthetic construct) | Hormone_recep | ||
| 1qur | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | BIVALENT INHIBITOR (BZA-2 HIRULOG);HUMAN THROMBIN (BETA CHAIN) (Homo sapiens;synthetic construct) | Trypsin | ||
| 1xdk | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RETINOIC ACID RECEPTOR, BETA (Mus musculus;synthetic construct) | Hormone_recep | ||
| 1xiu | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RXR-LIKE PROTEIN (Biomphalaria glabrata;synthetic construct) | Hormone_recep | ||
| 2aof | FRD | Amphetamine (DB00182) | Amphetamine is a CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). | PEPTIDE INHIBITOR;POL POLYPROTEIN (Human immunodeficiency virus 1;synthetic construct) | RVP | ||
| 2aoj | FRD | Amphetamine (DB00182) | Amphetamine is a CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). | PEPTIDE INHIBITOR;POL POLYPROTEIN (Human immunodeficiency virus type 1 (bh5 isolate);synthetic construct) | RVP | ||
| 2v85 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | H3R2ME1K4ME3 PEPTIDE;VDJ RECOMBINATION-ACTIVATING PROTEIN 2 (Mus musculus;synthetic construct) | NA | ||
| 2z2p | DOL | Dalfopristin (DB01764) | Dalfopristin is an antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes. | VIRGINIAMYCIN B LYASE (Staphylococcus aureus;synthetic construct) | NA | ||
| 3brf | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A (Caenorhabditis elegans;synthetic construct) | NA | ||
| 3cld | GW6 | Fluticasone furoate (DB08906) | Fluticasone furoate is an inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3d6y | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3h0a | 9RA | Bexarotene (DB00307) | Bexarotene is a retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy. | RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3hm1 | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3kd5 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | DNA POLYMERASE (Enterobacteria phage rb69;synthetic construct) | DNA_pol_BDNA_pol_B_exo1 | ||
| 3kee | 30B | Simeprevir (DB06290) | Simeprevir is a direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. | GENOME POLYPROTEIN (Hepatitis c virus;synthetic construct) | Peptidase_S29 | ||
| 3l2u | ELV | Elvitegravir (DB09101) | Elvitegravir is an antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. | INTEGRASE (Human spumaretrovirus;synthetic construct) | Integrase_H2C2SH3_11rve | ||
| 3mnp | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | GLUCOCORTICOID RECEPTOR (Mus musculus;synthetic construct) | Hormone_recep | ||
| 3oll | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN RECEPTOR BETA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3oya | RLT | Raltegravir (DB06817) | Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. | PFV INTEGRASE (Human spumaretrovirus;synthetic construct) | Integrase_H2C2SH3_11rve | ||
| 3pqz | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | CYCLIC PEPTIDE;GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 (Homo sapiens;synthetic construct) | SH2 | ||
| 3q5p | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q5r | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q5s | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q95 | ESL | Estriol (DB04573) | Estriol is a weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3qx3 | EVP | Etoposide (DB00773) | Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 3rul | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | UBIQUITIN (Homo sapiens;synthetic construct) | ubiquitin | ||
| 3s3m | DLU | Dolutegravir (DB08930) | Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. | PFV INTEGRASE (Human spumaretrovirus;synthetic construct) | Integrase_H2C2SH3_11rve | ||
| 3sp6 | IL2 | Iloprost (DB01088) | Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3vn2 | TLS | Telmisartan (DB00966) | Telmisartan is an ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3vri | 1KX | Abacavir (DB01048) | Abacavir is an antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. | 10-MER PEPTIDE;HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN (Homo sapiens;synthetic construct) | C1-setMHC_I | ||
| 4csv | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | SRC-ABL TYROSINE KINASE ANCESTOR (Synthetic construct) | NA | ||
| 4dx5 | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli;synthetic construct) | ACR_tran | ||
| 4dx7 | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli;synthetic construct) | ACR_tran | ||
| 4e2j | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | ANCESTRAL GLUCOCORTICOID RECEPTOR 2 (Synthetic construct;synthetic construct) | NA | ||
| 4g0u | ASW | Amsacrine (DB00276) | Amsacrine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4g0v | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | DNA TOPOISOMERASE 2-BETA (Homo sapiens;synthetic construct) | DNA_topoisoIVTOPRIM_CToprim | ||
| 4laj | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN (Human immunodeficiency virus 1;lama glama;synthetic construct) | NA | ||
| 4mg8 | 27J | Zeranol (DB11478) | Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4oha | HFT | Flutamide (DB00499) | Flutamide is an antiandrogen used for locally confined stage B2-C and D-2 metastatic prostate carcinoma. | ANDROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4oir | RFV | Rifamycin (DB11753) | Rifamycin is an antibacterial used to treat traveler's diarrhea. | DNA DIRECTED RNA POLYMERASE SIGMA FACTOR A;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Thermus thermophilus;synthetic construct) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 4p6w | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4p6x | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4tv1 | 36M | Propylparaben (DB14177) | Propylparaben is used in allergenic testing. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4wvd | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | BILE ACID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 4zn7 | DES | Diethylstilbestrol (DB00255) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report... | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5cxv | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M1 (Homo sapiens;enterobacteria phage t4;synthetic construct) | 7tm_1Phage_lysozyme | ||
| 5dwq | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE-ARGININE METHYLTRANSFERASE CARM1;METHYLATED H3 PEPTIDE (Homo sapiens;synthetic construct) | PrmA | ||
| 5dxe | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5ent | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli k-12;synthetic construct) | NA | ||
| 5eyp | LOC | Colchicine (DB01394) | Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). | TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN (Synthetic construct;ovis aries) | TubulinTubulin_C | ||
| 5hp1 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT (Human immunodeficiency virus type 1 group m subtype b (isolate bh10);synthetic construct) | RVT_1RVT_connectRVT_thumb | ||
| 5icx | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | CETUXIMAB FAB LIGHT CHAIN;MEDITOPE (Mus musculus;homo sapiens;synthetic construct) | NA | ||
| 5ji0 | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5jmn | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli (strain k12);synthetic construct) | ACR_tran | ||
| 5lrv | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | OTU DOMAIN-CONTAINING PROTEIN 7B;POLYUBIQUITIN-B (Homo sapiens;synthetic construct) | OTUubiquitin | ||
| 5lxm | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | AURORA KINASE A;TARGETING PROTEIN FOR XKLP2 (Homo sapiens;synthetic construct) | Pkinase | ||
| 5nfp | 8W5 | Budesonide (DB01222) | Budesonide is a corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5o45 | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 5o4y | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2 (Homo sapiens;synthetic construct) | NA | ||
| 5ock | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | CEP1 PEPTIDE (FROM ENOLASE);HUMAN ACPA E4 FAB FRAGMENT - LIGHT CHAIN (Homo sapiens;synthetic construct) | NA | ||
| 5tsx | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | HIV-1 CA PROTEIN (Human immunodeficiency virus type 1 group m subtype b (isolate ny5);synthetic construct) | Gag_p24Gag_p24_C | ||
| 5va6 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE H3.1;PROBABLE HISTONE-LYSINE N-METHYLTRANSFERASE ATXR5 (Ricinus communis;synthetic construct) | NA | ||
| 6bsg | EFZ | Efavirenz (DB00625) | Efavirenz is a non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. | REVERSE TRANSCRIPTASE P66 SUBUNIT (Human immunodeficiency virus 1;synthetic construct) | RNase_HRVT_1RVT_connectRVT_thumb | ||
| 6bzo | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA;RNA POLYMERASE-BINDING PROTEIN RBPA (Mycobacterium tuberculosis;synthetic construct) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7RbpASigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6hl1 | JN3 | Chenodeoxycholic acid (DB06777) | Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. | BILE ACID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 6iwg | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BETA-2-MICROGLOBULIN (Macaca mulatta;synthetic construct) | C1-set | ||
| 6ktn | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 6n9h | 308 | Amantadine (DB00915) | Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. | AMANTADINE-BINDING PROTEIN (Synthetic construct) | NA | ||
| 6nk0 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens;synthetic construct) | NA | ||
| 6nwk | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 6nwl | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 6oi3 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | MONOMETHYL H3R2 PEPTIDE;WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens;synthetic construct) | WD40 | ||
| 6oyv | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | CYTOCHROME P450 1B1 (Synthetic construct) | NA | ||
| 6pgs | 64Z | Geraniol (DB14183) | Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from... | RHODOPSIN (Bos taurus;synthetic construct) | 7tm_1Rhodopsin_N | ||
| 6puw | KLQ | Bictegravir (DB11799) | Bictegravir is an integrase inhibitor used to treat HIV infections. | CHIMERIC SSO7D AND HIV-1 INTEGRASE (Saccharolobus solfataricus (strain atcc 35092 / dsm 1617 / jcm 11322 / p2);human immunodeficiency virus 1;synthetic construct) | 7kD_DNA_bindingIN_DBD_CIntegrase_Znrve | ||
| 6vdk | DLU | Dolutegravir (DB08930) | Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. | INTEGRASE (Human immunodeficiency virus 1;synthetic construct) | IN_DBD_CIntegrase_Znrve | ||
| 6w70 | GG2 | Apixaban (DB06605) | Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. | DE NOVO DESIGNED ABLE (Synthetic construct) | NA | ||
| 6w9k | TUA | Prednisolone (DB00860) | Prednisolone is a glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers. | GLUCOCORTICOID RECEPTOR (Synthetic construct;synthetic construct) | Hormone_recep | ||
| 6xic | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | PEPTIDE 40;PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (Homo sapiens;synthetic construct) | Peptidase_S8 | ||
| 6ycr | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | FFIVIRDRVFR(CCS)G(NH2);PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 6ymo | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 14-3-3 PROTEIN ZETA/DELTA (Homo sapiens;synthetic construct) | 14-3-3 | ||
| 6ysx | 08D | Sulfamethoxazole (DB01015) | Sulfamethoxazole is an oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. | PROTHROMBIN (Homo sapiens;synthetic construct) | Trypsin | ||
| 6zo9 | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli k-12;synthetic construct) | ACR_tran | ||
| 6zoc | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli k-12;synthetic construct) | ACR_tran | ||
| 7bpz | PEM | Bezafibrate (DB01393) | Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 7bq0 | F5A | Fenofibric acid (DB13873) | Fenofibric acid is a fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 7cx2 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE (Homo sapiens;synthetic construct) | 7tm_1 | ||
| 7d77 | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ADHESION G PROTEIN-COUPLED RECEPTOR G3; GPR97 (Homo sapiens;synthetic construct) | NA | ||
| 7jvr | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR (Escherichia coli;homo sapiens;synthetic construct) | 7tm_1 | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |