LIST OF BINDING INTERFACES for query 'Synthetic construct' in category 'SOURCE ORGANISM'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
PDB Ligand Drug Indication Macromolecule/
Organism
Pfam Binding_Interfaces (View) Details
1ffy MRCMupirocin
(DB00410)
Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes.ISOLEUCYL-TRNA SYNTHETASE
(Staphylococcus aureus;
synthetic construct
)
Anticodon_1
tRNA-synt_1
zf-FPG_IleRS
1ilp ACAAminocaproic acid
(DB00513)
Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively.C-X-C CHEMOKINE RECEPTOR TYPE 1;
INTERLEUKIN-8 (PRECURSOR)
(Homo sapiens;
synthetic construct
)
IL8
1l2i CCSCarbocisteine
(DB04339)
Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
1mv9 HXADoconexent
(DB03756)
Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health.RXR RETINOID X RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
1osv CHCObeticholic acid
(DB05990)
Obeticholic acid is a bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.BILE ACID RECEPTOR
(Rattus norvegicus;
synthetic construct
)
Hormone_recep
1ot7 IU5Ursodeoxycholic acid
(DB01586)
Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.BILE ACID RECEPTOR
(Rattus norvegicus;
synthetic construct
)
Hormone_recep
1qur ABUGamma-aminobutyric acid
(DB02530)
The most common inhibitory neurotransmitter in the central nervous system.BIVALENT INHIBITOR (BZA-2 HIRULOG);
HUMAN THROMBIN (BETA CHAIN)
(Homo sapiens;
synthetic construct
)
Trypsin
1xdk 9CRAlitretinoin
(DB00523)
Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.RETINOIC ACID RECEPTOR, BETA
(Mus musculus;
synthetic construct
)
Hormone_recep
1xiu 9CRAlitretinoin
(DB00523)
Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.RXR-LIKE PROTEIN
(Biomphalaria glabrata;
synthetic construct
)
Hormone_recep
2aof FRDAmphetamine
(DB00182)
Amphetamine is a CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).PEPTIDE INHIBITOR;
POL POLYPROTEIN
(Human immunodeficiency virus 1;
synthetic construct
)
RVP
2aoj FRDAmphetamine
(DB00182)
Amphetamine is a CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).PEPTIDE INHIBITOR;
POL POLYPROTEIN
(Human immunodeficiency virus type 1 (bh5 isolate);
synthetic construct
)
RVP
2v85 NMMTilarginine
(DB11815)
Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.H3R2ME1K4ME3 PEPTIDE;
VDJ RECOMBINATION-ACTIVATING PROTEIN 2
(Mus musculus;
synthetic construct
)
NA
2z2p DOLDalfopristin
(DB01764)
Dalfopristin is an antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes.VIRGINIAMYCIN B LYASE
(Staphylococcus aureus;
synthetic construct
)
NA
3brf SORSorbitol
(DB01638)
Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A
(Caenorhabditis elegans;
synthetic construct
)
NA
3cld GW6Fluticasone furoate
(DB08906)
Fluticasone furoate is an inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis.GLUCOCORTICOID RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
3d6y BERBerberine
(DB04115)
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal...MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR
(Bacillus subtilis;
synthetic construct
)
GyrI-like
MerR
3h0a 9RABexarotene
(DB00307)
Bexarotene is a retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy.RETINOIC ACID RECEPTOR RXR-ALPHA
(Homo sapiens;
synthetic construct
)
Hormone_recep
3hm1 J3ZEstrone
(DB00655)
Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms.ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
3kd5 PPFFoscarnet
(DB00529)
Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections.DNA POLYMERASE
(Enterobacteria phage rb69;
synthetic construct
)
DNA_pol_B
DNA_pol_B_exo1
3kee 30BSimeprevir
(DB06290)
Simeprevir is a direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.GENOME POLYPROTEIN
(Hepatitis c virus;
synthetic construct
)
Peptidase_S29
3l2u ELVElvitegravir
(DB09101)
Elvitegravir is an antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.INTEGRASE
(Human spumaretrovirus;
synthetic construct
)
Integrase_H2C2
SH3_11
rve
3mnp DEXDexamethasone
(DB01234)
Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.GLUCOCORTICOID RECEPTOR
(Mus musculus;
synthetic construct
)
Hormone_recep
3oll ESTEstradiol
(DB00783)
Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.ESTROGEN RECEPTOR BETA
(Homo sapiens;
synthetic construct
)
Hormone_recep
3oya RLTRaltegravir
(DB06817)
Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals.PFV INTEGRASE
(Human spumaretrovirus;
synthetic construct
)
Integrase_H2C2
SH3_11
rve
3pqz CCSCarbocisteine
(DB04339)
Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.CYCLIC PEPTIDE;
GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
(Homo sapiens;
synthetic construct
)
SH2
3q5p TACTetracycline
(DB00759)
Tetracycline is an antibiotic used to treat a wide variety of susceptible infections.MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR
(Bacillus subtilis;
synthetic construct
)
GyrI-like
MerR
3q5r KANKanamycin
(DB01172)
Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR
(Bacillus subtilis;
synthetic construct
)
GyrI-like
MerR
3q5s ACHAcetylcholine
(DB03128)
Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR
(Bacillus subtilis;
synthetic construct
)
GyrI-like
MerR
3q95 ESLEstriol
(DB04573)
Estriol is a weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching.ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
3qx3 EVPEtoposide
(DB00773)
Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors.DNA TOPOISOMERASE 2-BETA
(Homo sapiens;
synthetic construct
)
DNA_topoisoIV
TOPRIM_C
Toprim
3rul CCSCarbocisteine
(DB04339)
Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.UBIQUITIN
(Homo sapiens;
synthetic construct
)
ubiquitin
3s3m DLUDolutegravir
(DB08930)
Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.PFV INTEGRASE
(Human spumaretrovirus;
synthetic construct
)
Integrase_H2C2
SH3_11
rve
3sp6 IL2Iloprost
(DB01088)
Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
(Homo sapiens;
synthetic construct
)
Hormone_recep
3vn2 TLSTelmisartan
(DB00966)
Telmisartan is an ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
(Homo sapiens;
synthetic construct
)
Hormone_recep
3vri 1KXAbacavir
(DB01048)
Abacavir is an antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.10-MER PEPTIDE;
HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN
(Homo sapiens;
synthetic construct
)
C1-set
MHC_I
4csv STIImatinib
(DB00619)
Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.SRC-ABL TYROSINE KINASE ANCESTOR
(Synthetic construct)
NA
4dx5 MIYMinocycline
(DB01017)
Minocycline is a tetracycline analog used to treat a wide variety of infections in the body.ACRIFLAVINE RESISTANCE PROTEIN B
(Escherichia coli;
synthetic construct
)
ACR_tran
4dx7 DM2Doxorubicin
(DB00997)
Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma.ACRIFLAVINE RESISTANCE PROTEIN B
(Escherichia coli;
synthetic construct
)
ACR_tran
4e2j MOFMometasone furoate
(DB14512)
Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.ANCESTRAL GLUCOCORTICOID RECEPTOR 2
(Synthetic construct;
synthetic construct
)
NA
4g0u ASWAmsacrine
(DB00276)
Amsacrine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.DNA TOPOISOMERASE 2-BETA
(Homo sapiens;
synthetic construct
)
DNA_topoisoIV
TOPRIM_C
Toprim
4g0v MIXMitoxantrone
(DB01204)
Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.DNA TOPOISOMERASE 2-BETA
(Homo sapiens;
synthetic construct
)
DNA_topoisoIV
TOPRIM_C
Toprim
4laj ACAAminocaproic acid
(DB00513)
Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively.HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN
(Human immunodeficiency virus 1;
lama glama;
synthetic construct
)
NA
4mg8 27JZeranol
(DB11478)
Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x...ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
4oha HFTFlutamide
(DB00499)
Flutamide is an antiandrogen used for locally confined stage B2-C and D-2 metastatic prostate carcinoma.ANDROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
4oir RFVRifamycin
(DB11753)
Rifamycin is an antibacterial used to treat traveler's diarrhea.DNA DIRECTED RNA POLYMERASE SIGMA FACTOR A;
DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA
(Thermus thermophilus;
synthetic construct
)
RNA_pol_Rpb2_1
RNA_pol_Rpb2_2
RNA_pol_Rpb2_3
RNA_pol_Rpb2_45
RNA_pol_Rpb2_6
RNA_pol_Rpb2_7
Sigma70_r1_2
Sigma70_r2
Sigma70_r3
Sigma70_r4
4p6w MOFMometasone furoate
(DB14512)
Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.GLUCOCORTICOID RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
4p6x HCYHydrocortisone
(DB00741)
Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.GLUCOCORTICOID RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
4tv1 36MPropylparaben
(DB14177)
Propylparaben is used in allergenic testing.ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
4wvd IVMIvermectin
(DB00602)
Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.BILE ACID RECEPTOR
(Homo sapiens;
synthetic construct
)
NA
4zn7 DESDiethylstilbestrol
(DB00255)
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report...ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
5cxv 0HKTiotropium
(DB01409)
Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M1
(Homo sapiens;
enterobacteria phage t4;
synthetic construct
)
7tm_1
Phage_lysozyme
5dwq NMMTilarginine
(DB11815)
Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.HISTONE-ARGININE METHYLTRANSFERASE CARM1;
METHYLATED H3 PEPTIDE
(Homo sapiens;
synthetic construct
)
PrmA
5dxe ESTEstradiol
(DB00783)
Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.ESTROGEN RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
5ent MIYMinocycline
(DB01017)
Minocycline is a tetracycline analog used to treat a wide variety of infections in the body.MULTIDRUG EFFLUX PUMP SUBUNIT ACRB
(Escherichia coli k-12;
synthetic construct
)
NA
5eyp LOCColchicine
(DB01394)
Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF).TUBULIN ALPHA CHAIN;
TUBULIN BETA CHAIN
(Synthetic construct;
ovis aries
)
Tubulin
Tubulin_C
5hp1 PPFFoscarnet
(DB00529)
Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections.HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT
(Human immunodeficiency virus type 1 group m subtype b (isolate bh10);
synthetic construct
)
RVT_1
RVT_connect
RVT_thumb
5icx SC2Acetylcysteine
(DB06151)
Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.CETUXIMAB FAB LIGHT CHAIN;
MEDITOPE
(Mus musculus;
homo sapiens;
synthetic construct
)
NA
5ji0 9CRAlitretinoin
(DB00523)
Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.RETINOIC ACID RECEPTOR RXR-ALPHA
(Homo sapiens;
synthetic construct
)
Hormone_recep
5jmn FUAFusidic acid
(DB02703)
Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.MULTIDRUG EFFLUX PUMP SUBUNIT ACRB
(Escherichia coli (strain k12);
synthetic construct
)
ACR_tran
5lrv ABUGamma-aminobutyric acid
(DB02530)
The most common inhibitory neurotransmitter in the central nervous system.OTU DOMAIN-CONTAINING PROTEIN 7B;
POLYUBIQUITIN-B
(Homo sapiens;
synthetic construct
)
OTU
ubiquitin
5lxm NH3Ammonia
(DB11118)
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium...AURORA KINASE A;
TARGETING PROTEIN FOR XKLP2
(Homo sapiens;
synthetic construct
)
Pkinase
5nfp 8W5Budesonide
(DB01222)
Budesonide is a corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis.GLUCOCORTICOID RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
5o45 CCSCarbocisteine
(DB04339)
Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2;
PROGRAMMED CELL DEATH 1 LIGAND 1
(Homo sapiens;
synthetic construct
)
V-set
5o4y CCSCarbocisteine
(DB04339)
Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2
(Homo sapiens;
synthetic construct
)
NA
5ock ACAAminocaproic acid
(DB00513)
Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively.CEP1 PEPTIDE (FROM ENOLASE);
HUMAN ACPA E4 FAB FRAGMENT - LIGHT CHAIN
(Homo sapiens;
synthetic construct
)
NA
5tsx FLUFluorescein
(DB00693)
Fluorescein is a dye used in angiography or angioscopy of the iris and retina.HIV-1 CA PROTEIN
(Human immunodeficiency virus type 1 group m subtype b (isolate ny5);
synthetic construct
)
Gag_p24
Gag_p24_C
5va6 NMMTilarginine
(DB11815)
Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.HISTONE H3.1;
PROBABLE HISTONE-LYSINE N-METHYLTRANSFERASE ATXR5
(Ricinus communis;
synthetic construct
)
NA
6bsg EFZEfavirenz
(DB00625)
Efavirenz is a non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.REVERSE TRANSCRIPTASE P66 SUBUNIT
(Human immunodeficiency virus 1;
synthetic construct
)
RNase_H
RVT_1
RVT_connect
RVT_thumb
6bzo FI8Fidaxomicin
(DB08874)
Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection.DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;
DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';
RNA POLYMERASE SIGMA FACTOR SIGA;
RNA POLYMERASE-BINDING PROTEIN RBPA
(Mycobacterium tuberculosis;
synthetic construct
)
RNA_pol_Rpb1_1
RNA_pol_Rpb1_2
RNA_pol_Rpb1_3
RNA_pol_Rpb1_4
RNA_pol_Rpb1_5
RNA_pol_Rpb2_1
RNA_pol_Rpb2_2
RNA_pol_Rpb2_3
RNA_pol_Rpb2_45
RNA_pol_Rpb2_6
RNA_pol_Rpb2_7
RbpA
Sigma70_r1_2
Sigma70_r2
Sigma70_r3
Sigma70_r4
6hl1 JN3Chenodeoxycholic acid
(DB06777)
Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis.BILE ACID RECEPTOR
(Homo sapiens;
synthetic construct
)
Hormone_recep
6iwg BO3Boric acid
(DB11326)
Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,...BETA-2-MICROGLOBULIN
(Macaca mulatta;
synthetic construct
)
C1-set
6ktn STIImatinib
(DB00619)
Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
(Homo sapiens;
synthetic construct
)
Hormone_recep
6n9h 308Amantadine
(DB00915)
Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.AMANTADINE-BINDING PROTEIN
(Synthetic construct)
NA
6nk0 ACAAminocaproic acid
(DB00513)
Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively.EPHRIN TYPE-A RECEPTOR 2
(Homo sapiens;
synthetic construct
)
NA
6nwk DEXDexamethasone
(DB01234)
Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.GLUCOCORTICOID RECEPTOR
(Homo sapiens;
synthetic construct
)
NA
6nwl HCYHydrocortisone
(DB00741)
Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.GLUCOCORTICOID RECEPTOR
(Homo sapiens;
synthetic construct
)
NA
6oi3 NMMTilarginine
(DB11815)
Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.MONOMETHYL H3R2 PEPTIDE;
WD REPEAT-CONTAINING PROTEIN 5
(Homo sapiens;
synthetic construct
)
WD40
6oyv ESTEstradiol
(DB00783)
Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.CYTOCHROME P450 1B1
(Synthetic construct)
NA
6pgs 64ZGeraniol
(DB14183)
Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from...RHODOPSIN
(Bos taurus;
synthetic construct
)
7tm_1
Rhodopsin_N
6puw KLQBictegravir
(DB11799)
Bictegravir is an integrase inhibitor used to treat HIV infections.CHIMERIC SSO7D AND HIV-1 INTEGRASE
(Saccharolobus solfataricus (strain atcc 35092 / dsm 1617 / jcm 11322 / p2);
human immunodeficiency virus 1;
synthetic construct
)
7kD_DNA_binding
IN_DBD_C
Integrase_Zn
rve
6vdk DLUDolutegravir
(DB08930)
Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.INTEGRASE
(Human immunodeficiency virus 1;
synthetic construct
)
IN_DBD_C
Integrase_Zn
rve
6w70 GG2Apixaban
(DB06605)
Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.DE NOVO DESIGNED ABLE
(Synthetic construct)
NA
6w9k TUAPrednisolone
(DB00860)
Prednisolone is a glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.GLUCOCORTICOID RECEPTOR
(Synthetic construct;
synthetic construct
)
Hormone_recep
6xic DHLCysteamine
(DB00847)
Cysteamine is a cystine depleting agent used to treat the effects of cystinosis.PEPTIDE 40;
PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
(Homo sapiens;
synthetic construct
)
Peptidase_S8
6ycr CCSCarbocisteine
(DB04339)
Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.FFIVIRDRVFR(CCS)G(NH2);
PROGRAMMED CELL DEATH 1 LIGAND 1
(Homo sapiens;
synthetic construct
)
V-set
6ymo SALSalicylic acid
(DB00936)
Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.14-3-3 PROTEIN ZETA/DELTA
(Homo sapiens;
synthetic construct
)
14-3-3
6ysx 08DSulfamethoxazole
(DB01015)
Sulfamethoxazole is an oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.PROTHROMBIN
(Homo sapiens;
synthetic construct
)
Trypsin
6zo9 RBTRifabutin
(DB00615)
Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV.MULTIDRUG EFFLUX PUMP SUBUNIT ACRB
(Escherichia coli k-12;
synthetic construct
)
ACR_tran
6zoc ERYErythromycin
(DB00199)
Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections.MULTIDRUG EFFLUX PUMP SUBUNIT ACRB
(Escherichia coli k-12;
synthetic construct
)
ACR_tran
7bpz PEMBezafibrate
(DB01393)
Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
(Homo sapiens;
synthetic construct
)
Hormone_recep
7bq0 F5AFenofibric acid
(DB13873)
Fenofibric acid is a fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
(Homo sapiens;
synthetic construct
)
Hormone_recep
7cx2 P2EDinoprostone
(DB00917)
Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE
(Homo sapiens;
synthetic construct
)
7tm_1
7d77 HCYHydrocortisone
(DB00741)
Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.ADHESION G PROTEIN-COUPLED RECEPTOR G3;
GPR97
(Homo sapiens;
synthetic construct
)
NA
7jvr 08YBromocriptine
(DB01200)
Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR
(Escherichia coli;
homo sapiens;
synthetic construct
)
7tm_1
PDB Ligand Drug Indication Macromolecule/
Organism
Pfam Binding_Interfaces (View) Details