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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1afs | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Rattus norvegicus) | Aldo_ket_red | ||
| 1e6w | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (Rattus norvegicus) | adh_short | ||
| 1epb | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN (Rattus norvegicus) | Lipocalin | ||
| 1ie4 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | TRANSTHYRETIN (Rattus norvegicus) | Transthyretin | ||
| 1osv | CHC | Obeticholic acid (DB05990) | Obeticholic acid is a bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA. | BILE ACID RECEPTOR (Rattus norvegicus;synthetic construct) | Hormone_recep | ||
| 1ot7 | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | BILE ACID RECEPTOR (Rattus norvegicus;synthetic construct) | Hormone_recep | ||
| 1pb9 | 4AX | Cycloserine (DB00260) | Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). | N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 1 (Rattus norvegicus) | NA | ||
| 1qkn | RAL | Raloxifene (DB00481) | Raloxifene is a selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. | ESTROGEN RECEPTOR BETA (Rattus norvegicus) | Hormone_recep | ||
| 1sa1 | POD | Podofilox (DB01179) | Podofilox is a topical agent used for the treatment of external genital warts and perianal warts. | TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN (Rattus norvegicus;bos taurus) | TubulinTubulin_C | ||
| 1wyg | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | XANTHINE DEHYDROGENASE/OXIDASE (Rattus norvegicus) | Ald_Xan_dh_CAld_Xan_dh_C2CO_deh_flav_CFAD_binding_5Fer2Fer2_2 | ||
| 2rk8 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP] (Rattus norvegicus) | PEPCK_GTPPEPCK_N | ||
| 2v95 | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | CORTICOSTEROID-BINDING GLOBULIN (Rattus norvegicus) | Serpin | ||
| 3eau | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-2 (Rattus norvegicus) | Aldo_ket_red | ||
| 3hl4 | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A (Rattus norvegicus) | CTP_transf_like | ||
| 3ik6 | HCZ | Hydrochlorothiazide (DB00999) | Hydrochlorothiazide is a thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3ilu | HFZ | Hydroflumethiazide (DB00774) | Hydroflumethiazide is a thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3lsf | PZI | Piracetam (DB09210) | Piracetam is a nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3qel | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2;NMDA GLUTAMATE RECEPTOR SUBUNIT (Xenopus laevis;rattus norvegicus) | ANF_receptor | ||
| 3s68 | TCW | Tolcapone (DB00323) | Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. | CATECHOL O-METHYLTRANSFERASE (Rattus norvegicus) | Methyltransf_3 | ||
| 3tkd | CYZ | Cyclothiazide (DB00606) | As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides... | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3tz5 | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL (Rattus norvegicus) | BCDHK_Adom3HATPase_c | ||
| 4daj | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME (Rattus norvegicus;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 4ffw | 715 | Sitagliptin (DB01261) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Rattus norvegicus;mus musculus) | DPPIV_NPeptidase_S9 | ||
| 4mvc | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A (Rattus norvegicus) | CTP_transf_like | ||
| 4pe5 | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1;GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B (Rattus norvegicus) | ANF_receptorLig_chanLig_chan-Glu_bd | ||
| 4u15 | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3 (Rattus norvegicus;enterobacteria phage t4) | 7tm_1 | ||
| 4u16 | 3C0 | Methscopolamine (DB11315) | Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... | MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3 (Rattus norvegicus;enterobacteria phage t4) | 7tm_1 | ||
| 4wre | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PULMONARY SURFACTANT-ASSOCIATED PROTEIN A (Rattus norvegicus) | Lectin_C | ||
| 4xp3 | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | MITOGEN-ACTIVATED PROTEIN KINASE 1 (Rattus norvegicus) | Pkinase | ||
| 5j2t | VLB | Vinblastine (DB00570) | Vinblastine is a vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
| 5jh7 | 6K9 | Eribulin (DB08871) | Eribulin is a microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
| 5l1f | 6ZP | Perampanel (DB08883) | Perampanel is a non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | ANF_receptorLig_chanLig_chan-Glu_bd | ||
| 6baa | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Rattus norvegicus;cricetus cricetus) | ABC_membraneABC_tran | ||
| 6dw0 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 (Rattus norvegicus) | Neur_chan_LBDNeur_chan_memb | ||
| 6dw1 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 (Rattus norvegicus) | Neur_chan_LBDNeur_chan_memb | ||
| 6fgc | D95 | Artesunate (DB09274) | Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. | GEPHYRIN (Rattus norvegicus) | MoCF_biosynthMoeA_CMoeA_N | ||
| 6fgd | D8Z | Artemether (DB06697) | Artemether is an antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. | GEPHYRIN (Rattus norvegicus) | MoCF_biosynthMoeA_CMoeA_N | ||
| 6u88 | P0T | Cannabidiol (DB09061) | Cannabidiol is an active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. | TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2 (Rattus norvegicus) | Ank_2Ion_trans | ||
| 6uz0 | K4D | Flecainide (DB01195) | Flecainide is a class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). | SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA,GREEN FLUORESCENT PROTEIN (Rattus norvegicus;aequorea victoria) | GFPIon_transNa_trans_assoc | ||
| 6vms | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | ENDOLYSIN,D(2) DOPAMINE RECEPTOR,D(2) DOPAMINE RECEPTOR (Rattus norvegicus;homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |