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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1ea1 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYTOCHROME P450 51-LIKE RV0764C (Mycobacterium tuberculosis) | p450 | ||
| 1kpg | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 (Mycobacterium tuberculosis) | CMAS | ||
| 1m4d | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m4g | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m4i | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1tpy | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | METHOXY MYCOLIC ACID SYNTHASE 2 (Mycobacterium tuberculosis) | CMAS | ||
| 1x8v | ESL | Estriol (DB04573) | Estriol is a weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching. | CYTOCHROME P450 51 (Mycobacterium tuberculosis) | p450 | ||
| 2b35 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Mycobacterium tuberculosis) | adh_short_C2 | ||
| 2byo | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | LIPOPROTEIN LPPX (Mycobacterium tuberculosis) | LppX_LprAFG | ||
| 2fum | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | PROBABLE SERINE/THREONINE-PROTEIN KINASE PKNB (Mycobacterium tuberculosis h37rv) | Pkinase | ||
| 2ij7 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYTOCHROME P450 121 (Mycobacterium tuberculosis) | p450 | ||
| 3avp | MV2 | Dexpanthenol (DB09357) | Dexpanthenol is an alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN). | PANTOTHENATE KINASE (Mycobacterium tuberculosis) | PRK | ||
| 3dcj | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN (Mycobacterium tuberculosis) | Formyl_trans_N | ||
| 3m6b | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nbl | DXF | Cefuroxime (DB01112) | Cefuroxime is a cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nck | NFF | Nafcillin (DB00607) | Nafcillin is a penicillin derivative antibiotic used to treat susceptible staphylococcal infections. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nde | 9EP | Cefalotin (DB00456) | Cefalotin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3ny4 | SMX | Cefamandole (DB01326) | Cefamandole is a beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3twp | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (Mycobacterium tuberculosis) | Glycos_trans_3NGlycos_transf_3 | ||
| 3zuk | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | ENDOPEPTIDASE, PEPTIDASE FAMILY M13 (Mycobacterium tuberculosis) | Peptidase_M13Peptidase_M13_N | ||
| 4fox | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Mycobacterium tuberculosis) | Thymidylat_synt | ||
| 4jd6 | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | ENHANCED INTRACELLULAR SURVIVAL PROTEIN (Mycobacterium tuberculosis) | Acetyltransf_17Acetyltransf_9SCP2_2 | ||
| 4km0 | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4km2 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4m2x | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4wrz | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URACIL-DNA GLYCOSYLASE (Mycobacterium tuberculosis) | UDG | ||
| 4xt7 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | RV2671 (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RibD_C | ||
| 4xt8 | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | RV2671 (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RibD_C | ||
| 5i0a | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | INTEIN (Mycobacterium tuberculosis) | NA | ||
| 5iao | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | BIFUNCTIONAL PROTEIN PYRR (Mycobacterium tuberculosis (strain atcc 25177 / h37ra)) | Pribosyltran | ||
| 5li8 | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | PUTATIVE CYTOCHROME P450 126 (Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)) | p450 | ||
| 5nz0 | ZLD | Linezolid (DB00601) | Linezolid is an oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. | HTH-TYPE TRANSCRIPTIONAL REGULATOR ETHR (Mycobacterium tuberculosis) | TetR_N | ||
| 5x7z | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5x80 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5yk2 | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | ABC1 | ||
| 6b6d | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | BETA-LACTAMASE (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | Beta-lactamase2 | ||
| 6bzo | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA;RNA POLYMERASE-BINDING PROTEIN RBPA (Mycobacterium tuberculosis;synthetic construct) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7RbpASigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6fbv | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6kgu | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | PENICILLIN-BINDING PROTEIN PBPB (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | PBP_dimerTranspeptidase | ||
| 6nl4 | GEO | Gemcitabine (DB00441) | Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. | ATP-DEPENDENT DETHIOBIOTIN SYNTHETASE BIOD (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | AAA_26 | ||
| 6za5 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE SYNTHASE (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | Chorismate_bind | ||
| 7bvf | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | PROBABLE ARABINOSYLTRANSFERASE B (Mycobacterium tuberculosis h37rv;mycolicibacterium smegmatis mc2 155) | Arabino_trans_CArabino_trans_NArabinose_trans | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |