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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1u7g | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | PROBABLE AMMONIUM TRANSPORTER (Escherichia coli) | NA | ||
| 2q6h | CXX | Clomipramine (DB01242) | Clomipramine is a tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 2q72 | IXX | Imipramine (DB00458) | Imipramine is a tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 2qb4 | DSM | Desipramine (DB01151) | Desipramine is a tricyclic antidepressant used in the treatment of depression. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 2rin | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN (Rhizobium meliloti) | OpuAC | ||
| 3d6y | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3gwu | SRE | Sertraline (DB01104) | Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 3ip9 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | ABC TRANSPORTER, SUBSTRATE BINDING PROTEIN (AMINO ACID) (Agrobacterium tumefaciens) | Peripla_BP_6 | ||
| 3q5p | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q5r | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q5s | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 4euo | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | ABC TRANSPORTER, SUBSTRATE BINDING PROTEIN (POLYAMINE) (Agrobacterium tumefaciens) | SBP_bac_8 | ||
| 4irx | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | SUGAR ABC TRANSPORTER, PERIPLASMIC SUGAR-BINDING PROTEIN (Caulobacter crescentus) | Peripla_BP_4 | ||
| 4m48 | 21B | Nortriptyline (DB00540) | Nortriptyline is a tricyclic antidepressant used in the treatment of depression. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4mm4 | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 4mm9 | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 4mmc | 29J | Desvenlafaxine (DB06700) | Desvenlafaxine is an antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 4mmd | 29E | Duloxetine (DB00476) | Duloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 4mme | 29Q | Mazindol (DB00579) | Mazindol is a sympathomimetic used to treat obesity in combination with lifestyle modifications. | TRANSPORTER (Aquifex aeolicus) | SNF | ||
| 4o8m | 2Q2 | Gluconic acid (DB13180) | Gluconic Acid is an electrolyte supplement used in total parenteral nutrition. | TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT (Actinobacillus succinogenes) | DctP | ||
| 4ru1 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | MONOSACCHARIDE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN, CUT2 FAMILY (Acidothermus cellulolyticus) | Peripla_BP_4 | ||
| 4rxm | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | POSSIBLE SUGAR ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Mannheimia haemolytica) | NA | ||
| 4xnx | 41X | Reboxetine (DB00234) | Reboxetine is a drug used for the acute treatment of major depression and for maintenance therapy of depression. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4xp1 | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | DOPAMINE TRANSPORTER, ISOFORM B (Drosophila melanogaster;mus musculus) | SNF | ||
| 4xp6 | B40 | Metamfetamine (DB01577) | Metamfetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4xp9 | 1WE | Dextroamphetamine (DB01576) | Dextroamphetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. | TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 4yo7 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | SUGAR ABC TRANSPORTER (SUGAR-BINDING PROTEIN) (Bacillus halodurans) | Peripla_BP_4 | ||
| 5hko | 62W | Mannitol (DB00742) | Mannitol is a sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis. | ABC TRANSPORTER, CARBOHYDRATE UPTAKE TRANSPORTER-2 (CUT2) FAMILY, PERIPLASMIC SUGAR-BINDING PROTEIN (Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)) | Peripla_BP_4 | ||
| 5i6x | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i71 | 68P | Escitalopram (DB01175) | Escitalopram is a selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5i73 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 5yk2 | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | ABC1 | ||
| 6awo | SRE | Sertraline (DB01104) | Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 6awp | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens;mus musculus) | SNF | ||
| 6gz9 | TXC | Valaciclovir (DB00577) | Valaciclovir is an guanine nucleoside antiviral used to treat herpes exacerbations. | PEPTIDE ABC TRANSPORTER PERMEASE (Staphylococcus hominis) | PTR2 | ||
| 6hzp | FVT | Aminolevulinic acid (DB00855) | Aminolevulinic acid is a porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma. | PEPTIDE ABC TRANSPORTER PERMEASE (Staphylococcus hominis) | PTR2 | ||
| 6m38 | 29E | Duloxetine (DB00476) | Duloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. | SODIUM-DEPENDENT DOPAMINE TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 6m3z | F0F | Milnacipran (DB04896) | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. | SODIUM-DEPENDENT DOPAMINE TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 6m47 | F1U | Tramadol (DB00193) | Tramadol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. | SODIUM-DEPENDENT DOPAMINE TRANSPORTER (Drosophila melanogaster;mus musculus) | SNF | ||
| 6r4l | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1-RELATED PROTEIN 1 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | NPC1_NPatched | ||
| 6vkt | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | EFFLUX PUMP MEMBRANE TRANSPORTER (Neisseria gonorrhoeae) | ACR_tran | ||
| 6vrz | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | MULTIDRUG TRANSPORTER MDFA (Escherichia coli) | MFS_1 | ||
| 6vxh | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2 (Homo sapiens) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7bcr | 2Q2 | Gluconic acid (DB13180) | Gluconic Acid is an electrolyte supplement used in total parenteral nutrition. | PUTATIVE TRAP TRANSPORTER SOLUTE RECEPTOR DCTP (Advenella mimigardefordensis dpn7) | DctP | ||
| 7m4p | YQM | Eravacycline (DB12329) | Eravacycline is a tetracycline antibiotic used to treat complicated intra-abdominal infections. | EFFLUX PUMP MEMBRANE TRANSPORTER (Acinetobacter baumannii) | ACR_tran | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |