
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
---|---|---|---|---|---|---|---|
1aeg | 4AP | Dalfampridine (DB06637) | Dalfampridine is a potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS). | CYTOCHROME C PEROXIDASE (Saccharomyces cerevisiae) | peroxidase | ||
1qzr | CDX | Dexrazoxane (DB00380) | Dexrazoxane is a cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. | DNA TOPOISOMERASE II (Saccharomyces cerevisiae) | HATPase_c | ||
1zhz | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | KES1 PROTEIN (Saccharomyces cerevisiae) | Oxysterol_BP | ||
2e91 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (Saccharomyces cerevisiae) | polyprenyl_synt | ||
2uy4 | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | ENDOCHITINASE (Saccharomyces cerevisiae) | NA | ||
2v2e | ISZ | Isoniazid (DB00951) | Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. | CYTOCHROME C PEROXIDASE (Saccharomyces cerevisiae) | peroxidase | ||
3uf8 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (Saccharomyces cerevisiae;burkholderia pseudomallei) | FKBP_Cubiquitin | ||
4a6z | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL (Saccharomyces cerevisiae) | peroxidase | ||
4pd4 | AOQ | Atovaquone (DB01117) | Atovaquone is an antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. | CYTOCHROME B (Mus musculus;saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Cytochrom_B_CCytochrome_B | ||
4qvp | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3 (Saccharomyces cerevisiae) | Pr_beta_CProteasome | ||
4qvp | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6 (Saccharomyces cerevisiae) | Proteasome | ||
4qvp | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2 (Saccharomyces cerevisiae) | Pr_beta_C | ||
4ze1 | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae (strain yjm789)) | p450 | ||
5d0s | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Pr_beta_CProteasome | ||
5d0s | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Proteasome | ||
5d0s | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Pr_beta_C | ||
5esg | 1YN | Itraconazole (DB01167) | Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae (strain yjm789)) | p450 | ||
5esm | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae (strain yjm789)) | p450 | ||
5hs1 | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae) | p450 | ||
5l5e | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 (Saccharomyces cerevisiae (strain atcc 204508 / s288c);homo sapiens;saccharomyces cerevisiae) | Proteasome | ||
5l5f | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 (Saccharomyces cerevisiae (strain atcc 204508 / s288c);homo sapiens;saccharomyces cerevisiae) | Proteasome | ||
5l5y | 3BV | Carfilzomib (DB08889) | Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma. | PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6 (Homo sapiens;saccharomyces cerevisiae (strain atcc 204508 / s288c);saccharomyces cerevisiae) | Proteasome | ||
5l5z | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6 (Homo sapiens;saccharomyces cerevisiae (strain atcc 204508 / s288c);saccharomyces cerevisiae) | Proteasome | ||
5w3j | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | TUBULIN BETA CHAIN (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | TubulinTubulin_C | ||
5ys0 | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | MEMBRANE-ANCHORED LIPID-BINDING PROTEIN YSP2 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | VASt | ||
6cay | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | STEROL-BINDING PROTEIN (Saccharomyces cerevisiae) | VASt | ||
6l0b | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | DIHYDROOROTASE (Saccharomyces cerevisiae) | NA | ||
6r4l | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1-RELATED PROTEIN 1 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | NPC1_NPatched | ||
6r4n | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | PHOSPHATIDYLGLYCEROL/PHOSPHATIDYLINOSITOL TRANSFER PROTEIN (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | E1_DerP2_DerF2 | ||
6xjs | V6A | Selinexor (DB11942) | Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. It is currently approved for the treatment of multiple myeloma, a cancer which forms from antibody-producing plasma cells.[L7117,L7120] This... | EXPORTIN-1 (Homo sapiens;saccharomyces cerevisiae) | CRM1_CCRM1_repeatCRM1_repeat_2CRM1_repeat_3IBN_NXpo1 | ||
7brn | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | AUTOPHAGY-RELATED PROTEIN 40,AUTOPHAGY-RELATED PROTEIN 8 (Saccharomyces cerevisiae s288c) | ATG8 | ||
PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |