LIST OF BINDING INTERFACES for query 'Saccharomyces cerevisiae' in category 'SOURCE ORGANISM'

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PDB Ligand Drug Indication Macromolecule/
Organism		 Pfam Binding_Interfaces (View) Details
1aeg 4APDalfampridine
(DB06637)		Dalfampridine is a potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS).CYTOCHROME C PEROXIDASE
(Saccharomyces cerevisiae)		peroxidase
1qzr CDXDexrazoxane
(DB00380)		Dexrazoxane is a cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer.DNA TOPOISOMERASE II
(Saccharomyces cerevisiae)		HATPase_c
1zhz ERGErgosterol
(DB04038)		A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...KES1 PROTEIN
(Saccharomyces cerevisiae)		Oxysterol_BP
2e91 ZOLZoledronic acid
(DB00399)		Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.GERANYLGERANYL PYROPHOSPHATE SYNTHETASE
(Saccharomyces cerevisiae)		polyprenyl_synt
2uy4 AZMAcetazolamide
(DB00819)		Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.ENDOCHITINASE
(Saccharomyces cerevisiae)		NA
2v2e ISZIsoniazid
(DB00951)		Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.CYTOCHROME C PEROXIDASE
(Saccharomyces cerevisiae)		peroxidase
3uf8 FK5Tacrolimus
(DB00864)		Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
(Saccharomyces cerevisiae;
burkholderia pseudomallei)		FKBP_C
ubiquitin
4a6z JZ3Guaiacol
(DB11359)		Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin....CYTOCHROME C PEROXIDASE, MITOCHONDRIAL
(Saccharomyces cerevisiae)		peroxidase
4pd4 AOQAtovaquone
(DB01117)		Atovaquone is an antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.CYTOCHROME B
(Mus musculus;
saccharomyces cerevisiae (strain atcc 204508 / s288c))		Cytochrom_B_C
Cytochrome_B
4qvp BO2Bortezomib
(DB00188)		Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.PROTEASOME SUBUNIT BETA TYPE-2;
PROTEASOME SUBUNIT BETA TYPE-3
(Saccharomyces cerevisiae)		Pr_beta_C
Proteasome
4qvp BO2Bortezomib
(DB00188)		Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.PROTEASOME SUBUNIT BETA TYPE-5;
PROTEASOME SUBUNIT BETA TYPE-6
(Saccharomyces cerevisiae)		Proteasome
4qvp BO2Bortezomib
(DB00188)		Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.PROTEASOME SUBUNIT BETA TYPE-1;
PROTEASOME SUBUNIT BETA TYPE-2
(Saccharomyces cerevisiae)		Pr_beta_C
4ze1 X2NPosaconazole
(DB01263)		Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.LANOSTEROL 14-ALPHA DEMETHYLASE
(Saccharomyces cerevisiae (strain yjm789))		p450
5d0s 3BVCarfilzomib
(DB08889)		Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.PROTEASOME SUBUNIT BETA TYPE-2;
PROTEASOME SUBUNIT BETA TYPE-3
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		Pr_beta_C
Proteasome
5d0s 3BVCarfilzomib
(DB08889)		Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.PROTEASOME SUBUNIT BETA TYPE-5;
PROTEASOME SUBUNIT BETA TYPE-6
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		Proteasome
5d0s 3BVCarfilzomib
(DB08889)		Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.PROTEASOME SUBUNIT BETA TYPE-1;
PROTEASOME SUBUNIT BETA TYPE-2
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		Pr_beta_C
5esg 1YNItraconazole
(DB01167)		Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.LANOSTEROL 14-ALPHA DEMETHYLASE
(Saccharomyces cerevisiae (strain yjm789))		p450
5esm TPFFluconazole
(DB00196)		Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis.LANOSTEROL 14-ALPHA DEMETHYLASE
(Saccharomyces cerevisiae (strain yjm789))		p450
5hs1 VORVoriconazole
(DB00582)		Voriconazole is a triazole compound used to treat fungal infections.LANOSTEROL 14-ALPHA DEMETHYLASE
(Saccharomyces cerevisiae)		p450
5l5e 3BVCarfilzomib
(DB08889)		Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;
PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5
(Saccharomyces cerevisiae (strain atcc 204508 / s288c);
homo sapiens;
saccharomyces cerevisiae)		Proteasome
5l5f BO2Bortezomib
(DB00188)		Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;
PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5
(Saccharomyces cerevisiae (strain atcc 204508 / s288c);
homo sapiens;
saccharomyces cerevisiae)		Proteasome
5l5y 3BVCarfilzomib
(DB08889)		Carfilzomib is a proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;
PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6
(Homo sapiens;
saccharomyces cerevisiae (strain atcc 204508 / s288c);
saccharomyces cerevisiae)		Proteasome
5l5z BO2Bortezomib
(DB00188)		Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;
PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6
(Homo sapiens;
saccharomyces cerevisiae (strain atcc 204508 / s288c);
saccharomyces cerevisiae)		Proteasome
5w3j TA1Paclitaxel
(DB01229)		Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.TUBULIN BETA CHAIN
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		Tubulin
Tubulin_C
5ys0 ERGErgosterol
(DB04038)		A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...MEMBRANE-ANCHORED LIPID-BINDING PROTEIN YSP2
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		VASt
6cay ERGErgosterol
(DB04038)		A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...STEROL-BINDING PROTEIN
(Saccharomyces cerevisiae)		VASt
6l0b URFFluorouracil
(DB00544)		Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.DIHYDROOROTASE
(Saccharomyces cerevisiae)		NA
6r4l ERGErgosterol
(DB04038)		A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1-RELATED PROTEIN 1
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		NPC1_N
Patched
6r4n ERGErgosterol
(DB04038)		A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...PHOSPHATIDYLGLYCEROL/PHOSPHATIDYLINOSITOL TRANSFER PROTEIN
(Saccharomyces cerevisiae (strain atcc 204508 / s288c))		E1_DerP2_DerF2
6xjs V6ASelinexor
(DB11942)		Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. It is currently approved for the treatment of multiple myeloma, a cancer which forms from antibody-producing plasma cells.[L7117,L7120] This...EXPORTIN-1
(Homo sapiens;
saccharomyces cerevisiae)		CRM1_C
CRM1_repeat
CRM1_repeat_2
CRM1_repeat_3
IBN_N
Xpo1
7brn ALEEpinephrine
(DB00668)		Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.AUTOPHAGY-RELATED PROTEIN 40,AUTOPHAGY-RELATED PROTEIN 8
(Saccharomyces cerevisiae s288c)		ATG8
PDB Ligand Drug Indication Macromolecule/
Organism		 Pfam Binding_Interfaces (View) Details