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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1ffy | MRC | Mupirocin (DB00410) | Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. | ISOLEUCYL-TRNA SYNTHETASE (Staphylococcus aureus;synthetic construct) | Anticodon_1tRNA-synt_1zf-FPG_IleRS | ||
| 1jt6 | DEQ | Dequalinium (DB04209) | Dequalinium is a quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis. | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1jtx | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1kny | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | KANAMYCIN NUCLEOTIDYLTRANSFERASE (Staphylococcus aureus) | KNTase_C | ||
| 1qvt | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1rkw | PNT | Pentamidine (DB00738) | Pentamidine is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. | TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 2olv | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | PENICILLIN-BINDING PROTEIN 2 (Staphylococcus aureus) | TransglyTranspeptidase | ||
| 2w9h | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Staphylococcus aureus) | DHFR_1 | ||
| 2w9s | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003 (Staphylococcus aureus) | DHFR_1 | ||
| 2z2p | DOL | Dalfopristin (DB01764) | Dalfopristin is an antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes. | VIRGINIAMYCIN B LYASE (Staphylococcus aureus;synthetic construct) | NA | ||
| 3bti | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | HTH-TYPE TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 3hzs | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | MONOFUNCTIONAL GLYCOSYLTRANSFERASE (Staphylococcus aureus subsp. aureus) | Transgly | ||
| 3v1h | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Staphylococcus aureus subsp. aureus) | PI-PLC-X | ||
| 3zfz | 1W8 | Ceftaroline fosamil (DB06590) | Ceftaroline fosamil is an antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. | PENICILLIN BINDING PROTEIN 2 PRIME (Staphylococcus aureus subsp. aureus mu50) | PBP_dimerTranspeptidase | ||
| 4ali | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] (Staphylococcus aureus) | adh_short_C2 | ||
| 4dki | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | PENICILLIN-BINDING PROTEIN 2' (Staphylococcus aureus) | MecA_NPBP_dimerTranspeptidase | ||
| 4em0 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4em2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4urn | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA TOPOISOMERASE IV, B SUBUNIT (Staphylococcus aureus) | NA | ||
| 4uro | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | DNA GYRASE SUBUNIT B (Staphylococcus aureus) | HATPase_c | ||
| 5iqb | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iqd | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iqe | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5txi | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | PENICILLIN BINDING PROTEIN 4 (Staphylococcus aureus) | DUF1958Peptidase_S11 | ||
| 5ty2 | NFF | Nafcillin (DB00607) | Nafcillin is a penicillin derivative antibiotic used to treat susceptible staphylococcal infections. | PENICILLIN-BINDING PROTEIN 4 (Staphylococcus aureus (strain col)) | DUF1958Peptidase_S11 | ||
| 5znj | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLINE--TRNA LIGASE (Staphylococcus aureus) | NA | ||
| 6cav | 84D | Dibekacin (DB13270) | Dibekacin is an aminoglycoside antibiotic marketed in Japan . | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 6cgd | AKN | Amikacin (DB00479) | Amikacin is an aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 6un8 | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE (Staphylococcus aureus) | KNTase_C | ||
| 7d8j | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | SINGLE-STRANDED DNA-BINDING PROTEIN (Staphylococcus aureus (strain ed98)) | SSB | ||
| 7jm2 | AM2 | Apramycin (DB04626) | Apramycin is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals. | AMINOCYCLITOL ACETYLTRANSFERASE APMA (Staphylococcus aureus) | NA | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |