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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1acj | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1gpk | HUP | Huperzine a (DB04864) | Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of... | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1mx1 | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | LIVER CARBOXYLESTERASE I (Homo sapiens) | COesterase | ||
| 1tbf | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1u65 | CP0 | Irinotecan (DB00762) | Irinotecan is an antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1w6r | GNT | Galantamine (DB00674) | Galantamine is a cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1xmu | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoq | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 1xos | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xot | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoz | CIA | Tadalafil (DB00820) | Tadalafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xp0 | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 2ace | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 2ack | EDR | Edrophonium (DB01010) | Edrophonium is a cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 2dqy | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | LIVER CARBOXYLESTERASE 1 (Homo sapiens) | COesterase | ||
| 2ha2 | SCK | Succinylcholine (DB00202) | Succinylcholine is a depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2ha4 | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2wey | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 2xud | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 3ea2 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Bacillus thuringiensis) | PI-PLC-X | ||
| 3iak | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 3jwq | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA (Homo sapiens) | PDEase_I | ||
| 3tvx | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (Homo sapiens) | PDEase_I | ||
| 3v1h | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Staphylococcus aureus subsp. aureus) | PI-PLC-X | ||
| 4bds | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4ey5 | HUP | Huperzine a (DB04864) | Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of... | ACETYLCHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4ey6 | GNT | Galantamine (DB00674) | Galantamine is a cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. | ACETYLCHOLINESTERASE (Homo sapiens) | COesterase | ||
| 5e4j | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 5ov9 | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 6ap6 | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia hybrida) | Abhydrolase_6 | ||
| 6ep4 | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 6eqp | BUW | Profenamine (DB00392) | Profenamine is an antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 6iey | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | ESTERASE (Uncultured bacterium) | Abhydrolase_3 | ||
| 6l6e | E6L | Avanafil (DB06237) | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 6tuz | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM (Homo sapiens) | PAE | ||
| 6tv4 | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM (Homo sapiens) | PAE | ||
| 7cbq | A9L | Apremilast (DB05676) | Apremilast is a non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA (Bos taurus) | GAFPDEase_I | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA (Bos taurus) | GAFPDEase_I | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |