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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1cet | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | PROTEIN (L-LACTATE DEHYDROGENASE) (Plasmodium falciparum) | Ldh_1_CLdh_1_N | ||
| 1j3j | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium falciparum) | DHFR_1 | ||
| 1tv5 | A26 | Teriflunomide (DB08880) | Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. | DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum) | DHO_dh | ||
| 2vn1 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | 70 KDA PEPTIDYLPROLYL ISOMERASE (Plasmodium falciparum) | FKBP_C | ||
| 2y8d | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | ERYTHROCYTE MEMBRANE PROTEIN 1 (Plasmodium falciparum) | Duffy_binding | ||
| 3am5 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-ACP REDUCTASE (Plasmodium falciparum) | adh_short_C2 | ||
| 4fgz | CQA | Amodiaquine (DB00613) | Amodiaquine is an antimalarial drug. | PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE (Plasmodium falciparum) | Methyltransf_25 | ||
| 4n0z | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | GLUTAREDOXIN (Plasmodium falciparum) | Glutaredoxin | ||
| 4qt3 | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE (Plasmodium falciparum 3d7) | FKBP_C | ||
| 4ydq | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLINE--TRNA LIGASE (Plasmodium falciparum) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 4zcs | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE (Plasmodium falciparum (isolate 3d7)) | CTP_transf_like | ||
| 5ifu | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | PROLINE--TRNA LIGASE (Plasmodium falciparum (isolate 3d7)) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5znc | QI9 | Quinine (DB00468) | Quinine is an alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | PURINE NUCLEOSIDE PHOSPHORYLASE (Plasmodium falciparum) | PNP_UDP_1 | ||
| 5zni | YMZ | Mefloquine (DB00358) | Mefloquine is an antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. | PURINE NUCLEOSIDE PHOSPHORYLASE (Plasmodium falciparum) | PNP_UDP_1 | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |