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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1dvt | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1dvx | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1f86 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | TRANSTHYRETIN THR119MET VARIANT (Homo sapiens) | Transthyretin | ||
| 1ie4 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | TRANSTHYRETIN (Rattus norvegicus) | Transthyretin | ||
| 1sn0 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | TRANSTHYRETIN (Sparus aurata) | Transthyretin | ||
| 1sn5 | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | TRANSTHYRETIN (Sparus aurata) | Transthyretin | ||
| 1tlm | MIL | Milrinone (DB00235) | Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1tt6 | DES | Diethylstilbestrol (DB00255) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report... | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 1tyr | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 3ozl | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4d7b | TCW | Tolcapone (DB00323) | Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4his | 3MI | Tafamidis (DB11644) | Tafamidis is a medication used to treat transthyretin-mediated amyloidosis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4ik6 | LUR | Lumiracoxib (DB01283) | Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in... | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4iki | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4ikk | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 4pwj | 30Z | Masoprocol (DB00179) | A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in... | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 5boj | 4TX | Gemfibrozil (DB01241) | Gemfibrozil is a lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| 6e78 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | TRANSTHYRETIN (Homo sapiens) | Transthyretin | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |