(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1c6y | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | PROTEIN (PROTEASE) (Human immunodeficiency virus 1) | RVP | ||
| 1c6z | ROC | Saquinavir (DB01232) | Saquinavir is an HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | PROTEIN (PROTEASE) (Human immunodeficiency virus 1) | RVP | ||
| 1hsh | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | HIV-II PROTEASE (Human immunodeficiency virus 2) | RVP | ||
| 1rl8 | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | PROTEASE RETROPEPSIN (Human immunodeficiency virus 1) | RVP | ||
| 1sdv | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | PROTEASE RETROPEPSIN (Human immunodeficiency virus 1) | RVP | ||
| 2b7z | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 2hs1 | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 2idw | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 2nmz | ROC | Saquinavir (DB01232) | Saquinavir is an HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 2r5p | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 2r5q | 1UN | Nelfinavir (DB00220) | Nelfinavir is a viral protease inhibitor used in the treatment of HIV infection. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 2rkf | AB1 | Lopinavir (DB01601) | Lopinavir is an HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. | PROTEASE RETROPEPSIN (Human immunodeficiency virus 1) | RVP | ||
| 3d1x | ROC | Saquinavir (DB01232) | Saquinavir is an HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | HIV-1 PROTEASE (Human immunodeficiency virus type 1) | RVP | ||
| 3ebz | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus type 2 (isolate rod)) | RVP | ||
| 3ekp | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | PROTEASE (Hiv-1 m:b_arv2/sf2) | RVP | ||
| 3ekw | DR7 | Atazanavir (DB01072) | Atazanavir is an antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. | PROTEASE (Hiv-1 m:b_arv2/sf2) | RVP | ||
| 3el0 | 1UN | Nelfinavir (DB00220) | Nelfinavir is a viral protease inhibitor used in the treatment of HIV infection. | PROTEASE (Hiv-1 m:b_arv2/sf2) | RVP | ||
| 3el5 | 1UN | Nelfinavir (DB00220) | Nelfinavir is a viral protease inhibitor used in the treatment of HIV infection. | PROTEASE (Hiv-1 m:b_arv2/sf2) | RVP | ||
| 3ggu | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus type 1 (bru isolate)) | RVP | ||
| 3lzu | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 3mws | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 3ndx | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 3nu3 | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 3ogp | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | FIV PROTEASE (Feline immunodeficiency virus) | RVP | ||
| 3ogq | AB1 | Lopinavir (DB01601) | Lopinavir is an HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. | FIV PROTEASE (Feline immunodeficiency virus) | RVP | ||
| 3s45 | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | PROTEASE (Human immunodeficiency virus 2) | RVP | ||
| 3spk | TPV | Tipranavir (DB00932) | Tipranavir is a protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. | HIV-1 PROTEASE (Human immunodeficiency virus type 1) | RVP | ||
| 3sug | SUE | Grazoprevir (DB11575) | Grazoprevir is an antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections. | NS3 PROTEASE, NS4A PROTEIN (Hepatitis c virus) | Peptidase_S29 | ||
| 3sv6 | SV6 | Telaprevir (DB05521) | Telaprevir is an NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. | NS3 PROTEASE, NS4A PROTEIN (Hepatitis c virus) | Peptidase_S29 | ||
| 3t3c | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus type 1) | RVP | ||
| 3tne | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | SECRETED ASPARTIC PROTEASE (Candida parapsilosis) | Asp | ||
| 3ttp | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus type 1) | RVP | ||
| 3ucb | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 3ufn | ROC | Saquinavir (DB01232) | Saquinavir is an HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | HIV-1 PROTEASE (Homo sapiens) | RVP | ||
| 3wsj | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | PROTEASE (Human t-lymphotropic virus 1) | RVP | ||
| 4eyr | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4j5j | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4l1a | AB1 | Lopinavir (DB01601) | Lopinavir is an HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. | MDR769 HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4njt | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4nju | TPV | Tipranavir (DB00932) | Tipranavir is a protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4njv | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4npt | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4q1y | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | ASPARTYL PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4q5m | ROC | Saquinavir (DB01232) | Saquinavir is an HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | PROTEASE (Human immunodeficiency virus type 1) | RVP | ||
| 4rvj | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4yoa | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4ypm | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE (Meiothermus taiwanensis) | Lon_C | ||
| 5t2z | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE (Human immunodeficiency virus 1) | NA | ||
| 6dif | TPV | Tipranavir (DB00932) | Tipranavir is a protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 6dj1 | AB1 | Lopinavir (DB01601) | Lopinavir is an HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. | HIV-1 PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 6hwm | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT (Thermus thermophilus) | CLP_protease | ||
| 6nzt | L9P | Voxilaprevir (DB12026) | Voxilaprevir is a nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. | HCV NS3/4A PROTEASE (Hepatitis c virus) | Peptidase_S29 | ||
| 6opv | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE NL4-3 (Human immunodeficiency virus 1) | RVP | ||
| 6p6l | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 1a (isolate 1)) | Peptidase_S29 | ||
| 6p6s | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 3a (isolate nzl1)) | Peptidase_S29 | ||
| 6p6v | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 5a (isolate sa13)) | Peptidase_S29 | ||
| 6p6z | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 4a (isolate ed43)) | Peptidase_S29 | ||
| 6p9a | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HIV-1 PROTEASE (Human immunodeficiency virus type 1 group m subtype b (isolate bru/lai)) | RVP | ||
| 6p9b | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | HIV-1 PROTEASE (Human immunodeficiency virus type 1 group m subtype b (isolate bru/lai)) | RVP | ||
| 6w6q | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HTLV-1 PROTEASE (Human t-cell leukemia virus type i) | RVP | ||
| 6x27 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE HOMOLOG, MITOCHONDRIAL (Homo sapiens) | NA | ||
| 7krz | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE HOMOLOG, MITOCHONDRIAL (Homo sapiens;escherichia coli bl21(de3)) | AAA | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |