
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
---|---|---|---|---|---|---|---|
3apv | TP0 | Amitriptyline (DB00321) | Amitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
3apw | DP0 | Disopyramide (DB00280) | Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
3apx | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
5j2t | VLB | Vinblastine (DB00570) | Vinblastine is a vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
5jh7 | 6K9 | Eribulin (DB08871) | Eribulin is a microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
5om2 | DXT | Doxycycline (DB00254) | Doxycycline is a tetracycline antibiotic used to treat a wide variety of bacterial infections. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
5om7 | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
6dw0 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 (Rattus norvegicus) | Neur_chan_LBDNeur_chan_memb | ||
6dw1 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 (Rattus norvegicus) | Neur_chan_LBDNeur_chan_memb | ||
6ftp | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
6hgf | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
6hgg | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
6hgk | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
6hgl | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
6huj | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
6huo | 08H | Alprazolam (DB00404) | Alprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
6huo | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
6jp5 | C5U | Nifedipine (DB01115) | Nifedipine is a dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. | VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S (Oryctolagus cuniculus) | CAC1F_CCa_chan_IQGPHHIon_trans | ||
6jpb | C9F | Diltiazem (DB00343) | Diltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable angina. | VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S (Oryctolagus cuniculus) | CAC1F_CCa_chan_IQGPHHIon_trans | ||
6x3t | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
6x3u | FYP | Flumazenil (DB01205) | Flumazenil is a benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
6x3v | V8D | Etomidate (DB00292) | Etomidate is a short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
7ddh | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1;SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1 (Sus scrofa) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPaseNa_K-ATPase | ||
7ddi | F9R | Digitoxin (DB01396) | Digitoxin is a cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1;SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1 (Sus scrofa) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPaseNa_K-ATPase | ||
7ddj | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 (Sus scrofa) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPase | ||
7jpx | 6UB | Levamlodipine (DB09237) | Levamlodipine is a calcium channel blocker used to treat hypertension. | VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S (Oryctolagus cuniculus) | CAC1F_CCa_chan_IQGPHHIon_trans | ||
PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |