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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1m17 | AQ4 | Erlotinib (DB00530) | Erlotinib is an EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1xkk | FMM | Lapatinib (DB01259) | Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4g5j | 0WM | Afatinib (DB08916) | Afatinib is an antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4i22 | IRE | Gefitinib (DB00317) | Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4i24 | 1C9 | Dacomitinib (DB11963) | Dacomitinib is a medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5yu9 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6lud | YY3 | Osimertinib (DB09330) | Osimertinib is a tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 7aem | 6GY | Brigatinib (DB12267) | Brigatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |