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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1fr6 | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | BETA-LACTAMASE (Citrobacter freundii) | Beta-lactamase | ||
| 1i2w | 1QL | Cefoxitin (DB01331) | Cefoxitin is a semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. | BETA-LACTAMASE (Bacillus licheniformis) | Beta-lactamase | ||
| 1vm1 | TAZ | Tazobactam (DB01606) | Tazobactam is a beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. | BETA-LACTAMASE SHV-1 (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 1ymx | 1QL | Cefoxitin (DB01331) | Cefoxitin is a semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. | BETA-LACTAMASE CTX-M-9 (Escherichia coli) | Beta-lactamase2 | ||
| 2zqc | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | BETA-LACTAMASE TOHO-1 (Escherichia coli) | Beta-lactamase2 | ||
| 3huo | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 3m6b | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nbl | DXF | Cefuroxime (DB01112) | Cefuroxime is a cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nck | NFF | Nafcillin (DB00607) | Nafcillin is a penicillin derivative antibiotic used to treat susceptible staphylococcal infections. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nde | 9EP | Cefalotin (DB00456) | Cefalotin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3ny4 | SMX | Cefamandole (DB01326) | Cefamandole is a beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3q07 | WPP | Piperacillin (DB00319) | Piperacillin is a penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 4c1d | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE CLASS B VIM-2 (Pseudomonas aeruginosa) | Lactamase_B | ||
| 4c1f | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE IMP-1 (Serratia marcescens) | NA | ||
| 4c1h | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE 2 (Bacillus cereus) | Lactamase_B | ||
| 4ey2 | 0RM | Meticillin (DB01603) | One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 4eyb | 0WO | Oxacillin (DB00713) | Oxacillin is a penicillin antibiotic used to treat a number of susceptible bacterial infections. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 4eyl | 0RV | Meropenem (DB00760) | Meropenem is a carbapenem antibiotic used to treat a wide variety of infections in the body. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 4fh2 | 0RN | Sulbactam (DB09324) | Sulbactam is an beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. | BETA-LACTAMASE SHV-1 (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 4pm5 | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | BETA-LACTAMASE CTX-M-14 (Klebsiella pneumoniae subsp. pneumoniae) | Beta-lactamase2 | ||
| 4qu3 | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE GES-2 (Pseudomonas aeruginosa) | Beta-lactamase2 | ||
| 4wbg | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | BETA-LACTAMASE (Klebsiella pneumoniae) | Beta-lactamase | ||
| 4x53 | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | CLASS D BETA-LACTAMASE OXA-160 (Acinetobacter baumannii) | Transpeptidase | ||
| 4xux | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | BETA-LACTAMASE (Enterobacter cloacae) | Beta-lactamase | ||
| 4xuz | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | BETA-LACTAMASE (Klebsiella pneumoniae subsp. pneumoniae) | Beta-lactamase2 | ||
| 5a5z | WJZ | Tiopronin (DB06823) | Tiopronin is a thiol agent indicated for the prevention of kidney stone formation in patients with severe homozygous cystinuria. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5axr | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METALLO-BETA-LACTAMASE (Serratia marcescens) | Lactamase_B | ||
| 5aya | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | METALLO-BETA-LACTAMASE (Serratia marcescens) | Lactamase_B | ||
| 5kmw | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | BETA-LACTAMASE TOHO-1 (Escherichia coli) | Beta-lactamase2 | ||
| 5ypi | 8YF | Imipenem (DB01598) | Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. | METALLO-BETA-LACTAMASE NDM-1 (Escherichia coli) | Lactamase_B | ||
| 5zio | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | METALLO-BETA-LACTAMASE TYPE 2 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5zj8 | 9DC | Dimercaprol (DB06782) | Dimercaprol is a chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium. | METALLO-BETA-LACTAMASE TYPE 2 (Klebsiella pneumoniae) | Lactamase_B | ||
| 6b6d | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | BETA-LACTAMASE (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | Beta-lactamase2 | ||
| 6c79 | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | BETA-LACTAMASE TOHO-1 (Escherichia coli) | Beta-lactamase2 | ||
| 6p99 | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Klebsiella pneumoniae) | Transpeptidase | ||
| 6p9c | O6P | Doripenem (DB06211) | Doripenem is an antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections. | BETA-LACTAMASE (Klebsiella pneumoniae) | Transpeptidase | ||
| 6pq8 | J01 | Clavulanic acid (DB00766) | Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 6rzr | 8YF | Imipenem (DB01598) | Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. | BETA-LACTAMASE (Pseudomonas aeruginosa) | NA | ||
| 6skr | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Escherichia coli) | Transpeptidase | ||
| 6td0 | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | CARBAPENEM-HYDROLYZING BETA-LACTAMASE KPC (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 6u10 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | PUTATIVE METALLO-BETA-LACTAMASE L1 (BETA-LACTAMASE TYPE II) (EC 3.5.2.6) (PENICILLINASE) (Stenotrophomonas maltophilia (strain k279a)) | Lactamase_B | ||
| 6unb | TJ7 | Temocillin (DB12343) | Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 6v61 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE (NA) | Lactamase_B | ||
| 6v7h | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 6whf | 9EP | Cefalotin (DB00456) | Cefalotin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase | ||
| 7kep | FYG | Avibactam (DB09060) | Avibactam is a non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia. | BETA-LACTAMASE (Clostridioides difficile) | Transpeptidase | ||
| 7lnl | 8YF | Imipenem (DB01598) | Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. | CARBAPENEM-HYDROLYZING BETA-LACTAMASE KPC (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |