LIST OF BINDING INTERFACES for query 'Trypanosoma cruzi' in category 'SOURCE ORGANISM'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
1i0l	7HP	Allopurinol (DB00437)	Allopurinol is a xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (Trypanosoma cruzi)	Pribosyltran	1I0L_A_7HPA800	Details
1yhl	RIS	Risedronic acid (DB00884)	Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease.	FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma cruzi)	polyprenyl_synt	1YHL_A_RISA1400	Details
2e6f	OXC	Oteracil (DB03209)	Oteracil is a chemotherapy agent used in combination with tegafur, cisplatin and gimeracil to treat advanced gastric cancer.	DIHYDROOROTATE DEHYDROGENASE (Trypanosoma cruzi)	DHO_dh	2E6F_A_OXCA1352	Details
2wx2	TPF	Fluconazole (DB00196)	Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis.	LANOSTEROL 14-ALPHA-DEMETHYLASE (Trypanosoma cruzi)	p450	2WX2_A_TPFA1460	Details
3clb	TMQ	Trimetrexate (DB01157)	Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.	DHFR-TS (Trypanosoma cruzi)	DHFR_1 Thymidylat_synt	3CLB_A_TMQA611	Details
3dmt	CCS	Carbocisteine (DB04339)	Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL (Trypanosoma cruzi)	Gp_dh_C Gp_dh_N	3DMT_C_CCSC166	Details
3iba	ZOL	Zoledronic acid (DB00399)	Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.	FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma cruzi)	polyprenyl_synt	3IBA_A_ZOLA901	Details
6sf9	CFF	Caffeine (DB00201)	Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.	FARNESYL DIPHOSPHATE SYNTHASE (Trypanosoma cruzi)	polyprenyl_synt	6SF9_A_CFFA402	Details
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["1i0l","7HP","Allopurinol (DB00437)","Trypanosoma cruzi","HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE","Pribosyltran"],["1yhl","RIS","Risedronic acid (DB00884)","Trypanosoma cruzi","FARNESYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt"],["2e6f","OXC","Oteracil (DB03209)","Trypanosoma cruzi","DIHYDROOROTATE DEHYDROGENASE","DHO_dh"],["2wx2","TPF","Fluconazole (DB00196)","Trypanosoma cruzi","LANOSTEROL 14-ALPHA-DEMETHYLASE","p450"],["3clb","TMQ","Trimetrexate (DB01157)","Trypanosoma cruzi","DHFR-TS","DHFR_1;Thymidylat_synt"],["3dmt","CCS","Carbocisteine (DB04339)","Trypanosoma cruzi","GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL","Gp_dh_C;Gp_dh_N"],["3iba","ZOL","Zoledronic acid (DB00399)","Trypanosoma cruzi","FARNESYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt"],["6sf9","CFF","Caffeine (DB00201)","Trypanosoma cruzi","FARNESYL DIPHOSPHATE SYNTHASE","polyprenyl_synt"]]