Results: Keyword

LIST OF BINDING INTERFACES for query 'Thermus thermophilus' in category 'SOURCE ORGANISM'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
1jzs	MRC	Mupirocin (DB00410)	Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes.	ISOLEUCYL-TRNA SYNTHETASE (Thermus thermophilus)	tRNA-synt_1	1JZS_A_MRCA1301
1kij	NOV	Novobiocin (DB01051)	Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,...	DNA GYRASE SUBUNIT B (Thermus thermophilus)	DNA_gyraseB HATPase_c	1KIJ_A_NOVA400
2a68	RBT	Rifabutin (DB00615)	Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV.	DNA-DIRECTED RNA POLYMERASE BETA CHAIN; RNA POLYMERASE SIGMA FACTOR RPOD (Thermus thermophilus)	RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_3 RNA_pol_Rpb2_45 RNA_pol_Rpb2_6 RNA_pol_Rpb2_7 Sigma70_r1_2 Sigma70_r2 Sigma70_r3 Sigma70_r4	2A68_C_RBTC8001
2a69	RPT	Rifapentine (DB01201)	Rifapentine is an antibiotic agent used in the treatment of pulmonary tuberculosis.	DNA-DIRECTED RNA POLYMERASE BETA CHAIN; RNA POLYMERASE SIGMA FACTOR RPOD (Thermus thermophilus)	RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_3 RNA_pol_Rpb2_45 RNA_pol_Rpb2_6 RNA_pol_Rpb2_7 Sigma70_r1_2 Sigma70_r2 Sigma70_r3 Sigma70_r4	2A69_C_RPTC8001
2dza	PAB	Aminobenzoic acid (DB02362)	Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults.	DIHYDROPTEROATE SYNTHASE (Thermus thermophilus)	Pterin_bind	2DZA_B_PABB1301
2ej3	GBN	Gabapentin (DB00996)	Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.	BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE (Thermus thermophilus)	Aminotran_4	2EJ3_A_GBNA2414
2wyw	TCL	Triclosan (DB08604)	Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.	ENOYL-[ACYL CARRIER PROTEIN] REDUCTASE (Thermus thermophilus)	adh_short_C2	2WYW_A_TCLA1261
3teh	DAH	Levodopa (DB01235)	Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	Phe_tRNA-synt_N tRNA-synt_2d	3TEH_A_DAHA351 3TEH_B_DAHB786
3teh	DAH	Levodopa (DB01235)	Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.	PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (Thermus thermophilus)	B3_4 B5 FDX-ACB tRNA_bind tRNA_synthFbeta	3TEH_A_DAHA351 3TEH_B_DAHB786
3zof	HQE	Hydroquinone (DB09526)	Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles.	FLAVOREDOXIN (Thermus thermophilus)	Flavin_Reduct	3ZOF_A_HQEA200
4odo	FK5	Tacrolimus (DB00864)	Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD (Thermus thermophilus)	FKBP_C	4ODO_A_FK5A205
4odr	FK5	Tacrolimus (DB00864)	Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA (Thermus thermophilus; homo sapiens)	FKBP_C	4ODR_A_FK5A201
4oir	RFV	Rifamycin (DB11753)	Rifamycin is an antibacterial used to treat traveler's diarrhea.	DNA DIRECTED RNA POLYMERASE SIGMA FACTOR A; DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Thermus thermophilus; synthetic construct)	RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_3 RNA_pol_Rpb2_45 RNA_pol_Rpb2_6 RNA_pol_Rpb2_7 Sigma70_r1_2 Sigma70_r2 Sigma70_r3 Sigma70_r4	4OIR_C_RFVC1201
6hwm	BO2	Bortezomib (DB00188)	Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.	ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT (Thermus thermophilus)	CLP_protease	6HWM_A_BO2A301
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["1jzs","MRC","Mupirocin (DB00410)","Thermus thermophilus","ISOLEUCYL-TRNA SYNTHETASE","tRNA-synt_1"],["1kij","NOV","Novobiocin (DB01051)","Thermus thermophilus","DNA GYRASE SUBUNIT B","DNA_gyraseB;HATPase_c"],["2a68","RBT","Rifabutin (DB00615)","Thermus thermophilus","DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD","RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_45;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7;Sigma70_r1_2;Sigma70_r2;Sigma70_r3;Sigma70_r4"],["2a69","RPT","Rifapentine (DB01201)","Thermus thermophilus","DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD","RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_45;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7;Sigma70_r1_2;Sigma70_r2;Sigma70_r3;Sigma70_r4"],["2dza","PAB","Aminobenzoic acid (DB02362)","Thermus thermophilus","DIHYDROPTEROATE SYNTHASE","Pterin_bind"],["2ej3","GBN","Gabapentin (DB00996)","Thermus thermophilus","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","Aminotran_4"],["2wyw","TCL","Triclosan (DB08604)","Thermus thermophilus","ENOYL-[ACYL CARRIER PROTEIN] REDUCTASE","adh_short_C2"],["3teh","DAH","Levodopa (DB01235)","Thermus thermophilus","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Phe_tRNA-synt_N;tRNA-synt_2d"],["3teh","DAH","Levodopa (DB01235)","Thermus thermophilus","PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN","B3_4;B5;FDX-ACB;tRNA_bind;tRNA_synthFbeta"],["3zof","HQE","Hydroquinone (DB09526)","Thermus thermophilus","FLAVOREDOXIN","Flavin_Reduct"],["4odo","FK5","Tacrolimus (DB00864)","Thermus thermophilus","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD","FKBP_C"],["4odr","FK5","Tacrolimus (DB00864)","Thermus thermophilus;homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA","FKBP_C"],["4oir","RFV","Rifamycin (DB11753)","Thermus thermophilus;synthetic construct","DNA DIRECTED RNA POLYMERASE SIGMA FACTOR A;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_45;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7;Sigma70_r1_2;Sigma70_r2;Sigma70_r3;Sigma70_r4"],["6hwm","BO2","Bortezomib (DB00188)","Thermus thermophilus","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT","CLP_protease"]]