
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
---|---|---|---|---|---|---|---|
5tl8 | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | PROTEIN CYP51 (Naegleria fowleri) | p450 | ||
6ay4 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri) | p450 | ||
6ay6 | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri) | p450 | ||
6ayb | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri) | p450 | ||
6ayc | 1YN | Itraconazole (DB01167) | Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. | PROTEIN CYP51 (Naegleria fowleri) | p450 | ||
6mke | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYLPROLYL ISOMERASE (Naegleria fowleri) | FKBP_C | ||
6uyh | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE (Naegleria fowleri) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |