LIST OF BINDING INTERFACES for query 'Naegleria fowleri' in category 'SOURCE ORGANISM'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
5tl8	X2N	Posaconazole (DB01263)	Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.	PROTEIN CYP51 (Naegleria fowleri)	p450	5TL8_A_X2NA502	Details
6ay4	TPF	Fluconazole (DB00196)	Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis.	CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri)	p450	6AY4_A_TPFA506	Details
6ay6	VOR	Voriconazole (DB00582)	Voriconazole is a triazole compound used to treat fungal infections.	CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri)	p450	6AY6_A_VORA501	Details
6ayb	KKK	Ketoconazole (DB01026)	Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.	CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri)	p450	6AYB_A_KKKA508	Details
6ayc	1YN	Itraconazole (DB01167)	Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.	PROTEIN CYP51 (Naegleria fowleri)	p450	6AYC_A_1YNA502	Details
6mke	FK5	Tacrolimus (DB00864)	Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.	PEPTIDYLPROLYL ISOMERASE (Naegleria fowleri)	FKBP_C	6MKE_A_FK5A201	Details
6uyh	HFG	Halofuginone (DB04866)	Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis...	PROLYL-TRNA SYNTHETASE (Naegleria fowleri)	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	6UYH_A_HFGA602	Details
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["5tl8","X2N","Posaconazole (DB01263)","Naegleria fowleri","PROTEIN CYP51","p450"],["6ay4","TPF","Fluconazole (DB00196)","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","p450"],["6ay6","VOR","Voriconazole (DB00582)","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","p450"],["6ayb","KKK","Ketoconazole (DB01026)","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","p450"],["6ayc","1YN","Itraconazole (DB01167)","Naegleria fowleri","PROTEIN CYP51","p450"],["6mke","FK5","Tacrolimus (DB00864)","Naegleria fowleri","PEPTIDYLPROLYL ISOMERASE","FKBP_C"],["6uyh","HFG","Halofuginone (DB04866)","Naegleria fowleri","PROLYL-TRNA SYNTHETASE","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b"]]