(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 4dtz | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | CYTOCHROME P450 BM3 VARIANT 8C8 (Bacillus megaterium) | p450 | ||
| 4o4p | 1C6 | Omeprazole (DB00338) | Omeprazole is a proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. | BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 4p6s | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | TYROSINASE (Bacillus megaterium) | Tyrosinase | ||
| 4zf8 | MYT | Metyrapone (DB01011) | Metyrapone is a steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. | BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 5i3a | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | TYROSINASE (Bacillus megaterium) | Tyrosinase | ||
| 5l94 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | CYTOCHROME P450 (Bacillus megaterium (strain dsm 319)) | p450 | ||
| 6h1l | FJQ | Tioconazole (DB01007) | Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1o | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1s | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1t | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6ly4 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium (strain atcc 14581 / dsm 32 / jcm 2506 / nbrc 15308 / ncimb 9376 / nctc 10342 / vkm b-512)) | p450 | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |