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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1tbf | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xmu | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoq | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 1xos | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xot | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoz | CIA | Tadalafil (DB00820) | Tadalafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xp0 | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 2wey | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 3ea2 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Bacillus thuringiensis) | PI-PLC-X | ||
| 3iak | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 3jwq | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA (Homo sapiens) | PDEase_I | ||
| 3tvx | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (Homo sapiens) | PDEase_I | ||
| 3v1h | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Staphylococcus aureus subsp. aureus) | PI-PLC-X | ||
| 6l6e | E6L | Avanafil (DB06237) | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 7cbq | A9L | Apremilast (DB05676) | Apremilast is a non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA (Bos taurus) | GAFPDEase_I | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA (Bos taurus) | GAFPDEase_I | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |