LIST OF BINDING INTERFACES for query 'Trypanosoma brucei' in category 'SOURCE ORGANISM'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
2wv2	TPF	Fluconazole (DB00196)	Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis.	LANOSTEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei)	p450	2WV2_A_TPFA1	Details
2x2n	X2N	Posaconazole (DB01263)	Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.	LANOSTEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei)	p450	2X2N_A_X2NA1480	Details
2x9v	TMQ	Trimetrexate (DB01157)	Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.	PTERIDINE REDUCTASE (Trypanosoma brucei brucei)	adh_short_C2	2X9V_A_TMQA1270	Details
3jq7	DX2	Triamterene (DB00384)	Triamterene is a potassium-sparing diuretic used in the treatment of edema and in the management of hypertension.	PTERIDINE REDUCTASE 1 (Trypanosoma brucei)	adh_short_C2	3JQ7_A_DX2A271	Details
3jqa	DX4	Tioguanine (DB00352)	Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias.	PTERIDINE REDUCTASE 1 (Trypanosoma brucei)	adh_short_C2	3JQA_A_DX4A270	Details
3qfx	CP6	Pyrimethamine (DB00205)	Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Trypanosoma brucei rhodesiense)	DHFR_1	3QFX_A_CP6A602	Details
4rxd	RIS	Risedronic acid (DB00884)	Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease.	FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma brucei)	polyprenyl_synt	4RXD_A_RISA1404	Details
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["2wv2","TPF","Fluconazole (DB00196)","Trypanosoma brucei","LANOSTEROL 14-ALPHA-DEMETHYLASE","p450"],["2x2n","X2N","Posaconazole (DB01263)","Trypanosoma brucei","LANOSTEROL 14-ALPHA-DEMETHYLASE","p450"],["2x9v","TMQ","Trimetrexate (DB01157)","Trypanosoma brucei brucei","PTERIDINE REDUCTASE","adh_short_C2"],["3jq7","DX2","Triamterene (DB00384)","Trypanosoma brucei","PTERIDINE REDUCTASE 1","adh_short_C2"],["3jqa","DX4","Tioguanine (DB00352)","Trypanosoma brucei","PTERIDINE REDUCTASE 1","adh_short_C2"],["3qfx","CP6","Pyrimethamine (DB00205)","Trypanosoma brucei rhodesiense","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1"],["4rxd","RIS","Risedronic acid (DB00884)","Trypanosoma brucei","FARNESYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt"]]