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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 3c7q | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3wzd | LEV | Lenvatinib (DB09078) | Lenvatinib is a receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3wze | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4ag8 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4agd | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |